Bone Surface Coating Patents (Class 623/23.6)
  • Publication number: 20100198357
    Abstract: A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
    Type: Application
    Filed: April 13, 2010
    Publication date: August 5, 2010
    Inventors: Thomas A. Fuller, Richard A. Wysk, Wayne J. Sebastianelli
  • Patent number: 7767250
    Abstract: A process for coating a surface of a metal-containing substrate with a bioceramic material includes activating the surface of the metal-containing substrate by applying a voltage to the substrate in a liquid containing an electrolyte; and, immersing the substrate in a deposition solution containing the bioceramic material or precursors for the bioceramic material. The coated substrate may be heat treated to enhance coating bond strength. The bioceramic material may be hydroxyapatite. Coated substrates are useful for the fabrication of prostheses.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: August 3, 2010
    Assignee: National Research Council of Canada
    Inventors: Benli Luan, Jianhui Xle
  • Publication number: 20100185299
    Abstract: The invention relates to bone implants and sets for producing bone implants. Said bone implants are made from pasty or cementitious preparations which are introduced into open-cell metal structures comprising an interconnected pore system as solid or porous materials and are optionally allowed to set, the metal structure per se being biocompatible in biological conditions and being stable or corrodible. The bone implant according to the invention contains at least one open-cell metal structure that has an interconnected pore system which is at least partially filled with a preparation made of at least one bone replacement material. The open-cell metal structure is significantly less rigid than the solid material made of the same metal.
    Type: Application
    Filed: November 27, 2007
    Publication date: July 22, 2010
    Inventor: Berthold Nies
  • Publication number: 20100125303
    Abstract: The present disclosure provides methods and apparatus for replacing biological joints, but applies also to the fixation of any solid implant for use in dental or orthopaedic applications. In general, an ideal amount of bone mineral substance is applied to the implant prior to going in to the operating room. Next, the setting (e.g., drying) process is suspended with a coating and/or a chemical. Once the implant(s) are needed in the operating room, the setting process is resumed. In this manner, the bone mineral substance does not need to be applied in the operating room, the surgeon does not need to “race the clock,” and each implant is placed with the ideal amount of bone mineral substance in the ideal consistency.
    Type: Application
    Filed: August 20, 2009
    Publication date: May 20, 2010
    Inventor: Robert J. Daley
  • Publication number: 20100125341
    Abstract: An intra-articular device comprises a membrane shaped like a cap having a peripheral geometry similar to that of a head of a bone for a joint to be restored and an open end sized to be applied over the bone proximate the head, so that the open end can be stretched over the head of the bone and held in position on the bone interposed between the head and its corresponding articular component of the joint. The membrane is made of a polyether-urethane-urea material selected to have a property of absorbing the joint's own synovial fluid so as to swell and have a viscoelastic property similar to the body's own articular hyaline cartilage. In a preferred embodiment, the membrane cap is adapted for use on a femoral bone for restoring a hip joint.
    Type: Application
    Filed: November 19, 2008
    Publication date: May 20, 2010
    Inventor: John T. FRAUENS
  • Publication number: 20100121439
    Abstract: A coating for an orbital implant has an anterior portion having a different bioabsorbability than a posterior portion. This allows the implant to have an insertion surface, to reduce irritation, to prevent implant exposure, and to anchor muscles. The coating has a visual indicator to facilitate orientation. Shell materials are further selected to allow for sterile packaging, to secure therapeutic agents thereon, and to secure the coating to the core. Passageways enhance fluid flow to and from the core, and expose the core surface to muscles. The passageways are sized and shaped to reduce irritation. In an alternate embodiment, the anterior coating portion has a vaulted zone creating a gap between the undersurface of the coating and the outer surface of the core through which a suture can easily pass. Perforations through the coating provide targets for passage of the suture through the coating.
