Method Of Manufacturing Prosthetic Device Patents (Class 623/901)
  • Patent number: 6790225
    Abstract: Stented tubular grafts of expanded, sintered polytetrafluoroethylene (PTFE). The stented PTFE grafts of the present invention include an integrally stented embodiment, an externally stented embodiment, and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure-expandable. Also, in each embodiment, the stent may be coated or covered with a plastic material capable of being affixed (e.g., heat fused) to PTFE. Manufacturing methods are also disclosed by the individual components of the stented grafts are preassembled on a mandrel and are subsequently heated to facilitate attachment of the PTFE layer(s) to one another and/or to the stent. Optionally, the stented graft may be post-flexed and post-expanded following it's removal from the mandrel to ensure that the stented graft will be freely radially expandable and/or radially contractible over it's full intended range of diameters.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: September 14, 2004
    Assignee: Edwards Lifesciences Corporation
    Inventors: Donald T. Shannon, Chris Kuo, John McIntyre, Ronald L. Clinkenbeard, Yizi Chu, Benny Tu
  • Patent number: 6786930
    Abstract: A customized prosthetic implant and method for producing a customized prosthetic implant for use in fully or partially replacing bone and/or tissue in a human or animal. The custom prosthetic implant is produced by obtaining information about the site of implant for the prosthetic implant, processing the obtained information to generate information on the size and shape of the prosthetic implant, and transferring at least a portion of the generated information to a molding machine to at least partially form the custom prosthetic implant from a moldable compound.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: September 7, 2004
    Assignee: Spineco, Inc.
    Inventor: Robert S. Biscup
  • Patent number: 6780338
    Abstract: The subject invention pertains instruments for use in nuclear spin tomography comprising a metal alloy comprising aluminum, vanadium, and titanium. In a specific embodiment, the subject invention relates to cardiovascular stents which can exhibit a low incidence of artifacts and are viewable in a nuclear spin tomography unit. The subject invention also pertains to a method for processing instruments for use in nuclear spin tomography. Such processing can comprise application of a wet chemical etching solution. In a specific embodiment, the wet chemical etching solution can comprise three parts hydrochloric acid and two parts saltpeter acid.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: August 24, 2004
    Assignee: MRI Devices Daum GmbH
    Inventors: Wolfgang Daum, Axel Winkel
  • Patent number: 6776860
    Abstract: A method of manufacturing a ceramic composite comprises the steps of preparing at least two ceramics bodies to be bonded together, each of the at least two ceramics bodies having a bonding surface; preparing a slurry in which primary particles of a bonding ceramic are dispersed; applying the slurry to the bonding surface of at least one of the ceramic bodies to be bonded; and sintering the ceramic bodies between which the slurry has been interposed to bond them. In this method, the bonding ceramic in the slurry is preferably constituted from the same ceramic starting material as that of the at least one of the ceramic bodies to be bonded. In this way, it becomes possible to manufacture, with a simple technique, a ceramic composite having a required strength and excellent biocompatibility and biosafety.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: August 17, 2004
    Assignee: PENTAX Corporation
    Inventors: Kaoru Arai, Masahiro Kohketsu, Asako Matsushima, Masanori Nakasu
  • Patent number: 6776938
    Abstract: The present invention relates to a method of forming a tissue implant that includes applying force to the tissue to form the implant which has a predetermined shape. The applied force against the tissue is monitored or controlled during the shaping of the tissue.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: August 17, 2004
    Assignee: Bonutti 2003 Trust-A
    Inventor: Peter M. Bonutti
  • Publication number: 20040158323
    Abstract: A system and method of processing an item at least partially formed of a hydrophilic material to reduce or increase the item's protein affinity. In one example, the system and method prevent or greatly reduce the formation of insoluble ionic materials in or on the item during processing, thereby reducing its affinity for binding with pertinacious materials. An example application involves reducing the protein affinity of an ocular item such as an intra ocular lens or a contact lens, thereby reducing the potential for in-eye or on-eye ossification of the item.
