Including Natural Bone Tissue Patents (Class 623/23.63)
  • Publication number: 20030045936
    Abstract: Implants for use in the spinal column are disclosed. The implants comprise a bone allograft coupled with a non-allogenic plate. The plate has ends that fasten to opposing spine segments, and an intermediate portion that engages the allograft using deformable fingers, or with a hollow portion sized to receive and hold part of the allograft, or with fixed tabs. Methods of using the implants are also disclosed.
    Type: Application
    Filed: August 29, 2001
    Publication date: March 6, 2003
    Inventors: Christopher M. Angelucci, Michael L. Boyer, David C. Paul, Christopher J. Ryan, Amit Sinha, Martin Walter
  • Publication number: 20030036801
    Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 20, 2003
    Inventors: Herbert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
  • Publication number: 20030036800
    Abstract: The present invention relates to a method of forming a bone composite, comprising: providing bone tissue; grinding said bone tissue to form ground tissue; molding the ground bone tissue into a bone composite; applying a binder to the bone composite; applying a vacuum to the mold, and optionally milling or refining the bone composite to the desired shape. The present invention also encompasses bone tissue composites made therefrom. The composites may be, for example, a bone pin, screw, or prosthesis.
    Type: Application
    Filed: April 23, 2002
    Publication date: February 20, 2003
    Inventor: Thomas L. Meredith
  • Publication number: 20030036799
    Abstract: A composition or device suitable for orthopedic or dental implantation to bone, characterized by tartrate-resistant acid phosphatase (TRAP) adsorbed to a porous hydroxyapatite substratum.
    Type: Application
    Filed: September 27, 2002
    Publication date: February 20, 2003
    Applicant: Washington Research Foundation
    Inventors: Minako Yoshioka Lee, David Rodney Eyre, Mary Ann Eklof Weis
  • Publication number: 20030036797
    Abstract: Methods and devices are provided for regenerating a meniscus. The devices comprise a layer of toughened naturally occurring extracellular matrix. The devices may, optionally, further comprise a biologic material to provide a framework for meniscus regeneration. The methods comprise the steps of removing a portion of a meniscus to provide a space, and inserting a device comprising a layer of toughened naturally occurring extracellular matrix into the space.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 20, 2003
    Inventors: Prasanna Malaviya, Herbert Eugene Schwartz, Terrence David Whalen, Mark Joseph Pelo, Phillip Joseph Jenks, Pamela Lynn Plouhar, Jerrry Lee Lower
  • Publication number: 20030033022
    Abstract: A method for the repair of a cartilagenous tissue defect, a cartilage repair device and a method of making a cartilage repair device are disclosed. In the method for the repair of a cartilagenous tissue defect, a device comprising a scaffold, for example an extracellular matrix material, is implanted into the defect, and a biological lubricant is administered to the defect. The device comprises a scaffold, for example a naturally occurring extracellular matrix material, and a biological lubricant.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 13, 2003
    Inventors: Pamela Lynn Plouhar, Prasanna Malaviya, Herbert Eugene Schwartz
  • Publication number: 20030033021
    Abstract: A method for the repair of a cartilaginous tissue defect, a cartilage repair device and a method of making a cartilage repair device are disclosed. In the method for the repair of a cartilaginous tissue defect, a device comprising a synthetic polymer is implanted into the defect, and a biological lubricant is administered to the defect. The device comprises a synthetic polymer and a biological lubricant.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 13, 2003
    Inventors: Pamela Lynn Plouhar, Herbert Eugene Schwartz, Prasanna Malaviya
  • Publication number: 20030019396
    Abstract: A kit and a method for making a porous cement which self sets to hydroxyapatite and has an interconnected porosity is produced by mixing a calcium source and a phosphate source with a carbonate source and mixing this powdered component with a liquid component having an acid component. The liquid component comprises water or an aqueous solution containing an acid. The acid and the carbonate react to form carbon dioxide thereby producing an interconnected porosity in the normally solid self-hardening bone cement. The method requires only a relatively low weight percent of the acid and base to be mixed with the liquid and powder cement components.