    Type: Application
    Filed: March 21, 2008
    Publication date: May 13, 2010
    Inventors: Arthur C. Perry, Roger G. Greenwald
  • Patent number: 7704546
    Abstract: A method and apparatus for a prosthesis. At least a portion of the prosthesis is made from a ceramic that is treated with ion implantation, which causes a controllable, bilateral compressive stress of the ceramic. A diamond-like-coating (DLC) can be coated on the ceramic and in the same chamber as the ion implantation. After treating by ion implantation and coating with DLC, the ceramic will be strengthened and have a low coefficient of friction and thereby be made much less likely to fracture under load.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: April 27, 2010
    Assignee: Southwest Research Institute
    Inventor: Geoffrey Dearnaley
  • Patent number: 7687098
    Abstract: A method for fabricating a substitute component for bone, including the processes of: provision of a chemical spray including at least three of calcium chloride, hydrogen phosphate, hydrogen carbonate and water to form a combined solution; reaction and precipitation of the combined solution onto a substrate; allowing the precipitated particles to form a porous structure on the substrate; applying substantially isostatic pressure to the porous structure to form a compressed structure; and (optional) providing one or more through-holes in the compressed structure to promote osteoinduction.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: March 30, 2010
    Inventor: Charlie W. Chi
  • Publication number: 20100076570
    Abstract: The present invention provides an implant (1) comprising a hollow body (2) having an opening (8), the body (2) having an inner (3) and an outer (4) surface, wherein the inner surface (3) of the body (2) has a surface structure (9) that enables bone in-growth. The present invention also provides a method of implantation, comprising: preparing a resected bone with an optional cavity in the bone canal; providing such an implant (1); and implanting the implant.
    Type: Application
    Filed: September 24, 2007
    Publication date: March 25, 2010
    Inventors: Tim Band, Derek McMinn
  • Patent number: 7670636
    Abstract: The invention relates to a method for the production of a metallic substrate having a biocompatible surface and to the substrate that is produced by means of said method. The method comprises treatment of a metal, i.e., Ti, Ti alloys with Al, V, Ta, Nb, Ni, Fe, Mo or mixtures thereof, Ta, Ta alloys with Fe, Al, Cr, stainless steel, with a melt of calcium nitrate and an additional component which is an oxygen salt of Na, K, Li, Mg and mixtures thereof, said treatment being effected at 180-480 ° C. for 0.1 to 12 hours. A substrate is obtained, wherein the overall layer thickness ranges from 10 to below 1600 nm and the fatigue strength of the substrate is in the same fatigue strength range as that of an untreated substrate at equal number of vibrations N.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: March 2, 2010
    Assignee: BAM Bundesanstalt fuer Materialforschung und -pruefung
    Inventors: Georg Berger, Ute Ploska
  • Publication number: 20100036502
    Abstract: A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of ion beam irradiation, preferably gas cluster ion beam irradiation for improving bone integration.
    Type: Application
    Filed: August 7, 2009
    Publication date: February 11, 2010
    Applicant: Exogenesis Corporation
    Inventors: Richard C. Svrluga, Laurence B. Tarrant
  • Publication number: 20100016985
    Abstract: The present invention provides polymeric substrates comprising a biocompatible coating and methods of preparation thereof. In particular, the coating may be a ceramic material, especially a calcium phosphate material, which may be functionally graded. The invention provides the ability to apply high quality coatings to polymeric substrates without damaging the substrate (e.g., melting the polymeric material). The functionally graded coating can provide crystalline calcium phosphate near the coating interface with the substrate and provide amorphous calcium phosphate at the outer surface of the coating.
    Type: Application
    Filed: July 17, 2009
    Publication date: January 21, 2010
    Inventor: Afsaneh Rabiei
  • Publication number: 20090317766
    Abstract: The invention relates to a method for producing a powder-filled ceramic coating made from a precursor ceramic compound (for example, a sol-gel), said coating having an advantageous surface roughness and wherein active ingredients may be eluted from the matrix or filler under physiological conditions and to an implant which can be produced according to the claimed method.
    Type: Application
    Filed: August 31, 2007
    Publication date: December 24, 2009
    Inventors: Frank Heidenau, Gunter Ziegler
  • Publication number: 20090306673
    Abstract: Kit of parts, comprising: a prosthesis or prosthesis part having at least one contact surface; metal granules having an internal porosity; bone cement; and further comprising titanium granules for use in a kit of parts, which granules preferably are osteoconductive, which granules preferably are coated with a coating from the group of osteoconductive or osteoinductive coatings, or coatings comprising bioceramic, bioglass or osteoconductive or osteoinductive molecules or fluids or cells.
    Type: Application
    Filed: May 8, 2009
    Publication date: December 10, 2009
    Applicant: Fondel Finance B.V.
