Having Bio-absorbable Component Patents (Class 623/23.75)
  • Publication number: 20040138758
    Abstract: An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
    Type: Application
    Filed: November 5, 2003
    Publication date: July 15, 2004
    Inventors: Douglas G. Evans, Scott M. Goldman, Russell T. Kronengold
  • Publication number: 20040138738
    Abstract: A temporary stent endoprosthesis that does not require an interventional procedure for removal. The disintegrating stent is preferably made from a bioabsorbable polymer, such as by braiding polymer monofilaments into a tubular mesh shape, and the polymer has fracture initiation sites within it that promotes the disintegration of the stent into small pieces that are harmlessly transported out of the body by the vessel contents. Fracture initiation sites may be created by controlling the heterogenous structure of amorphous and crystalline regions, by introducing internal or surface fracture initiation sites, or use of multiple strands with small section size.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Applicant: Scimed Life Systems, Inc.
    Inventor: Jonathan S. Stinson
  • Publication number: 20040138762
    Abstract: The present invention relates to a composite prosthesis (17) for reinforcement of a tissue structure, comprising a porous textile support (1) which includes an arrangement of threads each composed of at least one filament of nonabsorbable polymer material, said textile support defining a microporous texture comprising the interstices located between at least two threads at the sites of contact of one thread with at least one other thread, wherein, in at least one protected zone (18) of the textile support, a hydrophilic absorbable material coats the textile support, forming a film enveloping and penetrating into the arrangement of threads, occluding at least the microporous texture, but without forming a plane layer covering at least one face of the textile support.
    Type: Application
    Filed: October 23, 2003
    Publication date: July 15, 2004
    Applicant: Sofradim Production
    Inventors: Michel Therin, Philippe Gravagna
  • Publication number: 20040132365
    Abstract: The present invention relates to an intermediate composite part (1) designed for forming a composite reinforcement prosthesis and comprising:
    Type: Application
    Filed: October 23, 2003
    Publication date: July 8, 2004
    Applicant: SOFRADIM PRODUCTION
    Inventors: Michel Therin, Philippe Gravagna
  • Publication number: 20040122454
    Abstract: Polymeric fibers were microbraided around a mandrel to make a tubular guide tube for nerve regeneration. The polymer used for the fibers was one of poly(L-lactide-co-glycolide) (10:90 PLGA) and chitosan. These polymers are biodegradable and biocompatible. The tubes were studied for their surface morphology and swelling behavior. Biological performance of the tubes was examined in the rat sciatic nerve model with a 12 mm gap. One month after implantation nine out of ten rats showed successful nerve regeneration. Morphometric analysis of regenerated nerves confirmed the quality of the regeneration compatible with those offered by other types of biodegradable nerve guide tubes. The tubes were flexible, permeable and showed no swelling.
    Type: Application
    Filed: December 23, 2002
    Publication date: June 24, 2004
    Inventors: Shu Wang, Seeram Ramakrishna, Bini Thumbarathy Balakrishnan
  • Patent number: 6752834
    Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: June 22, 2004
    Assignee: Ed Geistlich Soehne AG Fuer Chemische Industrie
    Inventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlösser
  • Patent number: 6746488
    Abstract: A prosthetic implant, and method for making same, is described. The prosthetic implant preferably has a porous coating containing a plurality of pores therein. A biodegradable material is introduced into the pores, preferably under vacuum conditions, and substantially fills the pores. Because the pores are filled with the biodegradable material, they hinder infiltration of wear particles generated during loading of the prosthetic implant. Simultaneously, the biodegradable material permits infiltration of new bone tissue into the filled pores.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: June 8, 2004
    Assignee: Biomet, Inc.
