Single Valve Unit Patents (Class 73/863.72)
  • Patent number: 10371273
    Abstract: Valve assemblies are described that provide segmented shuttle of liquid into sample vessels and automatic mixing via bubbles in the segmented liquid. A valve assembly includes a first valve member having ports configured to receive a pressurized gas, a first fluid, and a second fluid. The valve assembly also includes a second valve member coupled adjacent to the first valve member. The second valve member comprises a plurality of channels configured to interface with the first valve member. In a first configuration, the first fluid is loaded into an external loop. In the second configuration, the second fluid is eluted from the column into a vial in a segmented stream via bubbles of pressurized gas. Bubbles of gas automatically mix the eluted sample fluid.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: August 6, 2019
    Assignee: ELEMENTAL SCIENTIFIC, INC.
    Inventors: Nathan Saetveit, Daniel R. Wiederin
  • Patent number: 10113995
    Abstract: A rotary shear valve having a rotor device and a stator device both with planar faces. The stator face includes a central port located at a common rotational axis, a second port radially spaced a radius R1 from the central port, and a third port spaced at radius R2. The second and third ports are in general linear alignment with the central port. The rotor face includes a first rotor groove extending radially outward from the common rotational axis to a position at radius R2 from the central port. The rotor device is rotatably mounted to the stator device for rotation thereof about the axis, providing fluid-tight, selective relative rotation therebetween between two or more discrete rotor positions. When in a discrete first rotor position, the first rotor groove is oriented in radial alignment with, and fluidly connects, the central port and the second port with the third port.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 30, 2018
    Assignee: IDEX Health & Science LLC
    Inventors: Daniel M. Hartmann, Darren Lewis, Jon Nichols, Jim Smyth
  • Patent number: 9038488
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: May 26, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: James E. Sinclair, B. Albert Griffin, Minh Vuong
  • Patent number: 8978491
    Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: March 17, 2015
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: James E. Sinclair, B. Albert Griffin, Minh Vuong
  • Patent number: 8974731
    Abstract: A sample processing apparatus includes a sample carrier receiving region configured to receive a sample carrier. The sample carrier includes at least one sample channel carrying at least one sample, at least one agent chamber carrying at least one agent to be moved to the at least one sample channel to facilitate processing of the at least one sample, and the at least one agent chamber includes at least one chamber cover covering at least one opening of the at least one agent chamber, inhibiting flow of the at least one agent from the at least one agent chamber to the at least one sample channel. The sample processing apparatus further includes a chamber opener configured to facilitate opening the at least one chamber cover. The sample processing apparatus further includes a fluid mover that moves the agent out of the at least one agent chamber after the at least one chamber cover is opened and into the at least one sample channel.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: March 10, 2015
    Assignee: Analogic Corporation
    Inventor: Ari Eiriksson
  • Publication number: 20140295479
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Application
    Filed: January 31, 2014
    Publication date: October 2, 2014
    Applicant: Cepheid
    Inventors: Douglas DORITY, Ronald CHANG
  • Patent number: 8673238
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: March 18, 2014
    Assignee: Cepheid
    Inventors: Douglas Dority, Ronald Chang
  • Patent number: 8522627
    Abstract: A pump portion for taking in and discharging solutions includes a first plunger pump with a small capacity and a second plunger pump with a large capacity. Intake ports of both the plunger pumps are connected in parallel to a common port of a switching valve with a first three-way valve interposed therebetween. The first three-way valve connects the intake port of one of the plunger pumps to the switching valve. Discharge ports of both the plunger pumps are connected in parallel to one port of the switching valve with a second three-way valve interposed therebetween. The second three-way valve connects the discharge port of one of the plunger pumps to the switching valve.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: September 3, 2013
    Assignee: Shimadzu Corporation
    Inventor: Yoshiaki Maeda
  • Patent number: 8431413
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: April 30, 2013
    Assignee: Cepheid
    Inventors: Douglas B. Dority, Ronald Chang
  • Publication number: 20130014597
    Abstract: A needle adaptor mounted to one of a plurality of pipe connecting ports provided to a flow path switching valve to form an injection port into which a needle is inserted to inject a sample from a tip end of the needle is described. The needle adaptor comprises a dummy pipe having the same outer diameter as a normal pipe connected to the flow path switching valve, a port fixing portion for fixing the dummy pipe to the port, a needle seal for retaining the tip end of the needle to connect the needle and the dummy pipe and a needle seal housing mounted to the port fixing portion to retain the needle seal. The port fixing portion has the same shape as a port fixing portion of a pipe connecting member for connecting the normal pipe to the pipe connecting port.
