Search Patents
  • Optical transmission link incorporating highpass optical filtering
    Patent number: 6466712
    Abstract: An optical fiber transmission link with reduced channel depletion due to stimulated Raman scattering is formed by including a high pass optical filter in the transmission fiber. The filter may comprise one or more discrete components, or may be formed as a “distributed” filter along the length of the optical fiber. The cut-off frequency for the high pass optical filter is selected to be immediately below the frequency of the input channel to be transmitted. When used in an arrangement with multiple input channels, the cut-off frequency is controlled to be immediately below the lowest input channel frequency.
    Type: Grant
    Filed: August 21, 2000
    Date of Patent: October 15, 2002
    Assignees: Lucent Technologies Inc., Lehigh University
    Inventors: Demetrios Nicolau Christodoulides, Jean-Marc Pierre Delavaux, Christopher Michael McIntosh, Jean Toulouse
  • Method and system for the analysis of saliva using a sensor array
    Publication number: 20050214863
    Abstract: A system for the rapid characterization of analytes in saliva. In one embodiment, a system for detecting analytes includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
    Type: Application
    Filed: December 13, 2004
    Publication date: September 29, 2005
    Inventors: John McDevitt, Eric Anslyn, Jason Shear, Dean Neikirk, Nick Christodoulides
  • TOPOLOGICAL INSULATOR LASER SYSTEM
    Publication number: 20200119524
    Abstract: A topological laser system is described. The laser system comprises an array of optical elements arranged in an array and coupled between them such that the array is configured for supporting one or more topological modes. The plurality of optical elements comprises optical elements carrying gain material configured for emitting optical radiation in response to pumping energy. The laser system further comprises a pumping unit configured to provide pumping of a group of the optical elements of the array within at least a portion of the spatial region corresponding with said topological mode; and at least one output port optically coupled to one or more of the optical elements associated with said topological mode. The at least one output ports is configured for extracting a portion of light intensity from said laser system.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 16, 2020
    Inventors: Mordechai SEGEV, Gal HARARI, Demetrios N. CHRISTODOULIDES, Miguel Angel BANDRES MOTOLA
  • Integration of fluids and reagents into self-contained cartridges containing sensor elements
    Publication number: 20060257993
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 16, 2006
    Inventors: John McDevitt, Karri Ballard, Pierre Floriano, Nick Christodoulides, Dean Neikirk, Eric Anslyn, Jason Shear
  • METHODS AND COMPOSITIONS RELATED TO DETERMINATION AND USE OF WHITE BLOOD CELL COUNTS
    Publication number: 20090215072
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: May 31, 2006
    Publication date: August 27, 2009
    Inventors: John T. McDevitt, