Abstract: A pipette is provided having a reduced operational vibration and noise and an increased operational accuracy. The pipette includes a body and a drive unit mounted within the body. The drive unit includes a motor, an operating rod configured for movement under control of the motor, a nut, and an elastic strip. The nut is mounted to the operating rod and is configured to allow translational movement of the operating rod with respect to the nut, but not to allow rotational movement of the operating rod with respect to the nut. The elastic strip is mounted to the nut and to the body to exert a rotational torque on the nut.

Abstract: A method and device for an automatic analyzer, in particular for blood analysis sampling consists in displacing a sampling needle (5) rotatable around an axis (X2) which forms an angle with the sampling needle. The method and device are particularly suitable for use in a small blood sampling automate.

Abstract: A fluid dispenser useful in methods and apparatuses for automated biological reaction systems including a barrel, a coupler, a piston associated with the barrel, and a sealing surface that seals the inner diameter against fluid flow at the lower extent of the piston.

Abstract: In reagent reaction experiments using microplates, the operator cannot just set dispensing tips in all the fixing holes of the dispensing tip container. It is necessary to carry out the time-consuming task of deciding in advance on a suitable arrangement of positions for the dispensing tips. It is also necessary for the operator to carry out the time-consuming task of determining in advance the quantity of reagent used and how the reagent is to be arranged. These problems are solved by providing a control device that includes a dispensing tip arrangement calculator and reagent quantity and arrangement calculator, and that can inform the operator of these results. The dispensing tip arrangement, the reagent quantity used, and the reagent arrangement is calculated from the information set in advance on specific reagent, the quantity of reagent dispensed into one well of the microplate, the range of wells in the microplate into which reagent is dispensed, and the direction of dispensing.

Abstract: In an improvement of a nozzle tip for a pipetting apparatus which is adapted to be removably attached to a nozzle base of the pipetting apparatus, the nozzle tip includes a head portion having an opening adapted to fit onto the nozzle base, a cylindrical portion extending downward from the head portion, a tip portion provided on the lower side of the cylindrical portion and having a tip opening for aspirating and dispensing a liquid, the tip portion having a diameter smaller than the diameter of the cylindrical portion, and a step portion formed between the cylindrical portion and the tip portion. A plurality of fins are integrally formed from the lower end portion of the cylindrical portion to the peripheral surface of the tip portion through the step portion with the same spacing in a circumferential direction for making the insertion of the nozzle tip into an upper opening of a target container smoothly and for structurally reinforcing the step portion.

Abstract: A system and method extracts/deposits fluid and includes a pipette having a pipette body portion and a pipette tip. A stirring/agitation mechanism including a fiber or a rod extends through the interior of the pipette tip, wherein a fiber end or rod end of the fiber or rod, extends out of a narrowed end of the pipette tip, and the fiber end or rod end is configured to stir or agitate the fluid.

Abstract: Described are pipette tips and methods of making the same. The pipette tips may include at least two components, an annular component and a tubular body component. The annular component may comprise a different and relatively more compliant material. The annular component may be partially or entirely telescopically received within the tubular body component. Alternatively, the annular component may comprise a proximal end of the pipette tip and the tubular body component may comprise a distal end of the pipette tip. A portion of the tubular body component may be telescopically received by the annular component or otherwise attached thereto. The pipette tip may be formed by first molding the annular component and next molding the tubular body component. Alternatively, the tubular body component may be molded first and the annular component may be molded within, adjacent, or about the tubular body component.

Abstract: A pipette has a preferably thermoplastic pipette shaft, for slipping on a likewise preferably thermoplastic pipette tip, has a slip-on section which opens at least slightly conically, and an attachment section which is formed on the lower end of the pipette shaft and onto which the slip-on section of the pipette tip is slipped. A sealing section which is made of an elastically-flexible plastic material which seals well with low withdrawal forces is provided on the attachment section. Furthermore, preferably, a fixing section is formed on the plastic material of the attachment section of the pipette shaft at a location that is axially offset relative to the sealing section. The sealing section of elastic-flexible plastic material is molded directly, retentively, on the preferably thermoplastic material of the pipette shaft.