    Type: Application
    Filed: September 9, 2002
    Publication date: January 30, 2003
    Applicant: Howmedica Osteonics Corp.
    Inventors: Brian Edwards, Paul Higham, Joseph Zitelli
  • Patent number: 6511509
    Abstract: The present invention is directed to a textured bone allograft for implantation in a patient, having one or more textured bone surfaces, and methods of making and using the textured bone graft. The textured surface preferably includes a plurality of closely spaced discrete, continuous, or a combination thereof, protrusions. The textured bone allograft is useful for repairing bone defects caused by congenital anomaly, disease, or trauma, in a patient, for example, for restoring vertical support of the anterior column. Implantation of the textured bone allograft results in improved graft stability and osteoinductivity, without a decrease in mechanical strength. The textured bone allograft does not shift, extrude or rotate, after implantation.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: January 28, 2003
    Assignee: LifeNet
    Inventors: Louis Ford, Lloyd Wolfinbarger, Jr., Jon C. Serbousek, Laine Mashburn, Jr.
  • Publication number: 20030014124
    Abstract: The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one or more alkaline solutions. Incubation is optionally carried out with one or more debriding agents including inert dry granular or particulate material including for example beads, and the granular phase of an alkaline agent, including for example granular sodium hydroxide. The incubating may be carried out with agitation. In another embodiment, the medullary canal of the bone is subjected to a positive pressure stream of debriding solution under conditions sufficient to loosen the associated soft tissue from the bone at the interface of the soft tissue and bone. In a further embodiment, the debriding solution is provided as a gel.
    Type: Application
    Filed: March 27, 2002
    Publication date: January 16, 2003
    Inventors: Lloyd Wolfinbarger, Robert K. O'Leary, Louis Ford, Alyce Linhurst Jones
  • Publication number: 20030009235
    Abstract: An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
    Type: Application
    Filed: May 2, 2002
    Publication date: January 9, 2003
    Inventors: Albert Manrique, Jean T. Edwards, Nelson L. Scarborough, Scott D. Boden, Kathy Traianedes, Lawrence A. Shimp, James L. Russell
  • Publication number: 20020177903
    Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.
    Type: Application
    Filed: April 7, 2000
    Publication date: November 28, 2002
    Inventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlosser
  • Patent number: 6478825
    Abstract: An implant is provided as a solid aggregate of bone-derived elements, e.g., particles, powders, granules, fibers, strips and/or large pieces of xenogenic, allogenic, transgenic, tissue engineered or autologous cortical and/or cancellous bone, employing as binding agent for the bone-derived elements a precipitate or crystalline bridge of metal oxide, metal hydroxide, metal salt of an inorganic acid, metal salt of an organic acid, metal-containing silica based glass, or mixture thereof, the binding agent possessing at least slight solubility in polar solvent, adjacent bone-derived elements being bonded to each other through engagement with particles or bridge-like structures of bonding agent.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: November 12, 2002
    Assignee: Osteotech, Inc.
    Inventors: John M. Winterbottom, Lawrence Shimp, Todd M. Boyce, David Kaes
  • Publication number: 20020161449
    Abstract: A composite bone marrow graft material is provided having an enriched population of uniformly distributed progenitor cells. The graft material includes clot material preferably derived from non-anticoagulated bone marrow aspirate, which significantly improves the efficacy of the graft. A method for preparing such bone graft material is also provided. A kit is also provided containing sterilized implements useful in preparing enriched composite bone marrow graft material.
