Including Bioactive Coating Patents (Class 623/23.57)
  • Patent number: 7014661
    Abstract: A transcutaneous prosthesis is disclosed comprising a first component (1) shaped for implantation into a bone (2), a second component (4) intended for location between the bone (2) and the skin, and a third component (5) intended for location exterior to the skin surface, having a low surface energy which deters bacterial adhesion. The second component (4) may carry an adhesion-promoting protein.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: March 21, 2006
    Assignee: University College London
    Inventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
  • Patent number: 7015206
    Abstract: The invention concerns the use of a polysaccharide excreted by the Vibrio diabolicus species for making a medicine with cicatrising activity, in particular bone repair activity. The invention also concerns a bone reconstruction biomaterial comprising said polysaccharide and a bone endoprosthesis whereof the surface is coated with such a polysaccharide.
    Type: Grant
    Filed: July 4, 2001
    Date of Patent: March 21, 2006
    Assignee: Institut Francais de le Recherche pour l'Exploitation de la Mer
    Inventors: Jean Guezennec, Philippe Zanchetta
  • Patent number: 7004975
    Abstract: Joint endoprostheses are provides which respectively have a joint part with a metallic core, wherein the metallic core is coated, in regions that roll and/or slide on another joint part during execution of the joint function, with a glass-ceramic composite mixture. In one embodiment, the glass-ceramic has the following composition with approximate amounts in wt. %: Component Amount (wt %) SiO2 45–50% Al2O3 15–20% ZrO2 ?8–12% K2O 0–8% Na2O ??0–7.5% CaO ??0–2.5% TiO2 ??0–1.5% and furthermore a residual amount of up to about 12.5% of MnO2 and/or Fe2O3 and/or Co2O3.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: February 28, 2006
    Assignee: ESKA Implants GmbH & Co.
    Inventor: Hans Grundei
  • Patent number: 6926919
    Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include blends of hydrophilic and hydrophobic polymers. The methods provide for treatment of the coatings to cause enrichment a region close to the outer surface of the coating with the hydrophilic polymers.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: August 9, 2005
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Yiwen Tang, Andrew C. Tung, Stephen D. Pacetti
  • Patent number: 6863693
    Abstract: A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: March 8, 2005
    Assignees: Destiny Pharma Limited, University of Brighton
    Inventors: Andrew W. Lloyd, Matteo Santin, Stephen P. Denyer, William Rhys-Williams, William G. Love
  • Publication number: 20040249471
    Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises at least one structural member combined with at least one flexible planar member to retain the at least one structural member to form the implant.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 9, 2004
    Inventors: James J. Bindseil, William F. McKay, Cary R. Reeves, T. Andrew Simonton, Eddie F. Ray
  • Publication number: 20040249472
    Abstract: A method including forming a first coating layer derived from an alkoxide on a substrate having a dimension suitable for an implant and forming a second coating layer on the first coating layer that promotes osseointegration. An apparatus comprising a substrate having a dimension suitable as a medical or dental implant and a coating on a surface of a first coating layer derived from an alkoxide and a second coating layer that promotes osseointegration.
    Type: Application
    Filed: June 4, 2003
    Publication date: December 9, 2004
    Inventors: Jiankai Liu, Yuhong Huang, Ichiro Nishimura
  • Publication number: 20040249463
    Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of bone pieces formed into at least one load bearing layer.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 9, 2004
    Inventors: James J. Bindseil, T. Andrew Simonton, Cary R. Reeves, William F. McKay, Eddie F. Ray
  • Patent number: 6827743
    Abstract: The present invention relates to orthopedic implants made from a mesh material. The mesh material can be treated in order to promote bone growth, to provide antibiotics, or to provide other beneficial treatment. Specific applications for the implants include, for example, a prosthetic ligament, a tension band, an interbody device, or a fixation device that extends across one or more joints or fractures.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: December 7, 2004
    Assignee: SDGI Holdings, Inc.