    Type: Application
    Filed: November 18, 2003
    Publication date: August 12, 2004
    Inventors: James R. Lisk, Phillip V. Robledo, Thomas R Paul
  • Publication number: 20040158320
    Abstract: A biomaterial useful for bioprostheses such as bioprosthetic heart valves is provided in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater elasticity in a cross direction. For instance, the biological material has an elastin content of about 30% by weight. In one embodiment, the biological material is vena cava tissue.
    Type: Application
    Filed: November 24, 2003
    Publication date: August 12, 2004
    Inventors: Dan T. Simionescu, Narendra R. Vyavahare
  • Patent number: 6770087
    Abstract: Partially encapsulated stents are made using gaps cut into ePTFE covering material. Ring stents are placed over an inner ePTFE tube (e.g., supported on a mandrel) and are covered by a “lacey” graft sleeve, which is constructed by cutting apertures into an ePTFE tube so that a series of circumferential and longitudinal strips is created. This “lacey” sleeve is then laminated to the inner ePTFE tube to capture the stents. By selecting the size and position of the apertures in the ePTFE covering, it is possible to leave critical parts of the stent unencapsulated to facilitate flexibility and expansion. Alternatively, the gaps can consist of slits cut into the ePTFE covering material. These slits can be cut in any direction including longitudinally, radially, or diagonally. In addition, the slits can be spaced at varying intervals around the covering material to maximize flexibility and expandability.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: August 3, 2004
    Assignee: Bard Peripheral Vascular, Inc.
    Inventors: Richard Layne, Sandra Cundy, Debra Bebb
  • Patent number: 6770091
    Abstract: A bifurcated stent for insertion into a bifurcated vessel such as a blood vessel. In one embodiment, a first sheet is formed into a first leg, a second sheet is formed into a second leg, a third sheet is formed into a stem, and the two legs are attached to the stem. In a second embodiment, a first sheet is formed into a member having a first leg and half of a stem, a second sheet is formed into a second member having a second leg and half of a stem, and the two stem halves are combined to form the bifurcated stent. In a third embodiment, the stent comprises two sections that are serially inserted and assembled within the vessel at the site of the bifurcation to be treated.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: August 3, 2004
    Assignee: Medinol Ltd.
    Inventors: Jacob Richter, Gregory Pinchasik
  • Publication number: 20040138591
    Abstract: A method for modeling an implant to be applied to a defect of a bone comprises the steps of obtaining a plurality of tomographic image data of the bone based on measurement data by MRI, producing three-dimensional image data of the bone based on the plurality of tomographic image data, and estimating a shape of a missing born that was previously present or should have been present in the defect of the bone to obtain three-dimensional data of the implant. The estimating step comprises the steps of estimating a provisional shape of the implant which has a contour conformable with the shape of a contour of periphery of the side walls of the defect at the distal surface of the bone and has a predetermined thickness; and deleting data of portions of the provisional shape of the implant that overlap the bone from the data of the provisional shape of the implant so that the three-dimensional data of the implant has an outer peripheral shape that is conformable with the shape of the side walls of the defect.
    Type: Application
    Filed: July 25, 2003
    Publication date: July 15, 2004
    Applicants: Hiroshi ISEKI, PENTAX Corporation
    Inventors: Hiroshi Iseki, Keita Abe, Yoshiyuki Ogawara
  • Patent number: 6761735
    Abstract: A method and apparatus for limiting longitudinal stretch during fixation of a harvested aortic root including valve leaflets and the product produced. The apparatus includes an inflow plug inserted into the inflow section of the aortic root and having an apertured tube or cannula extending through the valve leaflets to an outflow plug inserted into the outflow section of the aortic root. Apertures in the tube are located on either side of the valve leaflets and the tube is coupled to a fluid inlet, preferably located on the outflow plug. The outflow plug is slidable relative to the tube and is provided with an engagement mechanism such as a setscrew for fixing the location of the outflow plug relative to the tube and the inflow plug. After assembly of the aortic root to the apparatus, the fluid inlet is coupled to a source of defined pressure and the root is inflated.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: July 13, 2004
    Assignee: Medtronic, Inc.
    Inventors: Carol E. Eberhardt, Christopher G. Toomes, Mark J Capps, Billie Millwee, Janice Shay, Tom Hessler, Faisal Kalam
  • Patent number: 6755863
    Abstract: Living fibrocytes are combined with rotator cuff extracellular matrix obtained from recently deceased human or animal donors to eliminate pain in patients with tendonitis and other rotator cuff deficiencies. According to the method, fibrocytes from a living donor, preferably the patient, and rotator cuff tissue is harvested from a recently deceased human or animal donor in a manner which retains the extracellular matrix. The harvested cells are combined with the extracellular matrix to produce an engineered rotator cuff tissue, which is then transplanted into or onto a patient's rotator cuff to be repaired. Additional therapeutic substances such as culture medium, growth factors, differentiation factors, hydrogels, polymers, antibiotics, anti-inflammatory medications, or immunosuppressive medications could be added to the transplanted annulus fibrosis tissue.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 29, 2004
    Inventor: Bret A. Ferree
  • Publication number: 20040122507
    Abstract: The present invention provides an implantable graft, including a primary tubular body having a first outer wall surface and a first inner wall surface defining a primary blood contacting lumen, and a secondary tubular body having a second outer wall surface and a second inner wall surface. The secondary tubular body is located about the primary tubular body to form a space therebetween. The primary and secondary tubular bodies are joined by at least one rib.
    Type: Application
    Filed: December 23, 2002
    Publication date: June 24, 2004
    Applicant: Scimed Life Systems, Inc.
    Inventor: Jamie S. Henderson
  • Publication number: 20040122515
    Abstract: The present invention relates to noval design of mechanical valve prostheses and manufacturing methods. A series of prosthetic valves with novel design and a unique manufacturing approach are disclosed. These devices possess unique designs and are made of nanostructurely engineered biomaterial. In addition, a novel manufacturing approach will be used to produce these devices because the convention technique is incapable of fabricating the devices due to the small size, design requirements and material properties restrain. Furthermore, it provides the convenience and thus low cost in manufacturing. The devices are particularly but not exclusively useful in human circulation system to restore the normal functions.
    Type: Application
    Filed: November 20, 2003
    Publication date: June 24, 2004
    Inventor: Xi Chu
  • Publication number: 20040122509
    Abstract: A radiopaque implantable prosthesis including a polymeric prosthesis made from ePTFE having a node and fibril structure and a radiopaque filler integral with at least a portion of the node and fibril structure of the ePTFE. A method of making the prosthesis is also provided.
    Type: Application
    Filed: December 20, 2002
    Publication date: June 24, 2004
    Applicant: Scimed Life Systems, Inc.
    Inventor: Christopher Brian Brodeur
  • Publication number: 20040116999
    Abstract: The present invention provides for reinforced and drug eluting stent-grafts and related methods of implanting and manufacturing the stent-grafts. A stent-graft of the present invention may include a tubular stent, a biocompatible covering surrounding the stent, and a supporting collar coupled to the proximal end of the stent-graft. A drug agent may be applied to a textured external surface layer of the biocompatible covering, or alternatively to a space between the textured external surface layer and a smooth luminal surface layer of the biocompatible covering, and allowed to elute over time into a wall of a body lumen after the stent-graft is deployed. The collar of the stent-graft absorbs pressure exerted on the stent-graft by fluid flow within the body lumen in order to minimize potential damage to the stent-graft, and may also include barbs to further secure the stent-graft to the body lumen.
    Type: Application
    Filed: October 31, 2003
    Publication date: June 17, 2004
    Inventor: Walter J. Ledergerber
  • Publication number: 20040117033
    Abstract: This invention is a method for the implantation of a combination of cells or cell-microcarrier aggregates wherein one component comprises a solid implantable construct and a second component comprises an injectable formulation. For example, in one embodiment, the solid implant may be first implanted to fill the majority of the cavity receiving the implant, and then cells or cell-microcarrier aggregates in an injectable format, with or without the addition of gelling materials to promote rapid gelling in situ, may be injected into spaces surrounding the solid implant in order to secure the solid implant in the site and/or to promote rapid adherence and/or integration of the solid implant to surrounding tissues. Also contemplated in this embodiment is that the cellular composition of the injectable component may differ from that of the solid component.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 17, 2004
    Inventors: Carmelita G. Frondoza, David S. Hungerford, Alan H. Shikani, Abraham J. Domb, David J. Fink, Leonard Bloom
  • Publication number: 20040106991
    Abstract: The invention provides a replacement heart valve which contains an acellular matrix as a structural scaffold. The scaffold is seeded with isolated myofibroblasts and/or endothelial cells prior to implantation into a recipient mammal.