    Inventors: Pier Buma, Berend Willem Schreurs, Nicolaas Jacobus Joseph Verdonschot, Lucas Hubert Bernard Walschot, Thomas Johannes Josephus Hubertus Slooff, Willem Cornelis Van't Wout, SR.
  • Publication number: 20090270997
    Abstract: The present invention proposes novel materials and methods, for preparation of coatings based on titanium dioxide for osteointegrated biomedical prostheses. The coatings are realized with nanomaterials having antibacterial properties, and have the purpose of: promoting osteointegration of the implants, and, at the same time, reducing reaction attributable to inflammatory processes which derive from infections which may develop in the neighborhood of the implants.
    Type: Application
    Filed: June 14, 2006
    Publication date: October 29, 2009
    Inventors: Carlo Alberto Bignozzi, Francesco Carinci, Stefano Caramori, Valeria Dissette
  • Publication number: 20090254191
    Abstract: Systems and methods are described for implants with composite coatings to promote tissue in-growth and/or on-growth. An implant includes: a substrate; a structured surface formed on at least a portion of the substrate; and a biocompatible coating deposited on at least a fraction of the structured surface. The systems and methods provide advantages in that the implant has good biocompatibility while the biocompatible coating has good strength.
    Type: Application
    Filed: November 4, 2008
    Publication date: October 8, 2009
    Inventors: Alfred S. Despres, III, Eugene J. Elwood, Robert R. Aharonov, Peter Ehlers, Knut Andersen
  • Publication number: 20090248170
    Abstract: In a prosthesis and method for manufacturing the same, the prosthesis has an outer articulating surface and an inner bone-contacting surface. The inner surface of the prosthesis has at least one osteo-integration zone with one or more surface formations integrally cast with the wall of the prosthesis. In some instances the prosthesis may be a femoral head prosthesis. To manufacture the prosthesis, a mold is prepared and the prosthesis is cast to include the surface formations.
    Type: Application
    Filed: February 27, 2009
    Publication date: October 1, 2009
    Applicant: Finsbury (Development) Limited
    Inventors: Michael Antony Tuke, Andrew Clive Taylor
  • Publication number: 20090228115
    Abstract: Disclosed are a gradient bioceramic coating comprising a rare earth oxide, a broadband laser method for preparing the bioceramic coating, and the use of the bioceramic coating in the field of medical materials.
    Type: Application
    Filed: October 16, 2008
    Publication date: September 10, 2009
    Applicant: Guizhou University
    Inventors: Qibin LIU, Wenfei Li, Ling Wu
  • Publication number: 20090198344
    Abstract: An implant with a metal structure for use in a surgical procedure, in which at a region of the implant to be in contact with bone the metal structure is provided with a roughened surface. The roughened region is then provided with a ceramic coating comprising hydroxyapatite by a thermal spraying process. Biocidal ions of silver are absorbed into the ceramic coating, and gradually leach out into body fluids after implantation. The hydroxyapatite enhances bone regrowth into the implant, while the silver ions suppress infection.
    Type: Application
    Filed: June 11, 2007
    Publication date: August 6, 2009
    Applicant: Accentus PLC
    Inventors: Thomas Campbell Prentice, Martin Edward Lee Pickford, David Richard Lewis, Andrew Derek Turner
  • Publication number: 20090187253
    Abstract: The present invention relates to a method of making a coated medical bone implant comprising the step of providing a substrate and then onto said substrate depositing a bioactive crystalline TiO2 coating using PVD (Physical Vapor Deposition) technique at a temperature of more than about 50° C. but less than about 800° C. Coated implants obtained by the method according to the invention display an enhanced biomimetic response.
    Type: Application
    Filed: January 16, 2009
    Publication date: July 23, 2009
    Applicant: Sandvik Intellectual Property AB
    Inventors: Maria Astrand, Axel Genvad
  • Publication number: 20090062926
    Abstract: An orthopaedic implant for replacing the surface of a bone, such as in a joint arthroplasty, includes a bone facing surface for mating with the prepared end of the bone. The surface includes a porous coating to promote bone ingrowth. A bioresorbable post extends from the bone facing surface for engagement within a prepared cavity or bore in the bone. The bioresorbable material of the post is selected so that the post will not be substantially resorbed into the existing bone until substantial bone ingrowth has been achieved in the porous coating.
    Type: Application
    Filed: November 13, 2008
    Publication date: March 5, 2009
    Applicant: DePuy Products, Inc.
    Inventor: Joseph Wyss
  • Publication number: 20090012624
    Abstract: The invention provides a medical implant device or component thereof comprising a metal substrate, an intermediate coating, and an outer coating of aluminum oxide, as well as a method of making such a medical implant device or component thereof.
    Type: Application
    Filed: September 11, 2008
    Publication date: January 8, 2009
    Applicant: DePuy Products, Inc.
    Inventors: Ronald OVERHOLSER, Bryan Smith
  • Patent number: 7473278
    Abstract: A coating of blue-black or black oxidized zirconium of uniform and controlled thickness on a zirconium or zirconium alloy material is accomplished through the oxidative treatment of an amorphous zirconium or zirconium alloy substrate having an altered surface roughness. An oxidized zirconium coating of uniform and controlled thickness is especially useful on orthopedic implants of zirconium or zirconium-based alloys to provide low friction, highly wear resistant surfaces on artificial joints, such as, but not limited to, hip joints, knee joints, shoulders, elbows, and spinal implants. The uniformly thick oxidized zirconium surface of controlled depth on prostheses provide a barrier against implant corrosion caused by ionization of the metal prostheses. The invention is also useful in non-articulating implant devices such as bone plates, bone screws, etc.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: January 6, 2009
    Assignee: Smith & Nephew, Inc.
    Inventors: Gordon Hunter, Shilesh C. Jani, Vivek Pawar
  • Publication number: 20090005868
    Abstract: A prosthetic implant for securing to bone to form an articulating joint is provided. The implant is prepared by a process which includes the steps of preparing a porous surface on a component to form a prosthetic implant, placing the prosthetic implant including the porous surface in a fixture closely conforming to the porous surface of the implant and having an inlet and an opposed outlet, and directing a biological compound including stem cells into the inlet, through the porous surface of the implant and out of the outlet to form a prosthetic implant having a porous surface coated with a portion of the biological compound.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 1, 2009
    Applicant: DePuy Products, Inc.
    Inventors: RamaRao V. Gundlapalli, Dennis R. Cassell, JR., Barry A. Schnieders, Derek R. Edgar, Karuna Patil
  • Publication number: 20090005880
    Abstract: The method includes the following steps: formulation of liquid, non-gelled and stable precursor by solvolysis of Ti(IV) compounds; precursor deposition on endosseous implant surface; thermal treatment to achieve film densification, in the presence of oxygen, of a complex formed by the above mentioned endosseous implant and precursor, to obtain on the implant surface a thin film of nanocrystalline titanium dioxide with good mechanical and chemical stability. The complex above, under a persistent W irradiation modify its surface status conferring a sensible increasing of wettability chemical and biological decontamination.
    Type: Application
    Filed: October 13, 2005
    Publication date: January 1, 2009
    Applicant: GUYA BIOSCIENCE S.r.l.
    Inventors: Francesco Carinci, Carlo Alberto Bignozzi, Claudio Minero, Valter Maurino
  • Publication number: 20080281431
    Abstract: Ceramic materials operable to repair a defect in bone of a human or animal subject comprising a porous ceramic scaffold having a bioresorbable coating, and a carrier comprising denatured demineralized bone. The ceramic may contain a material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium phosphates, calcium carbonates, calcium sulfates, and combinations thereof. The compositions may also contain a bone material selected from the group consisting of: bone powder, bone chips, bone shavings, and combinations thereof. The bioresorbable coating may be, for example, demineralized bone matrix, gelatin, collagen, hyaluronic acid, chitosan, polyglycolic acid, polylactic acid, polypropylenefumarate, polyethylene glycol, or mixtures thereof.
    Type: Application
    Filed: May 10, 2007
    Publication date: November 13, 2008
    Applicant: Biomet Manufacturing Corp.
    Inventor: Nicholas Missos
  • Publication number: 20080281429
    Abstract: A device, for example a medical implant, and a method of making the same, the device having a metal or metal alloy substrate, for example CoCr, and a diffusion hardened metallic surface, for example a plasma carburized surface, contacting a non-diffusion hardened surface or a diffusion hardened surface having a diffusion hardening species different from that of the opposing surface.
    Type: Application
    Filed: January 18, 2007
    Publication date: November 13, 2008
    Applicant: Smith & Nephew, Inc.
    Inventors: Vivek D. Pawar, Abraham B. Salehi, Jeffrey J. Shea, Gordon B. Hunter, Shilesh C. Jani, Mark L. Morrison
  • Publication number: 20080195222
    Abstract: A method for constantly controlling a direct application of pressure for bonding porous coatings to substrate materials used in orthopaedic implants. The direct pressure is applied to an interface between the porous coating and the substrate material via a pressure application mechanism unaffected by heat and air pressure conditions of the bonding process. The pressure application mechanism maintains a pressure on the implant which is constantly controlled throughout the bonding process.
    Type: Application
    Filed: March 2, 2007
    Publication date: August 14, 2008
    Applicant: ZIMMER TECHNOLOGY, INC.
    Inventors: Brad L. Rauguth, William G. Hutchison, Clarence M. Panchison
  • Patent number: 7410502
    Abstract: The invention relates to a medical prosthetic device having a metal material, such as titanium or an alloy thereof, where the surface parts of the metal material are coated with a layer of a corresponding hydroxide material, such as titanium hydroxide. Preferably, the hydroxide layer includes one or more biomolecule substances associated therewith. The invention also relates to an electrolytic process for the preparation of a medical prosthetic device.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: August 12, 2008
    Assignee: Numat AS
    Inventors: Jan Eirik Ellingsen, Staale Petter Lyngstadaas
  • Patent number: 7377943
    Abstract: The invention relates to a metallic implant, which has vitreous-crystalline bioactive material on the surface thereof. According to the invention, a metallic implant base body arranged on the surface of the particles has a bioactive, vitreous-crystalline material consisting of 15-45 wt. % CaO, 40-45 wt. % P2O5, 10-40 wt. % ZrO2 and 0.7-3.5 wt. % fluoride, having apatite and calcium zirconium phosphate as main crystalline and a glass phase as an auxiliary component. Said vitreous crystalline material contains at least 35 wt. % main crystal phases and at least 5-15 wt. % auxiliary compounds. All of the percentage data is expressed in relation to the total weight of the vitreous crystalline material and the particle size of the vitreous crystalline material is between 60-350 ?m.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: May 27, 2008
    Assignees: Humboldt-Universitaet Berlin, Charite Universitaetsklinikum, BAM Bundesanstalt fuer Materialforschung und - pruefung
    Inventors: Wolf-Dieter Müller, Georg Berger
  • Publication number: 20080114465
    Abstract: A method for enhancing the binding of growth factors and/or cells to an allograft structure by applying an effective quantity of a coating material to the surface of the allograft structure, producing a thin coated allograft structure, administering to the thin coated allograft structure a growth factor, cells or a combination thereof, and implanting the thin coated allograft structure into a host bone.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 15, 2008
    Inventors: John M. Zanella, William F. McKay
  • Publication number: 20070299520
    Abstract: A device includes a sterilizing system configured to sterilize an implantable device and includes a coating system configured to apply an osteal functional coating to the implantable device.
    Type: Application
    Filed: June 26, 2006
    Publication date: December 27, 2007
    Applicant: WARSAW ORTHOPEDIC, INC.
    Inventors: Hai H. Trieu, Jeffrey H. Nycz, Michael C. Sherman, Jon C. Serbousek
  • Patent number: 7270679
    Abstract: This invention relates to an implantable medical device to treat a patient. The implantable device can be an orthopedic device such as a spinal implant including, but not restricted to, a disc or nucleus pulposus prosthesis, a spinal rod assembly, or a bone fixation plate. The orthopedic device can be formed to include a metal matrix composite that provides enhanced wear and diagnostic imaging techniques. In other forms, the present invention provides an implantable medical device that includes a porous metal matrix composite that can deliver a therapeutic composition to a patient. In still other forms, the present invention provides an implantable electrical device or lead formed to include a metal matrix composite that provides lower polarization and interfacial impedance and allows enhanced sensing of the physiological signals.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: September 18, 2007
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Naim Istephanous, Joseph Lessar, Greg Marik, Darrel Untereker
  • Patent number: 7251893
    Abstract: One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: August 7, 2007
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert E. Cohen, Prem V. Pavoor, Anuj Bellare, Brian P. Gearing
  • Patent number: 7192445
    Abstract: Disclosed are medical prosthetic devices or medical implants which exhibit improved biocompatitibly. The devices or implants include a metal material, e.g. titanium, in which the metal surface parts are coated with a corresponding hydride material that contains one or more biomolecule substance. This biomolecule substance may contain one or more biologically active molecules, e.g. bio-adhesives, biopolymers, blood proteins, enzymes, extra cellular matrix proteins, extra cellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, enzyme inhibitors, drugs, biologically active anions and cations, vitamins, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), marker biomuolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: March 20, 2007
    Assignee: Astra Tech AB
    Inventors: Jan Eirik Ellingsen, Staale Petter Lyngstadaas
  • Patent number: 7163920
    Abstract: The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: January 16, 2007
    Assignee: Ethicon, Inc.