    Inventor: Joel Patrick Bales
  • Patent number: 6716957
    Abstract: A bioabsorbable material such as a terpolymer of poly-(L-lactide/D-lactide/glycolide). The material may consist of 85 molar percent L-lactide, 5 molar percent D-lactide, and 10 molar percent glycolide. The material may have a heat of fusion of about 15-25 J/G, tensile strength retention at 26 weeks of incubation of at least about 50%, and tensile strength retention at 52 weeks of incubation of at most about 25%. The material may be used in implantable devices such as bone fixation devices.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: April 6, 2004
    Assignee: Stryker Technologies Corporation
    Inventor: Deger C. Tunc
  • Patent number: 6716251
    Abstract: The invention concerns an injection implant for filling up wrinkles, thin lines, skin cracks and scars, for reparative or plastic surgery, aesthetic dermatology, and for filling up gums in dental treatment. The invention concerns the use of biologically absorbable polymer microspheres or microparticles suspended in a gel. Said suspension is produced either ready-for-use or freeze-dried. The biological absorbability of the microspheres is controlled and enables the production of implants having well defined persistence and deliberately limited to 3 years.
    Type: Grant
    Filed: February 8, 1999
    Date of Patent: April 6, 2004
    Assignee: Aventis Pharmaceuticals Holdings, Inc.
    Inventors: Jérôme Asius, Hatem Fessi, Franck Gouchet, Bénédicte Laglenne, Elisabeth Laugier-Laglenne
  • Publication number: 20040049269
    Abstract: A breast implant has at least an outer shell which is composed of a resorbable material. The implant, which can be formed entirely of bioresorbable material such as a collagen foam, is sized and shaped to replace excised tissue. The implant supports surrounding tissue upon implantation, while allowing for in-growth of fibrous tissue to replace the implant. According to various alternative embodiments, the implant is elastically compressible, or can be formed from self-expanding foam or sponges, and can be implanted through a cannula or by injection, as well as by open procedures. The implant can carry therapeutic and diagnostic substances.
    Type: Application
    Filed: July 28, 2003
    Publication date: March 11, 2004
    Inventors: John D. Corbitt, Lori A. Leonetti
  • Publication number: 20040034418
    Abstract: An implant that contains a membrane and a polymeric matrix covered by the membrane. Both the matrix and the membrane are biocompatible and bioresorbable. Also disclosed is a method of preparing such an implant.
    Type: Application
    Filed: July 23, 2002
    Publication date: February 19, 2004
    Inventors: Shu-Tung Li, Tom Smestad, Julie Pon, Robert McNeill
  • Publication number: 20040034434
    Abstract: An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
    Type: Application
    Filed: August 14, 2003
    Publication date: February 19, 2004
    Inventors: Douglas G. Evans, Scott M. Goldman, Russell T. Kronengold
  • Publication number: 20040028717
    Abstract: Implantable substrate for the healing and/or protection of connective tissue, preferably cartilage, comprising at least one composition for the activation of locally present cells for tissue regeneration and at least one structure for cell invasion in vivo and/or for the formation of cell matrix and/or for the release of constituents of the employed composition.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 12, 2004
    Applicant: TRANSTISSUE TECHNOLOGIES, GmbH
    Inventors: Michael Sittinger, Olaf Schultz, Gerd-Rudiger Burmester
  • Patent number: 6679919
    Abstract: The present invention provides an artificial dura mater prepared from an biodegradable and bioabsorbable synthetic polymer sheet and having a total light transmittance of 30% or more as defined by JIS K7105, a haze (cloudiness value) of 80% or less as defined by JIS K7105 or a specular glossiness at 60° (Gs 60°) of 10-20% as defined by JIS Z8741.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: January 20, 2004
    Assignee: Gunze Limited
    Inventors: Koji Yamauchi, Tomohiko Asahara
  • Publication number: 20040002759
    Abstract: Arthroplasty devices having improved bone in growth to provide a more secure connection within the body. Different embodiments disclosed include devices having threaded intramedullary components, devices configured to receive bone growth promoting substances, devices with resorbable components, and devices configured to reduce shear stress.