    Type: Application
    Filed: May 23, 2012
    Publication date: January 17, 2013
    Applicant: SHIMADZU CORPORATION
    Inventor: Kenichi Yasunaga
  • Patent number: 8286663
    Abstract: A rotary valve for selectively connecting at least one component (51, 52) into a fluid path. According to the invention the inner stator face (111a, 211a) comprises orifices (131b-136b; 231b-236b) and said inner rotor face (112a, 212a) comprises at least a first groove (121, 221), a second groove (122, 222), and a third groove (123, 223) so arranged that the rotary valve can take at least three different rotary positions, in which either both components are bypassed, only one of the components is connected and the other bypassed or both components are connected to a main flow.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: October 16, 2012
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Patrik Kallback, Anders Wilen
  • Publication number: 20120186664
    Abstract: A water uptake measurement system for measuring uptake of a fluid by a sample includes a sample chamber, a suspension component and a supply interface. A suspension aperture is located at a first end of the sample chamber and extends from an outer surface of the sample chamber to an inner surface of the sample chamber. The suspension component passes through the suspension aperture and is configured to support the sample within the internal cavity such that the sample is spaced apart from the inner surface of the sample chamber. The supply interface is configured to deliver the fluid to the internal cavity of the sample chamber.
    Type: Application
    Filed: January 20, 2011
    Publication date: July 26, 2012
    Applicant: NISSAN NORTH AMERICA, INC.
    Inventors: Gregory DiLeo, Rameshwar Yadav, Kevork Adjemian
  • Patent number: 8225817
    Abstract: A rotary valve (10) for distributing a flow of a fluid is provided, the valve comprising a stator (11) and a rotor (12). Furthermore a chromatography system, comprising such a rotary valve and three different components or component groups connected to the valve is provided. With this rotary valve according to the invention the flow direction is kept constant through one of the three components or component groups while the flow direction through the other two component or component groups can be changed.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: July 24, 2012
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Anders Wilen
  • Patent number: 8109157
    Abstract: A fluid sampling and analysis module for a downhole fluid characterization apparatus configured for operation downhole, within a borehole. The fluid sampling and analysis module comprises a primary flowline for fluids withdrawn from a formation to flow through the fluid sampling and analysis module, a bypass flowline in fluid communication with the primary flowline and a single valve, interconnecting the primary flowline and the bypass flowline, operable to a first position for formation fluids to flow in the primary flowline and to a second position for formation fluids to flow, via the bypass flowline, in the primary flowline.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: February 7, 2012
    Assignee: Schlumberger Technology Corporation
    Inventors: Kazumasa Kanayama, Tsuyoshi Yanase, Sihar Marpaung
  • Patent number: 8065928
    Abstract: A vented filter is placed at the HPLC (High Performance Liquid Chromatography) loop entry port of an HPLC injector valve. The vented filter prevents the push gas used to deliver the crude radiolabeled product from over-pushing the liquid to waste. Push gas is vented off when the entire crude liquid product has passed through the vented filter and been loaded onto the HPLC loop.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: November 29, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Johanna Santiago, Thomas Lee Collier, Steven Zigler
  • Patent number: 8048386
    Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: November 1, 2011
    Assignee: Cepheid
    Inventors: Douglas B. Dority, Ronald Chang
  • Patent number: 7771658