    Inventors: Lukas Eisermann, Eddie F. Ray, III
  • Publication number: 20040167633
    Abstract: The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also provides a metallic orthopaedic implant comprising a metallic body and metallic elements adhered to a portion of the surface of the metallic body to define a three-dimensional porous surface geometry, wherein at least some of the metallic elements have a micron or nanometer-scale surface roughness.
    Type: Application
    Filed: February 2, 2004
    Publication date: August 26, 2004
    Applicant: DePuy Products, Inc.
    Inventors: Hai Bo Wen, Panjian Li, Todd Smith
  • Publication number: 20040158330
    Abstract: The invention relates to a metallic implant, which has vitreous-crystalline bioactive material on the surface thereof. According to the invention, a metallic implant base body arranged on the surface of the particles has a bioactive, vitreous-crystalline material consisting of 15-45 wt. % CaO, 40-45 wt. % P2O5, 10-40 wt. % ZrO2 and 0.7-3.5 wt. % fluoride, having apatite and calcium zirconium phosphate as main crystalline and a glass phase as an auxiliary component. Said vitreous crystalline material contains at least 35 wt. % main crystal phases and at least 5-15 wt. % auxiliary compounds. All of the percentage data is expressed in relation to the total weight of the vitreous crystalline material and the particle size of the vitreous crystalline material is between 60-350 &mgr;m.
    Type: Application
    Filed: December 15, 2003
    Publication date: August 12, 2004
    Inventors: Wolf-Dieter Mller, Georg Berger
  • Publication number: 20040153165
    Abstract: The invention provides an implantable article, a method of preparing the same, and methods of modifying a ceramic-coated implantable article. The implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon with a composition comprising (i) a biological agent, (ii) calcium ions, (iii) phosphate ions, and (iv) a liquid carrier.
    Type: Application
    Filed: January 31, 2003
    Publication date: August 5, 2004
    Applicant: DePuy Products, Inc.
    Inventors: Panjian Li, Hai Bo Wen, Elizabeth A. Hippensteel
  • Publication number: 20040148031
    Abstract: The surface of a device that is surgically implantable in living bone is prepared. The device is made of titanium with a native oxide layer on the surface. The method of preparation comprises the steps of removing the native oxide layer from the surface of the device and performing further treatment of the surface substantially in the absence of unreacted oxygen.
    Type: Application
    Filed: November 5, 2003
    Publication date: July 29, 2004
    Inventor: Keith D. Beaty
  • Patent number: 6749639
    Abstract: A prosthesis for implanting into a bone having a cavity is disclosed. The prosthesis comprises a body and a stem. A first coating including a bone ingrowth promoting material that promotes ingrowth of bone onto the stem and a bioabsorbable material that delays the ingrowth of bone onto the stem is disposed on a proximal portion of the stem outer surface. A second coating including the bone ingrowth promoting material and the bioabsorbable material is disposed on a distal portion of the stem outer surface. The ratio of bone ingrowth promoting material to bioabsorbable material in the first coating is greater than the ratio of bone ingrowth promoting material to bioabsorbable material in the second coating whereby the affixation of the bone to the proximal zone of the stem is faster and stronger over time than the affixation of the bone to the distal zone of the stem.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: June 15, 2004
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: David G. Lewallen
  • Publication number: 20040109937
    Abstract: The invention relates to a method for producing bioactive implant surfaces consisting of metallic or ceramic materials, to be used for implants such as artificial joints or very small implants such as so-called stents. The invention also relates to implants produced according to this method.
    Type: Application
    Filed: August 15, 2003
    Publication date: June 10, 2004
    Inventors: Herbert P. Jennissen, Maria Chatzinikolaidou, Heike Rumpf
  • Publication number: 20040106994
    Abstract: The method comprises the ion implantation of controlled quantities of elements such as CO, C or O in endo-osseous implants or prostheses manufactured in metals, metallic alloys or biocompatible compound materials. This surface treatment originates some modifications in the characteristics of the surface of the endo-osseous implants or prostheses which increases significantly their degree of osseointegration.
