Having Bio-absorbable Component Patents (Class 623/23.75)
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Publication number: 20110029078Abstract: Synthetic structures for soft tissue repair include a multi-layer planar fibrillar structure having layers which are intermittently secured to each other and which approximates mechanical properties comparable to those of soft tissue. In embodiments, the fibrillar structure possesses an intermittently secured edge portion secured by intermittent welds. In embodiments, the multi layer planar fibrillar structure includes a bioactive agent.Type: ApplicationFiled: July 31, 2009Publication date: February 3, 2011Inventors: Anthony Ratcliffe, Andreas Kern, Mohammad Sotoudeh, Fatemeh Ratcliffe
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Patent number: 7875296Abstract: A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.Type: GrantFiled: November 29, 2007Date of Patent: January 25, 2011Assignee: Depuy Mitek, Inc.Inventors: Francois Binette, Joseph J. Hammer, Krish Mukhopadhyay, Joel Rosenblatt
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Patent number: 7842097Abstract: A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix.Type: GrantFiled: May 27, 2004Date of Patent: November 30, 2010Assignee: DePuy Spine, Inc.Inventors: Ronald K. Yamamoto, Michael K. Kwan, Stephen D. Pacetti
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Patent number: 7837645Abstract: An endoscopic device separates ingested food from gastric fluids or gastric fluids and digestive enzymes, to treat obesity. In a particular embodiment a gastric bypass stent comprises a tubular member and two or more stent members defining a lumen. The tubular member has a substantially liquid impervious coating or covering and one or more lateral openings to permit one-way liquid flow.Type: GrantFiled: March 5, 2007Date of Patent: November 23, 2010Assignee: The Trustees of Columbia University in the City of New YorkInventors: Marc Bessler, John D. Allendorf
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Patent number: 7838122Abstract: Compounds exhibiting angiogenic properties incorporating the structure of Formula I: R3—NH—NH—C(?O)—R2—P—R1??(I) wherein P is a water-soluble, biodegradable polymer, R1 is hydrogen, lower alkyl, lower alkoxy or —R2—C(?O)—NH—NH—R3; each R2 is independently —CH2—, —NH— or O; and each R3 is independently hydrogen or a residue of a naturally occurring alpha-L-amino acid or dipeptide thereof. Polymer networks crosslinked with hydrazide compounds are also disclosed, together with implantable medical devices incorporating the compounds and crosslinked polymers, and angiogenesis-promoting treatment methods, including wound-treatment methods.Type: GrantFiled: May 6, 2008Date of Patent: November 23, 2010Assignee: Rutgers, the State University of New JerseyInventors: Joachim B. Kohn, Kristen S. Labazzo, Durgadas Bolikal
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Patent number: 7824699Abstract: Bioabsorbable drug delivery devices including modular drug delivery devices having shapes and sizes adapted to be inserted within a recess on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having controllable drug release characteristics that depend on the composition of individual modules comprising the device. The modules may be cylinders, disks, tiles or tubes comprised of a bioabsorbable polymer and a therapeutic agent. The therapeutic agent(s) may be homogeneously distributed throughout the polymeric body of the device or contained within a cavity within a module comprising the device, or both. The device(s) may be threaded or attached to a prosthesis by a biodegradable adhesive. The modular devices may also be formed into tapered plugs for insertion into a mating receptacle.Type: GrantFiled: May 23, 2005Date of Patent: November 2, 2010Assignee: BioDynamics LLCInventors: James D. Ralph, Stephen L. Tatar
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Publication number: 20100266660Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.Type: ApplicationFiled: January 8, 2010Publication date: October 21, 2010Applicant: Warsaw Orthopedic, Inc.Inventors: William F. McKay, Scott D. Boden, Neil Beals
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Publication number: 20100256747Abstract: The invention relates to an implant of a biocorrodible metallic material with a passivating coating of a nanoparticle-containing silane coating and an associated method for producing the implant.Type: ApplicationFiled: March 4, 2010Publication date: October 7, 2010Inventors: Timo Hausbeck, Alexander Rzany
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Publication number: 20100249944Abstract: Medical devices having more than one degradation zone or degradation mechanism are used for orthopedic repair devices and soft tissue fixation devices.Type: ApplicationFiled: March 11, 2010Publication date: September 30, 2010Inventors: Jonathan D. Thomas, Joshua Stopek