    Abstract: A disposable cartridge for characterizing particles suspended in a liquid, especially a self-contained disposable cartridge for single-use analysis, such as for single-use analysis of a small quantity of whole blood. The self-contained disposable cartridge facilitates a straightforward testing procedure, which can be performed by most people without any particular education. Furthermore, the apparatus used to perform the test on the cartridge is simple, maintenance free, and portable.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: August 10, 2010
    Assignee: Chempaq A/S
    Inventor: Ulrik Darling Larsen
  • Publication number: 20100147086
    Abstract: Method for injecting a liquid sample in an HPLC analyzing device (43), using an apparatus (50) which comprises a first liquid circuit (11), a second liquid circuit (12), a valve assembly (30) of the stator/rotor type, and a sample loop (14). In a first and a second valve position, respectively, the sample loop is either part of the first or of the second circuit, respectively. During the switching of the valve assembly from the second valve position into the first valve position, the valve assembly automatically and temporarily assumes an intermediate valve position in which the sample loop is automatically decompressed via a fourth connection chamber (24) and a third valve outlet (7). In that intermediate valve position the sample loop is neither part of the first circuit nor part of the second circuit.
    Type: Application
    Filed: October 29, 2009
    Publication date: June 17, 2010
    Applicant: SPARK HOLLAND B.V.
    Inventors: Emile Hermannus Maarten Koster, Hermannus Geert Gijlers, Rudolf Herman Robert Poot, Otto Halmingh
  • Publication number: 20090178495
    Abstract: Sampling valve with which samples containing mechanically sensitive material are removed in a sterile manner from a bioreactor, and process analysis system with analysis stations, in particular chromatography systems, biosensors and cell determination devices, permitting automated, sterile removal of a sample from a bioreactor and gentle transport of the sample, containing mechanically sensitive material, in particular cells, to the analysis station
    Type: Application
    Filed: April 17, 2007
    Publication date: July 16, 2009
    Applicant: BAYER TECHNOLOGY SERVICES GMBH
    Inventors: Stefan Steigmiller, Hans Tups, Karsten Sommer, Sonja Danstedt, Martin Schiffhauer, Sebastian Schmidt, Jörg Kauling, Arndt Braun
  • Publication number: 20090050212
    Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.
    Type: Application
    Filed: January 31, 2006
    Publication date: February 26, 2009
    Applicant: WATERS INVESTMENTS LIMITED
    Inventors: Theodore A. Dourdeville, Russell L. Keene, Theodore D. Ciolkosz, James E. Usowicz
  • Publication number: 20080295617
    Abstract: The invention relates to a method for substance mixtures, particularly complex chemical and/or biochemical substance mixtures. According to said method, a substance mixture that is to be analyzed is fed to a separating device, the substances of the substance mixture that is to be analyzed are separated from each other in the separating device by means of a chemically and/or physically induced conveying process, and the separated substances are detected in an evaluation unit. The invention further relates to methods and devices for producing pulsed substance mixtures, particularly complex chemical and/or biochemical substance mixtures. In order to improve the analysis of substance mixtures especially regarding the duration of the analysis, the throughput, and the resolution, the substance mixture that is to be analyzed is fed to the separating device in pulses having an unique binary sequence.
    Type: Application
    Filed: October 17, 2006
    Publication date: December 4, 2008
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventor: Oliver Trapp
  • Publication number: 20080178693
    Abstract: A sample injector includes a rotary valve element with a straight passageway through it, which element may be rotated to connect a port communicating with a source of solvent with a port communicating with an inlet to a column. Another passageway connects two adjacent ports. The valve element may be rotated to one position in which it provides a straight path for sample to be injected, a second position in which it provides a path that connects a source of purge gas to the chromatographic system and a third position in which it provides a path that connects solvent to the column for preconditioning.