Abstract: An ergonomically designed pipette tip that can be securely mounted to a barrel of a pipetter yet is designed to substantially reduce the axial force necessary to install and eject the pipette tip from the pipetter. The ergonomic pipette tip includes molded-in expansion joints and/or the addition of a second elastic material to decrease the amount of force necessary to radially expand the entrance to the pipette tip when the pipetter barrel is guided and stability oriented towards the sealing region of the pipette tip. Also disclosed is an ergonomic adapter with similar features as the tip that can also be mounted to the barrel of the pipetter and attached to a standard pipette tip or a combination of tips. Therefore, the relatively small axial forces necessary for mounting and ejecting the new ergonomic tip and adapter can substantially help to reduce the hand and thumb forces, that due to repeated use, will sometimes result in repetitive stress injury.

Abstract: Apparatus for withdrawing a liquid sample from a vessel, the apparatus affixed to the vessel and having (a) a plunger forming a sample-receiving space movable from the vessel interior to and beyond a sample-delivery site, and (b) a valve for closing the vessel when the plunger is beyond the sample-delivery site. In the sampling apparatus, the sample-delivery site is incorporated in the valve.

Abstract: The sampling pipette includes an ejector arm for separating from the pipette a cone that is fixed to the pipette. The pipette includes adjustment means enabling the length of the arm to be varied continuously over a range of values.

Abstract: The invention relates to a digital burette having a manual drive for suctioning and applying an adjustable dose volume, a gear unit connected downstream and a digital display device controlled thereby for setting the dose volume. The control comprises an incremental encoder which is functionally connected to the gear unit, at least one sensor for detecting the signals produced by the incremental encoder and a processor connected to the sensor and the display device for calculating the dose volume corresponding to the number of signals. The incremental encoder is, in particular, a sector disc with two groups of sectors of different magnetic field strength disposed alternately in the peripheral direction of the sector disc. A sensor detects the number of turns of the sector disc.

Abstract: An automatic sampler for automatically sampling liquid samples to be introduced into apparatuses that analyze liquid samples, such as liquid chromatographs, includes a needle with a tapered tip end for suctioning and ejecting liquid, a mechanism for moving the needle in the horizontal and vertical directions, and an injection port having an insertion hole into which the tip end of the needle can be inserted. The outer diameter of the tip end of the needle is at least 0.1 mm and at most 0.6 mm. By reducing the needle-to-port contact area, the automatic sampler facilitates high-sensitivity and high-precision analyses by significantly reducing the amount of cross-contamination, regardless of the type of samples.

Abstract: A pre-filled disposable pipette (10) consisting of a hollow bulb (12) dimensioned to enclose a medicinal product. From a lower end (16) of the bulb (12) is attached sequentially a medicinal transfer tube (24) and a medication fill tube (32), from where the medicinal product is applied. Between a lower end (28) of the tube (24) and an upper end (34) of the tube (32) is formed a break-away notch (40). When the tube (24) or the tube (32) is rotated, the notch (40) is twisted and breaks-off, thus allowing the medicinal product to flow from the bulb (12) and be released from the tube (24). The pipette (10) includes a primary grasping tab (46) attached to an upper end (14) of the bulb (12); a secondary grasping tab (54) attached to each side of the tube (24); and a support tab (70) attached to each side of the tube (32). The invention also discloses several methods for sealing the lower tip (36) of the medication fill tube (32).

Abstract: A high throughput microarraying or colony picking robot with an automatic mechanism for exchanging pin heads and an automated washing and drying apparatus. The robot allows a dirty pin head to be deposited on the automated washing and drying apparatus for cleaning without use of the xyz-positioner, while spotting or picking can continue by picking up a clean pin head without having to wait for the dirty pin head to be cleaned. In this way, the speed of operation can be increased without any increase in the acceleration or speed of the x-, y- and z-drives. The dead time normally associated with the washing and drying cycle, which is usually several minutes, is therefore eliminated, and replaced with the much shorter dead time, of only a few tens of seconds, needed for changing between heads.