    Type: Application
    Filed: February 28, 2001
    Publication date: October 31, 2002
    Inventor: George F. Muschler
  • Publication number: 20020161442
    Abstract: An interbody spinal implant comprising cortical bone having a width less than one-half the width of the disc space into which it is adapted to be inserted. The implant has a leading end that is asymmetrical from side to side and/or includes a straight portion adapted to be used in side-by-side pairs.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 31, 2002
    Inventor: Gary K. Michelson
  • Patent number: 6464729
    Abstract: A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized biological material. The mineralized biological material is characterized by having a biochemical composition and physiological organization substantially similar to the deep and contiguous calcified cartilage zones of articular cartilage found in animals in vivo. Methods for preparing the biological materials and methods of using the biological materials are described.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: October 15, 2002
    Assignee: Mount Sinai Hospital Corporation
    Inventor: Rita Kandel
  • Publication number: 20020147497
    Abstract: Apparatus and methods for treating a spinal disc are disclosed. An opening is created in the annulus fibrosis, and nucleus pulposus is removed from the interior of the disc. The interior is lined with a nonporous, bioabsorbable liner, and filled with a fill material, such as nucleus pulposus, to cause the liner to expand to engage tissue surrounding the interior. The liner may be a sheet of extra-cellular matrix material that is introduced into the interior, or a bladder of extra-cellular matrix material including a neck communicating with an interior region of the bladder. The sheet or bladder may be carried by a delivery device, e.g., a catheter or rod. After the interior region is filled, the opening is closed using a plug or other closure device. The plug may include threads on its external surface for securing the plug in the opening.
    Type: Application
    Filed: April 6, 2001
    Publication date: October 10, 2002
    Applicant: Integrated Vascular Systems, Inc.
    Inventors: William Martin Belef, Stephen M. Salmon, William N. Aldrich, Ronald J. Jabba
  • Publication number: 20020133235
    Abstract: Cells grown on a microcarrier are separated from the microcarrier by enzymatically digesting the microcarrier. More specifically, chondrocytes may be grown on dextran microcarrier beadlets and then the beadlets digested using dextranase to separate the chondrocytes from the carrier. Cells can also be grown on chitosan microcarriers to be used for implantation. In addition, cells can be grown on polysaccharide polymers to be used as implant devices. Various polymers serve as scaffolds for cells to be used for implantation. The polymers can be used for cell culture as well as for preparing scaffolds useful for tissue replacement such as cartilage tissue.
    Type: Application
    Filed: February 4, 2002
    Publication date: September 19, 2002
    Inventors: David S. Hungerford, Carmelita G. Frondoza, Afshin Sohrobi, Alan H. Shikani, Abraham J. Domb
  • Publication number: 20020120347
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Application
    Filed: August 13, 2001
    Publication date: August 29, 2002
    Inventors: Michael L. Boyer II, David C. Paul, Christopher M. Angelucci
  • Publication number: 20020120338
    Abstract: Selectively partially and demineralized bone-derived implants, their methods of preparation and use are provided. In one embodiment, a cranial void filler preferably having a T-shape formed of an upper mineralized cortical bone section and at least a partially demineralized lower section adapted to fill a cranial void is disclosed. In another embodiment, a plate preferably having a dog-bone-shape having mineralized and at least partially demineralized sections is disclosed. In a further embodiment, a unitary cord having a first mineralized section with a plurality of slits to provide flexibility and a second at least partially demineralized section is described. Also disclosed is an implant for laminoplasty having at least a partially demineralized section and a mineralized section. A method of forming an implant of demineralized fibers also is disclosed.
    Type: Application
    Filed: August 13, 2001
    Publication date: August 29, 2002
    Inventors: Michael L. Boyer, David C. Paul, Christopher M. Angelucci
  • Publication number: 20020120346
    Abstract: Selectively demineralized bone-derived implants are provided. In one embodiment, a bone sheet for implantation includes a demineralized field surrounding mineralized regions. In another embodiment, a bone defect filler includes a demineralized cancellous bone section in a first geometry. The first geometry is compressible and dryable to a second geometry smaller than the first geometry, and the second geometry is expandable and rehydratable to a third geometry larger than the second geometry.