    Type: Application
    Filed: June 27, 2003
    Publication date: January 1, 2004
    Inventor: Bret A. Ferree
  • Patent number: 6666893
    Abstract: A method of reconstructing tissue is provided. The method includes implanting an absorbable tissue expander having a fluid-tight or semipermeable envelope and having a bio-absorbable biocompatible shell defining a chamber. The envelope is inflatable upon infusion of a fluid into the chamber and deflatable upon removal of the fluid from the chamber. The tissue expander also has an injection port for the controlled inflation and deflation of the envelope after the device is implanted in a tissue. The method also may include a plurality of envelopes.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: December 23, 2003
    Assignee: Charlotte-Mecklenburg Hospital
    Inventors: Karen J. L. Burg, Craig Reed Halberstadt, Walter Dalton Holder, Jr.
  • Publication number: 20030220700
    Abstract: The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.
    Type: Application
    Filed: May 22, 2002
    Publication date: November 27, 2003
    Inventors: Joseph J. Hammer, Joseph H. Contiliano, Murty N. Vyakarnam, Kelly R. Brown
  • Patent number: 6652582
    Abstract: A bioabsorbable implantable endoprosthesis having elongate elements including hollow, cavity or porous portions adapted to accumulate by-product from the degradation of the bioabsorbable material and shortening the diffusion distance for water absorption and thereby relatively increasing the degradation of the structure.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: November 25, 2003
    Assignee: Boston Scientific SciMed, Inc.
    Inventor: Jonathan S. Stinson
  • Publication number: 20030199993
    Abstract: Bioresorbable medical implants are designed to have different resorption rates over time or over the topography of the implants. The resorption of the medical implants are controlled by including layers having differing resorption rates. The layers resorb sequentially over time through sequential exposure to body fluids. A resorption-controllable medical implant includes a series of two or more layers. The first layer includes a first bioresorbable material. The second layer includes a second bioresorbable material and resorbable particles of a first kind dispersed within the second bioresorbable material. Additional layers of bioresorbable material alone or including resorbable particles may be added to slow or speed resorption and achieve desired control over the resorption of the implant. Resorbable particles can be added in differing amounts or kinds in various segments of the implant to provide topographically differing resorption rates.
    Type: Application
    Filed: April 23, 2002
    Publication date: October 23, 2003
    Applicant: Scimed Life Systems, Inc.
    Inventors: Barry N. Gellman, Jianmin Li
  • Publication number: 20030195625
    Abstract: A synthetic or natural human hair end is encapsulated with a biodegradable implantable material, to form an artificial follicle suitable for implantation. The biodegradable material can be programmed to be reabsorbed by the body in a predetermined term of time. Once the material is substantially absorbed by the body the hair shaft will lose its anchor hold into the derma. The degenerated hair will shed by simply combing or washing the hair. The created artificial hair must be implanted individually to create a natural appearance.
    Type: Application
    Filed: April 15, 2002
    Publication date: October 16, 2003
    Inventors: Marco A. Garcia Castro, Jose L. Garcia Huichan
  • Patent number: 6626950
    Abstract: A prosthetic implant having a tissue scaffold and a fixation device with a scaffold support and an anchoring post. The anchoring post extends from a surface of the scaffold support at a selected angle with the scaffold support embedded within the scaffold. The scaffold has a porous ceramic phase and a porous polymer phase. The polymer is foamed while in solution that is infused in the pores of the ceramic to create a interphase junction of interlocked porous materials and embedding the scaffold support portion of the fixation device. The preferred method for foaming is by lyophilization. The scaffold may be infused or coated with a variety of bioactive materials to induce ingrowth or to release a medicament. The mutilayered porous scaffold can mimic the morphology of an injured tissue junction with a gradient morphology and cell composition.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: September 30, 2003
    Assignee: Ethicon, Inc.
    Inventors: Kelly R. Brown, Mark C. Zimmerman, Yufu Li
  • Publication number: 20030171824
    Abstract: The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
    Type: Application
    Filed: March 3, 2003
    Publication date: September 11, 2003
    Applicant: Organogenesis, Inc.
    Inventors: Ginger A. Abraham, Robert M. Carr
  • Publication number: 20030167093
    Abstract: A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.
