Chromatography Patents (Class 73/61.52)
  • Publication number: 20130074585
    Abstract: A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography.
    Type: Application
    Filed: November 20, 2012
    Publication date: March 28, 2013
    Applicant: OKSUKA CHEMICAL CO., LTD.
    Inventor: OKSUKA CHEMICAL CO., LTD.
  • Patent number: 8397553
    Abstract: A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 19, 2013
    Assignees: The Curators of the University of Missouri, W.R. Grace & Co.-Conn
    Inventors: Zhi Xu, Rakesh Bose, James M. Anderson
  • Publication number: 20130059799
    Abstract: The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
    Type: Application
    Filed: May 2, 2011
    Publication date: March 7, 2013
    Inventors: Liping Liu, Lawrence Gu
  • Publication number: 20130031965
    Abstract: A method of testing for a trisaccharide in milk includes the step of providing a predetermined amount of milk. The method also includes the step of isolating a trisachharide of the milk with a hydride insertion reaction to identify the molecule as phosphorylated. Also included in the method is the step of obtaining a mass spectrum of the isolated milk trisaccharide sample. The method further includes the step of identifying a molecular structure of the isolated milk trisaccharide sample.
    Type: Application
    Filed: March 22, 2012
    Publication date: February 7, 2013
    Inventor: Michael Madson
  • Publication number: 20130026099
    Abstract: The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
    Type: Application
    Filed: May 4, 2012
    Publication date: January 31, 2013
    Applicant: Dionex Corporation
    Inventors: Xiadong Liu, Christopher A. Pohl, Andrei V. Bordunov, Nebojsa Avdalovic
  • Publication number: 20130029365
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 31, 2013
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventor: MOMENTA PHARMACEUTICALS, INC.
  • Publication number: 20130024133
    Abstract: Method of conducting chromatography comprising controlling a retention time of one or more chemical species in a mixture by determining at least one conceptual segment of: a) the one or more chemical species, b) a mobile phase component, and c) a stationary phase component. The method further includes defining an identity and an equivalent number of each of the at least one conceptual segment.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 24, 2013
    Applicant: Aspen Technology, Inc.
    Inventor: Chau-Chyun Chen
  • Publication number: 20130020263
    Abstract: A method in a separation system (31) comprising parallel fluid paths (F1?,F2?, . . . Fn?) each comprising a separation module (M1?,M2?, . . . Mn?). According to the invention said method comprises the steps of: providing a sensor (S1,S2, . . . Sn) of the same type in at least each of said parallel fluid paths except one; measuring a characteristic fluid property with at least one of said sensors in the parallel fluid paths; possibly measuring the same characteristic fluid property with a system sensor (45) positioned in the outlet of the separation system (31); and comparing measured characteristic fluid properties to evaluate and/or qualify the performance of the separation system.
    Type: Application
    Filed: March 30, 2011
    Publication date: January 24, 2013
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Klaus Gebauer
  • Publication number: 20130008238
    Abstract: The present invention provides a processes for preparing 5-Azacytidine, and intermediates thereof. The present invention further provides an analytical method for determining the purity of 5-Azacytidine in a sample.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Inventors: Ettore BIGATTI, Giovanna Lux, Maurizio Paiocchi, Andrea Giolito, Simone Tosi
  • Publication number: 20130012402
    Abstract: The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder.
    Type: Application
    Filed: December 20, 2010
    Publication date: January 10, 2013
    Applicant: Psynova Neurotech Ltd.
    Inventors: Sabine Bahn, Emanuel Schwarz
  • Publication number: 20130008237
    Abstract: Described are techniques for force sensing. A computing device is configured to have a desired force setting. A first vertical position of a needle is determined using the computer device. A control signal is sent from the computing device to a positioning device. In response to the control signal, the needle is positioned at the first vertical position. When in the first vertical position, surfaces of a tip of the needle are in contact with surfaces of an opening of a sealing member and positioning the needle causes application of a force at surfaces of the opening in contact with surfaces of the tip of the needle. In response to application of the force, a spring is compressed a distance that is proportional to the force. The force is measured using a force sensor.
    Type: Application
    Filed: January 10, 2011
    Publication date: January 10, 2013
    Inventors: James E. Usowicz, Tony A. Lin, Joshua A. Burnett, Marc Lemelin
  • Patent number: 8349615
    Abstract: The invention relates to a method of finding suitable parameters for the chromatographic purification of biomolecules. The method consists of equilibration, charging, washing and eluting steps, this sequence of steps being carried out by the partial batch method. The parameters determined in small, preferably numerous parallel test batches provide conclusions as to the chromatography conditions under which a given biomolecule can be purified optimally by column chromatography, optionally even on a larger scale.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: January 8, 2013
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Christian Eckermann, Sybille Ebert, Stefanie Rubenwolf, Dorothee Ambrosius
  • Publication number: 20130005588
    Abstract: Described herein are methods for establishing the non-toxicity of a substance. For example, described herein are methods for the construction of a comprehensive database of toxicity associated pathways and methods of using such a database.
    Type: Application
    Filed: March 15, 2011
    Publication date: January 3, 2013
    Inventor: Thomas Hartung
  • Publication number: 20130000389
    Abstract: Disclosed are a method for analyzing chemical profiles of components from a herbal medicine product. Components may include quinone (including rhein, sennoside A and/or aloe-emodin), stilbene containing resveratroloside, flavone including baicalin, and/or alkaloid including berberine and/or palmatine. The method includes steps of: (a) respectively chromatographing a methanol extract of product and standard(s) corresponding to the component(s) using HPLC; (b) comparing HPLC chromatogram of extract and standard(s); and (c) analyzing the chemical profiles of the product from the comparison results.
    Type: Application
    Filed: June 20, 2012
    Publication date: January 3, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: FANG-RONG CHANG, TUNG-YING WU, YANG-CHANG WU
  • Patent number: 8342007
    Abstract: A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: January 1, 2013
    Assignee: Dionex Corporation
    Inventors: Jun Cheng, Petr Jandik, Christopher A. Pohl
  • Patent number: 8343774
    Abstract: An analytical apparatus includes a sample-injection valve, a sample pump, at least two sources of standards, and a selection valve. The sample-injection valve has an output port in fluid communication with a LC column, and an input port in fluid communication with a mobile-phase supply line. The at least two sources of standards are associated with at least two pharmaceutical compounds. The selection valve fluidically and selectably connects the sample pump to the at least two sources of standards, to the sample-injection valve, and to at least two pharmaceutical-manufacturing process lines associated with the at least two pharmaceutical compounds. A method for controlling a pharmaceutical manufacturing process includes switching the selection valve to alternately and repeatedly sample the at least two sources of standards and material flowing through the at least two pharmaceutical-manufacturing process lines.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: January 1, 2013
    Assignee: Waters Technologies Corporation
    Inventor: Sylvain Cormier
  • Publication number: 20120324986
    Abstract: An Advanced Laser Fluorometer (ALF) can combine spectrally and temporally resolved measurements of laser-stimulated emission (LSE) for characterization of dissolved and particulate matter, including fluorescence constituents, in liquids. Spectral deconvolution (SDC) analysis of LSE spectral measurements can accurately retrieve information about individual fluorescent bands, such as can be attributed to chlorophyll-a (Chl-a), phycobiliprotein (PBP) pigments, or chromophoric dissolved organic matter (CDOM), among others. Improved physiological assessments of photosynthesizing organisms can use SDC analysis and temporal LSE measurements to assess variable fluorescence corrected for SDC-retrieved background fluorescence. Fluorescence assessments of Chl-a concentration based on LSE spectral measurements can be improved using photo-physiological information from temporal measurements.
    Type: Application
    Filed: December 3, 2010
    Publication date: December 27, 2012
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF
    Inventor: Alexander Chekalyuk
  • Patent number: 8336371
    Abstract: Separating trihalomethanes from drinking water samples (via a process such as capillary membrane sampling, and the like) followed by gas chromatograph analysis to determine quantity measurements and species identification of such trihalomethane (THM4) contaminants therein is provided. With the necessity to chlorinate drinking water to remove harmful bacteria and other potential toxins, trihalomethane byproducts are generated that may harm humans after consumption as well due to suspect carcinogenicity of such compounds. A reliable manner of measuring such drinking water supplies for such THM4 contaminants at locations far from the source and closer to dispensers is highly desirable.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: December 25, 2012
    Assignee: University of Memphis Research Foundation
    Inventors: Gary Lynn Emmert, Michael Andrew Brown
  • Publication number: 20120322835
    Abstract: A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the impurity H168/79 that is no greater than about 1.5%, or where the ratio between clevidipine and H168/79 is equal or above 60 to 1.
    Type: Application
    Filed: August 30, 2012
    Publication date: December 20, 2012
    Inventors: Rajeshwar Motheram, Gopal Krishna, Min Ding, Keith Flood, Kornepati Ramakrishna
  • Publication number: 20120314203
    Abstract: A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
    Type: Application
    Filed: August 8, 2012
    Publication date: December 13, 2012
    Inventors: Urszula J. Slomczynska, Bobby N. Trawick, Dennis P. Riley, Arati Naik
  • Patent number: 8323569
    Abstract: Apparatus for GPC/TREF and TREF/GPC characterization of a polymer sample. The apparatus provides for the automated and integrated use of multiple TREF columns and a GPC system employing a multiple flow through detectors. In addition, a method for TREF/GPC characterization of a polymer sample by GPC analysis of TREF fractions at increasing TREF elution temperatures from multiple TREF columns operated in a coordinated and synchronized temperature cycle for increased sample throughput. Also, a method for GPC/TREF characterization of a polymer sample by GPC fractionation followed by TREF fractionation of the GPC fractionations.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: December 4, 2012
    Assignee: Dow Global Technologies LLC
    Inventors: David T. Gillespie, Colin Lipishan, Lonnie G. Hazlitt, Alexander W. Degroot, Peter B. Arnoudse, Charles A. Williams
  • Publication number: 20120296189
    Abstract: Provided are methods of measuring analyte concentrations in interstitial fluid samples, methods of determining accuracy of subcutaneously implantable analyte sensors, methods of manufacturing and determining calibration factors for subcutaneously implantable analyte sensors, as well as subcutaneously implantable analyte sensors manufactured according to the described methods and having a high level of accuracy. Methods of determining the concentration of an analyte in a bodily sample, and methods of extracting interstitial fluid are also provided.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 22, 2012
    Inventors: John Bhogal, Shridhara Alva Karinka, Timothy P. Henning, David Cunningham, Udo Hoss, Andrew H. Naegeli, John LaTour
  • Publication number: 20120295928
    Abstract: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof: and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
    Type: Application
    Filed: May 14, 2012
    Publication date: November 22, 2012
    Applicant: F.I.S. FABBRICA ITALIANA SINTETICI S.p.A.
    Inventors: Francesco Fontana, Alessandro Leganza, Sergio Osti
  • Publication number: 20120289416
    Abstract: Methods of assessing the risk of recurrence of endometrial cancer on the basis of the presence or absence of mutations in FGFR2 are disclosed.
    Type: Application
    Filed: July 19, 2010
    Publication date: November 15, 2012
    Applicants: WASHINGTON UNIVERSITY, THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventors: Pamela Pollock, Paul J. Goodfellow
  • Patent number: 8297936
    Abstract: A method for controlling movement of a piston in a metering device is described. The method comprises supplying a fluid by actuating the metering device's piston, wherein compression or expansion of the fluid causes corresponding temperature variations. The method further comprises superposing a corrective movement onto the piston movement, with the corrective movement at least partly compensating for at least one of thermal expansion and contraction of the fluid induced by the temperature variations. In one embodiment, the corrective movement imposed onto the piston movement comprises two components: a reduction (74) of the compression jump (73), and a subsequent increase (75) of the piston's forward displacement rate (71) during a period (76) of time (72).
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: October 30, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Klaus Witt, Konstantin Choikhet, Alexander Bierbaum
  • Patent number: 8292990
    Abstract: A High Performance Liquid Chromatography (HPLC) system including a pressure reducer assembly for reducing pressurized streams to ambient pressure. The pressure reducer assembly includes first and second flow restrictors, each coupled to a common chamber that acts as a surge suppressor that mitigates pressure spikes in the discharge lines. The flow restrictors may comprise tubes having a high length-to-diameter ratio. The pressure losses through the flow restrictors, in combination with transition losses as the flow stream enters and exits the chamber, are sufficient to reduce a discharge stream from a specified inlet pressure to substantially ambient pressure, thus eliminating the need for pressurized waste containers.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: October 23, 2012
    Assignee: TSI, Incorporated
    Inventors: Michael Schumacher, Robert Montividas
  • Publication number: 20120258123
    Abstract: The present invention inter alia provides a method, and uses thereof, of predicting statin-induced muscle toxicity or its complications, such as myalgia, myopathy and rhabdomyolysis, by detecting the lipid concentrations or lipid-lipid concentration ratios of a biological sample and comparing them to a control. This method has identified lipid markers that are more specific and sensitive in detecting these statin-induced muscle toxicity than the currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, statin-induced muscle toxicity. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of statin-induced muscle toxicity.