    Type: Application
    Filed: August 13, 2001
    Publication date: August 29, 2002
    Inventors: Michael L. Boyer, David C. Paul, Christopher M. Angelucci
  • Patent number: 6437018
    Abstract: The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier contain a sodium phosphate saline buffer, the hydrogel component of the carrier ranging from about 0.75 to 4.5% of the composition and having a molecular weight of about at least 160,000 Daltons. The composition has a pH between 6.8-7.4 contains about 25% to about 35% bone powder and can be additionally provided with BMP's.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: August 20, 2002
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Arthur A. Gertzman, Moon Hae Sunwoo
  • Publication number: 20020107570
    Abstract: Methods of repairing a joint formed by at least two bone sections are provided wherein a biocompatible osteogenic band fabricated from an osteogenic biological material such as bone, tendon, ligament and collagen is affixed to two or more bone sections.
    Type: Application
    Filed: December 8, 2000
    Publication date: August 8, 2002
    Inventors: Daryl R. Sybert, Lawrence A. Shimp, Todd M. Boyce, John W. Boyle
  • Publication number: 20020082694
    Abstract: Osteogenic sponge compositions having enhanced osteoinductive properties for use in bone repair are described. The compositions include a quickly resorbable porous carrier, a more slowly resorbed mineral scaffold and an osteogenic factor, preferably a bone morphogenetic protein. The compositions enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at an implant site. Methods for therapeutic use of the compositions are also described.
    Type: Application
    Filed: August 6, 2001
    Publication date: June 27, 2002
    Inventor: William F. McKay
  • Publication number: 20020082704
    Abstract: Osteoarticular allografts are transplanted by techniques which ensure substantial surface contour matching. Specifically, surgical techniques are provided whereby a plug from an osteochondral allograft may be transplanted to a cavity site which remains after a condylar defect is removed from a patient's condyle. In this regard, the present invention essentially includes placing an osteochondral allograft in substantially the same orientation as the patient condyle, and then removing the transplantable plug therefrom and forming the cavity site in the patient condyle while maintaining their relative same orientation. In this manner, the surface of the transplanted plug is matched to the contour of the excised osteochondral tissue.
    Type: Application
    Filed: February 28, 2002
    Publication date: June 27, 2002
    Applicant: CRYOLIFE, INC.
    Inventor: Daniel G. Cerundolo
  • Patent number: 6409765
    Abstract: Open chambered spacers, implanting tools and methods are provided. The spacers 500′ include a body 505′ having a wall 506′ which defines a chamber 530′ and an opening 531′ in communication with the chamber 530′. In one embodiment the wall 506′ includes a pair of arms 520′, 521′ facing one another and forming a mouth 525′ to the chamber 530′. Preferably, one of the arms 520′ is truncated relative to the other, forming a channel 526. In one aspect the body 505′ is a bone dowel comprising an off-center plug from the diaphysis of a long bone. The tools 800 include spacer engaging means for engaging a spacer and occlusion means for blocking an opening defined in the spacer. In some embodiments, the occlusion means 820 includes a plate 821 extendable from the housing 805.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: June 25, 2002
    Assignees: SDGI Holdings, Inc., University of Florida Tissue Bank, Inc.
    Inventors: John R. Bianchi, Kevin C. Carter, Bradley T. Estes, Larry Boyd, John A. Pafford
  • Publication number: 20020072804
    Abstract: This invention provides a method and means for securing a tissue to a bone or non-tissue prosthesis by affixing a collagenous material to said bone or non-tissue prosthesis, and affixing said tissue to said collagenous material.