    Type: Application
    Filed: March 1, 2002
    Publication date: September 4, 2003
    Applicant: American Dental Association Health Foundation
    Inventors: Huakun Xu, Laurence C. Chow, Shozo Takagi, Frederick C. Eichmiller
  • Patent number: 6599323
    Abstract: A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component is bioabsorbable as well. The tissue implant provided can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: July 29, 2003
    Assignee: Ethicon, Inc.
    Inventors: Mora Carolynne Melican, Yufu Li, Kelly R. Brown, Iksoo Chun, John McAllen, III, Alireza Rezania, Angelo G. Scopelianos, Murty N. Vyakarnam
  • Publication number: 20030132546
    Abstract: The present invention provides an artificial dura mater characterized by comprising at least a sheet of a biodegradable and bioabsorbable synthetic polymer and having a storage modulus at ordinary temperature of from 1×107 to 5×108 (Pa); and a process for producing an artificial dura mater characterized by dissolving a lactide/&egr;-caprolactone copolymer (in a molar ratio ranging from 40/60 to 60/40) in a solvent, filtering the resultant solution and casting the same followed by air drying.
    Type: Application
    Filed: December 5, 2002
    Publication date: July 17, 2003
    Inventors: Koji Yamauchi, Yoshito Ikada, Susumu Miyamoto, Keisuke Yamada, Tomohiko Asahara
  • Patent number: 6592622
    Abstract: An apparatus for securing soft tissue to a prosthesis includes a retaining member secured to the prosthesis. The apparatus also includes a first band constructed of a resorbable material. The first band has a first end portion, a middle portion, and a second end portion. The apparatus also includes a second band constructed of a biologically inert material. The second band has a first end portion, a middle portion, and a second end portion. The middle portion of the first band is positioned around a retaining portion of the retaining member such that both the first end portion and the second end portion of the first band extend outwardly from the retaining member. The middle portion of the second band is positioned around the retaining portion of the retaining member such that both the first end portion and the second end portion of the second band extend outwardly from the retaining member.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: July 15, 2003
    Assignee: DePuy Orthopaedics, Inc.
    Inventor: Joe W. Ferguson
  • Publication number: 20030130747
    Abstract: The invention is directed to bioengineered graft prostheses made from two or more superimposed, chemically bonded layers of processed tissue material prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
    Type: Application
    Filed: March 3, 2003
    Publication date: July 10, 2003
    Applicant: Organogenesis, Inc.
    Inventors: Ginger A. Abraham, James Murray, Nathaniel M. Bachrach
  • Publication number: 20030120352
    Abstract: A method for repairing defects and reconstructing urothelial structures in vivo has been developed using a fibrous, open synthetic, biodegradable polymeric matrix which is configured to provide the desired corrective structure. The matrix is shaped to correct the defect, then implanted surgically to form a scaffolding for the patient's own cells to grow onto and into. The implantation of the matrix initiates an inflammatory reaction, resulting in urothelial cells, endothelial cells and mesenchymal cells, to migrate into the matrix. The polymer forming the matrix is selected to be biocompatible and degradable in a controlled manner over a period of one to six months, in the preferred embodiment. A preferred material is a poly(lactic acid-glycolic acid) in a fibrous form, such as a woven or non-woven mesh. Examples demonstrate the repair of defects in bladder in rabbits.
    Type: Application
    Filed: February 10, 2003
    Publication date: June 26, 2003
    Inventor: Anthony Atala
  • Publication number: 20030114937
    Abstract: This invention provides biodegradable, biocompatible polymeric films having uniform selected thicknesses between about 60 micrometers and about 5 mm useful in the manufacture of therapeutic implants for insertion into a patient's body and methods of making them. The films may be shaped to cover implants made of other materials to improve their biocompatibility. The films may be coated with or incorporate bioactive agents. They may have differing properties, e.g., porosity, thickness, and degradation rate, in different areas.