    Type: Application
    Filed: December 21, 2011
    Publication date: October 11, 2012
    Applicant: Zora Biosciences Oy
    Inventors: Reijo Laaksonen, Kim Ekroos, Reini Hurme, Minna Jänis, Riikka Katainen, Kirill Tarasov
  • Publication number: 20120252041
    Abstract: The present invention relates to the use of soluble CD163 as a prognostic marker for the assessment of the risk for contracting a disorder, in particular for contracting diabetes and/or a liver disorder. The invention also relates to the use of CD163 as a prognostic marker for assessing lifetime expectancy.
    Type: Application
    Filed: October 12, 2010
    Publication date: October 4, 2012
    Applicants: Region Midjylland, Aarhus Universitet
    Inventors: Søren Moestrup, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Holger J. Møller
  • Publication number: 20120244594
    Abstract: The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide.
    Type: Application
    Filed: June 28, 2007
    Publication date: September 27, 2012
    Inventors: John Rush, Hui Zhang, Xiangming Zha, Michael J. Comb, Yi Tan
  • Publication number: 20120241321
    Abstract: The invention relates to a method for diagnosing vascular diseases, comprising the step in which the presence, absence or amplitude of at least three polypeptide markers is determined in a urine sample, wherein the polypeptide markers are selected from the markers characterized in table 1 by values for the molecular masses and the migration time.
    Type: Application
    Filed: September 14, 2010
    Publication date: September 27, 2012
    Inventor: Harald Mischak
  • Patent number: 8268626
    Abstract: A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.
    Type: Grant
    Filed: November 24, 2005
    Date of Patent: September 18, 2012
    Inventor: Mitsuyo Okazaki
  • Publication number: 20120220493
    Abstract: The application discloses MCAM as a new biomarker for acute heart failure; methods for predicting, diagnosing, prognosticating and/or monitoring acute heart failure based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.
    Type: Application
    Filed: October 21, 2010
    Publication date: August 30, 2012
    Applicant: Pronota N.V.
    Inventor: Koen Kas
  • Publication number: 20120214875
    Abstract: The invention provides methods for measuring concentrations of basic or neutral compounds, such as phenoxybenzamine, in biological samples, and methods for treating patients based on the compound concentrations in the biological samples from the patients.
    Type: Application
    Filed: February 22, 2012
    Publication date: August 23, 2012
    Inventors: Nicola Christine HUGHES, Mei Li
  • Publication number: 20120196935
    Abstract: Materials and methods for detecting the early onset of shock and multi-organ failure by production of tissue breakdown products in biological samples (e.g., expired air).
    Type: Application
    Filed: September 18, 2009
    Publication date: August 2, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Geert W. Schmid-Schonbein, Frank Delano
  • Publication number: 20120187284
    Abstract: Test method checks and compensates ion yield variances in a mass spectrometer and includes feeding an eluate of a chromatographic separation to the spectrometer, continuously ad-mixing a separate target analyte solution at known concentration and constant flow rate to the eluate, injecting the mixture into the spectrometer and generating a detector signal for the mixture. A spectrogram is captured which includes an integration line and a mass-spectrographic peak of the target analyte, the integration line being a lasting background signal underlaid to the mass-spectrometric analysis of the eluate, then evaluating the spectrogram by capturing an integrated mass-spectrographic peak area above the integration line and an area which is found under the integrated peak area of the target analyte by perpendicular drop lines from the peak integration line and forming a mathematical relationship from the determined mass-spectrographic areas.
    Type: Application
    Filed: June 18, 2010
    Publication date: July 26, 2012
    Inventors: Roland Geyer, Werner Halg, Michael Vogeser
  • Publication number: 20120190055
    Abstract: This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein. The individual metabolites or a pattern of secreted metabolites provide metabolic signatures of autism, which can be used to provide a diagnosis thereof.
    Type: Application
    Filed: April 29, 2011
    Publication date: July 26, 2012
    Applicants: STEMINA BIOMARKER DISCOVERY, INC., WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Gabriela Gebrin Cezar, Alan M. Smith
  • Publication number: 20120190871
    Abstract: Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well as the stereo structures and the amounts of the triterpenoid compositions. The cytotoxicity of triterpenoids is also revealed. Based on the aforementioned techniques, the presence and amounts of ergostane and lanostane in the drugs, healthcare food or other goods are able to be detected.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 26, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, MEI-CHIN LU, YING-CHI DU, TUNG-YING WU, YU-MING HSU
  • Publication number: 20120178945
    Abstract: Disclosed are a method for preparing an n-hexane extract of the fruiting body of Antrodia cinnamomea (AC), wherein the fruiting body of AC is sequentially extracted with the ethanol solution and the n-hexane solution to obtain the n-hexane extract containing at least one benzenoid compound. The amounts of 4,7-dimethoxy-5-(3-methylbut-3-en-1-ynyl)-6-methyl-1,3-benzodioxole, 4,7-dimethoxy-5-methyl-1,3-benzodioxole, antrocamphine A and the combination thereof in the at least one benzenoid compound are determined using chromatography, NMR and HPLC. In addition, the present invention is applicable on detecting the amounts of benzenoid compounds in the AC healthcare food/drug or the fruiting body of AC, and thus owns the industrial values.
    Type: Application
    Filed: January 9, 2012
    Publication date: July 12, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, MEI-CHIN LU, YING-CHI DU, TUNG-YING WU, YU-MING HSU
  • Patent number: 8216515
    Abstract: An apparatus for capillary ion chromatography having a suppressor having flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: July 10, 2012
    Assignee: Dionex Corporation
    Inventors: Yan Liu, Victor Manuel Berber Barreto, Christopher A. Pohl, Nebojsa Avdalovic
  • Publication number: 20120171772
    Abstract: At least one of these or other problems is reduced using a building material that is uniquely identifiable. A method of making an identifiable gypsum-based building product includes selecting a tagging material occurring naturally in a component of the building material and choosing a carrier substance having a high concentration of the tagging material. By selecting an amount of the carrier substance and adding it to the building material, a building product having a unique product characteristic is created. In a second embodiment of the invention, a second tagging material is combined with the first tagging material to create a unique product. In yet another embodiment of the invention, a supplemental amount of the tagging material is added to the gypsum-based composition in addition to the carrier substance. Some tagging materials are useful in a gypsum-based composition to produce a visual confirmation of the presence of the tagging material.
    Type: Application
    Filed: June 1, 2011
    Publication date: July 5, 2012
    Inventors: Salvatore C. Immordino, JR., Brett R. Link, Charles J. Miller, Guy L. Rosenthal, Richard B. Stevens, Lee K. Yeung
  • Publication number: 20120167671
    Abstract: The invention relates to an apparatus and method for testing transdermal medicaments, wherein the sample tested in a membrane penetration cell resides in the open sample compartment of said cell and is exposed to environmental factors such as temperature, air flow, light and air humidity during testing the absorption and penetration.
    Type: Application
    Filed: February 8, 2010
    Publication date: July 5, 2012
    Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Endre Mikulásik, Patrik Fazekas, Péter Szakály
  • Publication number: 20120160754
    Abstract: A method of manufacturing a component (400) having a flow path (402), wherein the method comprises forming a high pressure resistant casing (102) with a cavity (202) therein, inserting a bioinert material (302) into the cavity (202) to thereby form a composite block (300), and further processing the composite block (300) for at least partially forming the flow path (402) defined by the component (400).
    Type: Application
    Filed: November 22, 2011
    Publication date: June 28, 2012
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventor: Stefan Falk-Jordan
  • Publication number: 20120160015
    Abstract: Disclosed is a method involving the steps of (a) precipitating an amount of asphaltenes from a liquid sample of a first hydrocarbon-containing feedstock having solvated asphaltenes therein with one or more first solvents in a column; (b) determining one or more solubility characteristics of the precipitated asphaltenes; (c) analyzing the one or more solubility characteristics of the precipitated asphaltenes; and (d) correlating a measurement of feedstock fouling tendencies for the first hydrocarbon-containing feedstock sample with a mathematical parameter derived from the results of analyzing the one or more solubility characteristics of the precipitated asphaltenes.
    Type: Application
    Filed: March 11, 2011
    Publication date: June 28, 2012
    Applicant: Chevron U.S.A. Inc.
