Including Natural Bone Tissue Patents (Class 623/23.63)
  • Patent number: 8702809
    Abstract: The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 22, 2014
    Assignee: Purdue Research Foundation
    Inventors: Eric A. Nauman, Darryl A. Dickerson
  • Patent number: 8686064
    Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: April 1, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, David Knaack
  • Patent number: 8673019
    Abstract: Methods and compositions are provided for reduction of inflammation and improved allograft/host tissue integration comprising placing at least one anti-inflammatory compound onto a site of the defect and placing a graft structure onto the site of the defect.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: March 18, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 8652503
    Abstract: A bone paste useful in the orthopedic arts, for example in the repair of non-union fractures, periodontal ridge augmentation, craniofacial surgery, implant fixation, impaction grafting, or any other procedure in which generation of new bone is deemed necessary, is provided by a composition comprising a substantially bioabsorbable osteogenic compound in a gelatin matrix. In various embodiments, the osteogenic compound is selected from (i) demineralized bone matrix (DBM); (ii) bioactive glass ceramic, BIOGLASS®, bioactive ceramic, calcium phosphate ceramic, hydroxyapatite, hydroxyapatite carbonate, corraline hydroxyapatite, calcined bone, tricalcium phosphate, or like material; (iii) bone morphogenetic protein, TGF-?, PDGF, or mixtures thereof, natural or recombinant; and (iv) mixtures of (i)-(iii).
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: February 18, 2014
    Assignees: University of Florida Research Foundation, Inc., Regeneration Technologies, Inc.
    Inventors: John F. Wironen, Jamie M. Grooms
  • Publication number: 20140005793
    Abstract: The present application is directed to the field of implants comprising processed hard or soft biological tissues for use in implantation in humans. The molded biological tissue implants of the present application are preferably made from allograft soft tissue sources and demineralized bone matrix. The present application provides biological implants exhibiting advantageous properties of absorption, expansion, resiliency and shape retention. The properties of the biological implants produced by the methods of the present application are leveraged in the creation and development of novel biological implant constructs and of novel methods of treatment and surgical technique.
    Type: Application
    Filed: March 12, 2013
    Publication date: January 2, 2014
    Inventors: Keith Cameron Koford, Nathaniel Scott Long, Erica Lee Scharringhausen, Randall Keith Hilliard
  • Patent number: 8609127
    Abstract: Embodiments of the invention include a medical device and a method of manufacturing a medical device having a porous scaffold in combination with a bioactive material. In some embodiments, particularly limited thicknesses of the bioactive material are applied within pores of the porous structure.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: December 17, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Heather M. Savage-Erickson
  • Patent number: 8579986
    Abstract: The present invention provides an apparatus and method that will allow surgeons to produce bone growth masses for use in spinal surgery that are capable of maintaining their physical integrity during placement and during the acute post operative period.
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: November 12, 2013
    Assignee: University of South Florida
    Inventors: Thomas B. Freeman, Wesley M. Johnson, Ben Guiot
  • Publication number: 20130297038
    Abstract: Bone implant compositions and methods are provide that have an outer surface, the outer surface comprising demineralized bone and having a cavity disposed in the outer surface, the cavity having a demineralized bone material coated therein; and an inner surface of the bone implant comprising cortical bone, the inner surface contacting the outer surface. The bone implant compositions and methods provided are osteoinductive and allow rapid bone fusion.
    Type: Application
    Filed: May 7, 2012
    Publication date: November 7, 2013
    Applicant: Warsaw Orthopedic, Inc. An Indiana Corporation
    Inventor: William F. McKay
  • Publication number: 20130282128
    Abstract: A bone graft implant device for treating a tissue site is provided, the device including an implant body including a demineralized allograft bone material portion, and at least one engagement member protruding from the implant body including a mineralized allograft bone material portion. The engagement member may be integrally formed with the implant body, or alternatively, the implant body may include an aperture and the engagement member may be insertable therein. At least one of the amount of demineralization or area of the demineralized allograft bone material portion is adjustable to impart a desired flexibility to the implant body.
    Type: Application
    Filed: April 24, 2012
    Publication date: October 24, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130274892
    Abstract: The present invention relates to an electrospun chitosan scaffold. The scaffold mimics natural bone mechanical properties and structure through mineralization without hindering the biocompatibility for osteoblasts. The electrospun mineralized scaffold is useful in bone regeneration therapies.
    Type: Application
    Filed: October 7, 2011
    Publication date: October 17, 2013
    Applicant: Drexel University
    Inventors: Peter I. Lelkes, Michael Frohbergh
  • Publication number: 20130274890
    Abstract: A composite interbody bone implant device is provided including a body having a non-bone composition, such as a polymer, formed into a shape and including one or more cavities. An osteoinductive material, such as bone allograft tissue, may be retained in the one or more cavities of the body. The body is formable via injection molding and/or machining into a shape and size adapted for implantation at a surgical site. The dimensions of the body include a length, a width and a thickness, and the thickness of the body may be less than at least one of the length and width.
    Type: Application
    Filed: April 17, 2012
    Publication date: October 17, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130173014
    Abstract: Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided.
    Type: Application
    Filed: July 13, 2012
    Publication date: July 4, 2013
    Inventors: Antonios G. Mikos, Mark E. Wong, Simon W. Young, Meng Shi, F. Kurtis Kasper, Patrick Spicer, James D. Kretlow
  • Publication number: 20130131826
    Abstract: An artificial bone-cartilage composite comprising a first composite material layer comprising collagen, proteoglycan and hyaluronic acid, and a second composite material layer comprising collagen and calcium phosphate, which are bonded to each other via a bonding layer comprising collagen, proteoglycan, hyaluronic acid and calcium phosphate.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 23, 2013
    Applicant: HOYA CORPORATION
    Inventor: HOYA CORPORATION
  • Publication number: 20130079889
    Abstract: There is disclosed an irradiated cortical bone sheet allograft. In an embodiment, the allograft includes a unitary sheet of at least partially demineralized, irradiated cortical bone having a thickness, a width, and a length. The thickness of the unitary sheet of irradiated cortical bone is less the width and the length. In another embodiment, a method of forming the allograft includes obtaining a natural bone from a donor different than a recipient. The natural bone contains a layer of a cortical bone. The method includes cleaning the natural bone to produce a unitary sheet of cortical bone. The method includes at least partially demineralizing the unitary sheet of cortical bone. The method includes freezing the unitary into a frozen state within a sealed package. The method includes irradiating the unitary sheet in the frozen state within the sealed package to sterilize the cortical bone and produce the irradiated cortical bone sheet for implantation in the recipient other than the donor.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 28, 2013
    Inventor: Deborah Marie Spillman
  • Publication number: 20130030547
    Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged in a core/outer layer structure.
    Type: Application
    Filed: January 28, 2012
    Publication date: January 31, 2013
    Inventor: Brian Burkinshaw
  • Patent number: 8353967
    Abstract: A biocompatible, self-supporting, curved, collagen membrane adapted to be secured by bone tacks or bone screws over exposed bone at a desired bone graft site in the alveolar ridge of a patient such that the membrane defines a space having a predetermined height and width over the exposed bone, in which the membrane maintains its structural integrity for at least 4 months after implantation at the bone graft site and then naturally breaks down and is resorbed by the patient's body, a method of making such a membrane, and a method of using such a membrane for vertical augmentation of the alveolar ridge of the patient.
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: January 15, 2013
    Assignee: Osseous Technologies of America
    Inventors: Jay Malmquist, David Cheung, William Knox
  • Publication number: 20130013071
    Abstract: An osteoimplant is made up of a coherent aggregate of elongate bone particles.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Randal R. Betz, Scott D. Boden, Christine Clark, Nanette Forsyth, John W. Morris, Kathy Traianedes
  • Publication number: 20130013080
    Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of a cavity of a bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the support structure by an adhesive. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining the channel between the pair of components.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Zimmer, Inc.
    Inventors: Arlen D. Hanssen, David G. Lewallen
  • Patent number: 8343229
    Abstract: Implantable pliable bone blocks comprising a solid block of cortical bone characterized by a length, width and thickness, having a first and a second face on opposite sides of the block. The first and second faces have a plurality slot features. The angle of incidence of the slot features of the first face and the x-axis and the angle of incidence of the slot features of the second face and the x-axis (a2) are such that the slots would intersect if they were in the same plane. Methods are provided for making implantable pliable bone blocks.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: January 1, 2013
    Assignee: EBI, LLC
    Inventor: Bradford J. Coale
  • Publication number: 20120330436
    Abstract: A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.
    Type: Application
    Filed: March 9, 2010
    Publication date: December 27, 2012
    Applicant: MATHYS AG BETTLACH
    Inventors: Marc Bohner, Reto Luginbuhl
  • Patent number: 8328876
    Abstract: The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and/or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions.