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Publication number: 20100249854Abstract: Medical devices having more than one degradation zone or degradation mechanism are used for orthopedic repair devices and soft tissue fixation devices.Type: ApplicationFiled: March 11, 2010Publication date: September 30, 2010Inventors: Jonathan D. Thomas, Joshua Stopek
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Patent number: 7758629Abstract: A stent that can be made of self-expandable members and balloon expandable members is described. The members can be held together by a polymer layer, polymer rings or discreet polymer connectors. Methods of making and using the stent are also described.Type: GrantFiled: March 8, 2006Date of Patent: July 20, 2010Assignee: Thoratec CorporationInventors: Ken A. Holloway, Christofer T. Christoforou
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Patent number: 7758643Abstract: A method of distributing a load to a cartilage defect repair plug is provided. A load is applied to a first articulation layer. The load is distributed to a second layer and the load is transferred in the normal direction to the first density of subchondral bone. The load is distributed to a third layer and the load is transferred in the normal direction to a second density of subchondral bone. The load is then distributed to a fourth layer and the load is transferred in the normal direction to a third density of subchondral bone.Type: GrantFiled: February 26, 2007Date of Patent: July 20, 2010Assignee: Biomet Sports Medicine, LLCInventors: Kevin T Stone, Karen Troxel
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Patent number: 7749267Abstract: Expandable devices and methods for treating and enlarging a tissue, an organ or a cavity. The device is composed of a hollow expanding pouch made of a resorbable material or a perforated material that can be attached to a filling element. The pouch can be filled with a biocompatible materials, one or more times in few days interval, after the insertion of the device. While filling the pouch every few days the tissue expands and the filling material if it is bioactive start to function. The devices allow immediate direct contact between the filling material and the tissue. These devices and methods can be used for example for: horizontal and vertical bone augmentation in the jaws, soft tissue augmentation, fixating bone fractures etc.Type: GrantFiled: May 11, 2005Date of Patent: July 6, 2010Inventor: Ben-Zion Karmon
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Patent number: 7736393Abstract: Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/?-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater, 2<L(LA)<[LA%/(LA%+GA%+CL%)]×X×0.058??(1) 1<L(GA)<[GA%/(LA%+GA%+CL%)]×X×0.58??(2) 1<L(CL)<[CL%/(LA%+GA%+CL%)]×X×0.Type: GrantFiled: April 18, 2005Date of Patent: June 15, 2010Assignee: Kawasumi Laboratories, Inc.Inventors: Noriaki Shirahama, Tomokazu Mukai, Takao Okada, Yukari Imamura, Yoshimichi Fujiyama
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Patent number: 7731758Abstract: The invention concerns an injection implant for filling up wrinkles, thin lines, skin cracks and scars, for reparative or plastic surgery, aesthetic dermatology, and for filling up gums in dental treatment. The invention concerns the use of biologically absorbable polymer microspheres or microparticles suspended in a gel. Said suspension is produced either ready-for-use or freeze-dried. The biological absorbability of the microspheres is controlled and enables the production of implants having well defined persistence and deliberately limited to 3 years.Type: GrantFiled: March 26, 2004Date of Patent: June 8, 2010Assignee: Aventis Pharmaceuticals Holdings, Inc.Inventors: Jérôme Asius, Hatem Fessi, Franck Gouchet, Bénedicte Laglenne, Elisabeth Laugier-Laglenne
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Publication number: 20100137999Abstract: Remodeling of body tissue using a bioabsorbable implant that maintains or otherwise mechanically assists a more permanent implant or other treatment take, for example, by the treatment causing fibrosis. For example, the apparatus and methods can be used for hernia, organ prolapse and cosmetic purposes, such as breast and face lifts.Type: ApplicationFiled: March 13, 2008Publication date: June 3, 2010Applicant: BIOPROTECT LED.Inventor: Shaul SHOHAT
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Patent number: 7718556Abstract: A medical film that is excellent in biocompatibility and bioabsorbability and has an excellent strength in suturing and bonding is provided. A reinforcing material 12 made of a biodegradable polymer is placed in a gelatin solution so as to allow the solution to infiltrate in the reinforcing material 12 and then the gelatin is dried. This allows the gelatin that has infiltrated entirely in an internal part of the reinforcing material 12 to gel, thereby forming a gelatin film 11. Thus, a medical film 1 in which the reinforcing material 12 and the gelatin film 11 are integrated is obtained. The gelatin film 11 preferably is a cross-linked gelatin film.Type: GrantFiled: December 8, 2003Date of Patent: May 18, 2010Assignees: Gunze Limited, JMS Co., Ltd.Inventors: Shojiro Matsuda, Hitoshi Ohtani, Yoshimi Tanaka, Hideki Tadokoro
