Including Natural Bone Tissue Patents (Class 623/23.63)
  • Publication number: 20120296441
    Abstract: A device for containing bone graft material comprises a body including an inner sleeve extending longitudinally from a proximal end to a distal end and an outer sleeve surrounding the inner sleeve and extending longitudinally from a proximal end to a distal end such that a bone graft collecting space is formed therebetween.
    Type: Application
    Filed: November 15, 2011
    Publication date: November 22, 2012
    Inventors: George MIKHAIL, Ross HAMEL
  • Patent number: 8313742
    Abstract: This invention relates to a musculoskeletogenic MSG graft composite made from whole bone marrow aspirate BMA having native levels of musculoskeletal progenitor cells MSPCs, comprising: a) a suspension of fractionated BMA comprising: i) MSPCs present at a level greater than their native level in whole BMA, and ii) red blood cells RBCs present at a level less than their native level in whole BMA, and b) a porous sterile matrix having an average pore size of at least 20 ?m.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: November 20, 2012
    Assignee: DePuy AcroMed, Inc.
    Inventors: Sudhakar Kadiyala, Scott P. Bruder
  • Publication number: 20120271418
    Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.
    Type: Application
    Filed: February 28, 2012
    Publication date: October 25, 2012
    Applicant: TISSUE REGENERATION SYSTEMS, INC.
    Inventors: Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
  • Publication number: 20120251609
    Abstract: A demineralized cancellous bone matrix comprising a cancellous bone matrix that has been demineralized is described herein. The demineralized cancellous bone matrix is rigid and has certain dimensions, including a certain length. Implants comprising at least one demineralized cancellous bone matrix are also described. Also disclosed are methods for treating bone having a void or defect in a patient using at least one demineralized cancellous bone matrix. In addition, methods of making a demineralized cancellous bone matrix are disclosed.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 4, 2012
    Inventors: Yen-Chen Huang, Moon Hae Sunwoo, Arthur A. Gertzman
  • Publication number: 20120219599
    Abstract: The present disclosure describes an implant for improving bone growth including an osteoconductive scaffold and an osteoinductive small molecule. The osteoconductive scaffold can further include a polymeric binder. The implant can also include an osteogenic material to provide a viable cell population to assist the bone repair and remodeling. Also disclosed is a system for forming an implant for improving bone growth, as well as methods for forming the implant according to the disclosure, in addition to methods of therapeutic use of the implant.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 30, 2012
    Inventors: Meredith Hans Moore, Doug Buechter, Melissa Brown, Lisa Hughes, Stephen Hornsby
  • Patent number: 8241673
    Abstract: A method for obtaining of biomaterials for osteoplasty and tissue engineering cleans a bone of natural origin, which is sawn to plates with a thickness of 0.2 to 2.0 cm, washed twice in 0.1 M phosphate buffer at 65° C., pH 5.8-6.0, calculated as two volumetric parts of the buffer solution per one part of bone, digested in a solution of activated 0.1-0.4% papain at 65° C. for 24 hours. The plates are washed with 5 volumes of water at the temperature 40-80° C., treated with 0.4 N alkali solution at room temperature for 10-24 hours, washed with flowing water, dried, defatted in ethanol/chloroform mixtures in proportion of 1:2 and then in proportion of 2:1, decalcified in 0.4-1 N hydrochloric acid, treated with 1.5-3% hydrogen peroxide for 4 hours, washed with treated water, then washed with ethanol, dried at room temperature, packed and sterilized.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: August 14, 2012
    Inventor: Andrey Fedorovich Panasyuk
  • Publication number: 20120165954
    Abstract: A three-dimensional biomedical device having an osteoinductive first area with a controlled porosity and a second area, which is produced by laser technology from a powder including one of ceramics, metals, metal alloys, bioactive glasses, lead zirconate titanate and biocompatible polymers, or mixtures thereof. The ratio of the porosities from the second area to the first area is equal or less than one, preferably from 0.001 to 0.9. A method for manufacturing the device for fitting in a bone defect, wherein a virtual object is designed with a computer-aid designed software, and the device is manufactured by laser technology including layering a powder onto a plate (7) so that a layer of a predetermined thickness is formed; the laser beam (8) selectively processes the powder to produce a processed layer, and, thus, layer after layer, the layers are joined together until the biomedical device is formed.