    Type: Application
    Filed: November 24, 2003
    Publication date: June 3, 2004
    Inventors: Richard A. Hopkins, Diane Hoffman-Kim
  • Publication number: 20040106992
    Abstract: A multi-zonal monofocal opthalmic lens comprises an inner zone, an intermediate zone, and an outer zone. The inner zone has a first optical power. The intermediate zone surrounds the inner zone and has a second optical power that is different from the first power by a magnitude that is less than at least about 0.75 Diopter. The outer zone surrounds the intermediate zone and has a third optical power different from the second optical power. In certain embodiments, the third optical power is equal to the first optical power.
    Type: Application
    Filed: November 10, 2003
    Publication date: June 3, 2004
    Inventors: Alan J. Lang, Huawei Zhao
  • Patent number: 6740186
    Abstract: An orthopaedic implant having a porous metal surface in a preferred embodiment, the implant comprises three layers including a biocompatible metal core of desired shape, a polymer intermediary layer, and a surface layer comprising a porous biocompatible metal, shaped appropriately to act as the surface of an orthopaedic implant is provided. The core and the pad are placed in an injection molding device wherein a polymer intermediary layer is injection molded between the pad and the metal core, thereby bonding the pad to the metal core.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: May 25, 2004
    Assignee: Zimmer Technology, Inc.
    Inventors: Michael Hawkins, Steven James Charlesbois, Jerry W. Howard
  • Publication number: 20040098110
    Abstract: Novel endoprostheses comprising one or more photocurable materials are disclosed. Said endoprostheses may comprise regions wherein said photocurable materials are selectively disposed about said endoprosthesis and are cured according to desired parameters to achieve varying desired properties. Said properties may include but are not limited to cross-linking density, material density, modulus of elasticity, rate of erosion, extensibility, compressibility, mechanical strength, tensile strength, crystallinity, diffusion coefficient, and permeability.
    Type: Application
    Filed: January 15, 2003
    Publication date: May 20, 2004
    Inventors: Michael S. Williams, Kevin D. Holbrook, Richard A. Glenn, Jeffrey A. Smith, Joseph M. DeSimone
  • Publication number: 20040082991
    Abstract: Heart valve leaflet selection methods and apparatuses which subject individual leaflets to loads and measure the resulting deflection to more reliably group leaflets of similar physical characteristics for later assembly in prosthetic heart valves. The deflection testing may be accomplished using a variety of test set ups which are designed to impart a load on the leaflet which simulates the actual loading within a heart valve. The results from a number of deflection tests are used to categorize individual leaflets, which data can be combined with other data regarding the characteristics of the leaflet to better select leaflets for assembly into a multi-leaflet heart valve. In one embodiment, the deflection test is combined with an intrinsic load test, and leaflets having similar deflection and intrinsic load values used in the same heart valve.
    Type: Application
    Filed: October 20, 2003
    Publication date: April 29, 2004
    Inventors: Than Nguyen, Hung Ly Lam, Jianbo Zhou, Carlos M. Romero, Ralph Kafesjian, Xiaoming G. Guo, Van Le Huynh
  • Patent number: 6725901
    Abstract: The invention relates to methods of manufacturing various medical devices and starting materials by utilizing the processes of high speed injection molding and slurry-based, semi-solid die casting applied to biocompatible metals or metal alloys that may have a high melting point temperature. These devices may be made fully consolidated or porous to allow the devices to act as a functional drug delivery vehicle.