    Type: Application
    Filed: January 28, 2003
    Publication date: June 19, 2003
    Inventors: Neil C. Leatherbury, Kristine Kieswetter, Michael A. Slivka, Gabriele Niederauer
  • Publication number: 20030109935
    Abstract: A porous weave of bioabsorbable filaments having an open mesh configuration is formed into an oblate shape having dimensions greater than the esophageal opening and gastric outlet of a stomach. The resulting prosthesis is deployed in the stomach and is of a size to be retained in the proximate portion thereof for exerting pressure on the upper fundus. The prosthesis limits the amount of food that may be held within the stomach, and exerts pressure on the fundus to create a sensation of being full, resulting in weight loss.
    Type: Application
    Filed: January 25, 2002
    Publication date: June 12, 2003
    Applicant: Boston Scientific Corporation
    Inventor: Kurt Geitz
  • Publication number: 20030105525
    Abstract: The present invention provides synthetic, biocompatible, bioabsorbable, porous foam tissue scaffolds possessing physicochemical properties suitable for use in the repair and regeneration of dermal tissue and to methods of preparing such foam scaffolds.
    Type: Application
    Filed: November 30, 2001
    Publication date: June 5, 2003
    Inventors: Murty Narayan Vyakamam, Mark Charles Zimmerman, Anna Gosiewska
  • Publication number: 20030100955
    Abstract: The surgical device has a non-bioabsorbable layer, generally in the form of a mesh for strength and ease of handling, and a bioabsorbable layer including urea derivatives of hyaluronic acid or carboxymethyl cellulose with the two layers bound by an adhesive. The surgical device may be used for tissue repair such as to seal an opening in a tissue of the body of a patient. The non-bioabsorbable layer integrates within the tissue, while the bioabsorbable layer prevent adhesion of the device to other tissues before it is absorbed by the body. Methods of manufacturing the device are also disclosed.
    Type: Application
    Filed: January 13, 2003
    Publication date: May 29, 2003
    Applicant: Genzyme Corporation
    Inventors: Keith E. Greenawalt, Timothy J. Butler
  • Patent number: 6551355
    Abstract: A method by which immune responses to cortical bone grafts and other substrates (e.g., cement, IPN, etc.) can be minimized and at the same time graft osteoinductive potential can be improved, and improved graft substrate materials are disclosed. The method of the invention provides new types of bone grafts that incorporate into host bone more thoroughly and more rapidly, eliminating long-term complications, such as fracture, non-union, infection, and rejection. In the method of the invention, bone grafts or other substrates are modified to have an osteoinductive surface modification that the recipient's body will accept as its own tissue type and therefore will not reject or otherwise cause to fail. The osteoinductive surface modification comprises a biopolymer matrix coating that is seeded with periosteal cells that have been previously harvested either from the graft recipient or from an allogenic or xenogenic donor source.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: April 22, 2003
    Assignee: Cambridge Scientific, Inc.
    Inventors: Kai-Uwe Lewandrowski, Shrikar Bondre, Debra J. Trantolo, Maurice V. Cattaneo, Joseph D. Gresser, Donald L. Wise
  • Publication number: 20030065386
    Abstract: A radially expandable endoprosthesis device and method of deployment with an at least two stage deployment capability. More particularly, the device pertains to an annularly expandable heart valve prosthesis which is adapted for the long-term treatment of valvular diseases in infants, children and adolescents. The device is constituted of a combination of superelastic alloys and bioresorabable materials which facilitates the devices to undergo multistage deployments at predetermined intervals while emplaced in the body vessels or lumens of patients.
    Type: Application
    Filed: September 28, 2001
    Publication date: April 3, 2003
    Inventor: Kevin Shaun Weadock
  • Publication number: 20030050711
    Abstract: Tissue engineering devices with enhanced cell adhesion, cell proliferation and directional growth are provided which are prepared from nonwoven nanofibril matrices.
