Abstract: An artificial retina device to electrically stimulate a neuroretina of an eye to produce artificial vision, the artificial retina device comprising: an electrical source; at least one stimulating electrode connected with the electrical source; and at least one ground return electrode connected with the electrical source, wherein the stimulating electrode and ground return electrode are configured to be disposed within the eye on opposite sides of the neuroretina.

Abstract: A medical device includes an array of electrodes, configured for implantation in contact with tissue in an eye of a living subject. Driver circuitry is configured to drive the electrodes in an alternating pattern, such that different groups of the electrodes are driven to stimulate the tissue during different, predetermined respective time periods. A power sensor, may be coupled to deactivate a first group of the electrodes when the available electrical power drops below a predetermined threshold, while a second group of the electrodes remains active. Other embodiments are also described.

Abstract: An intraocular camera for retinal prostheses may include an optical imaging system comprising a set of optical elements for forming an image of the external world on an image sensor array, wherein the optical elements and the image sensor array may be enclosed in an implantable biocompatible housing that may employ haptic elements for stabilization within the eye. The set of optical elements may be designed to have a short focal length and to provide adequate resolution images that can be transformed into a set of stimulation signals applied to a pixellated microstimulator array. Transmission of the signals from the intraocular camera to a microstimulator driver circuit may be accomplished either by a wired or wireless communication device. Power and control signals may be provided to the intraocular camera by a wired or wireless communication device, or optically by means of ambient illumination or an optical beam.

Abstract: The present invention relates to retinal prostheses, and in particular to the transfer of electrical power and data from outside of the human body to such a prosthesis. The retinal prosthesis comprises: A retinal electrode array implanted in the eye to stimulate the retina. A receiving coil implanted sub-sclerally to inductively receive power or data signals, or both. An electrical connection between the implanted receiving coil and the implanted retinal electrode array. Wherein the receiving coil is flexible and able to conform to scleral curvature, when it is implanted. And wherein power or data signals, or both, received by the receiving coil from a remote transmitting coil are automatically provided to the electrode array. According to a second aspect, the present invention provides a method for implanting a retinal prosthesis. In a further aspect the present invention further provides an ocular implant.

Abstract: Methods and apparatuses for configuring an implantable device to interface with retina cells are described. The device may comprise an array of pixel units capable of stimulating the retina cells are described. The pixel units may operate in a mode of operation selected from a plurality of modes including a normal mode and a calibration mode. A control circuitry of the device may be configured to switch the mode of operation for the pixel units. In one embodiment, the pixel units may be configured to receive light for stimulating the retina cells during the normal mode to enable perception of the light. During the calibration mode, the pixel units may be configured to adjust amount of stimulation to the retina cells.

Abstract: An implant apparatus comprising a plurality of photo sensors, a plurality of micro electrodes and circuitry coupled to the photo sensors and the micro electrodes are described. The photo sensors may receive incoming light. The circuit may drive the micro electrodes to stimulate neuron cells for enabling perception of a vision of the light captured by the photo sensors. The apparatus may be implemented in a flexible material to conform to a shape of a human eyeball to allow the micro electrodes aligned with the neuron cells for the stimulation.

Abstract: Apparatus for use with an external non-visible light source is provided. The apparatus comprises an intraocular device configured for implantation in a human eye, and comprising an energy receiver. The energy receiver is configured to receive light emitted from the external non-visible light source, and extract energy from the emitted light for powering the intraocular device. The intraocular device is configured to regulate a parameter of operation of the intraocular device based on a modulation of the light emitted by the external non-visible light source and received by the energy receiver. Other embodiments are also described.

Abstract: The present invention relates to thermoresponsive adhesives. The invention further relates to methods for the reversible attachment of retinal implants, other implants, and drug delivery devices.

Abstract: This invention is methods of reducing stress in the retina that are caused by the implanted electrode array body having an oval shape that is curved to conform to the curvature of the retina and having a mounting aperture in the body for attaching the electrode array to the retina with a tack where a strain relief internal tab is place around a strain relief slot.

Abstract: A method of testing subjects' perception of complex shapes created by patterned multi-electrode direct stimulation of a retinal prosthesis is described. The complex shapes can be geometric shapes or characters such as letters of the alphabet and numbers.

Abstract: An method and a device for implant into the eye of a patient configured in size to frictionally engage within a cup-like depression naturally occurring in the optic nerve of the eye. The implant has a reservoir for calculated disbursement of medicine to tissue surrounding it and in one mode is refillable and in another mode is formed of biodegradable material which is absorbed by the patient after use ceases.