    Type: Application
    Filed: October 14, 2003
    Publication date: June 3, 2004
    Inventors: Miguel Angel De Maeztus Martinez, Jose Inaki Alava Marquinez, Alberto Luis Garcia, Inigo Braceras Izaguirre, Jose Ignacio Onate De La Presa
  • Patent number: 6736849
    Abstract: A spinal implant is provided to integrate with and support vertebrae in a vertebral column. The spinal implant includes a body and a mineralized, bioactive surface coating chemically bonded to a portion of the body. The coating includes a non-hydroxyl containing carbonated calcium phosphate bone mineral nano-crystalline apatite with chemically adsorbed water having a crystal size less than about 1 &mgr;m. The body of the spinal implant is ring-shaped and defines a central passageway.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: May 18, 2004
    Assignee: DePuy Products, Inc.
    Inventors: Panjian Li, Todd Smith
  • Patent number: 6730129
    Abstract: An implant for application in bone, especially jaw bone, is provided. The implant includes a unit that can be applied in the bone, and which is made of a biocompatible material such as titanium. The unit is provided with one or more coatings including calcium phosphate and a bone-growth-stimulating substance that initiates and/or stimulates bone growth. The coating is applied at least to surface parts of the unit cooperating with the bone. A method of producing the implant is also provided.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: May 4, 2004
    Assignee: Nobel Biocare AB
    Inventor: Jan Hall
  • Publication number: 20040083006
    Abstract: The invention relates to a medical prosthetic device comprising a metal material, such as titanium or an alloy thereof, where the surface parts of the metal material are coated with a layer of a corresponding hydroxide material, such as titanium hydroxide. Preferably, the hydroxide layer comprises one or more biomolecule substances associated therewith.
    Type: Application
    Filed: April 9, 2003
    Publication date: April 29, 2004
    Applicant: Astra Tech AB
    Inventors: Jan Eirik Ellingsen, Staale Petter Lyngstadaas
  • Patent number: 6726718
    Abstract: A prosthesis is formed from a biocompatible material having one or more associated cell adhesion stimulating proteins. The biocompatible material can be a ceramic material or a carbon coated material. The cell adhesion stimulating protein can be a structural protein or a polypeptide growth factor, such as vascular endothelial growth factor. Viable cells can be adhered in vivo or in vitro to the biocompatible material with the cell adhesion stimulating protein.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: April 27, 2004
    Assignee: St. Jude Medical, Inc.
    Inventors: Wenda C. Carlyle, Avrom M. Brendzel
  • Patent number: 6719989
    Abstract: A sustained release drug carrier comprises a ceramic composite which is formed by bonding a plurality of ceramic bodies together, and drugs impregnated into the ceramic composite. A method of manufacturing the sustained release drug carrier comprises the steps of: (i) preparing ceramic bodies to be bonded together, each of the ceramic bodies having a bonding surface; (ii) preparing a slurry in which primary particles of a bonding ceramics are dispersed; (iii) applying the slurry to the bonding surface of at least one of the ceramic bodies to be bonded; (iv) sintering the ceramic bodies between which the slurry has been interposed to bond them together, to obtain a ceramic composite; and (v) impregnating a drug into the obtained ceramic composite.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: April 13, 2004
    Assignee: PENTAX Corporation
    Inventors: Asako Matsushima, Masanori Nakasu, Makoto Otsuka
  • Publication number: 20040054422
    Abstract: Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.
    Type: Application
    Filed: August 28, 2003
    Publication date: March 18, 2004
    Inventors: Pierre Descouts, Bjorn-Owe Aronsson, Michael Gratzel, Carine Viornery, Peter Pechy
  • Publication number: 20040030403
    Abstract: The invention concerns the use of a polysaccharide excreted by the Vibrio diabolicus species for making a medicine with cicatrising activity, in particular bone repair activity. The invention also concerns a bone reconstruction biomaterial comprising said polysaccharide and a bone endoprosthesis whereof the surface is coated with such a polysaccharide.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 12, 2004
    Inventors: Jean Guezennec, Philippe Zanchetta
  • Patent number: 6689473
    Abstract: A surface coating composition for providing a self-assembling monolayer, in stable form, on a material surface or at a suitable interface, as well as a method of preparing such a composition and a method of using such a composition to coat a surface, such as the surface of an implantable medical device, in order to provide the surface with desirable properties. The method provides the covalent attachment of a SAM to a surface in a manner that substantially retains or improves the characteristics and/or performance of both the SAM and the surface itself. Covalent attachment is accomplished by the use of one or more latent reactive groups, e.g., provided by either the surface and/or by the SAM-forming molecules themselves.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: February 10, 2004
    Assignee: SurModics, Inc.
