Abstract: Methods of manipulating pulses of ultrasonic energy for use with an ophthalmic surgical device.

Abstract: A composite ophthalmic device comprising an ophthalmic structure, means or lens having a photo-shifting material deployed thereon or therewithin so as to up-shift or down-shift the amplitude, wavelength (or both) of incident radiation into the visible wavelength range.

Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer which has only one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming comonomers are disclosed.

Abstract: An intraocular lens adapted for deployment within a lens capsule. At least part of a lens surface of the intraocular lens constitutes a cell inducing region in which are directly formed a multitude of microgrooves. The microgrooves take a form of minute linear grooves and lands of depth dimension between 0.01 and 1.0 ?m and width dimension between 0.1 and 2.0 ?m extending with prescribed length in a circumferential direction on the lens surface. The minute linear grooves and lands are formed with a chained pattern connected in the circumferential direction of the lens surface and with a periodic pattern arrayed periodically in a diametrical direction so that the minute linear grooves and lands are formed without intervening spaces throughout the entire cell inducing region and impart visible light transmittance of 60% or above to the cell inducing region.

Abstract: Azo compounds that block visible light are disclosed. These light absorbers are particularly suitable for use in intraocular lens materials.

Abstract: Selection of an appropriate intraocular lens (IOL) and/or the applicable surgical parameters for optimizing the results of refractive procedures on the eye. Features of the IOL are crucial for the selection and/or adjustment of the optimal IOL, but so is the IOL selection method (and parameters) from a surgical perspective. For the method, corresponding output parameters are determined from predetermined, estimated, or measured input parameters and/or their mean values, wherein at least two input parameters are varied with one another and which have at least one input parameter as a distribution function. The resulting function is optimized by means of corresponding target values and the determined distribution function of one or more output parameters is used as a decision aid. The present solution is used for selecting an appropriate IOL and/or the applicable surgical parameters and is applicable in the field of eye surgery for implanting IOLs.

Abstract: An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.

Abstract: The present invention relates generally to lens design and, more particularly, to a method for designing, evaluating and optimizing ophthalmic lenses and laser vision correction in order to optimally manage issues resulting from, or related to, halos.

Abstract: The present invention is a system for mapping a high resolution image to a lower resolution electrode array and, by applying varying stimulus to neighboring electrodes, creating a perceived image greater in resolution than the electrode array. The invention is applicable to a wide range of neural stimulation devices including artificial vision and artificial hearing. By applying a sub-threshold stimulus to two neighboring electrodes where the sum of the stimuli is above the threshold of perception, a perception is created in neural tissue between the two electrodes. By adjusting the stimulus on neighboring electrodes, the location of stimulation can be altered. Further, noise can be applied to the stimulating electrode or its neighboring electrodes to reduce the threshold of stimulation.

Abstract: A lens provided for being implanted in a cornea, which comprises an optical portion having an optical axis; and a hole through the lens. The hole is concentric with the optical axis and the dimension and shape of the hole are chosen so that the hole does not impair the optical properties of the lens, but remains visible to one that manipulates the lens.

Abstract: Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract: Apparatus for use with an external non-visible light source is provided. The apparatus comprises an intraocular device configured for implantation in a human eye, and comprising an energy receiver. The energy receiver is configured to receive light emitted from the external non-visible light source, and extract energy from the emitted light for powering the intraocular device. The intraocular device is configured to regulate a parameter of operation of the intraocular device based on a modulation of the light emitted by the external non-visible light source and received by the energy receiver. Other embodiments are also described.

Abstract: Methods, devices, and systems establish an optical surface shape that mitigates or treats a vision condition in a patient. An optical surface shape for a particular patient can be determined using a set of patient parameters for the specific patient by using a compound modulation transfer function (CMTF). The compound modulation transfer function can include a combination of modulation transfer functions (MTF's) at a plurality of distinct frequencies.

Abstract: A method for predicting initial postoperative IOL power of a patient undergone IOL surgery. A method for predicting future refractive growth of a pediatric patient's eye.

Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

Abstract: Disclosed are ophthalmic device materials having improved light transmission characteristics. The materials contain a combination of certain UV absorbers and blue-light absorbing chromophores.

Abstract: Disclosed are soft, high refractive index device materials having improved strength. The materials contain a polystyrene macromer.

Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.

Abstract: An ophthalmic lens for modifying or reducing non-axisymmetric higher order aberrations includes an optic body disposed about an optical axis having a primary meridian and an orthogonal secondary meridian. The optic body comprises an anterior surface and an opposing posterior surface. The optic body includes an optic zone comprising a base shape that is configured to form an image or focus from light incident on the surfaces, either alone or when used within an optical system. The optic body also includes a higher order toric shape that is imposed on or added to one of the surfaces. The higher order toric shape also includes a first profile disposed along the primary meridian and a second profile disposed along the secondary meridian that is different in shape from the first profile. The higher order toric shape is characterized by a profile along at least one meridian of the lens that changes with increasing radius from the optical axis raised to a power that is greater than two.

Abstract: The current invention provides a method of forming a foldable intraocular having a high refractive index from a copolymer comprising a first monomer comprising an aryl acrylate or an aryl methacrylate; a second monomer comprising an aromatic ring comprising a substituent having one ethylenic unsaturation, provided that the second monomer is not an aryl acryate or aryl methacrylate, and a third monomer comprising one ethylenic unsaturation that, if polymerized into a homopolymer, forms a high water content hydrogel; and, optionally, a cross-linking agent.

Abstract: Implantation of an accommodating intraocular lens in an eye may require the accurate measurement of the size, circumference, or diameter of the capsular bag of the eye. A flexible ring or ring portion may be temporarily or permanently inserted into the capsular bag for measuring the circumference of the capsular bag, for example, after extraction of a natural lens from the capsular bag. The ring or ring portion is generally compressible to fit through a surgical incision, then expands to fill the capsular bag along an equatorial region. The ring or ring portion includes a central component that changes shape and/or angle as the ring or ring portion is compressed. The shape change is generally correlated to the size of the capsular bag and may be visually measured through the cornea, the measurement being generally independent of corneal magnification. The measurement may be used to determine or calculate information about the capsular bag such as its size, elasticity, accommodative range, and so forth.

Abstract: The invention relates to a novel artificial intraocular lens (IOL) and a method for improving such a lens in the field of ophthalmology, with surface shape modifications that differ from perfect spherical geometries. The intraocular lens takes into account the natural optical configuration of the human vision apparatus, for example, visual axis tilt and pupil decentration. In addition, the method accounts for potential positioning errors caused by implantation and surgery effects.

Abstract: The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.

Abstract: A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag.

Abstract: Certain exemplary embodiments include methods of determining ophthalmic prescriptions to ameliorate presbyopia. Certain exemplary embodiments provide an ophthalmic lens having spherical aberration of the same sign as the patient's eye and of a magnitude effective to substantially provide a desired net spherical aberration for an optical system including the patient's eye and the ophthalmic lens where the desired net spherical aberration provides a desired increase in near vision. Certain exemplary embodiments include contact lenses, intraocular lenses, corneal onlays, corneal inlays, or corneal surgeries providing spherical aberration of the same sign as the patient's eye and of a magnitude effective to substantially provide a desired net spherical aberration for an optical system including the patient's eye and the ophthalmic lens where the desired net spherical aberration provides a desired increase in near distance vision.

Abstract: Systems and methods for designing and implanting a customized intra-ocular lens (IOL) is disclosed. In one embodiment, a system includes an eye analysis module that analyzes a patient's eye and generates biometric information relating to the eye. The system also includes eye modeling and optimization modules to generate an optimized IOL model based upon the biometric information and other inputted parameters representative of patient preferences. The system further includes a manufacturing module configured manufacture the customized IOL based on the optimized IOL model. In addition, the system can include an intra-operative real time analyzer configured to measure and display topography and aberrometry information related to a patient's eye for assisting in proper implantation of the IOL.

Abstract: This invention relates to a method of making an intraocular lens insertion device comprising a lubricious insertion tip assembly and to the device itself.

Abstract: Embodiments of the present invention relate to an electro-active element having a dynamic aperture. The electro-active element provides increased depth of field and may be used in a non-focusing ophthalmic device that that is spaced apart from but in optical communication with an intraocular lens, a corneal inlay, a corneal onlay, a contact lens, or a spectacle lens that provide an optical power. The electro-active element provides increased depth of field and may also be used in a focusing or non-focusing device such as an intraocular optic, an intraocular lens, a corneal inlay, a corneal onlay, or a contact lens which may or may not have an optical power. By changing the diameter of dynamic aperture either increased depth of field or increased light reaching the retina may be achieved.

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract: An ophthalmic toric lens to be worn on an eye or implanted inside of an eye, the lens includes an anterior surface, a posterior surface, and a toric shape formed into one of the anterior and posterior surfaces, the toric shape comprising two non-spherical principle meridians each having a region within an annular area of optical zone and the region of one principle meridian being configured for producing a longitudinal ray aberration of a different sign than a longitudinal ray aberration sign from the region of another principle meridian.