    Type: Application
    Filed: September 20, 2001
    Publication date: June 13, 2002
    Inventor: Russell S. Donda
  • Patent number: 6383221
    Abstract: An intervertebral implant having a composite wedge/dowel configuration is provided. The intervertebral implant includes a central body portion and a pair of radially extending wings. The radially extending wings can be tapered from a first end of the implant to the second end of the implant along an axis parallel to the longitudinal axis of the central body portion. Alternately, the radially extending wings can be tapered along an axis transverse to the longitudinal axis of the cylindrical body portion or along any other axis between parallel and transverse to the longitudinal axis. A throughbore or plurality of throughbores extend from a top surface of the implant through the implant to a bottom surface of the implant. The implant may be formed from a cortical ring cut from the diaphysis of a long bone by milling the top and bottom surfaces of the cortical ring to form the substantially central body portion and the tapered radially extending wings.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: May 7, 2002
    Assignee: Osteotech, Inc.
    Inventors: Nelson L. Scarborough, John W. Boyle
  • Patent number: 6371988
    Abstract: Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: April 16, 2002
    Assignee: SDGI Holdings, Inc.
    Inventors: John Pafford, Lawrence M. Boyd, William F. McKay, Eddie F. Ray, III, James E. Van Hoeck
  • Publication number: 20020040246
    Abstract: A tissue press for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed. tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site.
    Type: Application
    Filed: November 21, 2001
    Publication date: April 4, 2002
    Inventor: Peter M. Bonutti
  • Publication number: 20020029084
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Application
    Filed: March 22, 2001
    Publication date: March 7, 2002
    Inventors: David C. Paul, Hansjuerg W. Emch, Beat Schenk, Michael L. Boyer, Thomas B. Higgins
  • Publication number: 20020029081
    Abstract: An intervertebral implant having a composite wedge/dowel configuration is provided. The intervertebral implant includes a central body portion and a pair of radially extending wings. The radially extending wings can be tapered from a first end of the implant to the second end of the implant along an axis parallel to the longitudinal axis of the central body portion. Alternately, the radially extending wings can be tapered along an axis transverse to the longitudinal axis of the cylindrical body portion or along any other axis between parallel and transverse to the longitudinal axis. A throughbore or plurality of throughbores extend from a top surface of the implant through the implant to a bottom surface of the implant. The implant may be formed from a cortical ring cut from the diaphysis of a long bone by milling the top and bottom surfaces of the cortical ring to form the substantially central body portion and the tapered radially extending wings.
    Type: Application
    Filed: August 8, 2001
    Publication date: March 7, 2002
    Inventors: Nelson L. Scarborough, John W. Boyle
  • Publication number: 20020013627
    Abstract: A method of promoting regeneration of surface cartilage of a joint includes the steps of covering the area to be treated with a patch which includes a sheet of collagen membrane material. The collagen membrane material has at least one barrier layer to prevent passage of cells therethrough. The collagen membrane further includes a matrix layer predominantly of collagen II having an open sponge-like texture. The patch is fixed over the area to be treated, and the area is allowed to regenerate cartilage.
    Type: Application
    Filed: August 10, 2001
    Publication date: January 31, 2002
    Applicant: Ed. Geistlich Soehne AG fur Chemische Industrie Switzerland
    Inventors: Peter Geistlich, Lothar Schloesser
  • Publication number: 20010051833
    Abstract: This invention provides molded, biodegradable porous polymeric implant materials having a pore size distribution throughout the material which is substantially uniform. These materials can be molded into implants of any desired size and shape without loss of uniformity of pore size distribution. The implants are useful as biodegradable scaffolds for cell growth in healing of tissue defects. Particulate implant materials are provided, especially useful as autologous bone graft materials.
    Type: Application
    Filed: March 19, 2001
    Publication date: December 13, 2001
    Inventors: Mary Ann Walter, Neil C. Leatherbury, Mark Q. Niederauer
  • Publication number: 20010051834
    Abstract: This invention is a method for the implantation of a combination of cells or cell-microcarrier aggregates wherein one component comprises a solid implantable construct and a second component comprises an injectable formulation. For example, in one embodiment, the solid implant may be first implanted to fill the majority of the cavity receiving the implant, and then cells or cell-microcarrier aggregates in an injectable format, with or without the addition of gelling materials to promote rapid gelling in situ, may be injected into spaces surrounding the solid implant in order to secure the solid implant in the site and/or to promote rapid adherence and/or integration of the solid implant to surrounding tissues. Also contemplated in this embodiment is that the cellular composition of the injectable component may differ from that of the solid component.