    Inventors: Patrick E. Guire, Kristin S. Taton
  • Patent number: 6627321
    Abstract: An implant with a surface modified for improved bio-compatiability consisting of a metal or an alloy thereof, said implant surface comprising a modified outer layer is disclosed, wherein said metal preferably is titanium, zirconium, hafnium or tantalum, and most preferably titanium, and said modified outer layer preferably comprises a hydride of said metal. Also a method for the production of such an implant is disclosed.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: September 30, 2003
    Assignee: Astra Tech AB
    Inventors: Jan Eirik Ellingsen, Ketil Videm, Lars Opsahl, Hans Jacob Ronold
  • Publication number: 20030171820
    Abstract: A prosthesis is disclosed at least of the surface of which is of metal, said metal being covered by a layer of aluminium oxide which comprises phosphate and/or pores containing bioactive material, optionally with a layer of aluminium or an alloy thereof between the metal and the porous aluminium oxide layer.
    Type: Application
    Filed: March 7, 2003
    Publication date: September 11, 2003
    Inventors: Peter Richard Wilshaw, Anna Eva Maria Palsgard
  • Publication number: 20030171825
    Abstract: A transcutaneous prosthesis is disclosed comprising a first component (1) shaped for implantation into a bone (2), a second component (4) intended for location between the bone (2) and the skin, and a third component (5) intended for location exterior to the skin surface, having a low surface energy which deters bacterial adhesion. The second component (4) may carry an adhesion-promoting protein.
    Type: Application
    Filed: April 28, 2003
    Publication date: September 11, 2003
    Inventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
  • Patent number: 6582715
    Abstract: An orthopedic surgical implant of one or more components having a surface which is to be contacted by body tissue and/or fluid. The surface contains an inorganic antimicrobial agent either incorporated in the material forming a component having the surface or incorporated in a coating, such as of the adhesive or powder spray type, applied to the surface.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: June 24, 2003
    Assignee: AgION Technologies, Inc.
    Inventors: John E. Barry, Jeffrey A. Trogolo
  • Patent number: 6569547
    Abstract: A hard tissue repairing material including a base material and a surface layer having a crystalline zirconia covering the base material, being characterized in that the film includes a Zr—OH group. A middle layer may be formed between the base material and the surface layer and, in such case, includes at least one element of the base material and at least one element of the surface layer having a crystalline zirconia.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: May 27, 2003
    Assignees: Matsushita Electric Works, Ltd.
    Inventors: Masahiro Nawa, Tadashi Kokubo, Masaki Uchida
  • Publication number: 20030097180
    Abstract: The present invention provides a joint prosthesis system for the joining of two bones. The bioabsorbable joint prosthesis system includes at least one bioabsorbable spacer and at least one connector adapted to be fixedly attached to the two bones, at least a portion of the connector being in contact with the spacer to prevent lateral movement of the spacer. The present invention also includes embodiments drawn to methods of using the joint prosthesis system. In an embodiment of the present invention, the method includes interposing at least one bioabsorbable spacer between the surface of the bones to be joined and connecting the bones with at least one connector such that at least a part of the connector contacts the bioabsorbable spacer.
    Type: Application
    Filed: November 20, 2001
    Publication date: May 22, 2003
    Inventors: Pertti Tormala, Mauri Lehtimaki, Matti Lehto, Minna Kellomaki, Pirjo Honkanen
  • Publication number: 20030050689
    Abstract: Disclosed are methods of reducing undesired tissue growth adjacent to, upon, or within surgical implants. Surgical implants, especially endoprosthetic implants, are rendered bioactively suppressant by the presence of a galvanically releasable silver component and a metal more noble than silver such as gold, platinum, or rhodium, deposited on a surface of the implant, when contacted with a physiologic electrotyte, which is generally deposited as a surface coating, which provides in vivo a sustained release of silver ions in a concentration effective to reduce undesired tissue growth, but insufficient to cause serious damage to connective tissue.
