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  • Methods for diagnosing vitreo-retinal disease
    Patent number: 9295448
    Abstract: A quantitative method to analyze phase-resolved, raw backscatter echo data or the envelope of phase-resolved, raw backscatter echo data to characterize vitreous inhomogeneities as they relate to normal aging and vitreo-retinal disease. The technique can be applied to 2D or 3D data acquired from the vitreous. The approach provides an objective end value to characterize the vitreous and provide a tool for early diagnosis, monitoring and planning treatment of vitreo-retinal diseases.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 29, 2016
    Assignees: Riverside Research Institute, The Trustees of Columbia University in the City of New York
    Inventors: Jeffrey A. Ketterling, Jonathan Mamou, Ronald H. Silverman, Jerry Sebag
  • Dual band ultrasonic systems
    Patent number: 6312383
    Abstract: A dual-frequency band ultrasonic apparatus provides a first ultrasound signal to a region at a first frequency band and a second ultrasound signal at a second frequency band for monitoring the region. A processor controls the first and second ultrasound signals such that a predetermined phase relationship is achieved between the first frequency band signal and the second frequency band signal. The apparatus can employ a single transducer operable at both frequency bands or separate transducers for the first and second frequency bands.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: November 6, 2001
    Assignee: Riverside Research Institute
    Inventors: Frederic Louis Lizzi, Cheri Xiaoyu Deng
  • Ultrasonic systems and methods for contrast agent concentration measurement
    Patent number: 6423007
    Abstract: The concentration and/or radii of a contrast agent in a fluid can be estimated by acquiring ultrasound spectral data, performing spectral analysis to generate a linear estimation of the power spectrum, and correlating at least one spectral parameter to a predetermined distribution function for the contrast agent. If the mean radius squared of particles is known, then the concentration of contrast agent particles can be calculated. If the concentration is constant, then relative variations in mean radius squared can be determined.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: July 23, 2002
    Assignee: Riverside Research Institute
    Inventors: Frederic Louis Lizzi, Cheri Xiaoyu Deng
  • Local application of medication with ultrasound
    Patent number: 5016615
    Abstract: A method and an apparatus for applying a therapeutic substance to body tissue are provided in which ultrasonic radiation is used. The method allows the application of medication to be tailored to the needs of an individual patient. In particular, the timing, duration, intensity, and concentration of the application of medication can be adjusted according to individual requirements. Side effects of tissue adjacent to tissue in need oThe invention described herein was made in the course of work under a grant from the National Institute of Health.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: May 21, 1991
    Assignee: Riverside Research Institute
    Inventors: Jack Driller, William J. Faulkenberry, Frederic L. Lizzi
  • SYSTEM AND METHOD FOR DESIGN AND FABRICATION OF A HIGH FREQUENCY TRANSDUCER
    Publication number: 20080185937
    Abstract: Techniques for fabricating high frequency ultrasound transducers are provided herein. In one embodiment, the fabrication includes depositing a copperclad polyimide film, a layer of epoxy on the copperclad polyimide film, and a polyvinylidene fluoride film on the epoxy. The assembly of materials are then pressed to bond the polyvinylidene fluoride film to the copperclad polyimide film and to form an assembly. The polyvinylidene fluoride film being one surface and the copperclad polyimide film being the other surface. The area behind the copperclad polyimide film surface is filled with a second epoxy, and then cured to form an epoxy plug.
    Type: Application
    Filed: April 14, 2008
    Publication date: August 7, 2008
    Applicant: RIVERSIDE RESEARCH INSTITUTE
    Inventors: Jeffrey A. Ketterling, Frederic L. Lizzi, Mary Lizzi
  • Software control flow watermarking
    Patent number: 8661559
    Abstract: The present invention is a system and method of software control flow watermarking including the steps of obtaining a program for protection, generating at least one watermark value using a formula or process from an external file, and placing the at least one watermark value in CASE values of the program. The system and method may further include determining the at least one watermark value by a formula with at least one variable. The formula may also contain a variable from outside of the program. The system may also stop the program if the variable from outside of the program is incorrect.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: February 25, 2014
    Assignee: Riverside Research Institute
    Inventors: Kelce Steven Wilson, Jason Dean Sattler
  • Methods for estimating tissue strain
    Patent number: 6514204
    Abstract: Improved methods of signal processing for generating estimates of tissue strain are presented. These techniques generally employ the frequency shifting of post-compression spectral data to determine a scaling factor which approximates the applied tissue strain. The scaling factor can be determined by finding the maximum correlation between the frequency shifted post-compression data to the pre-compression data and can also be determined by minimizing the variance of the ratio of such data. Correlation tracking and maximum correlation magnitude techniques for improving the results of elastography are also presented.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: February 4, 2003
    Assignee: Riverside Research Institute
    Inventors: Sheikh Kaisar Alam, Ernest J. Feleppa, Frederic L. Lizzi
  • SYNTHETIC-FOCUSING STRATEGIES FOR REAL-TIME ANNULAR-ARRAY IMAGING
    Publication number: 20150196279
    Abstract: A method to increase the image formation speed in an annular-array digital ultrasound system consisting of N elements with a plurality of transmit and receive channels. Selectively dropping one or more transmit or receive channels during image formation reduces the amount of data needed to form an image, thus increasing the image formation frame rate through faster scan speeds or reducing the amount of digitized data required to process an image. The improved frame rate does result in some reduction in resolution, SNR and potentially DOF, but these drawbacks can be mitigated by synthetically recovering missing transmit-to-receive data pairs.
    Type: Application
    Filed: March 17, 2015
    Publication date: July 16, 2015
    Applicant: RIVERSIDE RESEARCH INSTITUTE
    Inventors: Jeffrey A. Ketterling, Erwan Filoux
  • System and method for design and fabrication of a high frequency transducer
    Patent number: 7474041
    Abstract: Techniques for fabricating high frequency ultrasound transducers are provided herein. In one embodiment, the fabrication includes depositing a copperclad polyimide film, a layer of epoxy on the copperclad polyimide film, and a polyvinylidene fluoride film on the epoxy. The assembly of materials are then pressed to bond the polyvinylidene fluoride film to the copperclad polyimide film and to form an assembly. The polyvinylidene fluoride film being one surface and the copperclad polyimide film being the other surface. The area behind the copperclad polyimide film surface is filled with a second epoxy, and then cured to form an epoxy plug.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: January 6, 2009
    Assignee: Riverside Research Institute
    Inventors: Jeffrey A. Ketterling, Mary Lizzi, legal representative, Frederic L. Lizzi
  • Ultrasonic method for visualizing brachytheraphy seeds
    Publication number: 20040039284
    Abstract: Methods are provided for enhancing the image of brachytherapy seeds implanted in tissue using a transrectal ultrasound apparatus. In a first arrangement the resonance of the seeds is determined and the seeds are insonified using acoustic signals having a resonance frequency of the seeds to cause the seeds to vibrate. The vibrating seeds have enhanced detection using a Doppler ultrasound device. In a second arrangement the acoustic signature of the seeds is determined and used to enhance the imaging of the seeds using a correlation function. In a third arrangement images are taken of the tissue and implanted seeds prior to and during the application of mechanical stress to the tissue. A correlation between the unstressed and stressed tissue can cause enhanced imaging of the seeds.