    Type: Grant
    Filed: December 31, 2004
    Date of Patent: December 11, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Keyvan Behnam, Christopher Cioffi
  • Publication number: 20120296441
    Abstract: A device for containing bone graft material comprises a body including an inner sleeve extending longitudinally from a proximal end to a distal end and an outer sleeve surrounding the inner sleeve and extending longitudinally from a proximal end to a distal end such that a bone graft collecting space is formed therebetween.
    Type: Application
    Filed: November 15, 2011
    Publication date: November 22, 2012
    Inventors: George MIKHAIL, Ross HAMEL
  • Patent number: 8313742
    Abstract: This invention relates to a musculoskeletogenic MSG graft composite made from whole bone marrow aspirate BMA having native levels of musculoskeletal progenitor cells MSPCs, comprising: a) a suspension of fractionated BMA comprising: i) MSPCs present at a level greater than their native level in whole BMA, and ii) red blood cells RBCs present at a level less than their native level in whole BMA, and b) a porous sterile matrix having an average pore size of at least 20 ?m.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: November 20, 2012
    Assignee: DePuy AcroMed, Inc.
    Inventors: Sudhakar Kadiyala, Scott P. Bruder
  • Publication number: 20120271418
    Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.
    Type: Application
    Filed: February 28, 2012
    Publication date: October 25, 2012
    Applicant: TISSUE REGENERATION SYSTEMS, INC.
    Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
  • Publication number: 20120251609
    Abstract: A demineralized cancellous bone matrix comprising a cancellous bone matrix that has been demineralized is described herein. The demineralized cancellous bone matrix is rigid and has certain dimensions, including a certain length. Implants comprising at least one demineralized cancellous bone matrix are also described. Also disclosed are methods for treating bone having a void or defect in a patient using at least one demineralized cancellous bone matrix. In addition, methods of making a demineralized cancellous bone matrix are disclosed.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 4, 2012
    Inventors: Yen-Chen Huang, Moon Hae Sunwoo, Arthur A. Gertzman
  • Publication number: 20120219599
    Abstract: The present disclosure describes an implant for improving bone growth including an osteoconductive scaffold and an osteoinductive small molecule. The osteoconductive scaffold can further include a polymeric binder. The implant can also include an osteogenic material to provide a viable cell population to assist the bone repair and remodeling. Also disclosed is a system for forming an implant for improving bone growth, as well as methods for forming the implant according to the disclosure, in addition to methods of therapeutic use of the implant.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 30, 2012
    Inventors: Meredith Hans Moore, Doug Buechter, Melissa Brown, Lisa Hughes, Stephen Hornsby
  • Patent number: 8241673
    Abstract: A method for obtaining of biomaterials for osteoplasty and tissue engineering cleans a bone of natural origin, which is sawn to plates with a thickness of 0.2 to 2.0 cm, washed twice in 0.1 M phosphate buffer at 65° C., pH 5.8-6.0, calculated as two volumetric parts of the buffer solution per one part of bone, digested in a solution of activated 0.1-0.4% papain at 65° C. for 24 hours. The plates are washed with 5 volumes of water at the temperature 40-80° C., treated with 0.4 N alkali solution at room temperature for 10-24 hours, washed with flowing water, dried, defatted in ethanol/chloroform mixtures in proportion of 1:2 and then in proportion of 2:1, decalcified in 0.4-1 N hydrochloric acid, treated with 1.5-3% hydrogen peroxide for 4 hours, washed with treated water, then washed with ethanol, dried at room temperature, packed and sterilized.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: August 14, 2012
    Inventor: Andrey Fedorovich Panasyuk
  • Publication number: 20120165954
    Abstract: A three-dimensional biomedical device having an osteoinductive first area with a controlled porosity and a second area, which is produced by laser technology from a powder including one of ceramics, metals, metal alloys, bioactive glasses, lead zirconate titanate and biocompatible polymers, or mixtures thereof. The ratio of the porosities from the second area to the first area is equal or less than one, preferably from 0.001 to 0.9. A method for manufacturing the device for fitting in a bone defect, wherein a virtual object is designed with a computer-aid designed software, and the device is manufactured by laser technology including layering a powder onto a plate (7) so that a layer of a predetermined thickness is formed; the laser beam (8) selectively processes the powder to produce a processed layer, and, thus, layer after layer, the layers are joined together until the biomedical device is formed.