    Type: Application
    Filed: October 17, 2001
    Publication date: March 13, 2003
    Applicant: Surgica Corporation
    Inventor: Louis R. Matson
  • Publication number: 20030050708
    Abstract: The present invention relates to a tissue grafting material that includes a first tissue element harvested from an individual, a carrier, and a therapeutic substance contained in the carrier. The carrier and therapeutic substance are incorporated into the first tissue element and the first tissue element, carrier, and therapeutic substance form a unitary implant.
    Type: Application
    Filed: October 24, 2002
    Publication date: March 13, 2003
    Inventor: Peter M. Bonutti
  • Patent number: 6530958
    Abstract: Solid free-form (SSF) techniques for making medical devices for implantation and growth of cells from polymers or polymer/inorganic composites using computer aided design are described. Examples of SFF methods include stereo-lithography (SLA), selective laser sintering (SLS), ballistic particle manufacturing (BPM), fusion deposition modeling (FDM), and three dimensional printing (3DP). The devices can incorporate inorganic particles to improve the strength of the walls forming the pores within the matrix and to provide a source of mineral for the regenerating tissue. The devices can contain tissue adhesion peptides, or can be coated with materials which reduce tissue adhesion. The macrostructure and porosity of the device can be manipulated by controlling printing parameters. Most importantly, these features can be designed and tailored using computer assisted design (CAD) for individual patients to optimize therapy.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 11, 2003
    Assignee: Massachusetts Institute of Technology
    Inventors: Linda G. Cima, Michael J. Cima
  • Publication number: 20030033021
    Abstract: A method for the repair of a cartilaginous tissue defect, a cartilage repair device and a method of making a cartilage repair device are disclosed. In the method for the repair of a cartilaginous tissue defect, a device comprising a synthetic polymer is implanted into the defect, and a biological lubricant is administered to the defect. The device comprises a synthetic polymer and a biological lubricant.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 13, 2003
    Inventors: Pamela Lynn Plouhar, Herbert Eugene Schwartz, Prasanna Malaviya
  • Publication number: 20030033022
    Abstract: A method for the repair of a cartilagenous tissue defect, a cartilage repair device and a method of making a cartilage repair device are disclosed. In the method for the repair of a cartilagenous tissue defect, a device comprising a scaffold, for example an extracellular matrix material, is implanted into the defect, and a biological lubricant is administered to the defect. The device comprises a scaffold, for example a naturally occurring extracellular matrix material, and a biological lubricant.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 13, 2003
    Inventors: Pamela Lynn Plouhar, Prasanna Malaviya, Herbert Eugene Schwartz
  • Patent number: 6508838
    Abstract: A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: January 21, 2003
    Assignee: Washington Research Foundation
    Inventors: Minako Yoshioka Lee, David Rodney Eyre, Mary Ann Eklof Weis
  • Patent number: 6497729
    Abstract: A tissue/implant interface, comprising an implant and a bioactive polymer layer adjacent at least a portion of the outer surface of the implant, wherein the polymer layer contains at least one tissue response modifier covalently attached to the polymer layer or entrapped within the polymer layer in a quantity effective to control the tissue response at the site of implantation. Preferably, the at least one tissue response modifier controls inflammation, fibrosis, and/or neovascularization. Exemplary tissue response modifiers include, but are not limited to, steroidal and non-steroidal anti-inflammatory agents, anti-fibrotic agents, anti-proliferative agents, cytokines, cytokine inhibitors, neutralizing antibodies, adhesive ligands, and combinations thereof. Use of the various combinations of tissue response modifiers with bioactive polymers provides a simple, flexible and effective means to control the implant/tissue interphase, improving implant lifetime and function.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: December 24, 2002
    Assignee: The University of Connecticut
    Inventors: Francis Moussy, Donald Kreutzer, Diane Burgess, Jeffrey Koberstein, Fotios Papadimitrakopoulos, Samuel Huang
  • Publication number: 20020165617
    Abstract: A prosthesis or implant has a surface carrying a coating comprising at least one phospholipid at a concentration to improve osteointegration. A method of making such a prosthesis or implant and a kit comprising a prosthesis or implant is also described.