    Type: Application
    Filed: October 8, 2002
    Publication date: March 13, 2003
    Inventors: Cato T. Laurencin, Frank K. Ko
  • Publication number: 20030045937
    Abstract: A band of biocompatible and/or bioabsorbable material is provided including threads on one or both of its ends. An area adjacent a spinal disc is accessed, and the band of material is wrapped around the disc to stabilize the disc and/or to facilitate healing. An elongate member is inserted around a posterior region of the disc, e.g., through tubular guide members. An end of the band is connected to a distal end of the elongate member, and the elongate member is pulled back around the disc to direct the band around the disc. The band is secured around the disc overlapping vertebrae adjacent the disc. Optionally, a relative location of the vertebrae is adjusted relative to the disc before wrapping the band around the disc, for example, using a fork member or traction. Energy may also be applied to the disc to enhance healing.
    Type: Application
    Filed: September 6, 2001
    Publication date: March 6, 2003
    Applicant: Integrated Vascular Systems, Inc.
    Inventor: Richard S. Ginn
  • Patent number: 6524345
    Abstract: A surgical implant comprising biodegradable polymer interspersed with ceramic particulate that is visible to radioscopy.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: February 25, 2003
    Assignee: Bionx Implants Oy
    Inventors: Tero Välimaa, Pertti Törmälä
  • Publication number: 20030036801
    Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.
    Type: Application
    Filed: July 15, 2002
    Publication date: February 20, 2003
    Inventors: Herbert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
  • Patent number: 6514286
    Abstract: This invention provides biodegradable, biocompatible polymeric films having uniform selected thicknesses between about 60 micrometers and about 5 mm useful in the manufacture of therapeutic implants for insertion into a patient's body. The films may be shaped to cover implants made of other materials to improve their biocompatibility. The films may be coated with or incorporate bioactive agents. They may have differing properties, e.g., porosity, thickness, and degradation rate, in different areas.
    Type: Grant
    Filed: May 5, 1999
    Date of Patent: February 4, 2003
    Assignee: Osteobiologics, Inc.
    Inventors: Neil C. Leatherbury, Kristine Kieswetter, Michael A. Slivka, Gabriele Niederauer
  • Patent number: 6514292
    Abstract: A prosthetic corporal cavernosal structure (PCCS) for use in penile reconstruction, for the correction of developmental defects, for postoperative reconstruction, and for reconstructive preprosthetic surgery. The prosthetic corporal cavernosal structure (PCCS) comprises live cells seeded onto pre-formed shaped structure which may be biodegradable. The live cells may comprise smooth muscle cells such as corporal cavernosal cells, and the prosthetic corporal cavernosal structure (PCCS) for use in reconstructive surgery may be constructed of polyglycolic acid. The implant structure is applicable to use for the regeneration and reconstruction or augmentation of semirigid erectile members of the body such as the penis, and the clitoris.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: February 4, 2003
    Assignee: Children's Medical Center Corporation
    Inventor: Anthony Atala
  • Publication number: 20030023209
    Abstract: A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-&bgr; activity is also provided.
    Type: Application
    Filed: January 25, 2002
    Publication date: January 30, 2003
    Applicant: United States Surgical Corporation
    Inventors: Elliott A. Gruskin, Christofer T. Chistoforou
  • Patent number: 6511511
    Abstract: A fiber-reinforced, polymeric implant material useful for tissue engineering, and method of making same are provided. The fibers are preferably aligned predominantly parallel to each other, but may also be aligned in a single plane. The implant material comprises a polymeric matrix, preferably a biodegradable matrix, having fibers substantially uniformly distributed therein. In preferred embodiments, porous tissue scaffolds are provided which facilitate regeneration of load-bearing tissues such as articular cartilage and bone. Non-porous fiber-reinforced implant materials are also provided herein useful as permanent implants for load-bearing sites.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: January 28, 2003
    Assignee: OsteoBiologics, Inc.
    Inventors: Michael Slivka, Gabriele G. Niederauer, Kristine Kieswetter, Neil C. Leatherbury
  • Publication number: 20030014127
    Abstract: A surgical implant, device, or part thereof, made of biodegradable material for performing at least one function selected from the group consisting of supporting, joining and separating tissue and keeping open a tissue cavity. One biodegradable rod which is wound around a winding center into a helical configuration in a manner that between successive winds there is provided a space free of material of the biodegradable rod, and which is reinforced with biodegradable reinforcement element in a biodegradable matrix said reinforcement elements being oriented substantially in a longitudinal direction of the biodegradable rod.