Abstract: A microarraying head 51 has a base portion 57 and a plurality of needles 53. The needles 53 are arranged in parallel with one another on the base portion 57. The needles 53 place a solution on substrates 3 with the top ends of the needles 53 touching substrates 3. Then, the needles 53 retain the solution including biological samples and form spots of the solution on the substrates 3. A space 58 for supplying cleansing fluid or the like is provided in the base portion 57 so as to extend all over the plurality of needles 53. Since the plurality of needles 53 can be all cleansed with substantially uniform pressure applied thereto, all the plurality of needles 53 can cleansed surely in a short time.

Abstract: The present application is directed to pipette configurations, arrays of the same and methods for using such pipettes and arrays to accomplish electrical measurements, including whole cell and on cell measurements. In one aspect of the present invention, a pipette includes a hollow tubular section having a distal portion and a tip portion. A bubble is formed at the tip and includes an interior chamber in communication with the hollow tubular section at an end adjacent to the bubble portion. The bubble may have a diameter greater than the diameter of an adjacent portion of the hollow tubular section. An aperture is formed between the internal chamber and an exterior surface of the bubble to accommodate seal formation.

Abstract: A liquid pipetting apparatus for dispensing liquid of minute volume for use in a survey instruments of a hemanalysis machine, a genetic screening, and a pharmaceutical screening, etc., is disclosed. The liquid pipetting apparatus comprises a liquid holding member for holding the liquid, and capable of dispensing the liquid from one end, and a driving member for moving the liquid holding member forward and backward along the dispensing direction, the liquid holding member being moved by the driving means, thereby dispensing the liquid held on the liquid holding member.

Abstract: A liquid level sensor confirms actual physical contact between a probe and a liquid by verifying that any change in capacitance of the sensor is constant over a given time period and thereby is not caused by spurious electrical disturbances or other measuring irregularities.

Abstract: A proportioning device, comprising a manually operable actuating device, a sensor associated with the actuating device for detecting a force manually exerted on the actuating device, an electric driving motor, an electric control connected to the sensor and electric driving motor for controlling the driving motor during the detection by the sensor of a force exerted on the actuating device, an electric voltage supply connected to the sensor, electric driving motor, and electronic control, and a displacement device coupled to the actuating device and electric driving motor for proportioning a liquid.

Abstract: A removable secondary liquid dispensing module for use with an existing, automated liquid handling system that defines a work area having a plurality of discrete work stations. Each of the work stations of the automated liquid handling system includes a lab ware site and alignment structure enabling the removable securing standardized microtiter-plates at respective lab ware site. A plate positioning mechanism is configured to move and position the microtiter plates to and from the lab ware sites of the respective work stations thereof and into engagement with the respective carrier alignment structure thereof. Further, a primary liquid dispensing device is configured for selective contact-type dispensing of discrete quantities of fluid, in the range of about one (1) microliter to about ten (10) milliliters, into the test sites of the microtiter plates secured in the respective alignment structure of the respective work station.

Abstract: A method of unblinding an alignment mark comprising the following steps. A substrate having a cell area and an alignment mark within an alignment area is provided. An STI trench is formed into the substrate within the cell area. A silicon oxide layer is formed over the substrate, filling the STI trench and the alignment mark. The silicon oxide layer is planarized to form a planarized STI within the STI trench and leaving silicon oxide within the alignment mark to form a blinded alignment mark. A wet chemical etchant is applied within the alignment mark area over the blinded alignment mark to at least partially remove the silicon oxide within the alignment mark. The remaining silicon oxide is removed from within the blinded alignment mark to unblind the alignment mark. A drop etcher apparatus is also disclosed.

Abstract: A material handling tool includes a piezoelectric motor that causes actuation of a needle. Actuation of the needle may include aspiration and/or dispensing of a fluid sample and/or movement of the needle to pick or place a material sample.