    Type: Grant
    Filed: December 27, 2002
    Date of Patent: April 27, 2004
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Pamela A. Kramer, James M. Carlson
  • Publication number: 20040068323
    Abstract: An implant and a process of modifying an implant surface, which implant is in particular a hip implant, a tooth implant, a bone screw, fixation pin or a fixation nail (pin-fixation), comprising a metallic base body (1), which implant has a surface modified by a tantalum or niobium, for the formation of a surface modification (4) where at least the tissue-friendly metal is alloyed with the surface and constitutes a uniform, diffusion-tight outer zone (2) on the body (1), which outer zone (2) has a higher ductility than the metallic base body (1) in order to obtain a tissue-friendly implant with increased fatigue strength.
    Type: Application
    Filed: August 26, 2003
    Publication date: April 8, 2004
    Inventor: John Christensen
  • Patent number: 6709467
    Abstract: The arterial prosthesis is produced based on weaving technology using biologically inert polyester and polyuretan yarns, braided in a complicated structure. Then the prosthesis is impregnated with a solution of gelatin and glycerin that, when drying up, binds the pores of the prosthesis and the filaments of the polyester yarn.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: March 23, 2004
    Inventors: Viktoria Kantsevitcha, Eriks Masteiko, Leonids Ribickis
  • Publication number: 20040049264
    Abstract: The present invention provides an expanded tubular graft formed of expanded polytetrafluoroethylene (ePTFE). The graft has first and second open ends and a surface longitudinally extending between the ends. The graft also includes an inner and outer cylindrical walls, where the walls have crimps located along the surface of the graft. Additionally, the graft is coated with biocompatible elastomer covering portions of the outer cylindrical walls of the PTFE graft. The resulting ePTFE crimped graft exhibits various enhanced properties, such as adjustable graft length, high kink resistance, improved suture retention and high crush resistance as compared to the same graft without the crimps.
    Type: Application
    Filed: September 6, 2002
    Publication date: March 11, 2004
    Applicant: SCIMED Life Systems, Inc.
    Inventors: Krzysztof Sowinski, Jamie S. Henderson
  • Publication number: 20040049283
    Abstract: An expandable medical implant capable of being inserted between adjacent vertebral endplates in a spine. The implant, when in an expanded position, includes a thicker peripheral portion and a thinner interior portion. Also, a method of manufacturing an expandable medical implant having a thicker peripheral portion and a thinner interior portion. Further, a method for reducing back pain that includes placing a medical implant between two adjacent vertebral endplates and positioning the implant such that the implant distributes stresses toward stronger portions of the endplates when pressure is placed on the implant.
    Type: Application
    Filed: June 3, 2003
    Publication date: March 11, 2004
    Inventor: Tushar Patel
  • Patent number: 6702856
    Abstract: A method of using body tissue includes removing tissue from a donor site and separating at least one component from the tissue while maintaining the tissue cells in a viable condition. The viable tissue cells are then implanted in a patient. The tissue cells may be positioned on a structural support before implantation in a patient. The method may also include harvesting cancellous bone and extruding the cancellous bone cells while maintaining the cells in a viable condition.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: March 9, 2004
    Assignee: The Bonutti 2003 Trust A
    Inventor: Peter M. Bonutti
  • Patent number: 6699286
    Abstract: A method and apparatus of making repairs with graft ligaments. In one form, the method for graft ligament reconstruction comprises (i) harvesting a graft ligament consisting entirely of soft tissue; (ii) compacting the graft ligament through compression so as to significantly reduce the cross-sectional area and increase the density of the collagen material of the graft ligament; and (iii) deploying the compressed graft ligament in the human body. In another form, the apparatus for graft ligament reconstruction comprises a graft ligament having a given diameter and a given cross-sectional area; and a compacting instrument having at least one surface to contact the graft ligament and to decrease the given cross-sectional area of the graft ligament to a reduced cross-sectional area, whereby the graft ligament with the decreased cross-sectional area may be positioned within a bone tunnel having a cross-sectional area smaller than the given cross-sectional area of the graft ligament in its original state.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: March 2, 2004
    Inventor: Joseph H. Sklar
  • Patent number: 6695833
    Abstract: A stent-graft is provided which includes a smooth continuous inside surface for efficient fluid flow therethrough. The stent-graft can be implanted intraluminally by radially expanding the stent-graft adjacent an area within the body lumen to be treated, or can be implanted utilizing direct surgical techniques. A cylindrical support structure is preferably provided which is at least partially embedded along with portions of the film. The cylindrical support structure can facilitate radial expansion and provide additional structural strength to the stent-graft. A woven fabric support structure can also be embedded within the film of solid material forming the stent-graft to provide additional support to the stent-graft and allow suturing of the stent-graft to walls of the body lumen. Various different geometric configurations can be provided for the stent-graft. To form the stent-graft a mandrel is placed within a vacuum and a film of material, such as parylene, is deposited upon the mandrel.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: February 24, 2004
    Assignee: Nellix, Inc.