    Inventors: Sridevi Dhanaraj, Anna Gosiewska, Ali Rezania, George A. Heavner, Xuanhan Lin, Chin-Feng Yi
  • Patent number: 7094418
    Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: August 22, 2006
    Assignee: SurModics, Inc.
    Inventors: Stephen J. Chudzik, David L. Clapper
  • Patent number: 7087087
    Abstract: The present invention relates to an implant comprising two or more bone fragments that are combined to form a single unit. Cancellous bone or cortical bone is removed from a source and fashioned into bone components with desirable shapes and sizes. The bone components may be integrated to form implants for implantation in the body. Bone stock may be formed by combining sections of various bones of the body, and the bone stock may be further fashioned for use as implants with particular geometries.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 8, 2006
    Inventors: Michael L. Boyer, II, David C. Paul, Thomas B. Higgins
  • Patent number: 7048767
    Abstract: The present invention provides orthopedic prosthesis having at least one metallic component that includes a metallic substrate on which an integrally formed nano-crystalline coating is formed. The coating and the substrate have at least one metallic constituent in common having an average atomic concentration in the coating that differs from an average atomic concentration in the substrate by less than about 10 percent. Further, the nano-crystalline coatings includes crystalline grains with an average size in a range of about 1 to 999 nanometers, and more preferably in a range of about 10 to 200 nanometers. A transition region that exhibits a graded reduction in average grain size separates the coating from the substrate. The coating advantageously exhibits an enhanced hardness, and a high degree of resistance to corrosion and wear. In one application, the nano-crystalline coatings of the invention are utilized to form articulating surfaces of various orthopedic devices.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: May 23, 2006
    Assignee: Spire Corporation
    Inventor: Fereydoon Namavar
  • Patent number: 7018411
    Abstract: A bone replacement endoprosthesis has a metallic support structure, at least part of the surface of which is galvanically silvered. Beneath the silver layer a bond layer is provided which can comprise gold.
    Type: Grant
    Filed: February 18, 2002
    Date of Patent: March 28, 2006
    Assignee: Implantcast GmbH
    Inventors: Georg Gosheger, Jens Sass
  • Publication number: 20040249469
    Abstract: One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass.
    Type: Application
    Filed: June 3, 2003
    Publication date: December 9, 2004
    Inventors: Robert E. Cohen, Prem V. Pavoor, Anuj Bellare, Brian P. Gearing
  • Patent number: 6821528
    Abstract: A process for applying a coating having a therapeutic agent such as an antibiotic or a bone morphogenic protein to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: November 23, 2004
    Assignee: Howmedica Osteonics Corp.
    Inventors: Christopher Scott, Joseph Zitelli, Paul Higham
  • Publication number: 20040199260
    Abstract: Prosthetic joints, components for prosthetic joints, superhard bearing and articulation surfaces, diamond bearing and articulation surfaces, substrate surface topographical features, materials for making joints, bearing and articulation surfaces, and methods for manufacturing and finishing the same, and related information are disclosed, including a prosthetic joint component having at least one sintered polycrystalline diamond compact articulation surface and substrate surface topographical features in said polycrystalline diamond compact.
    Type: Application
    Filed: January 9, 2004
    Publication date: October 7, 2004
    Inventors: Bill J. Pope, Jeffrey K. Taylor, Richard H. Dixon, Clayton F. Gardinier, Louis M. Pope, Dean C. Blackburn, Michael A. Vail, Kenneth M. Jensen
  • Patent number: 6800095
    Abstract: Prosthetic joints, components for prosthetic joints, superhard bearing and articulation surfaces, diamond bearing and articulation surfaces, substrate surface topographical features, materials for making joints, bearing and articulation surfaces, and methods for manufacturing and finishing the same, and related information are disclosed, including a diamond-surfaced femoral head for use in a prosthetic joint.