    Type: Application
    Filed: August 6, 2001
    Publication date: December 13, 2001
    Applicant: Chondros, Inc.
    Inventors: Carmelita G. Frondoza, David S. Hungerford, Alan H. Shikani, Abraham J. Domb, David J. Fink, Leonard Bloom
  • Publication number: 20010041941
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Application
    Filed: March 22, 2001
    Publication date: November 15, 2001
    Inventors: Michael L. Boyer, David C. Paul, Thomas B. Higgins
  • Publication number: 20010039456
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Application
    Filed: March 22, 2001
    Publication date: November 8, 2001
    Inventors: Michael L. Boyer, David C. Paul, Thomas B. Higgins
  • Publication number: 20010039458
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Application
    Filed: March 22, 2001
    Publication date: November 8, 2001
    Inventors: Michael L. Boyer, David C. Paul, Thomas B. Higgins
  • Publication number: 20010039457
    Abstract: The present invention relates to plugs for filling vacancies in bone tissue. The plugs include a body and at least one end cap that are coupled together and may be formed from bone. The body of the plug may be a sleeve, and the plug may further include an insert configured and dimensioned to be received in the sleeve.
    Type: Application
    Filed: March 22, 2001
    Publication date: November 8, 2001
    Inventors: Michael L. Boyer, David C. Paul, Thomas B. Higgins, Christopher M. Angelucci, Dominique D. Messerli, Kenneth I. Kobayashi
  • Publication number: 20010034556
    Abstract: The present invention provides a plasticized dehydrated or freeze-dried bone and/or soft tissue product that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in normal hydrated tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. The invention replaces water in the molecular structure of the bone or soft tissue matrix with one or more plasticizers allowing for dehydration of the tissue, yet not resulting in an increase in brittleness of the plasticized product, and resulting in compressive and/or tensile properties similar to those of normal hydrated bone. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the dehydrated bone or soft tissue plasticized product can be placed directly into an implant site without significant preparation in the operating room.
    Type: Application
    Filed: June 22, 2001
    Publication date: October 25, 2001
    Inventors: Lloyd Wolfinbarger, Robert K. O'Leary, Billy G. Anderson
  • Publication number: 20010032016
    Abstract: The invention relates to a method for an vitro production of bone tissue, comprising the steps of:
    Type: Application
    Filed: June 8, 2001
    Publication date: October 18, 2001
    Applicant: Iso Tis N.V.
    Inventors: Clemens Antoni Van Blitterswijk, Joost Dick De Bruijn, Yvonne Pearl Bovell
  • Publication number: 20010031799
    Abstract: A calcium phosphate bone graft material comprising an amorphous calcium phosphate glassy phase of from about 30 to about 100 volume % is obtained by plasma spraying calcium phosphate-containing powder onto a target to produce a deposited layer and removing the deposited layer from the target to provide the calcium phosphate bone graft material.
    Type: Application
    Filed: December 15, 2000
    Publication date: October 18, 2001
    Inventor: Lawrence A. Shimp
  • Patent number: 6299650
    Abstract: The invention relates to a method for in vitro production of bone tissue, comprising the steps of: (a) applying undifferentiated mammalian cells, in particular autologous marrow cells, on a substrate; (b) directly contacting said cells with a culture medium for a sufficient time to produce a continuous matrix; (c) removing the substrate with the matrix from the culture medium. The produced matrix can be used for joint prostheses, maxillofacial implants, special surgery devices, or bone fillers. The contacted culture medium can also be used for the production of active factors such as growth factors.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 9, 2001
    Assignee: IsoTis N.V.