    Type: Application
    Filed: March 12, 2003
    Publication date: February 26, 2004
    Applicant: Riverside Research Institute
    Inventors: Sheikh Kaisar Alam, Ernest Joseph Feleppa, Frederic Louis Lizzi
  • Ultrasonic detection of brachytherapy seeds based on singular spectrum analysis
    Publication number: 20090163804
    Abstract: The present invention provides a method for detecting and locating brachytherapy seeds using Singular Spectrum Analysis (SSA). The method exploits the presence of seed-specific repetitive echo signals in detecting seeds and determining their location. Radio frequency (rf) echo signals received from a scanned area of interest are converted to zero-mean envelope-detected signals and then processed using SSA to produce a spectral-power line (a P line). The P line indicates the relative likelihood of a seed being present. A colored P-mode image derived from a set of P lines is superimposed on a conventional ultrasound B-mode image to depict seed location.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 25, 2009
    Applicant: Riverside Research Institute
    Inventors: Ernest J. Feleppa, Jonathan Mamou
  • Neuromorphic architecture based signal detection
    Patent number: 10956812
    Abstract: A method and system for performing real time searches of large alphanumeric data sets including the following steps, combining a cognitive neuromorphic architecture with a neuron based encoding binary filter, wherein building the filter includes encoding input data as a concatenated binary representation, wherein the data becomes a binary value, connecting an axon to a neuron to create a synapse; wherein each binary value includes multiple axons and neurons, determining a weight to each synapse, applying the synaptic weight to the input data to determine an integrated value and determining if the integrated value is greater than or equal to a threshold value.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: March 23, 2021
    Assignee: Riverside Research Institute New
    Inventors: Theodore Lee Josue, Benjamin D. Ausdenmoore, Jeffrey Dustin Clark
  • Integrated out-of-band security for high security embedded systems
    Patent number: 10614231
    Abstract: A system and method for a enhancing security for a high security embedded system. The system on chip device including at least one central processing unit (CPU) component, input and output component blocks, an independent hard or soft core dedicated to the input and output blocks, and a built-in, on die interposer, wherein the interposer consists of a field programmable gate array (FPGA) fabric, the FPGA fabric surrounding the components of the system on chip. The method for includes separating system components using a FPGA fabric, redirecting or changing the appearance of system components unknown to other system components, separating system code from security and recovery code, and providing proactive security problem detection and resolutions.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: April 7, 2020
    Assignee: Riverside Research Institute
    Inventors: David Dozer, Adam Kouse
  • Integrated out-of-band security for high security embedded systems
    Patent number: 11321470
    Abstract: A system and method for enhancing security for a high security embedded system. The system on chip device including at least one central processing unit (CPU) component, input and output component blocks, an independent hard or soft core dedicated to the input and output blocks, and a built-in, on die interposer, wherein the interposer consists of a field programmable gate array (FPGA) fabric, the FPGA fabric surrounding the components of the system on chip. The method for includes separating system components using a FPGA fabric, redirecting or changing the appearance of system components unknown to other system components, separating system code from security and recovery code, and providing proactive security problem detection and resolutions.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: May 3, 2022
    Assignee: Riverside Research Institute
    Inventors: David Dozer, Adam Kouse
  • Ultrasonic systems and methods for fluid perfusion and flow rate measurement
    Patent number: 6186951
    Abstract: Fluid flow rate and perfusion rate are measured using ultrasound techniques by introducing a contrast agent into a fluid stream and then selectively modifying the contrast agent particles within a target area by the application of a focused pulse of relatively low frequency ultrasonic energy, thus creating a zone of reduced backscatter in the target area. The restoration of the zone of reduced backscatter or the movement of the zone of reduced backscatter is monitored, preferably using high frequency ultrasound, to determine the flow rate or perfusion rate of the fluid. Spectral parameters of ultrasound return signals are evaluated to determine an estimate of contrast agent concentration and/or mean particle size.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: February 13, 2001
    Assignee: Riverside Research Institute
    Inventors: Frederic Louis Lizzi, Cheri Xiaoyu Deng