    Type: Application
    Filed: January 23, 2012
    Publication date: June 28, 2012
    Inventor: Didier NIMAL
  • Publication number: 20120116515
    Abstract: Implants comprising a plurality of separate cortical bone units, which have been at least partially demineralized and are osteoinductive, are described herein. The implants can be used in methods for treating bone. Also, disclosed are methods for treating spinal conditions using these implants. The spinal conditions include but are not limited to repairing damage to or defects in the spine, such as fractures in a vertebral body or degeneration of spinal discs.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 10, 2012
    Inventors: Eric J. Semler, Clint Boylan, Karen Roche
  • Patent number: 8142502
    Abstract: An apparatus and method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: March 27, 2012
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T. Stone, Karen S. Troxel
  • Patent number: 8092529
    Abstract: Methods and devices are provided for regenerating a meniscus. The devices comprise a layer of toughened naturally occurring extracellular matrix. The devices may, optionally, further comprise a biologic material to provide a framework for meniscus regeneration. The methods comprise the steps of removing a portion of a meniscus to provide a space, and inserting a device comprising a layer of toughened naturally occurring extracellular matrix into the space.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: January 10, 2012
    Assignee: DePuy Products, Inc.
    Inventors: Prasanna Malaviya, Herbert Eugene Schwartz, Terrence David Whalen, Mark Joseph Pelo, Philip Joseph Jenks, Pamela Lynn Plouhar, Jerry Lee Lower
  • Publication number: 20110270408
    Abstract: The present invention relates to a bone-regenerating scaffold, and more particularly, to a bone-regenerating scaffold which is made of a mixture of fibrin glue and bone powder, the interior of which has a plurality of pores for accommodating bone growth factors, and which has a predetermined concrete shape.
    Type: Application
    Filed: February 2, 2009
    Publication date: November 3, 2011
    Inventors: Jun Lee, Dong-Yyeon Yoon
  • Patent number: 8012205
    Abstract: A cartilage repair device comprises a scaffold, for example a naturally occurring extracellular matrix material, and a biological lubricant. The biological lubricant is applied to the naturally occurring extracellular matrix material.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: September 6, 2011
    Assignee: DePuy Products, Inc.
    Inventors: Pamela Lynn Plouhar, Prasanna Malaviya, Herbert Eugene Schwartz
  • Patent number: 7981156
    Abstract: Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: July 19, 2011
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: John Pafford, Lawrence M. Boyd, William F. McKay, Eddie F. Ray, III, James E. Van Hoeck
  • Patent number: 7976861
    Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: July 12, 2011
    Assignee: Biomet Manufacturing Corp.
    Inventor: A. Hari Reddi
  • Publication number: 20110166672
    Abstract: An object of the invention is to provide a bone filling material capable of promoting the bone regeneration effect of a growth factor such as platelet rich plasma (PRP). Inventors of the invention anticipated that the bone filling material adsorbs a growth factor like PRP, and the combined use of the bone filling material with PRP, the bone regeneration effect of PRP might be impaired. Further, the invention is basically related to the inhibition of this adsorbing effect of the bone filling material by using a capping agent. Since the adsorbing effect of the bone filling material is thus inhibited, PRP can exert the bone regeneration effect thereof in the case of using the bone filling material together with PRP.
    Type: Application
    Filed: June 29, 2009
    Publication date: July 7, 2011
    Applicants: THE UNIVERSITY OF TOKYO, NEXT21 K.K.
    Inventors: Yuichi Tei, Nobuo Sasaki, Shigeki Suzuki
  • Publication number: 20110153028
    Abstract: Osteochondral implants for repair of chondral defects and providing bone fixation through bone ongrowth and/or ingrowth. The implant is provided with a base allowing for bone ongrowth and/or ingrowth and a top attached to the base, the top being formed of a material having a compressive resistance similar to that of the cartilage. The material of the top is polycarbonate urethane, for example. The base may comprise a porous substrate for bony ingrowth formed of metal or PEEK and having a pattern porosity about similar to the porosity of cancellous bone. One side of the top attaches to the base for stability, and the other side of the top forms a surface for articulating with the opposing cartilage surface of the joint.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 23, 2011
    Inventor: Ricardo E. ALBERTORIO
  • Publication number: 20110144766
    Abstract: The present invention provides a system, device, instruments and methods for inserting and/or improving the holding strength and purchase of a bone screw, bone pin, or bone dowel in bone. Embodiments include monolithic allograft tissue forms, multi-piece allograft tissue forms, distally expandable portions, partially and fully demineralized portions, and flexible connecting portions. Advantages of the allograft tissue forms of the present invention include improved pedicle screw blackout strength and improved filling of bone voids. Methods for making and instruments and techniques for inserting the augmentation device, system and screws or pins are also disclosed.