Abstract: An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space.

Abstract: A power supply for a retina implant at least partly located in the interior of a patient's eye is described. The power supply comprises a first transmission coil (4, 23), a second transmission coil (5, 24). The power supply further comprises a signal generation unit adapted for generating a first high frequency signal and a second high frequency signal, and for applying the first high frequency signal to the first transmission coil and the second high frequency signal to the second transmission coil, the second high frequency signal being phase shifted relative to the first high frequency signal. The first transmission coil is adapted for transmitting the first high frequency signal, and the second transmission coil is adapted for transmitting the second high frequency signal.

Abstract: A visual prosthesis system comprises a retina implant at least partly located in the interior of a patient's eye. The retina implant comprises an array of micro-contacts adapted for contacting ganglia of the patient's retinal tissue. The visual prosthesis system further comprises a data processing unit with an additional interface for receiving an external signal from an external signal source, the data processing unit being adapted for converting the external signal into corresponding stimulation data for the retina implant, and a wireless transmission unit adapted for transmitting the stimulation data to the retina implant via wireless transmission. The retina implant is adapted for receiving the stimulation data and for stimulating the micro-contacts according to the stimulation data.

Abstract: Disclosed are various methods and bioreactor devices for culturing retinal cells and/or tissues. The bioreactor devices may, in certain embodiments, include a microchannel network, a scaffold for culturing neuroretinal cells, and a porous membrane separating the microchannel network from the scaffold.

Abstract: A set formed of a scleral buckle and an encircling band is provided for use in connection with retinal detachment surgery to enable the implantation of both the scleral buckle and encircling band free of any suture. A self-assembling scleral buckle-encircling band combination is secured in place by surface scleral tunnels operative as belt loops to enable the securing of a scleral buckle and encircling band on the eyeball to exert an intended indentation effect for treatment of retinal detachment.

Abstract: An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

Abstract: A retinal prosthetic device comprises image capture means (20) arranged to capture an image, light producing means (30) arranged to define a plurality of light paths along each of which a light beam can be directed towards a respective position on a retina, and control means (24) arranged to process the captured image and control the light producing means so as to produce a stimulating array of light beams along a group of the light paths, the group being dependent upon the captured image.

Abstract: A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.

Abstract: Provided is an apparatus for driving an artificial retina using a medium-range power transmission technique. The apparatus can wirelessly transmit power to an artificial retina circuit within a medium range of about 1 m using resonance between a first coil equipped around a user's waist and a second coil implanted in a user's eye. Thus, it is possible to solve the difficulty of implanting a coil in a lens, provide convenience to a user by eliminating the necessity of artificial glasses, and stably supply power to the artificial retina circuit. In addition, it is possible to remarkably lessen the difficulty in connecting the second coil with the artificial retina circuit in an eye.

Abstract: The present invention is a visual prosthesis for the restoration of sight in patients with lost or degraded visual function. The visual prosthesis includes a user interface which controls function of the visual prosthesis to optimize operation for each individual patient. The user interface controls functions such as brightness, contrast, magnification, frequency, pulse width, or amplitude. The user interface may also individually control points of neural stimulation.

Abstract: The invention discloses a power controlling apparatus for a biochip including M regions. Each region includes a plurality of cells respectively. The power controlling apparatus includes a pulse generating module, a combinational circuit, and M controlling modules. The pulse generating module generates a pulse. The combinational circuit receives the pulse and generates M controlling signals. Each controlling signal has a predetermined phase which is different from the phase of the other controlling signal. The M controlling modules are electrically connected to the combinational circuit. Each of the M controlling signals corresponds to and activates one of the M controlling modules to selectively power on one corresponding region of the M regions. The cells in the corresponding region which is powered have an action potential refractory time that is longer than the power-on interval of the corresponding region.

Abstract: An artificial retina chip module including a signal processing chip, a first polymer bump layer, and a photodiode array chip is provided. The signal processing chip includes a plurality of first pad disposed on a surface thereof. The first polymer bump layer includes a plurality of polymer bumps insulated from one another. Each of the first polymer bumps is composed of a polymer material and a conductive layer coated on the polymer material. Each first polymer bump is embedded into the corresponding first pad and the signal processing chip, wherein one end of the first polymer bump protrudes from the first pad and the other end thereof protrudes from a back surface of the signal processing chip. The photodiode array chip is disposed at one side of the signal processing chip and is electrically connected to the signal processing chip through the first polymer bumps.

Abstract: This invention is for directly modulating a beam of photons onto the retinas of patients who have extreme vision impairment or blindness. Its purpose is to supply enough imaging energy to retinal prosthetics implanted in the eye which operate essentially by having light (external to the eye) activating photoreceptors, or photoelectrical material. The invention provides sufficient light amplification and does it logarithmically. While it has sufficient output light power, the output light level still remains at a safe level. Most preferred embodiments of this invention provide balanced biphasic stimulation with no net charge injection into the eye. Both optical and electronic magnification for the image, as for example, using an optical zoom lens, is incorporated. Otherwise, it would not be feasible to zoom in on items of particular interest or necessity. Without proper adjustment, improper threshold amplitudes would obtain, as well as uncomfortable maximum thresholds.

Abstract: The present invention is a system for mapping a high resolution image to a lower resolution electrode array and, by applying varying stimulus to neighboring electrodes, creating a perceived image greater in resolution than the electrode array. The invention is applicable to a wide range of neural stimulation devices including artificial vision and artificial hearing. By applying a sub-threshold stimulus to two neighboring electrodes where the sum of the stimuli is above the threshold of perception, a perception is created in neural tissue between the two electrodes. By adjusting the stimulus on neighboring electrodes, the location of stimulation can be altered. Further, noise can be applied to the stimulating electrode or its neighboring electrodes to reduce the threshold of stimulation.

Abstract: An implantable electronic device is formed within a biocompatible hermetic package. Preferably the implantable electronic device is used for a visual prosthesis for the restoration of sight in patients with lost or degraded visual function. The package may include a hard hermetic box, a thin film hermetic coating, or both.

Abstract: The invention relates to imparting photoreactivity to target cells, e.g., retinal cells, by introducing photoresponsive functional abiotic nanosystems (FANs), nanometer-scale semiconductor/metal or semiconductor/semiconductor hetero-junctions that in this case include a photovoltaic effect. The invention further provides methods of making and using FANs, where the hetero-junctions bear surface functionalization that localizes them in cell membranes. Illumination of these hetero-junctions incorporated in cell membranes generates photovoltages that depolarize the membranes, such as those of nerve cells, in which FANs photogenerate action potentials. Incorporating FANs into the cells of a retina with damaged photoreceptor cells reintroduces photoresponsiveness to the retina, so that light creates action potentials that the brain interprets as sight.

Abstract: A light powered microactuator device of the invention is an integrated device including a solar cell that provides sufficient energy to actuate an electroactive thin film coupled to a thin membrane. The lateral strain response of the electroactive thin film causes the thin membrane to move, providing an actuation force that can be applied in a wide variety of microactuator devices. A preferred embodiment light powered microactuator device of the invention includes a substrate that defines a flexible membrane in a portion thereof. An electroactive thin film is coupled to the flexible membrane such that lateral strain in the electroactive membrane causes flexing of the membrane. An integrated solar cell converts light to voltage that is applied to the electroactive thin film by an integrated electrode.

Abstract: Improved photosensing devices and methods are disclosed. Such devices and methods have application, among other things, as retinal implants and in imaging devices. In one embodiment, an exemplary retinal implant can include an array of photoreceptors adapted for positioning in the eye. Each photoreceptor can include a core, for example a carbon nanostructure, and a shell. The shell can include a light-responsive layer, and in many cases, the light-responsive layer can be formed of two semiconductor layers forming a heterojunction. The photoreceptors can be adapted to generate an electric field in response to incident light so as to stimulate a retinal neuron in its vicinity. The photoreceptors can be micron-sized or nano-sized, and can be arranged in densities similar to the density of rods and cones in the human eye. In one embodiment, an exemplary sensor for an imaging device can include a plurality of photosensors disposed on a substrate.

Abstract: A foldable polymer-based coil structure and a method for fabricating the same are disclosed. The coil structure has metal wirings and interconnections between the wirings. The wirings and connections are embedded by a polymer. The coil structure is foldable in two or more layers. In the folded condition, coils of one layer overlap the coils of another layer. A stackable structure and jigs for aligning the foldable and stackable structures are also disclosed.

Abstract: The present invention provides a method for capturing optical micro detectors for improved surgical handling during implantation into an eye comprising the steps of providing an optically active thin film heterostructure on a soluble substrate; forming an array comprising individual optical microdetectors from the optically active thin film heterostructure; attaching the optical microdetector array onto a biodegradable polymer carrier membrane; and separating the optical microdetector array attached to the biodegradable polymer carrier membrane from the soluble substrate thereby capturing the optical microdetectors in the bio-polymer carrier membrane for improved handling of the optical micro-detectors during transfer and implantation into the eye.

Abstract: A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.

Abstract: The present invention relates to thermoresponsive adhesives. The invention further relates to methods for the reversible attachment of retinal implants, other implants, and drug delivery devices.

Abstract: This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.

Abstract: It is an object of the invention to provide a vision regeneration assisting apparatus capable of assisting in vision regeneration without making a system structure complicated. In the invention, a vision regeneration assisting apparatus for regenerating a vision of a patient going blind by a disease of a retina includes a photosensor embedded in the retina of an eye of the patient and converting an optical signal into an electric signal, photographing means for photographing an object to be recognized by the patient, image processing means for carrying out an image processing to extract a feature with respect to an image of the object obtained by the photographing means, pulse light forming means for forming a luminous flux into a pulse light to induce a vision, and irradiating means provided before the eye of the patient and applying the pulse light toward the photosensor so as to be formed as an image processed by the image processing means.

Abstract: An electrode arrangement for electrical stimulation of biological material has at least one stimulation electrode via which the biological material can be fed a stimulus signal. Furthermore, a counter electrode is present which forms a counter pole to the stimulation electrode, one sensor electrode is provided with the aid of which it is possible to determine a polarization voltage across the stimulation electrode.

Abstract: An artificial eye system may include an extracorporeal unit mounted outside a user's body and an intracorporeal unit 3 mounted inside a user's eye. The extracorporeal unit 2 may include a visor and a power supply unit. The visor may include a primary coil, an image receiving element that receives a picture image, a light emitting element that transmits an electric stimulus signal produced based on an image signal from the image receiving element, and an eye-gaze point recognizing unit. The intracorporeal unit may include a secondary coil that is electro-magnetically induced by the primary coil, a light receiving element that receives the electric stimulus signal from the light emitting element, a signal processing circuit that processes the electric stimulus signal received by the light receiving element, and a plurality of electrodes that transmits the electric stimulus signal processed by the signal processing circuit to the retina.

Abstract: Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to the fluid to or through the aperture. The electrical means may take the form of electroosmotic force, piezoelectric movement of a diaphragm or electrolysis of a solution. The electrical means may be external to the host, implanted in the host or may be photodiodes activated by light, particularly where the neuronal site is associated with the retina.

Abstract: An artificial vision system for regenerating or restoring vision of an eye of a patient includes: a power acquiring unit which is disposed inside the eye, includes a magnetic core having an opening and a coil wound around the magnetic core, and is adapted to acquire power from outside a body using electromagnetic induction; and a plurality of electrodes which is provided at a retina and is adapted to electrically stimulate cells constituting the retina.

Abstract: A visual prosthesis including an enhanced receiving and stimulating portion for electrically stimulating retinal tissue to present an apparent image to a user. The prosthesis includes an extracellular camera which responds to a real image to generate a real image signal. The real image signal is coupled, e.g., RF coupling, from an extracellular primary coil to a secondary coil. The secondary coil is preferably affixed within the vitreous body of the user's eye positioned for good signal coupling to the primary coil and arranged to be in good thermal contact with the vitreous body which acts as a heat sink. A hermetically sealed housing containing signal processing circuitry is also preferably placed in the vitreous body to assure efficient heat transfer away from the housing. The circuitry is electrically connected to the secondary coil and responds to an output signal therefrom to produce an apparent image signal for driving an electrode array.

Abstract: The objective of the current invention is to restore color vision, in whole or in part, by electrically stimulating undamaged retinal cells, which remain in patients with, lost or degraded visual function. The invention is a retinal color prosthesis. Functionally, There are three main parts to this invention. One is external to the eye. The second part is internal to the eye. The third part is means for communication between those two parts. The external part has subsystems. These include an external imaging means, an eye-tracker, a head-motion tracker, a data processor, a patient's controller, a physician's local controller, a physician's remote controller, and a telemetry means. The imaging means may include a CCD or CMOS video camera. It gathers an image of what the eyes would be seeing if they were functional. Color information is acquired by the imaging means. The color data is processed in the video data processing unit.