    Inventor: John J Frantzen
  • Publication number: 20040034408
    Abstract: The present invention relates to a medical device, and more particularly to a method of forming a tubular membrane on a radially expandable structural frame. In one aspect, a structural frame is placed over a spinning mandrel and a fiber is electro-statically spun over at least a portion of the structural frame forming a membrane. A transfer sheath may be used between the mandrel and structural frame to prevent the electrostatically spun fiber from adhering to the mandrel. In another aspect, a first membrane is spun over the mandrel before the structural frame is placed over the mandrel. In this aspect, at least a portion of the structural frame is sandwiched between the membranes. The membrane or membranes and structural frame form a fiber spun frame assembly. The fiber spun frame assembly may be coated with an elastic polymer. In addition, the membrane or membranes may go through some post processing to achieve desired characteristics or configurations.
    Type: Application
    Filed: March 28, 2003
    Publication date: February 19, 2004
    Inventors: David Christopher Majercak, Vipul Bhupendra Dave, Iksoo Chun, Mark B. Roller
  • Patent number: 6685625
    Abstract: A method for making a curved implantable sheath includes placing a sheet of flexible material into engagement with a member having a curved surface having a desired configuration. The sheet and member are placed in a fixation solution so that the sheet assumes the configuration of the surface engaged thereby.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: February 3, 2004
    Inventor: Shlomo Gabbay
  • Publication number: 20040010311
    Abstract: The present invention provides an integrated prosthetic nipple and areola suitable for use with a breast prosthesis, wherein the prosthetic nipple and areola comprises a first curable gel zone configured to define a nipple region, and a second curable gel zone integrally connected to the first curable gel zone and configured to define an areola region.
    Type: Application
    Filed: July 15, 2002
    Publication date: January 15, 2004
    Inventors: Lora B. Reynolds, Robert J. Halley, Lisa Marie Hughey
  • Publication number: 20040010320
    Abstract: The present invention is based on the discovery of new methods for obtaining a tissue graft. The method can be carried out, for example, by implanting a biocompatible scaffold into a mammal and then removing the scaffold from the mammal. The scaffold is implanted in direct contact with (i.e. physically touching over at least a portion of its external surface), or adjacent to (i.e. physically separated from) mature or immature target tissue, for a period of time that is sufficient to allow cells of the target tissue to associate with the scaffold. The invention also features grafts generated by the methods described herein and methods for using those grafts to treat patients who have a defect in a target.
    Type: Application
    Filed: July 2, 2003
    Publication date: January 15, 2004
    Inventors: James William Huckle, Melissa Anderson, Allen E Goodship, Venkatram R Shastri
  • Publication number: 20030236473
    Abstract: A method and apparatus is disclosed for modeling a body part with a high precision. Image data of a body part is collected from an imaging system with a first resolution. After processing the image data collected from the imaging system, a 3-dimensional description of the body part is generated, the 3-dimensional description of the body part having a second resolution higher than the first one. A 3-dimensional parametric description of the body part is then generated. The 3-dimensional parametric description may be used to create a replica of the body part or an implant tightly fitting the said body part.
    Type: Application
    Filed: April 30, 2003
    Publication date: December 25, 2003
    Inventors: Sylvie Dore, Yves Goussard, Jerome Idier, Nicolas Villain
  • Patent number: 6663765
    Abstract: Method and device for manufacturing of expandable cylindrical metal meshes for use in expandable stents and in particular for customized manufacturing. The method includes determining the type and size of the stent to be implanted, electrochemically forming the stent with desired pattern of meshes and implanting the stent into patient. The method comprises using a cathode with desired pattern of meshes and a tubular blank, from which the stent is formed. Between the cathode and the blank is delivered an electrolyte and the cathode and the blank are simultaneously rotated during electrochemical forming process.