    Type: Application
    Filed: January 26, 2007
    Publication date: July 31, 2008
    Applicant: Teledyne Isco, Inc.
    Inventor: Dale A. Davison
  • Patent number: 7396512
    Abstract: A rugged, all-electronic fluid dispensing system for use with pipettes or in other contexts indirectly measures fluid flow by using a non-linear system model to correlate vacuum existing at the top of a column of suspended fluid. Non-contact operation is provided to eliminate the need for contact-type closed-loop fluid flow sensing and associated potential cross-contamination risks. In one particular exemplary non-limiting illustrative implementation, an electronic controller within a gun-shaped, cordless self-contained pipetter housing dynamically calculates valve opening time based on a non-linear equation. Calibration is used to derive equation constants, and column vacuum pressure before the valve is opened is used as the independent variable to derive a valve opening time that will result in accurate dispensing of a desired programmed fluid quantity.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: July 8, 2008
    Assignee: Drummond Scientific Company
    Inventors: Nicholas M. DiTrolio, Eric L. Canfield
  • Patent number: 7028564
    Abstract: An improved bailer which allows for the variance of flow into the bailer through use of attachments with varying inflow orifice sizes. As the size of the orifice changes, the weight of the apparatus can also be changed allowing for an only slightly negative buoyancy of the apparatus. The attachment may also be designed to include features for filtering unwanted particulates from the sample.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: April 18, 2006
    Inventor: Gene A. Voss
  • Patent number: 7019541
    Abstract: An electric conductivity water probe consisting of a test chamber having a wall, a fluids input/output port, and a water input port, the wall having a first and at least a second wall section, the first and at least second wall sections being electrically isolated from each other by an electrical insulator; and a valve connected operatively to the fluids input/output port, the valve being adapted for alternately and permitting and resisting flows of fluids through the fluids port.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: March 28, 2006
    Assignee: Crown Products, Inc.
    Inventor: Michael E. Kittrell
  • Patent number: 6890489
    Abstract: While a large primary stream (24) of analytes flow from a chromatographic column (20) to containers of a receiver (108), small samples of the analytes are diverted for flow to a mass spectrometer (54) for analysis, by use of a transfer module (102). The transfer module includes a stator (110) and a rotor or shuttle (114). The shuttle has an aliquot passage (120) that initially lies in a first position where the primary stream flows through it so the aliquot passage receives a small sample. The shuttle then moves to a second position where the aliquot passage (at 122) is aligned with a pump (134) that pumps fluid out of the aliquot passage to the mass spectrometer.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: May 10, 2005
    Assignee: Rheodyne, L.P.
    Inventors: Jon A. Nichols, Marc D. Foster
  • Patent number: 6874354
    Abstract: The sample injection valve for high-performance liquid chromatography (HPLC) devices comprises a stator with inlets for the sample and the mobile phase, outlets leading to the chromatography column and to a waste collector, as well as connections for both ends of a sample loop. Its rotor has the customary connection channels. An additional washing liquid inlet (7) opens into the connecting channel (9) that, in one valve position, connects the sample inlet (1) to the outlet (2) leading to the waste collector. This enables the sample inlet and the pipette or syringe located therein to be rinsed.
    Type: Grant
    Filed: November 12, 2001
    Date of Patent: April 5, 2005
    Assignee: CTC Analytics AG
    Inventors: Hansjörg Cueni, Heinrich Scherrer
  • Patent number: 6854346
    Abstract: A combination purging system and sampling system is provided for sampling gas from a pipeline. A flow path 40 provides fluid communication between a sample bottle 45 and the pipeline. The sample bottle 45 is initially filled with an inert gas for purging air from the flow path 40 and venting to atmosphere. A supply valve 24 controls flow between the pipeline and the flow path 40, and a bleed valve 35 controls venting from the flow path 40 to atmosphere. The relationship and positioning between the valves and the flow path prevents condensation from entering the sampled gas while purging and sampling.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: February 15, 2005
    Assignee: PGI International, Ltd.
