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  • Methods for Assessing CDK5 Activation and Function
    Publication number: 20080293073
    Abstract: As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states. Assays to identify modulators of these interactions are provided.
    Type: Application
    Filed: May 25, 2007
    Publication date: November 27, 2008
    Inventors: James A. Bibb, Ammar H. Hawasli
  • Methods for Assessing CDK5 Activation and Function
    Publication number: 20110065128
    Abstract: As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states. Assays to identify modulators of these interactions are provided.
    Type: Application
    Filed: October 4, 2010
    Publication date: March 17, 2011
    Inventors: James A. Bibb, Ammar H. Hawasli
  • Methods for assessing CDK5 activation and function
    Patent number: 7807381
    Abstract: As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states. Assays to identify modulators of these interactions are provided.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: October 5, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: James A. Bibb, Ammar H. Hawasli
  • Antibodies that bind selectively to P25 and uses therefor
    Patent number: 8728472
    Abstract: The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically to the cyclin-dependent kinase 5 (Cdk5) activating protein, p25 and not to p35, a hybridoma cell line producing the monoclonal antibody, and methods for the detection and/or isolation of p25, p25 fragments or homologs thereof from biological material. The invention further relates to the use of the monoclonal antibody or fragment thereof for detection and treatment of neuronal disorders and cancers.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: May 20, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: James A. Bibb, Janice W. Kansy
  • Antibodies That Bind Selectively To P25 And Uses Therefor
    Publication number: 20120141490
    Abstract: The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically to the cyclin-dependent kinase 5 (Cdk5) activating protein, p25 and not to p35, a hybridoma cell line producing the monoclonal antibody, and methods for the detection and/or isolation of p25, p25 fragments or homologs thereof from biological material. The invention further relates to the use of the monoclonal antibody or fragment thereof for detection and treatment of neuronal disorders and cancers.
    Type: Application
    Filed: June 3, 2010
    Publication date: June 7, 2012
    Inventors: James A. Bibb, Janice W. Kansy
  • Production of the lantibiotic cinnamycin with genes isolated from streptomyces cinnamoneus
    Publication number: 20040101963
    Abstract: A 17 kb nucleic acid fragment, which confers production of the lantihiotic cinnamycin on non-producer Strepto-mycete strains, has been isolated from Streptomyces cinnamoneus cinnamoneus DSM 40005 and characterised. Also provided are variants of the 17 kb fragment including variants in which non-essential genes are deleted and variants in which the propeptide sequence of the cinnamycin structural gene is altered, for example replaced with the propeptide sequence of similar B-type lantibiotics. Also provided are vectors, host cells and methods of lantibiotic production using the nucleic acid of the invention, and libraries of variants.
    Type: Application
    Filed: October 27, 2003
    Publication date: May 27, 2004
    Inventors: Mervyn James Bibb, David Andrew Widdick
  • Production of the lantibiotic cinnamycin with genes isolated from
    Patent number: 7166468
    Abstract: A 17 kb nucleic acid fragment, which confers production of the lantibiotic cinnamycin on non-producer Streptomycete strains, has been isolated from Streptomyces cinnamoneus cinnamoneus DSM 40005 and characterized. Also provided are variants of the 17 kb fragment including variants in which non-essential genes are deleted and variants in which the propeptide sequence of the cinnamycin structural gene is altered, for example replaced with the propeptide sequence of similar B-type lantibiotics. Also provided are vectors, host cells and methods of lantibiotic production using the nucleic acid of the invention, and libraries of variants.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: January 23, 2007
    Assignee: Plant Bioscience Limited
    Inventors: Mervyn James Bibb, David Andrew Widdick
  • Methods of treating dopamine dysregulation using agents that regulate phosphorylation/dephosphorylation in dopamine signaling
    Patent number: 6989362
    Abstract: The present invention discloses that DARPP-32 is substrate for the cyclin dependent kinase Cdk5. The phosphorylation takes place at a specific threonine residue of DARPP-32 (Threonine 75). The Cdk5 catalyzed phosphorylation of DARPP-32 converts this protein into an inhibitor of the cAMP dependent protein kinase (PKA) and furthermore prevents it from being converted to an inhibitor of protein phosphatase 1 (PP1). Methods of identifying agents that modulate the phosphorylation of DARPP-32 by Cdk5 are disclosed. Methods of treating dopamine dysfunction in animal subjects are also provided.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: January 24, 2006
    Assignee: The Rockefeller University
    Inventors: James A. Bibb, Paul Greengard
  • CENTRIFUGAL PUMP ASSEMBLY
    Publication number: 20220341436
    Abstract: A centrifugal pump assembly includes a pump head, a pump base defining a pump inlet and a pump outlet, a fluid outlet channel from the pump head to the pump outlet, impellers, defining an impeller fluid channel between an impeller inlet and outlet and connected with one of rotor shaft segments including a positive fit coupling for torque transfer between at least two rotor shaft segments, and one or more pump stage housing segments arranged between the pump base and the pump head. The pump stage housing segments have a structure defining a guide passage for receiving pumped fluid from the impeller outlet of the impellers and for guiding pumped fluid to the impeller inlet of another one of the impellers or to the pump head. The pump stage housing segments each have a structure defining at least a part of a wall section of the fluid outlet channel.
    Type: Application
    Filed: April 18, 2022
    Publication date: October 27, 2022
    Inventors: Martin Bang KRISTENSEN, Tom JÆGER, Patrick PRADEL, Joseph Arnold WHITE, Richard James BIBB
  • Centrifugal pump assembly
    Patent number: 11879474
    Abstract: A centrifugal pump assembly includes a pump head, a pump base defining a pump inlet and a pump outlet, a fluid outlet channel from the pump head to the pump outlet, impellers, defining an impeller fluid channel between an impeller inlet and outlet and connected with one of rotor shaft segments including a positive fit coupling for torque transfer between at least two rotor shaft segments, and one or more pump stage housing segments arranged between the pump base and the pump head. The pump stage housing segments have a structure defining a guide passage for receiving pumped fluid from the impeller outlet of the impellers and for guiding pumped fluid to the impeller inlet of another one of the impellers or to the pump head. The pump stage housing segments each have a structure defining at least a part of a wall section of the fluid outlet channel.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: January 23, 2024
    Assignee: GRUNDFOS HOLDING A/S
    Inventors: Martin Bang Kristensen, Tom Jæger, Patrick Pradel, Joseph Arnold White, Richard James Bibb
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