Abstract: The present invention relates to a method for creating shaped implants, such as intraocular lenses in vivo, as well as the novel implants themselves. Utilizing the method of the invention, it is possible to create an implant in vivo and to adjust either the physical properties such as refractive index, viscosity, etc., mechanical properties such as modulus, tensile strength, tear, etc., or the shape of the implant by noninvasive means. For example, using the method of the patent it is possible to create an intraocular lens in vivo and then adjust the shape and power of the lens through no invasion means. The novel implants are also addressed in this application.

Abstract: Iris fixated intraocular lenses include an optic and at least one fixation member or haptic. The fixation member is joined to the optic and has a distal segment including a through-iris portion adapted to extend through an iris hole, and an anchor portion. The anchor portion has or is adapted to have an anchor structure positioned to be disposed proximate to a side of the iris so as to be a effective in fixating the intraocular lens to the iris. The anchor structure may be formed prior to inserting the intraocular lens in the eye or may be formed after the intraocular lens is inserted in the eye. Methods for inserting such intraocular lenses in the eye are also provided.

Abstract: There is disclosed an accommodating intraocular lens for implantation in an eye having an optical axis. The lens comprises an anterior portion which in turn comprises an anterior viewing element and an anterior biasing element. The lens further comprises a posterior portion which in turn comprises a posterior viewing element in spaced relationship to the anterior viewing element and a posterior biasing element. The anterior portion and posterior portion meet at first and second apices of the intraocular lens. The anterior portion and the posterior portion and/or the apices are responsive to force thereon to cause the separation between the viewing elements to change. Additional embodiments and methods are also disclosed.

Abstract: A method of selecting an intraocular lens material for reducing the risk of posterior capsule opacification is disclosed. The method comprises determining the tack of the material.

Abstract: A method of crystalline lens replacement for eyes comprises the steps of forming a small hole that penetrates through the lens capsule, removing a part of the crystalline lens substance through the hole, refilling the lens capsule by injecting a composition comprising a hydrophilic polymer directly into the lens capsule, and closing the hole. The method of crystalline lens replacement may be performed on animals or humans. Furthermore, the method of crystalline lens replacement may be performed on a patient suffering from cataract, where the opaque crystalline lens substance in the lens capsule is removed.

Abstract: Optically clear, reinforced cross-linked silicone elastomers of the invention contain 12 to 18 mol percent of aryl substituted siloxane units of the formula R4,R5—SiO, end blockers containing silioxane units of the formula R1R2R3—Si—O, and dialkyl siloxane units of the formula R6R7—Si—O R1 and R2 are alkyl, aryl or substituted alkyl or substituted aryl groups, and R3 is an alkenyl group. R4 and R5 are phenyl or mono lower alkyl substituted phenyl groups. R6 and R7 are methyl or ethyl groups. The polymer has a degree of polymerization between 100 to 2000, and preferably approximately 250. The polymer also contains trimethyl silyl treated silica as a reinforcer in the weight ratio of approximately 15 to 45 parts of reinforcer to 100 parts of the polymer. After cross-linking, the polymer has properties of an optical refractive index which is at least 1.44, a type A durometer hardness of at least 35, tensile strength of at least 500 psi and tear strength of at least 20 phi.

Abstract: The present invention relates to polysiloxanes suitable for the preparation of intraocular lenses by a crosslinking reaction, having a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens and a viscosity suitable for injection through a standard cannula. The present invention includes an injectable intraocular lens material based on said polysiloxanes and methods of preparing intraocular lenses by direct injection into the capsular bag of the eye.

Abstract: Polysiloxanes suitable for the preparation of intraocular lenses by a crosslinking reaction, having a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens and a viscosity suitable for injection through a standard cannula are provided. Moreover, injectable intraocular lens material based on these polysiloxanes and methods of preparing intraocular lenses by direct injection into the capsular bag of the eye are also disclosed.

Abstract: The present invention refers to a method of restoring the vision of an eye having an impaired lens with an artificial lens implant. The method involves replacing the lens by a polymerizable material injected into the emptied lens capsule and thereby providing a new lens implant with a predetermined refractive value, while admitting the possibility of controlling and adjusting the refractive value of the eye during the surgical process.

Abstract: Disclosed is a two-step method of making soft, high refractive index, acrylic ophthalmic device materials.