    Type: Grant
    Filed: September 13, 2001
    Date of Patent: December 16, 2003
    Inventor: David Cherkes
  • Publication number: 20030225447
    Abstract: The present invention relates to a medical device and method for making the medical device. In particular, the present invention relates to membrane covered structural frame, and to a method of forming a tubular membrane on a structural frame. In one aspect, a polymeric tube is provided having a first diameter and a first tube wall thickness. A radially expandable and contractible structural frame is radially contracted, and inserted into at least a portion of the structural frame. The radially contracted structural frame then expands to expand the polymeric tube to a second diameter, wherein the second diameter is greater than the first diameter. As the polymeric tube radially expands, the tube wall thickness becomes thinner, so that the polymeric tube becomes a thin walled tubular membrane. The polymeric tube and structural frame are then mechanically attached to each other.
    Type: Application
    Filed: May 6, 2003
    Publication date: December 4, 2003
    Inventors: David Christopher Majercak, David Grewe
  • Publication number: 20030208269
    Abstract: A breast prosthesis may be formed by forming an outer layer on a mold, and filling the mold with a polymerizable foaming composition. The mold may be formed by forming a computer model of the prosthesis based on scanning a patient. The computer model may be used to form a solid model. A prosthesis may be coupled to the patient by coupling at least one metallic insert to the prosthesis and at least one magnet to the patient. Alternately, the prosthesis may be formed with a retaining harness integral to the prosthesis. In still another method, the prosthesis may be coupled to a retaining device surgically implanted in the patient.
    Type: Application
    Filed: May 3, 2002
    Publication date: November 6, 2003
    Inventors: L. Daniel Eaton, John J. Miller, John L. May
  • Publication number: 20030208279
    Abstract: This invention is directed to a tissue-engineered stent comprising a substantially cylindrical construct (10) having a first end (12) and a second end (14); a walled surface (16) disposed between the first end and the second end; the walled surface (16) comprising a biodegradable polymer scaffold seeded with disassociated chondrocytes. In one embodiment, the seeded scaffold is cultured in vitro prior to implantation in a host for a time period sufficient for cartilaginous tissue to form.
    Type: Application
    Filed: March 24, 2003
    Publication date: November 6, 2003
    Inventor: Anthony Atala
  • Publication number: 20030205554
    Abstract: This invention is directed to an intracorporeal device formed of a high strength Co—Ni—Cr alloy and is particularly suitable for forming a composite product with a pseudoelastic member formed of NiTi alloy. Suitable intracorporeal products include guidewires and stents. The high strength alloy consists essentially of about 28 to about 65% cobalt, about 2 to about 40% nickel, about 5 to about 35% chromium, up to about 12% molybdenum, up to about 20% tungsten, up to about 20% iron and the balance inconsequential amounts of impurities and other alloying constituents, with a preferred alloy composition including about 30 to about 45% cobalt, about 25 to about 37% nickel, about 15 to about 25% chromium and about 5 to about 15% molybdenum. Intravascular devices such as guidewires, stents and the like can be formed of this high strength Co—Ni—Cr alloy.
    Type: Application
    Filed: May 30, 2003
    Publication date: November 6, 2003
    Inventor: Sepehr Fariabi
  • Patent number: 6641608
    Abstract: A stent shaped as a three-dimensional body which is formed by interlaced threads (1) arranged in multistart turns of a helical line. The threads (1) are arranged in at least two groups (2 and 3) of the helical turns featuring opposite senses of helix. The stent ends are established by sections (5) where the turns of one helical line merge into those of the other helical line, said sections appearing as a single length of the thread (1).
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: November 4, 2003
    Assignee: Endovascular Technologies, Inc.