  • System and method for design and fabrication of a high frequency transducer
    Patent number: 7454024
    Abstract: Techniques for fabricating high frequency ultrasound transducers are provided herein. In one embodiment, the fabrication includes depositing a copperclad polyimide film, a layer of epoxy on the copperclad polyimide film, and a polyvinylidene fluoride film on the epoxy. The assembly of materials are then pressed to bond the polyvinylidene fluoride film to the copperclad polyimide film and to form an assembly. The polyvinylidene fluoride film being one surface and the copperclad polyimide film being the other surface. The area behind the copperclad polyimide film surface is filled with a second epoxy, and then cured to form an epoxy plug.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: November 18, 2008
    Assignee: Riverside Research Institute
    Inventors: Jeffrey A. Ketterling, Mary Lizzi, legal representative, Frederic L Lizzi
  • Ultrasonic method for visualizing brachytheraphy seeds
    Patent number: 7217242
    Abstract: Methods are provided for enhancing the image of brachytherapy seeds implanted in tissue using a transrectal ultrasound apparatus. In a first arrangement the resonance of the seeds is determined and the seeds are insonified using acoustic signals having a resonance frequency of the seeds to cause the seeds to vibrate. The vibrating seeds have enhanced detection using a Doppler ultrasound device. In a second arrangement the acoustic signature of the seeds is determined and used to enhance the imaging of the seeds using a correlation function. In a third arrangement images are taken of the tissue and implanted seeds prior to and during the application of mechanical stress to the tissue. A correlation between the unstressed and stressed tissue can cause enhanced imaging of the seeds.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: May 15, 2007
    Assignee: Riverside Research Institute
    Inventors: Sheikh Kaisar Alam, Ernest Joseph Feleppa, Frederic Louis Lizzi
  • Ultrasonic detection of brachytherapy seeds based on singular spectrum analysis
    Patent number: 8292812
    Abstract: The present invention provides a method for detecting and locating brachytherapy seeds using Singular Spectrum Analysis (SSA). The method exploits the presence of seed-specific repetitive echo signals in detecting seeds and determining their location. Radio frequency (rf) echo signals received from a scanned area of interest are converted to zero-mean envelope-detected signals and then processed using SSA to produce a spectral-power line (a P line). The P line indicates the relative likelihood of a seed being present. A colored P-mode image derived from a set of P lines is superimposed on a conventional ultrasound B-mode image to depict seed location.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: October 23, 2012
    Assignee: Riverside Research Institute
    Inventors: Ernest J. Feleppa, Jonathan Mamou
  • Method of fabricating a high frequency ultrasound transducer
    Patent number: 7356905
    Abstract: Techniques for fabricating high frequency ultrasound transducers are provided herein. In one embodiment, the fabrication includes depositing a copperclad polyimide film, a layer of epoxy on the copperclad polyimide film, and a polyvinylidene fluoride film on the epoxy. The assembly of materials are then pressed to bond the polyvinylidene fluoride film to the copperclad polyimide film and to form an assembly. The polyvinylidene fluoride film being one surface and the copperclad polyimide film being the other surface. The area behind the copperclad polyimide film surface is filled with a second epoxy, and then cured to form an epoxy plug.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: April 15, 2008
    Assignee: Riverside Research Institute
    Inventors: Jeffrey A. Ketterling, Mary Lizzi, legal representative, Frederic L Lizzi
  • METHOD FOR AUTOMATIC TISSUE SEGMENTATION OF MEDICAL IMAGES
    Publication number: 20170213349
    Abstract: A method to segment images that contain multiple objects in a nested structure including acquiring an image; defining the multiple objects by layers, each layer corresponding to one region, where a region contains an innermost object and all the objects nested within the innermost object; stacking the layers in an order of the nested structure of the multiple objects, the stack of layers having at least a top layer and a bottom layer; extending each layer with padded nodes; connecting the top layer to a sink and the bottom layer to a source, wherein each intermediate layer between the top layer and the bottom layer are connected only to the adjacent layer by undirected links; and measuring a boundary length for each layer.
    Type: Application
    Filed: January 23, 2017
    Publication date: July 27, 2017
    Applicants: Riverside Research Institute, New York University
    Inventors: Jen-wei Kuo, Jonathan Mamou, Xuan Zhao, Jeffrey A. Ketterling, Orlando Aristizabal, Daniel H. Turnbull, Yao Wang
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