    Inventor: Spencer M. Nimberger
  • Patent number: 6793819
    Abstract: An airtight sampling apparatus for effectively and accurately sampling a waste solution including volatile organic compounds (VOC's) from a main waste solution conduit having a first pressure P1, is provided.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: September 21, 2004
    Assignee: Xerox Corporation
    Inventors: Thomas B. Glenwright, Warren R. Smith, Brian L. Spencer, James F. Graf, Jr.
  • Publication number: 20040123679
    Abstract: The object of this invention is to provide a gas sampling system of taking discreet samples from a continuous flow of gas or fluid. Said apparatus offers a frame (1) and mounting components in the form of a fixed chuck (4) and a spring-loaded chuck with a sampled container (5) mounted therebetween. The sampling container has self-sealing end cap valve assemblies (76) that automatically open when the sample container (5) communicates with the fixed chuck (4) and the spring loaded chuck (6) and the end cap valve assembly automatically closes when the sample container is removed. A value system allows the gas flow to be directed from one sample container to the other alternatively opening and closing a gas flow path. A sample extraction assembly (14) allows the efficient removal of samples from the sample containers. An extension rod pressurized (117) in conjunction with the end cap value assembly, such as first end cap valve assembly (76) allow the sample to be pressurized to facilitate easy sample removal.
    Type: Application
    Filed: April 2, 2003
    Publication date: July 1, 2004
    Inventors: Dennis Coleman, Todd Coleman
  • Patent number: 6662826
    Abstract: A multi-disc liquid metering and transfer valve includes a port switch valve disc that has at least two inlet connections. Each of the connections is coupled to different fluid samples, such as blood. The remaining discs of the valve are used to provide measured samples that can be selectively routed to mixing chambers by pumped diluent reagents. The port valve switch can be rotated about its axis to select a desired inlet connection.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: December 16, 2003
    Assignee: Abbott Laboratories
    Inventor: Hidesuke Kokawa
  • Patent number: 6632404
    Abstract: A sample injector valve capable of introducing multiple samples of material into multiple liquid or gas streams is provided. Such a valve is particularly useful for injecting multiple samples under pressure into a combinatorial chemistry system with moving streams of fluid, such as a parallel pressure reactor or a rapid flow analysis system using multi-channel or parallel chromatography and related techniques. The valve is further capable of functioning on a small scale with automatic sampling equipment.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: October 14, 2003
    Assignee: Symyx Technologies, Inc.
    Inventors: J. Christopher Freitag, Miroslav Petro
  • Patent number: 6612153
    Abstract: A planar manifold that integrates all the control pneumatics, electronic pressure controls (EPC), and injector inlet onto a single plate, therefore eliminating numerous seals, fittings and transfer tubing between these devices. The planar manifold utilizes plates of specific geometry that minimizes heat transfer between the heated components and the unheated components in the planar manifold, while maintains the mechanical rigidity to support the attached components during shock and vibration. The planar manifold not only improves the reliability and manufacturability of micro gas chromatographs, but also lowers the cost of production.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: September 2, 2003
    Assignee: Agilent Technologies, Inc.
    Inventors: Richard P. White, Alan D. Loux
  • Patent number: 6524531
    Abstract: A hand-held, single-channel dispenser/aspirator is disclosed. The present dispenser/aspirator comprises a body portion for gripping the dispenser and a head portion. In some embodiments, the head portion includes a valve, a liquid conduit and a removable liquid reservoir. The liquid conduit places the liquid reservoir and the dispensing valve in fluid communication. A gas conduit received by the body portion of the dispenser is operable to pressurize the fluid reservoir, or draw a partial vacuum therein. Controls located on the body portion operate the dispenser. The liquid reservoir is advantageously disposed near the valve, so that a relatively short length of liquid conduit is required to operatively connect the reservoir and the dispensing valve, thereby improving the accuracy of the dispensing operation.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: February 25, 2003
    Assignee: Pharmacopeia, Inc.
    Inventor: Ilya Feygin
  • Patent number: 6490938
    Abstract: A gas injector comprises (1) a carrier gas channel through which a carrier gas can enter the injector, (2) an output channel through which the carrier gas and a gaseous sample can be injected from the device to an analytical instrument, (3) a sample gas channel capable of holding the gaseous sample, and (4) a switch structure regulating the connections among the sample gas channel, the carrier gas channel and the output channel. The injector also comprises at least a purge channel through which the carrier gas can flow across part of the device, purging therein and preventing contaminants from reaching the output channel. The gas injector provides a low baseline noise and a high signal to noise ratio when applied to a sensitive analytical instrument.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: December 10, 2002
    Assignee: Agilent Technologies, Inc.
    Inventor: Mahmoud F. Abdel-Rahman
  • Patent number: 6477906
    Abstract: A sampling system for capturing samples of trace elements in ambient air comprises a multi-port valve coupled to a plurality of sorbent tubes. Each tube is connected to the multi-port valve by means of pairs of the valve ports. The multi-port valve is constructed and operated in a predetermined sequence to create a flow path through the multi-port valve. The flow path directs an air sample to only one connected sorbent tube at a given time and for a given time interval.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: November 12, 2002
    Assignee: Roger Peterson Family Limited
    Inventor: Roger Peterson
  • Patent number: 6387710
    Abstract: Provided is a liquid handling device comprising: a cylindrical actuator cavity in a substrate, the actuator cavity intersected by two or more actuator channels; one or more chambers with an access channel adapted to connect to a separate one of actuator channels; and a actuator comprising (a) a cylindrical body having a cylinder axis and having therein a liquid-handling compartment with, arrayed along the cylinder axis, a first end and a second end, the liquid-handling compartment being closed at the second end, (b) a dispensing channel located at the second end and traversing the cylindrical body, the dispensing channel adapted to be separately aligned with the actuator channels, wherein the actuator is adapted to receive in a seal-tight manner a plunger that operates to confine an effective chamber defined by the plunger and the second end by moving toward the second end or to expand the effective chamber by moving toward the first end.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: May 14, 2002
    Assignee: Sarnoff Corporation
    Inventors: Zvi Gerald Loewy, Christopher Carter Gregory, Zygmunt Marian Andrevski
  • Patent number: 6382035
    Abstract: A multi-function valve apparatus for use with a Probe-In-Loop (PIL) architecture sample injection assembly which enables both Partial-Fill and Complete-Fill injections. The rotor element is rotatable about a rotation axis relative the stator between: a Load Position, an Overfill Position, and an Injection Position. In the Load Position, a first bridge channel fluidly couples a metering syringe to the sample loop assembly enabling the probe to aspirate one of a discrete volume of sample into the probe, during a Partial-Fill Mode, and a second volume of sample into the probe, during a Complete-Fill Mode. In the Overfill Position, in the Complete-Fill Mode, a second bridge channel fluidly couples a downstream loop portion to a waste port, and the first bridge channel fluidly couples the metering syringe to an upstream loop portion of the sample loop assembly.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: May 7, 2002
    Assignee: Rheodyne, LP
    Inventor: Jon A. Nichols
  • Patent number: 6176248
    Abstract: A submerged, valve assembly for controlling flow of fluid (e.g. ballast water) to and from a reservoir (e.g. a ballast tank of a ship. The valve assembly is comprised of a valve which is controlled by a hydraulic valve actuator. A fluid-tight housing encloses the actuator so that any leaking hydraulic fluid will be contained within the housing and will not pollute the surrounding fluid in the tank. The assembly includes a means for detecting any hydraulic fluid which may leak into the housing.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: January 23, 2001
    Assignee: Phillips Petroleum Company
    Inventors: William M. Croke, Robert A. Levine