    Type: Grant
    Filed: January 30, 2000
    Date of Patent: October 5, 2004
    Assignee: Diamicron, Inc.
    Inventors: Bill J. Pope, Jeffery K. Taylor, Richard H. Dixon, Clayton F. Gardinier, Louis M. Pope, Dean C. Blackburn, Michael A. Vail, Kenneth M. Jensen
  • Publication number: 20040167632
    Abstract: The invention provides a method of providing a metallic orthopaedic implant with a micron or nanometer-scale surface roughness to facilitate acceptance of tissue and bone growth or apposition after implantation while maintaining the structural integrity of the orthopaedic implant. The invention also provides a metallic orthopaedic implant comprising a metallic body and metallic elements adhered to a portion of the surface of the metallic body to define a three-dimensional porous surface geometry, wherein at least some of the metallic elements have a micron or nanometer-scale surface roughness.
    Type: Application
    Filed: February 24, 2003
    Publication date: August 26, 2004
    Applicant: DePuy Products, Inc.
    Inventors: Hai Bo Wen, Panjian Li, Todd Smith
  • Publication number: 20040088052
    Abstract: A method and apparatus for a prosthesis. At least a portion of the prosthesis is made from a ceramic that is treated with ion implantation, which causes a controllable, bilateral compressive stress of the ceramic. A diamond-like-coating (DLC) can be coated on the ceramic and in the same chamber as the ion implantation. After treating by ion implantation and coating with DLC, the ceramic will be strengthened and have a low coefficient of friction and thereby be made much less likely to fracture under load.
    Type: Application
    Filed: November 6, 2002
    Publication date: May 6, 2004
    Applicant: Southwest Research Institute
    Inventor: Geoffrey Dearnaley
  • Patent number: 6730129
    Abstract: An implant for application in bone, especially jaw bone, is provided. The implant includes a unit that can be applied in the bone, and which is made of a biocompatible material such as titanium. The unit is provided with one or more coatings including calcium phosphate and a bone-growth-stimulating substance that initiates and/or stimulates bone growth. The coating is applied at least to surface parts of the unit cooperating with the bone. A method of producing the implant is also provided.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: May 4, 2004
    Assignee: Nobel Biocare AB
    Inventor: Jan Hall
  • Publication number: 20040068320
    Abstract: A spinal motion device for implanting in the spine as a replacement for the natural disc, to permit motion between adjacent vertebral bodies or as a vertebral body replacement that permits motion at its ends. The spinal motion device comprises a composite structure formed by a body having at least one bearing member, made from a biocompatible material such as pyrolytic carbon, attached to a support surface thereof.
    Type: Application
    Filed: October 4, 2002
    Publication date: April 8, 2004
    Inventors: Bruce H. Robie, Eric Woodard
  • Publication number: 20040049287
    Abstract: Endosseous implant to be applied to human or animal bone, said implant having a surface made from a selected metal or a selected metal alloy or a ceramic, whereby said resp, metal alloy is selected from chromium, niobium, tantalum, vanadium, zirconium, aluminium, cobalt, nickel, stainless steels or an alloy thereof, said surface having a smooth or rough texture, characterized in that said surface has been treated with at least one pharmaceutically acceptable organic compound carrying at least one phosphonic acid group or a derivative thereof preferably acceptable salt or ester or amid thereof and method for producing said implant.
    Type: Application
    Filed: August 28, 2003
    Publication date: March 11, 2004
    Inventors: Pierre Descouts, Bjorn-Owe Aronsson, Michael Gratzel, Carine Viornery, Peter Pechy
  • Publication number: 20040030403
    Abstract: The invention concerns the use of a polysaccharide excreted by the Vibrio diabolicus species for making a medicine with cicatrising activity, in particular bone repair activity. The invention also concerns a bone reconstruction biomaterial comprising said polysaccharide and a bone endoprosthesis whereof the surface is coated with such a polysaccharide.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 12, 2004
    Inventors: Jean Guezennec, Philippe Zanchetta