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Publication number: 20100121463Abstract: The present invention relates to a bioabsorbable and bioactive composite material for surgical musculoskeletal applications comprising a bioabsorbable polymeric matrix material which is reinforced with bioabsorbable polymeric fibers and bioabsorbable ceramic fibers. The surgical bioabsorbable polymeric matrix material is reinforced with the bioabsorbable polymeric fibers and the bioabsorbable ceramic fibers from which at least a portion is longer than 150 ?m. The invention also relates to a method for manufacturing a bioabsorbable and bioactive composite material.Type: ApplicationFiled: April 27, 2006Publication date: May 13, 2010Applicant: BIORETEC OYInventors: Pertti Törmälä, Mikko Huttunen, Nureddin Ashammakhi, Mikko Tukiainen, Heimo Ylänen, Mikko Hupa, Minna Kellomäki
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Patent number: 7713637Abstract: Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: March 3, 2006Date of Patent: May 11, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Patent number: 7708712Abstract: This is directed to methods and devices suited for maintaining an opening in a wall of a body organ for an extended period. More particularly devices and methods are directed maintaining patency of channels that alter gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having chronic obstructive pulmonary disease.Type: GrantFiled: July 19, 2004Date of Patent: May 4, 2010Assignee: Broncus Technologies, Inc.Inventors: Loc Phan, Ed Roschak
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Patent number: 7704529Abstract: A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.Type: GrantFiled: March 25, 2005Date of Patent: April 27, 2010Inventors: Richard E Riman, Wojciech Suchanek, Pavel Shuk, Kevor S. TenHuisen, Chun-Wei Chen
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Patent number: 7695522Abstract: A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodizing, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.Type: GrantFiled: March 25, 2003Date of Patent: April 13, 2010Assignee: Accentus plcInventors: Martin Edward Lee Pickford, Andrew Derek Turner
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Publication number: 20100076556Abstract: In-vivo biodegradable medical implants, containing at least in part at least partially fine-grained metallic materials that are strong, tough, stiff and lightweight, are disclosed The in-vivo biodegradable implants are used in a number of stent applications, for fracture fixation, sutures and the like.Type: ApplicationFiled: September 24, 2008Publication date: March 25, 2010Applicant: Intergran technologies, Inc.Inventors: Klaus Tomantschger, Gino Palumbo, Diana Facchini
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Patent number: 7666230Abstract: An implant device for cartilage regeneration in loading-bearing regions uses the osteochondral defect model. The implant is formed of resorbable polymeric materials. The implant is designed such that load is transmitted from the articulating surface of the bone platform through the implant to the entire area of subchondral bone of the bone platform. Application of load in this manner results in reduced subchondral bone resorption, leading to joint stabilization and maintenance of normal joint biomechanics. The implant allows for the incorporation therein of a resorbable scaffold or matrix material. The present implant solves the current inability to regenerate cartilage in load-bearing articulating surfaces using engineered scaffold devices.Type: GrantFiled: December 8, 2003Date of Patent: February 23, 2010Assignee: DePuy Products, Inc.Inventors: Janine M. Orban, Herbert E. Schwartz, Nathaniel W. Grobe
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Patent number: 7659219Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. The web materials possess haemostatic properties.Type: GrantFiled: January 30, 2006Date of Patent: February 9, 2010Assignee: Gore Enterprise Holdings, Inc.Inventors: Roy Biran, Edward H. Cully, Ted R. Farnsworth, Charles Flynn, Philip P. Off, Charles F. White
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Patent number: 7655584Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a very high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof. In some embodiments, the web materials exhibit significant thrombogenic properties.Type: GrantFiled: July 29, 2005Date of Patent: February 2, 2010Assignee: Gore Enterprise Holdings, Inc.Inventors: Roy Biran, Edward H. Cully, Ted R. Farnsworth, Charles Flynn, Charles F. White