    Inventors: Cesar Ovalles, Estrella Rogel, Michael E. Moir
  • Publication number: 20120162637
    Abstract: A three-dimensional chromatographic detection method providing the detection of components inside a three-dimensional separation body (1) or at a boundary surface (10) by the time the components emerge from the body.
    Type: Application
    Filed: September 7, 2010
    Publication date: June 28, 2012
    Applicant: DIONEX BENELUX B.V.
    Inventors: Sebastiaan Eeltink, Peter J. Schoenmakers
  • Patent number: 8205485
    Abstract: Provided is a liquid chromatograph system and method configured to accurately obtain measurements by minimizing deviations in measurements due to a transfer from one measurement method to another measurement method. An aspect of the system and method includes minimizing deviations in measurements when a measurement method from a measurement system of a liquid chromatograph is transferred to measurement system under high pressure and high velocity. Such a transfer includes deviations due to differences in analysis conditions. The present subject matter uses a dwell volume value so as to minimize a deviation of measurement result due to methods before and after transfer. Another aspect includes calculating a correction value when there is a deviation in the measurement result, and automatically reflecting the correction value for the method transfer.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: June 26, 2012
    Assignee: Hitachi High-Technolgies Corporation
    Inventors: Takaaki Suzuki, Masato Fukuda, Masahito Ito
  • Patent number: 8206986
    Abstract: Markers are provided that are predictive of Alzheimer's disease. Levels of these markers, when different from a standard, are indicative of a patient being at risk of having or developing Alzheimer's disease.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: June 26, 2012
    Assignee: BG Medicine, Inc.
    Inventors: Doris Damian, Amir Handzel, Aram Adourian
  • Publication number: 20120141524
    Abstract: A preparation method for an ethanol extract of the fruiting body of Antrodia camphorata (EEAC) is provided. The preparation method includes steps of: (a) providing the fruiting body of A. camphorata (AC); (b) extracting the fruiting bodies with a first ethanol solution; and (c) obtaining EEAC. EEAC further can be sequentially extracted or fractioned by n-hexane, ethyl acetate and ethanol, and an n-hexane fraction (FC), an ethyl acetate fraction (FA) and an ethanol fraction (FB) respectively are generated. The growth inhibition and apoptosis induction of leukemia cell line HL 60 are effectively mediated by FA product, in which zhankuic acid A is the bioactive marker. The amount of triterpenoid in the fruiting body of AC can be determined by NMR and HPLC analysis.
    Type: Application
    Filed: February 16, 2012
    Publication date: June 7, 2012
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, Mei-Chin Lu, Fang-Rong Chang, Ying-Chi Du, Tung-Ying Wu
  • Publication number: 20120142784
    Abstract: The present invention relates to novel biomarker for breast cancer, namely LSD1 and its application in inter alia the diagnosis of breast cancer. Furthermore, the present invention discloses a method of determining the LSD1 protein amount and the effect of LSD1 inhibitors on cancer cells selected from breast cancer, lung carcinoma and sarcoma.
    Type: Application
    Filed: June 4, 2010
    Publication date: June 7, 2012
    Inventors: Roland Schüle, Eric Metzger, Reinhard Büttner, Jutta Kirfel
  • Publication number: 20120132794
    Abstract: The invention provides chromatographic apparatus and components manufactured from a corrosion resistant alloy typically comprising iron, nickel, chromium and molybdenum. The apparatus and components exhibit superior biocompatibility and corrosion resistance, especially to mobile phases containing chlorides. They are especially useful in HPLC and HPLC, and are particularly useful in conjunction with chromatographic separation media comprising particles smaller than 2 ?m diameter.
    Type: Application
    Filed: April 19, 2010
    Publication date: May 31, 2012
    Applicant: WATERS TECHNOLOGIES CORPORATION
    Inventors: John Buchanan, Edward J. Ognibene, Peter Kirby
  • Publication number: 20120129188
    Abstract: The present invention relates generally to the use of circulating cytochrome c as a biomarker of reperfusion injury that results from whole body ischemia. Circulating levels of cytochrome c can be used as predictor of survival rates and to assess the effects of interventions aimed at ameliorating mitochondrial injury during reperfusion. Whole body ischemia may be the result of cardiac arrest or from other hemodynamic crises, such as hemorrhagic shock.
    Type: Application
    Filed: November 4, 2011
    Publication date: May 24, 2012
    Applicant: Rosalind Franklin University of Medicine and Science
    Inventor: Raul J. Gazmuri