Abstract: “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea.

Abstract: The present invention relates to reversible hydrogel systems for medical applications. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. The solution can be dehydrated to produce the dry copolymer for storage. Furthermore, the present invention also relates to methods of making and using the reversible hydrogel systems.

Abstract: An intraocular lens introduces higher order aberrations, e.g., spherical aberration (SA), for different sub-optical zone diameters. For example, a lens may have a central sub-optical zone which introduces a spherical aberration. Alternatively, a full optical zone design can be used combining defocus with a higher-order aberration.

Abstract: A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome.

Abstract: Depth-of-focus (DoF) is extended in a presbyopic patient by inducing different higher order aberrations, e.g. spherical aberration, to each of the two eyes. That method will result in improving binocular through-focus visual performance and outperform traditional monovision. The aberration can be induced in any suitable way, such as by an intraocular lens or a contact lens.

Abstract: A transparent optical component (10) comprises at least one transparent set of cells (15) juxtaposed parallel to one surface of the component, each cell being separated by absorbing walls (18) parallel to the component surface, and each cell being hermetically sealed and containing at least one substance with an optical property. The optical component may be cut out along a predefined contour and optionally drilled. The invention also relates to a method of producing such an optical component and its use for the production of an optical element. The optical element may especially be a spectacle lens.

Abstract: A sensing system and method to detect and determine magnitude and direction of ciliary body movement within an eye of a patient is disclosed. The invention comprises a permanent magnet (PM) positioned in the ciliary body, and a sensing device (SD) positioned adjacent the ciliary body and configured to detect displacement of the permanent magnet relative to the sensing device via movement of the ciliary body. The invention also comprises a data processing device (DPD) configured to determine magnitude and direction of the ciliary body movement based on the displacement of the permanent magnet detected by the sensing device.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.

Abstract: The invention relates to a intra lens (1) comprising a posterior surface and an anterior surface, said posterior surface having a curvature which is optimised for providing a minimal spherical aberration, wherein said curvature is optimized using the posterior chamber depth of an eye in which the IOL is to be inserted.

Abstract: Biocompatible polymers useful in ophthalmic devices such as accommodating intraocular lenses. The polymers have improved resistance to the diffusion of fluid, relatively high refractive indexes, and mechanical properties to allow for deformation upon the application of force.

Abstract: The present invention relates to ophthalmic systems and coatings comprising a selective light wavelength filter, wherein said selective filter provides improved contrast sensitivity.

Abstract: The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye. Also disclosed are ophthalmic lenses as obtained by the methods which are capable reducing aberrations of the eye.

Abstract: Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s).

Abstract: A corneal inlay protects ocular structures from harmful wavelengths of light while maintaining acceptable color cosmetics, color perception, overall light transmission, photopic vision, scotopic vision, color vision, and/or cirdadian rhythms. The corneal inlay can also include a pinhole effect to increase depth of focus. In some embodiments, the corneal inlay can also correct refractive errors including, but not limited to, higher order aberration, lower order aberration, myopia, hyperopia, astigmatism, and/or presbyopia.

Abstract: A cartridge for folding an ophthalmic implant including pliers having two articulated arms which are provided with substantially coaxial channels and each of which is boarded by two longitudinal edges. The channels are open in front of each other and define a partially folded conduit containing the implant when the two arms are brought to each other. When the two arms are brought to each other, at least two edges positioned in front of the channels are driven apart transversally with respect to a conduit on a plane. The two arms are jointed in such a way that the arm delimits the supporting shoulder of the implant being projected in front of the channel embodied in the other arm.

Abstract: The invention relates to an ophthalmic lens comprising a main lens part, a recessed part, an optical centre, and an optical axis through said optical centre, said main lens part having at least one boundary with said recessed part, said main lens part having an optical power of between about ?20 to about +35 dioptre, said recessed part positioned at a distance of less than 2 mm from said optical centre and comprising a near part having a relative dioptre of about +1.0 to about +5.0 with respect to the optical power of said main lens part, said boundary or boundaries of said recessed lens part with said main lens part form a blending part or blending parts, are shaped to refract light away from said optical axis, and have a curvature resulting in a loss of light, within a circle with a diameter of 4 mm around said optical centre, of less than about 15%.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a functionalized alkyl ethoxylate to reduce glistenings.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.

Abstract: High refractive index copolymers with reduced glistenings are disclosed. The copolymers, which are particularly suitable for use as ophthalmic device materials, comprise a high molecular weight, reactive, linear polyethylene glycol component.