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Patent number: 7655288Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: GrantFiled: July 29, 2005Date of Patent: February 2, 2010Assignee: Gore Enterprise Holdings, Inc.Inventors: Ann M. Bauman, Ted R. Farnsworth, Charles Flynn, Daniel S. Gabrys, Charles F. White
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Patent number: 7652077Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.Type: GrantFiled: March 26, 2004Date of Patent: January 26, 2010Assignees: Cook Incorporated, Cook Biotech, Inc., MED Institute IncorporatedInventors: William A. Cook, Michael C. Hiles, Thomas G. Kozma, Umesh H. Patel
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Patent number: 7637948Abstract: A tissue marking implant includes a matrix material and a dye marker. The implant, which can be formed entirely of bioresorbable material such as a collagen foam, is sized and shaped to replace excised tissue. The implant supports surrounding tissue upon implantation, while allowing for in-growth of fibrous tissue to replace the implant. According to various alternative embodiments, the implant is elastically compressible, or can be formed from self-expanding foam or sponges, and can be implanted through a cannula or by injection, as well as by open procedures. The implant can carry therapeutic and diagnostic substances. The dye marker leaches from the implant such that a surgeon, upon subsequent surgical intervention, visibly recognizes the tissue marked by the dye marker.Type: GrantFiled: April 19, 2005Date of Patent: December 29, 2009Assignee: SenoRx, Inc.Inventor: John D. Corbitt, Jr.
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Publication number: 20090292367Abstract: Implants, such as interbody spacers, fusion devices and bone grafts, are provided having improved mechanical properties and/or degradation profiles. Such implants include a three-dimensional scaffold formed from particles, such as microspheres, which may in some embodiments be resorbable or biodegradable and which may have at least two different degradation rates. In some embodiments, the scaffold may be elastomeric. The three-dimensional scaffold may be for example, porous or semi-porous. Also provided are kits including such implants, and methods of producing and using the same.Type: ApplicationFiled: July 31, 2009Publication date: November 26, 2009Inventor: Mark BORDEN
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Patent number: 7615065Abstract: An areal implant has a long-term-stable, mesh-like basic structure which has pores of a size in the range from 1.5 mm to 8 mm and is provided, at least in a part area, on both sides with a synthetic, resorbable polymer film. The two polymer films are glued or welded together in pores of the basic structure.Type: GrantFiled: November 12, 2002Date of Patent: November 10, 2009Assignee: Ethicon Inc.Inventors: Jörg Priewe, Birgit Hartkop, Barbara Schuldt-Hempe, Christoph Walther, Jörg Holste
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Patent number: 7608101Abstract: Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.Type: GrantFiled: August 28, 2007Date of Patent: October 27, 2009Assignee: Boston Scientific Scimed, Inc.Inventors: Barry N. Gellman, Jianmin Li
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Publication number: 20090263442Abstract: A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix defining a first controlled pore architecture. The shell portion is coupled to the core portion and includes a second porous matrix defining a second controlled pore architecture that is different from the first controlled pore architecture.Type: ApplicationFiled: October 23, 2008Publication date: October 22, 2009Applicant: RUBICOR MEDICAL, INC.Inventors: Ary S. Chernomorsky, James W. Vetter, Simon Chernomorsky
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Patent number: 7604668Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: GrantFiled: July 29, 2005Date of Patent: October 20, 2009Assignee: Gore Enterprise Holdings, Inc.Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
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Publication number: 20090248172Abstract: The invention relates to a membrane comprising a biocompatible block copolymer and has a porous structure with regularly distributed pores. A method for preparing said membranes is also provided.Type: ApplicationFiled: May 30, 2007Publication date: October 1, 2009Applicant: EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICHInventor: Peter Neuenschwander