    Inventor: Sergei Appolonovich Pulnev
  • Patent number: 6638309
    Abstract: A method of using body tissue is disclosed. Pieces of body tissue are obtained, they are shaped to form an article having a desired configuration, and the article is implanted into a patient's body.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: October 28, 2003
    Assignee: Bonutti 2003 Trust A
    Inventor: Peter M. Bonutti
  • Patent number: 6629991
    Abstract: The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: October 7, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lilip Lau, William M. Hartigan, John J. Frantzen
  • Publication number: 20030181974
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises a biomaterial suturelessly bonded to the valve frame, avoiding sutures and substantially reducing medical complications in implantations.
    Type: Application
    Filed: March 21, 2002
    Publication date: September 25, 2003
    Inventors: Hua Xie, Lisa A. Buckley
  • Publication number: 20030181968
    Abstract: A bioprosthetic stent graft is disclosed, having a stent frame and a biomaterial sheath suturelessly bonded to the stent frame. Sutureless bonding avoids sutures and substantially reducing medical complications in implantation of the stent graft.
    Type: Application
    Filed: March 21, 2002
    Publication date: September 25, 2003
    Inventors: Hua Xie, Lisa A. Buckley
  • Publication number: 20030171820
    Abstract: A prosthesis is disclosed at least of the surface of which is of metal, said metal being covered by a layer of aluminium oxide which comprises phosphate and/or pores containing bioactive material, optionally with a layer of aluminium or an alloy thereof between the metal and the porous aluminium oxide layer.
    Type: Application
    Filed: March 7, 2003
    Publication date: September 11, 2003
    Inventors: Peter Richard Wilshaw, Anna Eva Maria Palsgard
  • Patent number: 6616699
    Abstract: A vascular prosthesis is constructed from a well-defined pore structure to allow uninterrupted ingrowth of connective tissue into a wall of the prosthesis. Several different methods can be used to produce the prosthesis, including a vacuum impregnation technique, a paste molding technique, a paste extrusion technique, a dip coating technique, and a melt extrusion technique. Furthermore, mechanical properties of the prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
    Type: Grant
    Filed: January 9, 2001
    Date of Patent: September 9, 2003
    Inventors: Peter Paul Zilla, Deon Bezuidenhout
  • Patent number: 6605119
    Abstract: A method is disclosed for making vascular prostheses from ePTFE said prostheses having a diameter which is larger, and a wall thickness which is smaller than previously achievable using ram extrusion techniques. The method consists of extruding a PTFE tube, finish processing the tube into an ePTFE tube, laterally dilating it by expansion in incremental steps, calendering the tube after each dilating step, while the tube is being maintained at an elevated temperature. Once the tube is dilated it can be sintered with another tube to form a laminate. Alternatively, a wire stent may be joined with one or more tubes, thereby biasing the laminate to a cylindrical configuration.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: August 12, 2003
    Assignee: Endomed, Inc.
    Inventors: William M. Colone, Kevin G. Farl, Barbara L. Teeter, William L. Creer, Joseph B. Sinnott
  • Patent number: 6597965
    Abstract: A method for fabricating a foam cosmetic cover for a prosthetic component. The steps comprise selection of an appropriate prosthetic component, collecting data regarding its shape from a replica of the prosthetic component, converting the data into the dimensions of two halves of an interior cavity, and providing this data to a computer-controlled milling machine. The computer-controlled milling machine then cuts a portion of one-half of the cavity into one side of the block and a portion of the other half of the cavity on the opposed side of the block. The cutting head is then advanced longitudinally so that additional portions of the cavity can be cut into the opposing sides of the block. The block is then removed from the milling machine and cut in half longitudinally between the indentations in the sides of a block. The two halves of the block are then attached to one another to form a cavity having the general shape of the prosthetic component.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: July 22, 2003
    Assignee: Prosthetics Research Specialists, Inc.
    Inventors: Ronnie N Graves, Jeffrey J. Peterman
  • Publication number: 20030125807
    Abstract: The present invention relates generally to intervertebral disc repair devices and methods of manufacture. A method of manufacturing a dynamically responsive encapsulated intervertebral disc repair device that prevents the flow of disc material out of the disc, provides support to the anulus fibrosus, and shields the nerves of the anulus and spinal cord, is provided.
    Type: Application
    Filed: July 10, 2002
    Publication date: July 3, 2003
    Inventors: Gregory Lambrecht, Sean Kavanaugh, Scott Stonebrook