    Type: Application
    Filed: February 28, 2002
    Publication date: November 7, 2002
    Applicant: DESTINY PHARMA LIMITED
    Inventors: Andrew W. Lloyd, Matteo Santin, Stephen P. Denyer, William Rhys-Williams, William G. Love
  • Publication number: 20020156529
    Abstract: A spinal implant is provided to integrate with and support vertebrae in a vertebral column. The spinal implant includes a body and a mineralized, bioactive surface coating chemically bonded to a portion of the body. The coating includes a non-hydroxyl containing carbonated calcium phosphate bone mineral nano-crystalline apatite with chemically adsorbed water having a crystal size less than about 1 &mgr;m The body of the spinal implant is ring-shaped and defines a central passageway.
    Type: Application
    Filed: March 29, 2002
    Publication date: October 24, 2002
    Inventors: Panjian Li, Todd Smith
  • Publication number: 20020143404
    Abstract: An implant includes a main body member having bio-compatibility, and particles formed of bioactive material and dispersedly provided at the surface of an embedded section of the main body member. Each of the particles has a part embedded in the embedded portion and the other part protruding from the embedded portion. The main body member is formed of titanium or titanium alloy. The particles having osteo-conduction are formed of a material selected from among a group consisting of sintered substances of hydroxylapatite, &agr;-tricalcium phosphate, &bgr;-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them. It is desirable that the embedded section surface has a surface roughness in a range of 5 to 50 &mgr;m.
    Type: Application
    Filed: May 28, 2002
    Publication date: October 3, 2002
    Applicant: BRAINBASE CORPORATION
    Inventors: Osamu Hayashi, Takamasa Sasoh, Fumisada Ozawa, Isao Furuta, Toshitake Furusawa, Eiji Ichida
  • Publication number: 20020128723
    Abstract: An implant includes a main body member having bio-compatibility, and particles formed ofbioactive material and dispersedly provided at the surface of an embedded section of the main body member. Each of the particles has a part embedded in the embedded portion and the other part protruding from the embedded portion. The main body member is formed of titanium or titanium alloy. The particles having osteo-conduction are formed of a material selected from among a group consisting of sintered substances of hydroxylapatite, &agr;-tricalcium phosphate, &bgr;-tricalcium phosphate, tetra-calcium phosphate, a single substance of amorphous calcium phosphate, monetite, brushite, 45S4 glass, and a mixture of them. It is desirable that the embedded section surface has a surface roughness in a range of 5 to 50 &mgr;m.
    Type: Application
    Filed: October 4, 2001
    Publication date: September 12, 2002
    Applicant: BRAINBASE CORPORATION
    Inventors: Osamu Hayashi, Takamasa Sasoh, Fumisada Ozawa, Isaq Furuta, Toshitake Furusawa, Eiji Ichida
  • Publication number: 20020128722
    Abstract: A process and product comprising collagen and demineralized bone particles. The product may contain a maximum of 20% by weight inorganic materials. The product may densified by compression. Additional osteogenic factors, mitogens, drugs or antibiotics may be incorporated therein. Inorganic materials may be bound to the organic matrix via precoating with a calcium or hydroxyapatite binding protein, peptide or amino acid. The materials also display long lasting drug release characteristics.