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Patent number: 7585320Abstract: A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer comprising a biologically active material and optionally a polymeric material is disposed on the surface of the medical device. A second coating layer comprising magnetic particles and a polymeric material is disposed on the first coating layer. The second coating layer, which is substantially free of a biologically active material, protects the biologically active material prior to delivery. The system includes the medical device and a source of energy, such as an electromagnetic or mechanical vibrational energy. When the patient is exposed to the energy source, the magnetic particles move out of the second coating layer and create channels therein through which the biologically active material can be released.Type: GrantFiled: September 1, 2006Date of Patent: September 8, 2009Assignee: Boston Scientific Scimed, Inc.Inventors: Mark A Hamm, Louis J Barbato, Robert J Crowley, Wendy Naimark, Hatal Patel
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Patent number: 7572298Abstract: An implantable medical device is disclosed. The device is fabricated at least in part from a biocompatible, biodegradable composition. The composition is composed of a biocompatible, biodegradable polymer and a biocompatible, biodegradable wax. The concentration of the wax at the surface of the device is greater than the concentration of the wax in the body of the implantable device. The increased concentration of wax at the device surface may be attained when the device is heated to a temperature greater than the melting point of the wax and the glass transition temperature of the polymer, but lower than melting point of the polymer.Type: GrantFiled: March 28, 2003Date of Patent: August 11, 2009Assignee: Ethicon, Inc.Inventors: Mark B. Roller, Yufu Li, Jenny J. Yuan
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Publication number: 20090187258Abstract: The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.Type: ApplicationFiled: December 23, 2008Publication date: July 23, 2009Inventors: Wing Yuk Ip, Chi Keung Yuen
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Publication number: 20090171388Abstract: A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber.Type: ApplicationFiled: October 30, 2008Publication date: July 2, 2009Inventors: Vipul Bhupendra Dave, Chao Chin-Chen
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Patent number: 7541049Abstract: Surgical osteosynthesis composite material which has three components: biodegradable polymer reinforcement, bioceramic or bioglass filler reinforcement and biodegradable polymer matrix. This invention relates to biodegradable materials used for bone fracture fixation devices and methods of their manufacture. Unlike other known materials used prior to this application, the composites of this invention have two different reinforcing phases and one matrix phase. One reinforcing element is referred as the polymeric reinforcing element and the other as the ceramic reinforcing element.Type: GrantFiled: September 2, 1997Date of Patent: June 2, 2009Assignee: Linvatec Biomaterials OyInventors: Pertti Törmälä, Minna Kellomäki, William Bonfield, Kathleen Elizabeth Tanner
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Publication number: 20090132042Abstract: An implantable device for body tissue, including an electrical subsystem that flexes within and interfaces with body tissue and a carrier that operates in the following two modes: provides structural support for the electrical subsystem during implantation of the device in body tissue and allows flexing of the electrical subsystem after implantation of the device in body tissue. The implantable device is preferably designed to be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The implantable device, however, may be alternatively used in any suitable environment and for any suitable reason.Type: ApplicationFiled: October 17, 2008Publication date: May 21, 2009Inventors: Jamille F. Hetke, Daryl R. Kipke, Rio J. Vetter
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Patent number: 7524335Abstract: A fiber-reinforced, polymeric implant material useful for tissue engineering, and method of making same are provided. The fibers are preferably aligned predominantly parallel to each other, but may also be aligned in a single plane. The implant material comprises a polymeric matrix, preferably a biodegradable matrix, having fibers substantially uniformly distributed therein. Inorganic particles may also be included in the implant material. In preferred embodiments, porous tissue scaffolds are provided which facilitate regeneration of load-bearing tissues such as articular cartilage and bone. Non-porous fiber-reinforced implant materials are also provided herein useful as permanent implants for load-bearing sites.Type: GrantFiled: August 31, 2004Date of Patent: April 28, 2009Assignee: Smith & Nephew, Inc.Inventors: Michael A. Slivka, Gabriele G. Niederauer, Kristine Kieswetter, Neil C. Leatherbury