    Type: Application
    Filed: January 23, 2012
    Publication date: June 28, 2012
    Inventor: Didier NIMAL
  • Publication number: 20120116515
    Abstract: Implants comprising a plurality of separate cortical bone units, which have been at least partially demineralized and are osteoinductive, are described herein. The implants can be used in methods for treating bone. Also, disclosed are methods for treating spinal conditions using these implants. The spinal conditions include but are not limited to repairing damage to or defects in the spine, such as fractures in a vertebral body or degeneration of spinal discs.
    Type: Application
    Filed: October 20, 2011
    Publication date: May 10, 2012
    Inventors: Eric J. Semler, Clint Boylan, Karen Roche
  • Patent number: 8142502
    Abstract: An apparatus and method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: March 27, 2012
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T. Stone, Karen S. Troxel
  • Patent number: 8092529
    Abstract: Methods and devices are provided for regenerating a meniscus. The devices comprise a layer of toughened naturally occurring extracellular matrix. The devices may, optionally, further comprise a biologic material to provide a framework for meniscus regeneration. The methods comprise the steps of removing a portion of a meniscus to provide a space, and inserting a device comprising a layer of toughened naturally occurring extracellular matrix into the space.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: January 10, 2012
    Assignee: DePuy Products, Inc.
    Inventors: Prasanna Malaviya, Herbert Eugene Schwartz, Terrence David Whalen, Mark Joseph Pelo, Philip Joseph Jenks, Pamela Lynn Plouhar, Jerry Lee Lower
  • Publication number: 20110270408
    Abstract: The present invention relates to a bone-regenerating scaffold, and more particularly, to a bone-regenerating scaffold which is made of a mixture of fibrin glue and bone powder, the interior of which has a plurality of pores for accommodating bone growth factors, and which has a predetermined concrete shape.
    Type: Application
    Filed: February 2, 2009
    Publication date: November 3, 2011
    Inventors: Jun Lee, Dong-Yyeon Yoon
  • Patent number: 8012205
    Abstract: A cartilage repair device comprises a scaffold, for example a naturally occurring extracellular matrix material, and a biological lubricant. The biological lubricant is applied to the naturally occurring extracellular matrix material.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: September 6, 2011
    Assignee: DePuy Products, Inc.
    Inventors: Pamela Lynn Plouhar, Prasanna Malaviya, Herbert Eugene Schwartz
  • Patent number: 7981156
    Abstract: Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: July 19, 2011
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: John Pafford, Lawrence M. Boyd, William F. McKay, Eddie F. Ray, III, James E. Van Hoeck
  • Patent number: 7976861
    Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: July 12, 2011
    Assignee: Biomet Manufacturing Corp.
    Inventor: A. Hari Reddi
  • Publication number: 20110166672
    Abstract: An object of the invention is to provide a bone filling material capable of promoting the bone regeneration effect of a growth factor such as platelet rich plasma (PRP). Inventors of the invention anticipated that the bone filling material adsorbs a growth factor like PRP, and the combined use of the bone filling material with PRP, the bone regeneration effect of PRP might be impaired. Further, the invention is basically related to the inhibition of this adsorbing effect of the bone filling material by using a capping agent. Since the adsorbing effect of the bone filling material is thus inhibited, PRP can exert the bone regeneration effect thereof in the case of using the bone filling material together with PRP.
    Type: Application
    Filed: June 29, 2009
    Publication date: July 7, 2011
    Applicants: THE UNIVERSITY OF TOKYO, NEXT21 K.K.