    Inventors: Clemens Antoni Van Blitterswijk, Joost Dick De Bruijn, Yvonne Pearl Bovell
  • Publication number: 20010027344
    Abstract: A tissue press for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site.
    Type: Application
    Filed: June 1, 2001
    Publication date: October 4, 2001
    Inventor: Peter M. Bonutti
  • Patent number: 6294041
    Abstract: The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are various other components which can be incorporated into the bone implant material such as bone-growth inducing substances; and a method of manufacture.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: September 25, 2001
    Assignee: Osteotech, Inc.
    Inventors: Todd M. Boyce, Albert Manrique
  • Patent number: 6293971
    Abstract: A composite allograft press comprises a loading frame and a two piece mold to form an composite allograft and in particular an acetabular cup from impacted cancellous bone chips and cement. Pressure is applied by a manually operated lever through a rack-and-pinion gear mechanism to a plunger attached to one part of the mold. Compression load switches in-line with the plunger indicate the correct loading to the mold to produce a composite allograft in which the inner surface is smooth and comprised essentially of hardened bone cement material. The outer portion of the allograft may have limited cement extrusions but the exterior of the cup primarily shows exposed cancellous bone surface. In surgery a composite allograft; e.g., an acetabular cup, is fixed in the acetabulum with bone screws to fill an acetabular defect. A plastic liner is affixed with bone cement directly to the composite allograft cup to receive the femoral component.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: September 25, 2001
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Carl Nelson, J. Marcus Hollis, Charlene Flahiff, William Hogue
  • Publication number: 20010020186
    Abstract: An intervertebral implant having a tabbed configuration is provided. The intervertebral implant includes a substantially cylindrical body portion and a pair of radially extending tabs. The radially extending tabs may be provided as a single or double pair and may assume various shapes and configurations for engaging the interior of a bore formed between adjacent vertebrae. A throughbore or plurality of throughbores extend from the top surface of the implant to the bottom surface of the implant. The implant may be formed from a cortical ring cut from the diaphysis of a long bone by milling. Alternatively, the implant may be formed of any biocompatible material having the requisite strength requirements via any known process, i.e., molding.
    Type: Application
    Filed: December 22, 2000
    Publication date: September 6, 2001
    Inventors: Todd M. Boyce, Erik O. Martz, Nelson L. Scarborough
  • Publication number: 20010020188
    Abstract: This invention provides a novel unitary bone implant having at least one rigid, mineralized bone segment, which may be machined to include threads, grooves, a driver head, perforations, a recess or a symmetric or asymmetric shape, and a flexible, demineralized segment, which may also be machined to any desired shape prior to demineralization, or after demineralization. The implant of this invention has wide orthopedic applicability, including but not limited to repair or replacement of ligaments, tendons and joints and for inducing vertebral fusions and fractured bone repair. In a particular embodiment of this invention, selective uptake of biologically active or inactive materials into the segmentally demineralized portion of the implant is disclosed.
    Type: Application
    Filed: February 5, 2001
    Publication date: September 6, 2001
    Inventor: Tom Sander
  • Publication number: 20010014830
    Abstract: A porous three-dimensional bone grafting matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix and having a particle size of 5 microns or less.
    Type: Application
    Filed: February 13, 2001
    Publication date: August 16, 2001
    Applicant: Orquest, California corporation
    Inventors: Michael K. Kwan, Stephen D. Pacetti, Ronald K. Yamamoto
  • Patent number: 6267786
    Abstract: The invention provides an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. The invention further provides methods for preparing a soft tissue xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and digesting the xenograft with a proteoglycan-depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft tissue xenograft for implantation into a human including a portion of a soft tissue from a non-human animal, wherein the portion has extracellular components and substantially only dead cells. The extracellular components have reduced proteoglycan molecules.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: July 31, 2001
    Assignee: CrossCart, Inc.
    Inventor: Kevin R. Stone