Abstract: Various polymers are provided that can be polymerized in the lens capsule with the ability to covalently bond an intraocular lens implant to the posterior capsule of the eye such that there is no space available between the intraocular lens implant and the lens capsule for lens epithelial cells to proliferate and thereby significantly reducing posterior capsule opacification.

Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights.

Abstract: Provided herein are small diameter inlays for correcting vision impairments by altering the shape of the anterior corneal surface. In an embodiment, inlays having diameters smaller than the pupil are provided for correcting presbyopia. To provide near vision, an inlay is implanted centrally in the cornea to induce an “effective” zone on the anterior corneal surface, within which diopter power is increased. Distance vision is provided by a region of the cornea peripheral to the “effect” zone. In another embodiment, small diameter inlays are provided that induce effective optical zones on the anterior corneal surface that are much larger in diameter than the inlays. The increase in the effective optical zone, due at least in part to a draping effect, allows an inlay to produce a much larger clinical effect on a patient's vision than the diameter of the inlay.

Abstract: Disclosed are soft, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers and a tack-reducing macromer additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other ophthalmic or otorhinolaryngological devices, such as contact lenses, keratoprostheses, corneal inlays or rings; otological ventilation tubes and nasal implants.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials contain a hydrophilic side-chain macromer for glistening resistance.

Abstract: Biomedical devices such as silicone hydrogels formed from a polymerization product of a mixture comprising (a) a siloxane-containing homopolymer comprising one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (RAFT) agent; and (b) one or more biomedical device-forming monomers are disclosed.

Abstract: The invention relates to a device for restoring the accommodating ability of the eye, which comprises: a) at least one optical system (3) b) at least one data acquisition system (8) that does not touch the ciliary muscle and has either acoustic or optical means to detect the movement of the ciliary body, or it has means to detect the spatial orientation of the two eyeballs with respect to each other, or it has means for measuring the diameter of the pupil and the luminance in at least one eye as a physiological control signal for accommodation c) at least one data processing system to produce a regulating signal for the optical system from the physiological control signal received d) at least one power supply system (10), and e) at least one system for attachment (22).

Abstract: A method of creating a statistical model for use in predicting vision correction prescriptions for patients is disclosed. The method comprises obtaining a plurality of wavefront aberration measurements from a plurality of patient's eyes, obtaining a plurality of visual acuity measurements from the plurality of patients, applying values associated with the plurality of wavefront measurements to an input layer of a statistical model, applying values associated with the plurality of visual acuity measurements to an output layer of the statistical model, and generating a plurality of weight values associated with respective nodes of the statistical model based on the applied values associated with the plurality of wavefront measurements and corresponding values associated with the plurality of visual acuity measurements.

Abstract: An intraocular lens implant includes a lens having an anterior portion, a posterior portion, and a circumferential edge located therebetween. An annular notch is formed in the anterior portion and oriented in an anteriorly-directed orientation.

Abstract: The present invention relates to a system and a method for determining the power of an artificial intraocular lens (IOL) in situ. The invention furthermore relates to a system and a method for predicting the optical outcome of IOL surgery. Use of the system may provide prevention, treatment, or amelioration of diseases and disorders affecting the lens of the eye and which may benefit from IOL surgery. Moreover, the invention relates to a computer-readable medium for implementing such a system on a computer.

Abstract: There is provided a diffractive multifocal lens, wherein a diffraction phase structure of a diffraction pattern has a structure expressed by the following formula: ? ? ( ? ) = { p 1 ? ? , 0 ? ? < w p 2 ? ( ? - 0.5 ) - q ? ? ? , w ? ? < 1 - w p 1 ? ( ? - 1 ) , 1 - w ? ? ? 1 ( 1 ) wherein ? indicates a position in a radial direction of the lens in one period of the diffraction pattern, and ?(?) indicates a value (radian) of a phase shift amount of light passing through the position of ? from the phase of light passing through a reference plane.

Abstract: An intraocular lens for insertion into a capsular bag in order to focus incoming light toward a retina and process for manufacturing thereof along with concomitant reduced glare and improved vision provides for a center lens portion of a lens for focusing incoming light toward the retina and the surrounding lens portion for mounting the lens within the capsular bag. A surface roughness disposed on the surrounding lens portion is provided for reducing the glare due to non-focused light directed toward the retina from the intraocular lens with the roughness having a roughness level of between about Ra 45 and about Ra 350.

Abstract: A visual prosthesis implant (1) is provided which comprises an SIMD-based processor array (6) adapted for receiving image signals from an image sensor (5) and outputting processed signals, and a bio-compatible electrode implant (7) receiving the processed signals and adapted for coupling to neurons. Using the SIMD-based processor array (6) provides high performance at small power dissipation and small chip area such that a fully implantable is visual prosthesis is achieved.