    Type: Application
    Filed: December 18, 2000
    Publication date: January 16, 2003
    Inventors: Martti Talja, Pertti Tormala, Pentti Rokkanen, Seppo Vainionpaa, Timo Pohjonen
  • Publication number: 20030014125
    Abstract: The present invention provides an artificial dura mater prepared from an biodegradable and bioabsorbable synthetic polymer sheet and having a total light transmittance of 30% or more as defined by JIS K7105, a haze (cloudiness value) of 80% or less as defined by JIS K7105 or a specular glossiness at 60° (Gs 60°) of 10-20% as defined by JIS Z8741.
    Type: Application
    Filed: April 19, 2000
    Publication date: January 16, 2003
    Inventors: KOJI YAMAUCHI, TOMOHIKO ASAHARA
  • Patent number: 6503278
    Abstract: This invention relates to a material that degrades after implantation into a patient's tissue, and resorbs into the patient's body, which material is manufactured of polymer, copolymer or polymer alloy. The material has a non-crystalline, i.e., amorphous structure and is molecularly oriented and reinforced by mechanical deformation. Further, the material can be formed into surgical devices, such as screws and pins, for implantation into a patient.
    Type: Grant
    Filed: August 26, 1998
    Date of Patent: January 7, 2003
    Assignee: Bionx Implants Oy
    Inventors: Timo Pohjonen, Pertti Törmälä
  • Publication number: 20020183856
    Abstract: The present invention provides an artificial dura mater which comprises an amorphous or low crystallinity polymer as a constituent component and which prevents the zerebrospinal fluid leakage.
    Type: Application
    Filed: April 30, 2002
    Publication date: December 5, 2002
    Inventors: Koji Yamauchi, Asahara Tomohiko
  • Publication number: 20020183855
    Abstract: A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix.
    Type: Application
    Filed: February 22, 2002
    Publication date: December 5, 2002
    Inventors: Ronald K. Yamamoto, Michael K. Kwan, Stephen D. Pacetti
  • Publication number: 20020177904
    Abstract: A removable stent for implantation into a lumen in a human body. The stent is made from a soft, flexible fiber having an outer surface. An outer bioabsorbable/degradable coating is applied to the outer surface of the filament causing it to become rigid. The coating softens in vivo through absorption and/or degradation such that the stent is readily passed or removed from the lumen as a softened filament after a pre-determined period of time through normal flow of body fluids passing through the lumen or by manual removal.
    Type: Application
    Filed: July 16, 2002
    Publication date: November 28, 2002
    Inventors: Shawn Thayer Huxel, Arindam Datta, Yufu Li, Dennis D. Jamiolkowski, E. Richard Skula
  • Publication number: 20020161450
    Abstract: This invention relates to an instrument for regenerating a living organism tissue or organ, characterized in that a support (A) formed from a biodegradable material or a bioabsorbable material includes a sponge-like fine matrix (B) formed from a biodegradable material or a bioabsorbable material and a linear guide channel (C) for a living organism tissue or organ.
    Type: Application
    Filed: April 26, 2002
    Publication date: October 31, 2002
    Inventors: Nobutoshi Doi, Kazuhisa Matsuda, Ken-Ichiro Hata, Kensuke Sakai
  • Publication number: 20020151986
    Abstract: An implantable article for cartilage repair by implantation in an animal. The implantable article includes a support matrix, and chondrocyte cells and a bio-compatible adhesive adhered to an edge of the support matrix, wherein the support matrix is absorbable by the animal. The support matrix is a biocompatible material such as collagen, and the adhesive is autologous fibrin.
    Type: Application
    Filed: October 3, 2001
    Publication date: October 17, 2002
    Inventors: Samuel S. Asculai, Ahmed Idouraine, Bruno Giannetti