Abstract: Improved ophthalmological surgical methods, systems and devices, employing a colorant.

Abstract: The present invention provides a method for capturing optical micro detectors for improved surgical handling during implantation into an eye comprising the steps of providing an optically active thin film heterostructure on a soluble substrate; forming an array comprising individual optical microdetectors from the optically active thin film heterostructure; attaching the optical microdetector array onto a biodegradable polymer carrier membrane; and separating the optical microdetector array attached to the biodegradable polymer carrier membrane from the soluble substrate thereby capturing the optical microdetectors in the bio-polymer carrier membrane for improved handling of the optical micro-detectors during transfer and implantation into the eye.

Abstract: A high density polymer-based integrated electrode apparatus that comprises a central electrode body and a multiplicity of arms extending from the electrode body. The central electrode body and the multiplicity of arms are comprised of a silicone material with metal features in said silicone material that comprise electronic circuits.

Abstract: An artificial retinal device, implanted in the subretinal space of the eye in persons with certain types of retinal blindness, induces artificial vision by electrical stimulation of the remaining viable cells of the retina. The artificial retina device includes a stimulating electrode unit preferably placed in the subretinal space, and a tail-like extension housing a distant electrical return ground electrode unit that may be placed in the vitreous cavity. The stimulating electrode unit includes an array of electrode subunits. Each electrode subunit includes one or more microphotodiodes electrically connected, for example, in series to provide increased voltage and current to its microelectrode. The stimulating electrode unit and the ground return electrode of the ground return electrode unit are preferably disposed on opposite sides of the neuroretina to allow for efficient and high resolution transretinal electrical stimulation of the neuroretinal cells.

Abstract: The invention provides microfabricated devices and methods for directing the growth of a cell process to form an artificial synapse. The devices are called artificial synapse chips. The artificial synapse comprises a nanofabricated aperture (about 50–100 nm in size) that connects the cell process to a chemical or electrical means of neuronal excitation. Such an aperture width mimics the length scales of a natural synapse and thus emphasizes the localized spatial relationship between a neuron and a stimulation source. The invention further provides devices and methods for regenerating a nerve fiber into an electrode. The invention thus provides a regeneration electrode that uses a novel neural interface for stimulation and that uses novel surface methods for directing neuronal growth making possible in vivo connection of the devices to neural circuitry in a retina and other anatomical locations.

Abstract: An ocular device that can more safely and effectively perform all functions needed of a retinal prosthesis with electronic components that are placed outside the wall of an eye, are powered wirelessly provided by an external power source, and which provide a patient with a view determined by natural motion of the eye and triggered by natural incident light converging at the retina. In one aspect, the invention is an externally powered, light-activated, sub-retinal prosthesis in which natural light entering the eye conveys visual details to the sub-retinal prosthesis, while wireless radiofrequency transmission provides the power needed to stimulate the retina, which would be insufficient if it were obtained from the intensity of incoming light alone.

Abstract: The invention relates to a spatially adaptive, implanted microcontact structure for neuroprostheses suitable for treating functional disorders of the nervous system for the purpose of reversible anchorage on nerve tissue. The spatially adaptive microcontact structure (RAM) is characterized in particular in that an optimum contact or active connection to nerve tissue is ensured. The implanted microcontact structure comprises subareas that are movable relative to one another and that can be brought into at least two permanent desired positions relative to one another and that can be brought into a desired position during implantation for the purpose of mechanical anchorage to the nerve tissue to be contacted and can also be brought out of one desired position into another during explantation to release the anchorage.

Abstract: Methods and apparatus for modifying membranous tissue, growing cells on modified membranous tissue, and for transplantation of modified tissues and modified tissues with attached cells are provided. In particular, the invention provides methods and apparatus for modifying membranous tissue such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial (IPE) cells and retinal pigment epithelial (RPE) cells on modified membranous tissue, and for modifying membranous tissue and growing cells on biodegradable polymer substrates. A method of modifying membranous tissues comprises depositing micropatterns of biomolecules onto membranous tissue with a contacting surface such as a stamp; other methods include mechanical ablation, photoablation, ion beam ablation, and modification of membranous tissues via the action of proteolytic enzymes.

Abstract: A macula cover having a flexible sheet member and including an contact surface, an outer surface, a perimeter, and an annular stiffener. The sheet member is sized to cover the fovea and the parafoveal area of the macula during retinal surgery.