    Inventors: Yuichi Tei, Nobuo Sasaki, Shigeki Suzuki
  • Publication number: 20110153028
    Abstract: Osteochondral implants for repair of chondral defects and providing bone fixation through bone ongrowth and/or ingrowth. The implant is provided with a base allowing for bone ongrowth and/or ingrowth and a top attached to the base, the top being formed of a material having a compressive resistance similar to that of the cartilage. The material of the top is polycarbonate urethane, for example. The base may comprise a porous substrate for bony ingrowth formed of metal or PEEK and having a pattern porosity about similar to the porosity of cancellous bone. One side of the top attaches to the base for stability, and the other side of the top forms a surface for articulating with the opposing cartilage surface of the joint.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 23, 2011
    Inventor: Ricardo E. ALBERTORIO
  • Publication number: 20110144766
    Abstract: The present invention provides a system, device, instruments and methods for inserting and/or improving the holding strength and purchase of a bone screw, bone pin, or bone dowel in bone. Embodiments include monolithic allograft tissue forms, multi-piece allograft tissue forms, distally expandable portions, partially and fully demineralized portions, and flexible connecting portions. Advantages of the allograft tissue forms of the present invention include improved pedicle screw blackout strength and improved filling of bone voids. Methods for making and instruments and techniques for inserting the augmentation device, system and screws or pins are also disclosed.
    Type: Application
    Filed: November 12, 2010
    Publication date: June 16, 2011
    Inventors: Shreedhar Kale, Dennis Chien, Robert Delurio, Curtis Compton
  • Patent number: 7959683
    Abstract: A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0 mm to about 4.0 mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: June 14, 2011
    Assignees: Musculoskeletal Transplant Foundation, Spineology, Inc.
    Inventors: Eric J. Semler, Judith I. Yannariello-Brown, Morris L. Jacobs, Karen Roche, Steve Wolfe
  • Patent number: 7931692
    Abstract: An implant which is particularly suitable for the repair and/or replacement of a skeletal joint, e.g., a vertebral joint, includes a unit of monolithic bone possessing at least one demineralized region exhibiting properties of flexibility and resilience, the demineralized region having diminished or insignificant capacity for promoting new bone growth.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: April 26, 2011
    Inventors: Daryl R. Sybert, Lawrence A. Shimp
  • Patent number: 7837740
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: November 23, 2010
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown
  • Patent number: 7824702
    Abstract: Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes. Alternatively, a mixing syringe is disclosed, which is useful for reconstituting a paste, inter alia, comprising a flexible midportion, whereby repeated compression of the flexible midportion results in mixing the contents of the syringe.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: November 2, 2010
    Assignee: RTI Biologics, Inc.
    Inventors: John F. Wironen, Penelope Kao, Andy Bernhardt
  • Patent number: 7819918
    Abstract: An implantable tissue repair device has a cover and tissue regeneration material. The cover includes a top panel and a bottom panel joined together along a leading edge. The tissue regeneration material is positioned between the top and bottom panels. The cover includes a continuous sheet of biocompatible material extending across the edge and into the top panel and bottom panel. The cover is thicker along the leading edge than at least a portion of the top panel and thicker than at least a portion of the bottom panel. At least a portion of one of the panels covering the tissue regeneration material is thicker than a portion of the other panel covering the tissue regeneration material. A method of making the device is also disclosed.
    Type: Grant
    Filed: December 29, 2003
    Date of Patent: October 26, 2010
    Assignee: Depuy Products, Inc.
    Inventors: Prasanna Malaviya, Herbert E. Schwartz, Anthony D. Zannis, Terrence David Whalen, Philip Joseph Jenks
  • Publication number: 20100256774
    Abstract: A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
    Type: Application
    Filed: December 12, 2008
    Publication date: October 7, 2010
    Applicant: Osteotech ,Inc.
    Inventors: Sherry Hsiu-Ying Wang, Michael Jaffe, Lawrence A. Shimp, Nels J. Lauritzen, Charles M. Schiff
  • Publication number: 20100191346
    Abstract: A bone implant derived from natural bone tissue material, wherein the bone implant is substantially free of non-fibrous tissue proteins, cells and cellular elements and lipids or lipid residues and comprises collagen displaying original collagen fibre architecture and molecular ultrastructure of the natural bone tissue material from which it is derived.