Abstract: A pipette includes a housing defining a suction chamber. A piston is configured to move in the suction chamber. A first retainer mechanism includes a first threading configured to limit a motion of the piston in the suction chamber. A second retainer mechanism includes a second threading configured to limit the motion of the piston in the suction chamber, the second threading having a pitch less than a pitch of the first threading.

Abstract: An automatic analyzer analyzes a measurement item by making a sample and reagent react with each other and measuring the reaction result. This apparatus allows parameters associated with reagent dispensing executed by a reagent dispensing mechanism to be set as a dispensing condition for each measurement item or each type of reagent, and controls the reagent dispensing mechanism on the basis of the dispensing condition.

Abstract: A volume displacement pipette that includes a channel within the piston. The channel allows for cleaning fluids to be continuously run through the pipette tip for cleaning the tip. One end of the channel may be closed during normal operation of the pipette. Multiple pipettes may be combined into an array pipetter.

Abstract: A pipette tip member has an elongated tubular receptacle including a sidewall with a plurality of stabilizing projections extending from the sidewall for aligning the pipette shaft, and a sidewall with a bifurcated section that includes first, second, and third sidewall portions. The first sidewall portion defines a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion is an outside branch wall, and the third sidewall portion is an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette shaft when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also enclosed.

Abstract: A pipette device has a coupling stud on which a pipette tip can be stuck in a slipping-on direction for coupling. The coupling stud has an adjustable pre-stress member that can be adjusted into a prestress state and a release state via an actuation device which is provided in the coupling stud. The pipette tip has an axial stop which interacts with a counter-stop of the coupling stud in an axial coupling position of the pipette tip. The prestress member in its prestress state acts upon a working surface of the stuck-on pipette tip having a surface component of the pipette tip, which extends radially inward, turned away from the stuck on direction, in such a way that it abuts sealingly on the working surface, and prestresses the pipette tip on the pipette unit into the axial coupling position. The prestress member, in its releasing state, substantially releases the working surface of the pipette tip (101).

Abstract: A microarrayer for spotting solution onto a receiving surface in an automated microarray dispensing device. Elements of the present invention include: at least one dispense head for spotting the receiving surface, at least one light source capable of illuminating the receiving surface, at least one camera operating in conjunction with the at least one light source. The at least one camera is capable of acquiring and transmitting surface image data to a computer. The computer is programmed to receive the surface image data and analyze it. The computer will then generate post analysis data based on the analysis of the surface image data. The post analysis data is available for improving the spotting of the solution onto the receiving surface. In a preferred embodiment, the surface image data includes information relating to receiving surface alignment, information relating to spot quality, and receiving surface identification information.

Abstract: A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. The plurality of samples is then formed into a plurality of films. Thereafter, the plurality of films is plastically deformed. Preferably, the plurality of films is deformed into a configuration appropriate for testing of properties or characteristics of the samples.

Abstract: Laboratory pipette composed particularly of a transparent tube comprising one end for sampling a liquid and one suction end into which a piece of fibrous material is inserted with a color corresponding to at least one characteristic of the pipette and particularly to its nominal volume, characterized in that the piece of fibrous material is in the form of a braid of interlaced threads of synthetic fibers, the said braid being folded such that the fold thus formed is located towards the inside of the pipette, and a method of identifying at least one characteristic of the pipette.

Abstract: A pipette dispenser unit having a hand-held pipette dispenser having a pipette connector and a handle, a source of positive and negative air pressure in fluid connection with said pipette connector, and a foot-operated controller for regulating the flow of air between said air pressure source and said pipette connector. A method of metering fluid through a pipette by connecting the pipette to the pipette dispenser, holding the dispenser with one hand, and controlling fluid flow through the pipette by operating the controller with at least one foot.

Abstract: A highly automated, high volume multichannel pipetting system which transfers liquid from mother plates to daughter plates, or from a fill station to daughter plates. The mother plates are stacked in one set of stacker assemblies, while the empty daughter plates are stacked in another stacker assembly. A plate handling assembly which is capable of moving the plates in three orthogonal directions retrieves the plates from the stacker assemblies, carries them to the pipetting head, and returns them to other stacker assemblies. The pipetting head is removable for replacement or repair thereof, or for insertion of another head assembly having a different number of pipetting channels. The head slides into the housing on slideways, and is retained in place by manually operable, threaded knobs mounted on shafts. The stacker assemblies include a chimney which is removable from a base. The plates may be stacked in the chimney and then inserted on the base.

Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

Abstract: Mechanisms are provided for automatically removing tips from a pipette nozzle and/or for detecting the type of tip mounted to the nozzle. For detipping, mechanical energy is stored when the tip is mounted to the nozzle and is released when the tip is to be removed to facilitate removal thereof. A mechanism is preferably provided which limits the force with which the tip is mounted to the nozzle and an overforce mechanism may be provided to facilitate removal of a stuck tip. For detecting tip type, each tip type has a different base configuration which results in a different relative displacement between the nozzle and a surrounding component as a result of the tip contacting both during tip mounting, the difference in relative displacement being detected to identify tip type.

Abstract: Disclosed is a microarray printing system and methods of printing probe microarrays. The system has a print-head formed of one or more capillary bundle, such as light-guiding capillaries. The bundles may especially be bundles of capillaries that provide a large number of probes on the surface of a substrate. Methods of registering or correlating the distal and proximal ends of the capillaries are also provided. Further, the invention provides methods and equipment for identifying defective microarrays that are missing one or more probes from the surface of the microarray.

Abstract: A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices.

Abstract: The invention disclosed in this application is a method and device for combining the sampling and analyzing of sub-dermal fluid samples, e.g., interstitial fluid or whole blood, in a device suitable for hospital bedside and home use. It is applicable to any analyte that exists in a usefully representative concentration in the fluid, and is especially suited to the monitoring of glucose.

Abstract: The invention relates to a method for evaluating a liquid dosing process in a container which is at least partially filled with a gas. According to the inventive method, a temporal course of at least one state variable p of a medium contained in said container is determined essentially over the entire duration of the dosing process. The temporal course (40; 40?) of the at least one state variable (p) is graphically or mathematically compared with a pre-determined state variable nominal range (42; 42?; 242) by means of a correlation method, and an evaluation result (S6, S14, S16) is obtained according to the results of the comparison.

Abstract: A method for calibrating a clinical analyzer having a dispenser, and for automatically aligning the dispenser of the clinical analyzer includes loading a calibration element at a portion of the clinical analyzer; moving a dispenser of the clinical analyzer in a pre-determined direction (Y) to a position over the calibration element; measuring the height (Z) from the dispenser to the calibration element and determining a position coordinate (Yi, Zi); storing the position coordinate (Yi, Zi); determining a maximum height (Zmax) for the dispenser positioned over the calibration element defined as position coordinate (Yopt, Zmax); and storing the position coordinate including the maximum height (Zmax) for the dispenser positioned over the calibration element.

Abstract: A hand-held pipettor comprising a piston received in one end of a cylinder, a pipettor tip removably secured to an opposite end of said cylinder, means for reciprocating said piston through a selected stroke to aspirate fluid into and to expel the thus aspirated fluid from said pipettor tip, mutually spaced stop members operatively associated with said manually driven means for defining the range of said stroke and motor driven means for varying the spacing between said stop members to thereby vary the volume of fluid being aspirated into and expelled from said pipettor tip.

Abstract: A method for improving the fluid dispense rate in a metering system utilizing speed includes the steps of modifying the fluid flow rate profile during a portion thereof so as substantially increase or decrease the speed of the motor during certain portions of a metering cycle in order to improve the efficiency of the metering system. For a variable speed pump producing a sinusoidal speed profile, the pump motor speed can be increased to increase the dispense velocity during the beginning and end of the dispense phase to reduce perfusion and improve metered volume precision or a motor speed profile can be applied which is inverted relative to that of the variable speed pump to produce a constant velocity flow. Alternately or in addition to the above, the home position of the variable speed pump can be shifted to produce fluid velocity during the entirety of a dispense portion of a metering system cycle.