    Type: Application
    Filed: November 12, 2010
    Publication date: June 16, 2011
    Inventors: Shreedhar Kale, Dennis Chien, Robert Delurio, Curtis Compton
  • Patent number: 7959683
    Abstract: A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0 mm to about 4.0 mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: June 14, 2011
    Assignees: Musculoskeletal Transplant Foundation, Spineology, Inc.
    Inventors: Eric J. Semler, Judith I. Yannariello-Brown, Morris L. Jacobs, Karen Roche, Steve Wolfe
  • Patent number: 7931692
    Abstract: An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bone possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: April 26, 2011
    Inventors: Daryl R. Sybert, Lawrence A. Shimp
  • Patent number: 7837740
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Patent number: 7824702
    Abstract: Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: November 2, 2010
    Assignee: RTI Biologics, Inc.
    Inventors: John F. Wironen, Penelope Kao, Andy Bernhardt
  • Patent number: 7819918
    Abstract: An implantable tissue repair device has a cover and tissue regeneration material. The cover includes a top panel and a bottom panel joined together along a leading edge. The tissue regeneration material is positioned between the top and bottom panels. The cover includes a continuous sheet of biocompatible material extending across the edge and into the top panel and bottom panel. The cover is thicker along the leading edge than at least a portion of the top panel and thicker than at least a portion of the bottom panel. At least a portion of one of the panels covering the tissue regeneration material is thicker than a portion of the other panel covering the tissue regeneration material. A method of making the device is also disclosed.
    Type: Grant
    Filed: December 29, 2003
    Date of Patent: October 26, 2010
    Assignee: Depuy Products, Inc.
    Inventors: Prasanna Malaviya, Herbert E. Schwartz, Anthony D. Zannis, Terrence David Whalen, Philip Joseph Jenks
  • Publication number: 20100256774
    Abstract: A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
    Type: Application
    Filed: December 12, 2008
    Publication date: October 7, 2010
    Applicant: Osteotech ,Inc.
    Inventors: Sherry Hsiu-Ying Wang, Michael Jaffe, Lawrence A. Shimp, Nels J. Lauritzen, Charles M. Schiff
  • Publication number: 20100191346
    Abstract: A bone implant derived from natural bone tissue material, wherein the bone implant is substantially free of non-fibrous tissue proteins, cells and cellular elements and lipids or lipid residues and comprises collagen displaying original collagen fibre architecture and molecular ultrastructure of the natural bone tissue material from which it is derived.
    Type: Application
    Filed: April 15, 2008
    Publication date: July 29, 2010
    Inventors: Stephen Bloor, Joanne Louise Proffitt, Paul Armitage, Christine Elizabeth Dawson
  • Patent number: 7758643
    Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: July 20, 2010
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T Stone, Karen Troxel
  • Patent number: 7753963
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: July 13, 2010
    Assignee: Synthes USA, LLC
    Inventors: Michael L. Boyer, II, David C. Paul, Christopher M. Angelucci
  • Patent number: 7749555
    Abstract: The present invention relates to a method for enhancing ingrowth of host bone comprising: modifying a bone graft structure to provide an ionic gradient to produce a modified bone graft structure; and implanting the modified bone graft structure. The present invention also relates to a method of enhancing the binding of growth factors and cell cultures to a bone graft structure comprising: applying ex vivo an effective quantity of an ionic force change agent to the surface of a bone graft structure to produce a binding-sensitized bone graft structure; implanting the binding-sensitized bone graft structure into a host bone; and administering to the binding-sensitized bone graft structure a molecule, a cell culture or a combination thereof.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: July 6, 2010
    Inventors: John M. Zanella, Sean M. Haddock, Catherine E. Taylor, Kathryn J. Kitching
  • Publication number: 20100152863
    Abstract: Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.
    Type: Application
    Filed: December 13, 2009
    Publication date: June 17, 2010
    Inventor: Amit Prakash Govil
  • Patent number: 7678385
    Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: March 16, 2010
    Assignee: Biomet Manufacturing Corp.
    Inventor: A. Hari Reddi