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Publication number: 20090069904Abstract: A biomaterial including a designed pattern of micropores one at least one surface of the biomaterial is described. The micropores can be provided in a regular or irregular pattern, and can be either continuous or discontinuous. The biomaterial may be formed from a variety of materials, such as a biocompatible polymer or biocompatible tissue. The biomaterial including micropores on a surface may be used for a variety of medical applications such as tissue scaffolding, drug delivery, or tissue fixation.Type: ApplicationFiled: September 12, 2008Publication date: March 12, 2009Applicant: Applied Medical ResearchInventor: George J. Picha
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Publication number: 20090054994Abstract: A method is effective for prophylactically treating discs and facet joints near a spinal section that requires surgery. The method comprises the steps of performing a surgical procedure on a section of a spine, and reinforcing a disc or a facet joint adjacent to the surgically treated area with an effective amount of an injected, in situ curable biocompatible matrix or biocompatible polymeric compound. The procedure delays or prevents the development of permanent or irreversible degenerative changes in the treated disc and/or facet joint, thus offering the spinal surgery patient a higher probability of long-term success for arresting disc and facet joint degeneration and prevention of latent adjacent disc/facet joint problems.Type: ApplicationFiled: August 21, 2007Publication date: February 26, 2009Inventors: James Rogan, Brian Burkinshaw, Steven I. Whitlock
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Publication number: 20090036997Abstract: Bioresorbable wall reinforcement implants include a bioresorbable porous matrix based on a collagen sponge which defines first pores, a bioresorbable porous three-dimensional knit which defines second pores, with the matrix filling the knit and all the first and second pores being at least partially interconnected with one another. Tissue engineering supports including such an implant and uses thereof are also described.Type: ApplicationFiled: July 30, 2007Publication date: February 5, 2009Inventors: Yves Bayon, Philippe Gravagna, Alfredo Meneghin, Michel Therin
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Publication number: 20090030528Abstract: An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.Type: ApplicationFiled: October 7, 2008Publication date: January 29, 2009Inventors: DOUGLAS G. EVANS, Scott M. Goldman, Russell T. Kronengold
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Publication number: 20090012613Abstract: The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can be formed into a variety of shapes and forms suitable for use as implantable medical devices or components thereof.Type: ApplicationFiled: September 18, 2008Publication date: January 8, 2009Inventors: Ted R. Farnsworth, Charles Flynn, Charles F. White
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Publication number: 20080319539Abstract: Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.Type: ApplicationFiled: August 28, 2007Publication date: December 25, 2008Applicant: Boston Scientific Scimed, Inc.Inventors: Barry N. Gellman, Jianmin Li
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Publication number: 20080294271Abstract: The present invention is related to an implant with anti-inflammatory or antibacterial effects, or both, the implant being intended for implantation in a human or an animal body, the implant comprising at least one porous grain or granule, wherein the at least one porous grain or granule comprises titanium, one or more titanium oxides or titanium alloy and has a titanium oxide layer on its surface; has a mean length from one side to the opposite side, through a geometrical centre, of up to 5 mm; has a mean specific surface area of at least 0.15 m2/g according to the BET method. Moreover, disclosed is also a method for treating a condition comprising an inflammation or/and an infection present in a human or animal body with implants according to the invention.Type: ApplicationFiled: February 21, 2008Publication date: November 27, 2008Inventors: Lars Magnus Bjursten, Bengt Mjoberg, Niklas Axen
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Patent number: 7445793Abstract: The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation. The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 ?m to not more than 500 ?m and pore length of not less than 20 ?m to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology.Type: GrantFiled: September 9, 2003Date of Patent: November 4, 2008Assignees: Kaneka Corporation, GC Corporation, Natl. Inst. of Adv. Ind. Science & Tech.Inventors: Hideo Niwa, Takeshi Fukuchi, Ichiro Shimizu, Masao Sato, Akiko Nishi, Kenji Yamashita, Tadashi Kaneko, Hajime Ohgushi, Koji Hattori, Kota Uematsu