Abstract: Exemplary embodiments provide a coated intraocular lens that has a lens body with a first refractive index and an anti-reflective coating. The coating covers at least a portion of the lens body and has a second index of refraction that is less than the first index of refraction of the lens body. The anti-reflective coating reduces the intensity of reflections produced from off axis light incident on the lens body by at least a factor of 2.5 times and enhancing light transmission.

Abstract: An exemplary embodiment provides a biocompatible polymer composition suitable for making intraocular lenses, especially posterior chamber phakic lenses, that includes a hydrogel having an equilibrium water content of less than about 55 wt. %. The hydrogel has a refractive index greater than about 1.41 and a sodium ion flux between about 16 to about 20 ?eq-mm/hr/cm2.

Abstract: A lens, particularly a contact lens or intraocular lens, for improving the image quality of incident polychromatic light exhibiting wave front errors, including a central zone and at least one annular zone, is characterized in that such that positive or negative optical wavelength differences exist between adjoining zones of the lens in the direction of the lens axis, said differences being at least as large as the coherence length of polychromatic light.

Abstract: An intraocular lens selection apparatus and an intraocular lens selection method for selecting an intraocular lens to be implanted into an examinee's eye. The apparatus has an input unit which inputs corneal wavefront aberration of the eye, a memory which stores wavefront aberrations of a plurality of intraocular lens models, an unit which sets, as a target value, desired post-operative residual wavefront aberration of the eye after the lens is implanted, an unit which calculates, as an estimated value, post-operative residual wavefront aberration of the eye to be obtained when each lens model is implanted, based on the inputted corneal wavefront aberration and the stored wavefront aberration of each lens model, and specifies one of the lens models which renders the estimated value close to the set target value, a monitor, and a display control unit which controls the monitor to display information of the specified lens model.

Abstract: This invention discloses methods and apparatus for providing an ophthalmic lens with media including an energy receptor. In some embodiments, the media includes an insert placed in a cavity formed to cast mold an ophthalmic lens from a reactive mixture.

Abstract: Provided herein are methods of manufacturing an optical lens using image simulation and/or predictive metrics to determine optical aberrations and an iterative algorithm to correct the aberrations to create a custom-designed surface for the optical lens and to implement the manufacture of the custom-designed surface onto the lens. Also, a computer program product storing the method is provided. In addition, there are provided a customized optical lens designed by the method and a method of correcting optical aberration to improve visual using the customized optical lens. Further provided is a method of manufacturing a custom lens effective to mimic a subset of optical aberrations.

Abstract: A liquid lens system comprises a liquid drop 10 whose shape can be influenced by electrical fields. A plurality of electrodes are arranged annularly around the liquid drop. The liquid lens system may be employed in an artificial eye, an accommodation measuring instrument and a dioptric telescope.

Abstract: The present invention relates to hydrophilic dicationic siloxane prepolymers with one polymerizable vinyl moiety instead of two polymerizable vinyl moieties, resulting in contact lenses and/or biomedical devices with reduced cross-link density and modulus without detracting from other properties.

Abstract: The present invention provides copolymers made up of alkoxyalkyl methacrylate and/or alkoxyalkyl acrylate monomers in combination with one or more additional hydrophobic monomers. The copolymers may be used in the manufacture of intraocular lenses, including both the optic and haptic portions of the lenses. The present invention also provide methods for making intraocular lenses from the copolymers.

Abstract: UV absorbing monomers that are particularly useful in ophthalmic devices are disclosed.

Abstract: Providing multi-focal visual correction includes determining a plurality of visual conditions to which an eye is to be exposed, determining effects of the visual conditions on a pupil of the eye, and determining a target wavefront profile on the basis of the effects.

Abstract: A system of ophthalmic lenses contains a first lens for a first eye of a subject and a second lens for a second eye of a subject. The first lens includes a first lens shape having a first base refractive power and a first diffractive pattern imposed on the first lens shape, the diffractive pattern having a first lower diffraction order with a first lower diffractive power and a first higher diffraction order with a first higher diffractive power. The first lens includes lower and higher optical powers equal to the first base refractive power plus the first lower and higher diffractive powers, respectively. The second lens includes a second lens shape having a second base refractive power and a second diffractive pattern imposed on the second lens shape, the second diffractive pattern having a second lower diffraction order with a second lower diffractive power and a second higher diffraction order with a second higher diffractive power.