    Type: Application
    Filed: April 14, 1995
    Publication date: September 12, 2002
    Inventor: STEVEN R. JEFFERIES
  • Publication number: 20020111694
    Abstract: A medical prosthetic device or medical implant containing a metal material (A) selected from the group consisting of titanium or an alloy thereof, zirconium or an alloy thereof, tantalum or an alloy thereof, hafnium or an alloy thereof, niobium or an alloy thereof and a chromium-vanadium alloy, wherein surface parts of the metal material (A) are coated with a layer of a corresponding hydride material (B) selected from titanium hydride, zirconium hydride, tantalum hydride, hafnium hydride, niobium hydride and chromium and/or vanadium hydride, respectively, said device or implant being characterized in that the layer of hydride material (B) comprises one or more biomolecule substances (C) associated therewith. The device or implant exhibits improved biocompatibility. The metal material (A) is preferably titanium.
    Type: Application
    Filed: December 6, 2001
    Publication date: August 15, 2002
    Applicant: BIOTI AS
    Inventors: Jan Eirik Ellingsen, Staale Petter Lyngstadaas
  • Publication number: 20020111695
    Abstract: A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized biological material. The mineralized biological material is characterized by having a biochemical composition and physiological organization substantially similar to the deep and contiguous calcified cartilage zones of articular cartilage found in animals in vivo. Methods for preparing the biological materials and methods of using the biological materials are described.
    Type: Application
    Filed: April 12, 2002
    Publication date: August 15, 2002
    Applicant: Mount Sinai Hospital Corporation
    Inventor: Rita Kandel
  • Publication number: 20020106611
    Abstract: Monolithic metallic parts having a dense core surrounded by a porous periphery. Metallic parts having a dense core surrounded by a porous periphery characterized by a multitude of interconnected pores. Dental implants and other prosthesis using such metal parts as a substrate coated with a bioactive material.
    Type: Application
    Filed: January 18, 2002
    Publication date: August 8, 2002
    Inventors: Sutapa Bhaduri, Sarit B. Bhaduri, Muralithran G. Kutty
  • Patent number: 6419708
    Abstract: The invention relates to an implant element for permanent anchorage in bone tissue in which at least the surface intended to face the tissue in the implantation region is made of a biocompatible material such as titanium and having a clinically well documented surface. The element is provided with a thin, uniform and adherent calcium-phosphate coating with a well controlled dissolution rate. The coating follows the topography of the underlying well documented surface in order to combine properties for rapid bone growth during the healing phase and properties for a guaranteed long-term stability during clinical loading conditions.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: July 16, 2002
    Assignee: Nobel Biocare AB
    Inventors: Jan Hall, Anatol Krozer, Peter Thomsen
  • Publication number: 20020072806
    Abstract: Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manutacture and use, are disclosed.
    Type: Application
    Filed: August 29, 2001
    Publication date: June 13, 2002
    Inventors: Dayna Buskirk, Chris Seid, John F. Wironen, James M. Gross, Gina Scurti
  • Patent number: 6371985
    Abstract: The invention is a surgically implantable bone and bone joint prosthesis which is designed to be directly attached during surgery and which includes ingrowth receptive zones or stationing sites for delayed ingrowth adhesion naturally over time. The ingrowth receptive zones preferably emulate cancellous bone and are at locations on the body member corresponding generally to the area where connective tissue naturally attaches in vivo.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: April 16, 2002
    Inventor: Robert S. Goldberg
  • Publication number: 20020042657
    Abstract: The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
    Type: Application
    Filed: October 4, 2001
    Publication date: April 11, 2002
    Applicant: Millenium Biologix, Inc.
    Inventors: Sydney M. Pugh, Timothy J.N. Smith, Michael Sayer, Sarah Dorthea Langstaff
  • Publication number: 20020038149
    Abstract: The invention relates to an implant element for permanent anchorage in bone tissue in which at least the surface intended to face the tissue in the implantation region is made of a biocompatible material such as titanium and having a clinically well documented surface. The element is provided with a thin, uniform and adherent calcium-phosphate coating with a well controlled dissolution rate. The coating follows the topography of the underlying well documented surface in order to combine properties for rapid bone growth during the healing phase and properties for a guaranteed long-term stability during clinical loading conditions.
    Type: Application
    Filed: January 20, 2000
    Publication date: March 28, 2002
    Inventors: JAN HALL, ANATOL KROZER, PETER THOMSEN