Abstract: The present invention relates to methods of implementing an optical element having a refraction modulating composition. The methods include using a wavefront sensor to provide an optical measurement of the optical element. The present invention also relates to systems comprising an optical element having a refraction modulating composition and a wavefront sensor.

Abstract: A method of preparing phakic intraocular lenses from hydrophobic materials is described. In this process, the lens is tested to determine whether it can float submerged in an aqueous medium. If it cannot (e.g., if it remains on top of the aqueous medium), the lens is surface treated (for example, by vacuum UV or corona discharge processes) to increase its wetting ability (e.g., to reduce its hydrophobicity). The lenses prepared by this process are also described.

Abstract: Optically clear, reinforced cross-linked silicone elastomers of the invention contain 12 to 18 mol percent of aryl substituted siloxane units of the formula R4R5-SiO, end blockers containing siloxane units of the formula R1R2R3SiO.5, and dialkyl siloxane units of the formula R6R7-SiO. R1 and R2 are alkyl, aryl or substituted alkyl or substituted aryl groups, and R3 is an alkenyl group. R4 and R5 are phenyl or mono lower alkyl substituted phenyl groups. R6 and R7 are methyl or ethyl groups. The polymer has a degree of polymerization between 100 to 2000, and preferably approximately 250. The polymer also contains trimethyl silyl treated silica as a reinforcer in the weight ratio of approximately 15 to 45 parts of reinforcer to 100 parts of the polymer. After cross-linking, the polymer has properties of an optical refractive index which is at least 1.44, a type A durometer hardness of at least 35, tensile strength of at least 500 psi and tear strength of at least 20 pli.

Abstract: An IOL that is free of glare and the halo effect associated with conventional IOLs and a method for using the same is provided. The IOL is adapted for implantation into an eye, in place of or in addition to the natural lens of the eye, to adjust a refractive power of an eye. The IOL includes at least one lens portion and a light-absorbing material. The lens portion has first and second surfaces and a perimeter connecting the first and second surfaces which extends entirely about the lens portion. The first and second surfaces can have any suitable shape to provide the lens portion with a suitable refractive power. The light-absorbing material is disposed to absorb light propagating in a direction towards the perimeter to thus eliminate glare and the halo effect caused by such light. One or more haptics which include a light absorbing material can be attached to the lens portion for mounting the IOL in the eye.

Abstract: Ophthalmic lenses, such as intraocular lenses, include cross-linked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of acrylates, methacrylates and mixtures thereof, and a second constituent derived from a second component in an amount effective as a cross linker in the cross-linked polymeric material. The cross-linked polymeric material has branched chain alkyl groups, preferably included with at least a portion of the first monomeric component, in an amount effective to reduce the tackiness of the cross-linked polymeric material relative to a substantially identical cross-linked polymeric material without the branched chain alkyl groups.

Abstract: Bicomposite intraocular lenses having an anterior surface material different from a posterior surface material are disclosed. The posterior surface material reduces the risk of posterior capsule opacification.

Abstract: A light-curable polymer material for making an intraocular lens is a mixture of components consisting of oligourethanemethacrylate, octylmethacrylate, oligocarbonatemetharcrylate, 2,2-dimethoxy-2-phenylacetophenone and 2,4-ditretbutylortoquinone, wherein the aforesaid components are taken in the following weight % ratio: 2,2-dimethoxy-2-phenylacetophenone 0.1-0.7 2,4-ditretbutylortoquinone 0.001-0.006 octylmethacrylate  8-42 oligocarbonatemethacrylate 2-8 oligourethanemethacrylate balance. Also proposed are a method for making an elastic intraocular lens in which the aforesaid compounds are used as the initial components, and an elastic intraocular lens produced by this method.

Abstract: Posterior capsular opacification can be prevented by modulating focal contacts, which mediate adhesion between lens epithelial cells and the lens capsule, using a treating solution containing a focal contact-modulating substance or a proenzyme, such as Lys-plasminogen, which is introduced into the lens capsular bag during cataract surgery. To secure the passage of a treating solution between the lens epithelial cells, a calcium chelating agent, such as ethylenediamine tetraacetic acid CEDTA), is included in a treating solution. To limit the effect of the treating solution to lens epithelial cells prior to, during, and/or after capsulotomy, an inhibitor, such as &ohgr;-amino acid, can be introduced into the anterior chamber before the treating solution as a mixture with a viscoelastic material, such as sodium hyaluronate, or into the lens capsular bag without a viscoelastic material during capsulotomy.