Abstract: An intraocular lens adapted for deployment within a lens capsule. At least part of a lens surface of the intraocular lens constitutes a cell inducing region in which are directly formed a multitude of microgrooves. The microgrooves take a form of minute linear grooves and lands of depth dimension between 0.01 and 1.0 ?m and width dimension between 0.1 and 2.0 ?m extending with prescribed length in a circumferential direction on the lens surface. The minute linear grooves and lands are formed with a chained pattern connected in the circumferential direction of the lens surface and with a periodic pattern arrayed periodically in a diametrical direction so that the minute linear grooves and lands are formed without intervening spaces throughout the entire cell inducing region and impart visible light transmittance of 60% or above to the cell inducing region.

Abstract: A method of manufacturing an implantable lens from liquid polymer precursor in an open mold includes metering the liquid into the mold in a measured amount that comes into contact with a functional shaping inner surface of the mold located under a peripheral circular sharp edge of the stationary mold or which reaches up to this peripheral circular sharp edge, at which point the open mold is rotated around it's vertical axis at a speed at which the edge of the surface of the liquid polymer precursor reaches the peripheral circular sharp edge of the open mold, after which the liquid polymer precursor is exposed to conditions under which it transforms itself into a state of a clear solid polymer by polymerization and/or cross-linking, until the transition is attained, and then the implantable intraocular lens is removed from the mold.

Abstract: A polymer material useful for manufacturing an intraocular lens (IOL) suitable for insertion through an IOL inserter barrel having an inner diameter of less than 3 mm is provided. Specifically, acrylic-silicone hybrids having a tensile strength of approximately 100 psi to 400 psi and a percent elongation at break of between 50% and 400% are disclosed.

Abstract: An imaging arrangement and method for extended the depth of focus are provided. The imaging arrangement comprises an imaging lens having a certain affective aperture, and an optical element associated with said imaging lens. The optical element is configured as a phase-affecting, non-diffractive optical element defining a spatially low frequency phase transition. The optical element and the imaging lens define a predetermined pattern formed by spaced-apart substantially optically transparent features of different optical properties. Position of at least one phase transition region of the optical element within the imaging lens plane is determined by at least a dimension of said affective aperture.

Abstract: “Universal improvement” of vision is achieved by effectively changing the shape of the anterior refracting surface of the cornea to an ideal “turtleback” shape, on which is imposed the necessary curvature adjustment to achieve correction of distance vision. In accordance with one embodiment, the cornea is actually formed to the turtleback shape through corneal surgery, preferably laser ablation surgery. In accordance with a second embodiment, a contact lens with the desired distance corrected ideal turtleback shape on its anterior surface is positioned over the cornea.

Abstract: Provided is an intraocular lens that inhibits secondary cataract which occurs after insertion of an intraocular lens and that is free from the adherence and deposition of a protein, etc., to/on the front surface of the lens, and the intraocular lens has an optic portion with a front surface and a back surface, said front surface and said back surface being different from each other in the property of adhering to a protein and satisfying the relationship of the expression (x), PAF<PAB??(x) wherein PAF is the property of adherence of said front surface to fibronectin and PAB is the property of adherence of said back surface to fibronectin in a fibronectin adherence test.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing hydrophilic side-chains. The materials have improved glistening resistance.

Abstract: UV absorbing monomers that are particularly useful in ophthalmic devices are disclosed.

Abstract: A system for providing an intraocular lens includes a processor and a computer readable memory. The computer readable memory is configured to communicate with the processor, the memory having stored therein at least one of: one or more ocular dimensions, and at least one predetermined refractive outcome. The memory further includes a sequence of instructions which, when executed by the processor, cause the processor to select an intraocular lens, select a power of an intraocular lens, or provide an intraocular lens. The sequence of instructions includes determining one or more dimensions of an eye. The instructions also include calculating, based on a mathematical relationship, a distance from an apex of a cornea of the eye to an apex or plane of the intraocular lens after insertion into the eye. The instructions further calculating an optical power of the intraocular lens suitable for providing a predetermined refractive outcome.

Abstract: Systems and methods for designing and implanting a customized intra-ocular lens (IOL) is disclosed. In one embodiment, a system includes an eye analysis module that analyzes a patient's eye and generates biometric information relating to the eye. The system also includes eye modeling and optimization modules to generate an optimized IOL model based upon the biometric information and other inputted parameters representative of patient preferences. The system further includes a manufacturing module configured manufacture the customized IOL based on the optimized IOL model. In addition, the system can include an intra-operative real time analyzer configured to measure and display topography and aberrometry information related to a patient's eye for assisting in proper implantation of the IOL.

Abstract: In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.