    Type: Application
    Filed: April 15, 2008
    Publication date: July 29, 2010
    Inventors: Stephen Bloor, Joanne Louise Proffitt, Paul Armitage, Christine Elizabeth Dawson
  • Patent number: 7758643
    Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.
    Type: Grant
    Filed: February 26, 2007
    Date of Patent: July 20, 2010
    Assignee: Biomet Sports Medicine, LLC
    Inventors: Kevin T Stone, Karen Troxel
  • Patent number: 7753963
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: July 13, 2010
    Assignee: Synthes USA, LLC
    Inventors: Michael L. Boyer, II, David C. Paul, Christopher M. Angelucci
  • Patent number: 7749555
    Abstract: The present invention relates to a method for enhancing ingrowth of host bone comprising: modifying a bone graft structure to provide an ionic gradient to produce a modified bone graft structure; and implanting the modified bone graft structure. The present invention also relates to a method of enhancing the binding of growth factors and cell cultures to a bone graft structure comprising: applying ex vivo an effective quantity of an ionic force change agent to the surface of a bone graft structure to produce a binding-sensitized bone graft structure; implanting the binding-sensitized bone graft structure into a host bone; and administering to the binding-sensitized bone graft structure a molecule, a cell culture or a combination thereof.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: July 6, 2010
    Inventors: John M. Zanella, Sean M. Haddock, Catherine E. Taylor, Kathryn J. Kitching
  • Publication number: 20100152863
    Abstract: Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.
    Type: Application
    Filed: December 13, 2009
    Publication date: June 17, 2010
    Inventor: Amit Prakash Govil
  • Patent number: 7678385
    Abstract: A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: March 16, 2010
    Assignee: Biomet Manufacturing Corp.
    Inventor: A. Hari Reddi
  • Patent number: 7670384
    Abstract: Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: March 2, 2010
    Assignee: Biomet Manufacturing Corp.
    Inventors: Mukesh Kumar, Ned M. Hamman, Michael D. Leach, John Manocchio, Paul D'Antonio, Daryl L. Carter
  • Patent number: 7662184
    Abstract: A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
    Type: Grant
    Filed: February 19, 2007
    Date of Patent: February 16, 2010
    Assignee: Osteotech, Inc.
    Inventors: Jean T. Edwards, Lawrence A. Shimp, Michele Diegmann, Todd M. Boyce, Nelson L. Scarborough, James L. Russell
  • Publication number: 20100036503
    Abstract: The invention is directed to a process for making a tissue repair implant having a porous sponge-like structure to repair bone, cartilage, or soft tissue defects by producing a connective tissue homogenate from one or more connective tissues; mixing the connective tissue homogenate with a carrier solution to produce a connective tissue carrier; optionally mixing one or more natural or synthetic bone fragements with said connective tissue carrier to produce a tissue repair mixture; freezing or freeze-drying the tissue repair mixture to produce a porous sponge-like structure and create a three-dimensional framework to entrap the natural or synthetic bone fragments, treating the frozen or freeze-dried porous sponge-like structure with one or more treatment solutions to produce a stabilized porous sponge-like structure. A crudely fragmented connective tissue from one or more connective tissues is optionally mixed with the tissue repair mixture before freezing or freeze-drying.
    Type: Application
    Filed: August 7, 2008
    Publication date: February 11, 2010
    Inventors: Silvia S. Chen, Jingsong Chen, Lloyd Wolfinbarger, JR.
  • Patent number: 7658768
    Abstract: Bone graft substitute compositions and methods of making the compositions are disclosed. In some embodiments, a method of making a composition includes contacting a mixing solution with a first mixture having calcium sulfate hemihydrate and a plasticizing material to form a second mixture; waiting a predetermined period of time after forming said second mixture; and then contacting demineralized bone with the second mixture to form the composition. A composition can be formed from a kit including a first mixture having calcium sulfate hemihydrate and a plasticizing substance, a second mixture having demineralized bone, and a mixing solution. The first and second mixtures and the mixing solution are unblended.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: February 9, 2010
    Assignee: Wright Medical Technology, Inc.
    Inventors: Leasa C. Miller, Kelly Coupe Richelsoph, Jon P. Moseley
  • Publication number: 20100015202
    Abstract: The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
    Type: Application
    Filed: July 24, 2009
    Publication date: January 21, 2010
    Inventors: Eric J. Semler, Roman Shikhanovich, Alex B. Callahan, Katherine Gomes Truncale, Judith I. Yannariello-Brown, Yen-Chen Huang
  • Publication number: 20090312842
    Abstract: Bifunctional and assembled implants are provided for osteochondral implantation.
    Type: Application
    Filed: June 16, 2008
    Publication date: December 17, 2009
    Inventors: Predrag Bursac, Lauren M. Brown, Eric J. Schmitt, Guy B. Grover
  • Patent number: 7621963
    Abstract: A bone graft material comprising about 50-90% quickly bioresorbable porogen particles and about 10-50% of a calcium matrix material. A bioactive substance can be included in the matrix material, the porogen particles, or both. Commercial packages containing the bone graft materials and methods for repairing bone therewith are also claimed.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: November 24, 2009
    Assignee: EBI, LLC
    Inventors: Bruce J. Simon, Robert M. Ronk, Paul D'Antonio, Jeffrey D. Schwardt
  • Patent number: 7608113
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: October 27, 2009
    Assignee: Synthes USA, LLC
    Inventors: Michael L. Boyer, II, David C. Paul, Christopher M. Angelucci
  • Publication number: 20090265017
    Abstract: A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix.
    Type: Application
    Filed: April 17, 2008
    Publication date: October 22, 2009
    Applicant: Warsaw Orthopedic, Inc.
    Inventor: William F. MCKAY
  • Publication number: 20090210057
    Abstract: A multi-layered matrix, a method of tissue repair using the same, and multi-layered implant prepared thereof are provided. The multi-layered matrix comprises a first element and a second element connected thereto, and the second element comprises a hollow cavity. The first and the second elements are composed of a composite material comprising a bioabsorbable porous material.
    Type: Application
    Filed: April 20, 2009
    Publication date: August 20, 2009
    Inventors: Chun-Jan Liao, Ching-Chuan Jiang, Hong-Sen Chiang, Yu-Ru Lin
  • Publication number: 20090187245
    Abstract: The invention is directed toward a sterile composite bone graft for use in implants comprising a central member constructed of biocompatible plastic with two end caps of cortical bone mated to opposite ends of the central member. The central member is cylindrically ring shaped with a plurality of ribs formed in the side wall of the cylinder.
    Type: Application
    Filed: January 22, 2009
    Publication date: July 23, 2009
    Inventors: Anton J. Steiner, Gary Thomas, Dennis McBride
  • Publication number: 20090171467
    Abstract: A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fibre lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fibre lay; with or without an integral means of firmly anchoring the device to a patient's bone.
    Type: Application
    Filed: August 17, 2006
    Publication date: July 2, 2009
    Applicant: OXFORD BIOMATERIALS LTD.
    Inventors: Stephen Mann, David Philip Knight, Nicholas James Vavasour Skaer, Caroline Bertram, Richard O.C. Oreffo, Helmtrud I. Roach, Andrew Michael Collins
  • Patent number: 7550007
    Abstract: Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilinear. At the recipient site of the host bone, a cutout is formed corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: June 23, 2009
    Assignee: Biomet Sports Medicine, LLC
    Inventor: Theodore I. Malinin
  • Patent number: 7537617
    Abstract: The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of bone pieces formed into at least one load bearing layer.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: May 26, 2009
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: James J. Bindsell, T. Andrew Simonton, Cary R. Reeves, William F. McKay, Eddie F. Ray
  • Publication number: 20090125110
    Abstract: The present invention is a system for a partially biological disc replacement that stimulates natural fibrous, cartilaginous or other tissue growth in the DDD cavity, resulting in a partial biological disc replacement. Multiplicities of fibronous pieces of fibro-cartilaginous tissue promoting material are inserted into the DDD cavity inducing tissue growth.
    Type: Application
    Filed: October 8, 2008
    Publication date: May 14, 2009
    Inventor: Stephen D. Kuslich
  • Patent number: 7530982
    Abstract: A graft formation and delivery instrument comprising an outer barrel, a piston, and an inner pin. The outer barrel has a center aperture. The piston is seated within the center aperture, has a through bore, and is operable to move within the center aperture. The inner pin is seated within the through bore of the piston and operable to move within the through bore. The outer barrel receives multiple graft components that are contacted by at least one of the piston and the inner pin to assemble a composite graft from the graft components. The instrument is operable to direct the composite graft to a desired implant area and deposit the composite graft at the implant area.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: May 12, 2009
    Assignee: Biomet Manufacturing Corp.
    Inventor: David Goshert
  • Patent number: 7507254
    Abstract: The present invention relates to inorganic bone graft materials and a method for preparing the bone graft materials. Particularly, the present invention relates to a method for preparing bone graft materials comprises the following steps: collecting cancellous bones from an animal; removing lipids and organic materials from the cancellous bones using organic solvent, sodium hypochlorite and hydrogen peroxide; and sterilizing the cancellous bones wherefrom the lipids and the organic materials are removed. The bone graft materials prepared by the method of the present invention meet requirements for use in bone grafting, including biocompatibility, sterilization, osteoinductivity and osteoconductivity with free from immunogenecity and toxicity to tissue and are suitable for use in osteogenesis and have morphogenesis.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: March 24, 2009
    Assignee: Oscotec, Inc.
    Inventors: Chang Joon Yim, Se Won Kim, Jung Keun Kim, Jong Yeo Kim, Hyung Gun Kim, Dong Ryung Shin, Yong Mok Yu, Sung Bin Yim, Seon Yle Ko, Sung Churl Lee
  • Publication number: 20090069901
    Abstract: The invention is directed toward a cartilage repair assembly comprising a shaped allograft structure of subchondral bone with an integral overlying cartilage cap which is treated to remove cellular debris and proteoglycans and milled allograft cartilage in a bioabsorbable carrier. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that either the shaped bone or the cartilage cap engage the side wall of the drilled bore in an interference fit and is in contact with a milled cartilage and biocompatible carrier mixture allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
    Type: Application
    Filed: July 24, 2008
    Publication date: March 12, 2009
    Inventors: Katherine Gomes Truncale, Arthur A. Gertzman, Moon Hae Sunwoo, William W. Tomford
  • Publication number: 20090062821
    Abstract: A composite resilient scaffold may be used to grow, repair, and/or regenerate tissue such as articular cartilage. The composite scaffold is porous and at least substantially bioremovable. The composite scaffold includes a support structure coated with a discontinuous coating of separate and discrete particles of a ceramic material such as calcium phosphate. The calcium phosphate material may have a porous reticulated structure.
    Type: Application
    Filed: August 31, 2007
    Publication date: March 5, 2009
    Applicant: PHILLIPS PLASTICS CORPORATION
    Inventors: James R. Johnson, Anita Tavakley
  • Patent number: 7494950
    Abstract: The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length/diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and/or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural toughness, and/or screw pullout strength.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: February 24, 2009
    Assignees: Synthes (U.S.A.), Synthes GmbH
    Inventors: Bryan Monro Armitage, Ira Ison, Mark Fulmer, Sean Kerr, Michael Lehmicke, Patrick Leamy, William Schiffer
  • Patent number: 7488348
    Abstract: The invention is directed toward a cartilage repair assembly comprising a cylindrically shaped allograft structure of subchondral bone with an integral overlying smaller diameter cartilage cap which is treated to remove cellular debris and proteoglycans. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the subchondral bone of the structure engages the side wall of the bone portion of the drilled bore in an interference fit while the cartilage cap is spaced from cartilage portion of the side wall of the drilled bore forming a gap in which a milled cartilage and biocompatible carrier mixture is placed allowing cell transfer throughout the defect area. A method for inserting the shaped allograft structure into a cartilage defect area is also disclosed.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: February 10, 2009
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Katherine G. Truncale, Moon Hae Sunwoo, Arthur A. Gertzman, William W. Tomford, Judith I. Yannariello-Brown