Abstract: A cannula for use in transferring small volumes of fluid materials, such as in a parallel reaction process. The cannula comprises a long thin needle having various end (port) configurations, and an adapter for connecting the needle to a fluid line. The adapter may include the combination of a reservoir and transition, or simply a transition.

Abstract: A method and apparatus for aspirating a liquid (e.g., blood) from a container uses an electrically biased thermistor element, mounted proximate the tip of a liquid-aspirating probe, to determine that the probe is safely submerged within a body of liquid to be aspirated at all times during the aspiration process. Also disclosed are different aspiration probe assemblies that are useful in the method and apparatus of the invention.

Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween.

Abstract: An injection pump assembly 10 in a chemical delivery system for simultaneously delivering reagents into a combinatorial reactor system having multiple injectors. The assembly 10 has a plurality of injectors 12, each injector 12 being in fluid communication with one of the multiple reactors. Each injector 12 has (1) a pump 14 in which a plunger 18 sealingly moves to ingest, store and discharge a flushing solvent 20; (2) a pipette assembly 22 for loading, storing, and discharging one or more reagents into one of the reactors in the combinatorial reactor system, first and second reservoirs for retaining some of the reagents; (3) one or more hollow needles 32, each for selectively delivering a reagent 24 to the first 28 or the second 24 reservoir; (4) a first valve 34 positioned downstream of the first 28 reservoir; and (5) a second valve 36 positioned downstream of the second 30 reservoir. When each valve 34, 36 is in a closed position, the reagents 24, 48 can be stored in isolation from each other.

Abstract: A method and apparatus are provided for automatically sensing the presence (or absence) of spot dispensers such as pins in various possible mounting locations in the printhead of a microarray spotting instrument. Pin-location data obtained by the method and apparatus is provided to the computer controller of the instrument, which uses the data to control the motion of the printhead during operation of the instrument. A pin detection apparatus includes one or more sensor elements that automatically sense possible pin locations in the printhead for the presence of pins. The sensor elements are preferably arranged in an array corresponding to the array of pin locations in the printhead so that pin detection at each pin location can be performed simultaneously. Various types of sensor elements can be used to locate pins in a printhead. For example, sensors can be used that are remote from or attached to a printhead.

Abstract: A micropipette usable for producing a biochip inclusive of DNA micro arrays capable of arraying and fixing droplets of a micro-volume on a substrate in a high density includes a main body, at least one cavity for storing a sample, at least one ejection port, a piezoelectic/electrostrictive element mounted on the outer surface of the main body, and at least one sample inlet port for supplying sample from the outside. A sample that is temporarily stored in the cavity is discharged from at least one ejection port, by virtue of the movement of the piezoelectric/electrostrictive element, to outside of the micropipette via a through hole in a nozzle portion formed in the pipette main body. The nozzle portion through hole has three or more projection radially protruding from the center of the through hole and having a specific shape.

Abstract: Devices and methods for depositing fluids on substrates in patterns of spots, lines, or other features use a nozzle, which is preferably configured similarly to a micropipette, having a piezoelectric crystal or other ultrasonic actuator coupled to one of its sides. The nozzle may be charged via capillary action by dipping it into a well containing the fluid to be deposited, and may then be positioned over a desired area of a substrate, at which point activation of the ultrasonic actuator at ultrasonic frequencies will eject the fluid onto the substrate. The needle may subsequently be dipped into a well of rinsing fluid for cleaning. Spots or lines on the order of 5 micrometers width may be generated, making the invention particularly suitable for use in biological applications such as microarray production and in microelectronics applications such as the printing of organic circuitry.

Abstract: A pipette for use with a pipette tip to aspirate and dispense a quantity of liquid, comprising a housing, a pipette tip mounting shaft extending from the housing to receive a pipette tip, a pipette tip ejector mechanism for ejecting the pipette tip from the mounting shaft, energy storage means, means for storing energy in the energy storage means and means for releasing energy from the energy storage means to assist the tip ejector mechanism in the ejecting of the pipette tip from the mounting shaft.