Abstract: An intraocular lens with an ordered polymer system contained within a lens capsule or a membrane in the lens capsule. The ordered polymer system includes at least one negatively charged copolymer comprising hydrophilic groups, anionic groups and hydrophobic groups, and at least one positively charged copolymer comprising hydrophilic groups, cationic groups and hydrophobic groups. The at least one negatively charged copolymer and the at least one positively charged copolymer are associatively arranged through non-covalent interactions in the lens capsule or the membrane.

Abstract: The present invention relates to a microelectronics element, such as an optical receiver element, for a medical implant device to be implanted in the human or animal body, particularly for a retinal implant device. The microelectronics element comprises a functional unit including application specific microelectronics, such as a photodiode, for performing a function in the medical implant device, and rectifier means adapted for converting an AC supply voltage into a DC voltage. The DC voltage provided by the rectifier means, or an operating voltage derived from the DC voltage, is configured to be supplied to the functional unit. Further, the functional unit and the rectifier means are integrated on a common semiconductor substrate and configured such that the rectifier means isolates the microelectronics element from application of an external DC supply voltage. The invention also relates to a medical implant device, such as a retinal implant, which incorporates such a microelectronics element.

Abstract: Benzotriazole UV/Visible light-absorbing monomers are disclosed. The UV/Vis absorbers are particularly suitable for use in intraocular lens materials.

Abstract: An intraocular lens for inhibiting posterior capsular opacification, or secondary cataract, includes an optic having a periphery provided with at least two sharp edges which lie radially spaced from each other with respect to the optical axis of the lens optic.

Abstract: Infinite gradient refractive index ophthalmic devices and methods of making same. The method involves diffusing a monomer which polymerizes to a lower or higher corresponding opposite refractive index polymer into a lower or higher index polymer structure and polymerizing same to create the gradient structure. The resulting polymeric structure is used to manufacture ophthalmic devices, e.g., intraocular lenses.

Abstract: An intraocular lens system for implantation in the human eye, haptic system and method include an intraocular lens formed of a transparent biocompatible material for replacing the natural lens of the eye. The lens includes an outer periphery and an optical axis. There is a haptic system for securely anchoring the intraocular lens in the posterior chamber of the eye. The haptic system includes at least two haptic portions formed of a rigid biocompatible material that are connected to and extend outwardly from the outer periphery the lens in a plane substantially perpendicular to the optical axis of the lens for holding the lens in the eye. Each haptic portion has an outer edge that is sized and shaped to extend from the lens to the scleral wall of the posterior chamber of the eye.

Abstract: The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye. Also disclosed are ophthalmic lenses as obtained by the methods which are capable reducing aberrations of the eye.

Abstract: Opthalmic devices, particularity intraocular lenses (IOL), with improved contrast sensitivity and methods of making same. In one aspect, blue light blocking chromophores (BLBC) are diffused into, e.g. an IOL lens body to create a BLBC gradient in the lens. Orange dyes are preferred BLBCs.

Abstract: A refractive intraocular lens (104) and method of locating the lens within the eye and attaching the lens to the iris. The refractive intraocular lens (104) may be attached via a staple (230), a fastener (312), anchor (412) or by the tip of the haptic (118). The intraocular lens (104) works in combination with the human crystalline lens to treat conditions selected from the group consisting of myopia, hyperopia and astigmatism.

Abstract: An intraocular lens for insertion into a capsular bag in order to focus incoming light toward a retina and process for manufacturing thereof along with concomitant reduced glare and improved vision provides for a center lens portion of a lens for focusing incoming light toward the retina and the surrounding lens portion for mounting the lens within the capsular bag. A surface roughness disposed on the surrounding lens portion is provided for reducing the glare due to non-focused light directed toward the retina from the intraocular lens with the roughness having a roughness level of between about Ra 45 and about Ra 350.

Abstract: Disclosed are soft, high refractive index, acrylic device materials. The materials comprise di-block or tri-block macromers containing a hydrophilic block in the polymer backbone. The materials have improved glistening resistance.

Abstract: The present invention relates to an intraocular lens which exhibits reduced or eliminated glistenings when implanted into the eye of a patient in need thereof and to a method of preparing such lens.

Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise two or more aryl hydrophobic monomers and a non-polymerizable propylene oxide-ethylene oxide-propylene oxide block copolymer surfactant having a molecular weight of approximately 3600 and approximately 40% ethylene oxide units by weight. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures compared to similar copolymers lacking the non-polymerizable surfactant.

Abstract: High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise a single aryl hydrophobic monomer as a device forming monomer. In addition, the copolymers comprise a non-polymerizable block copolymer surfactant. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures.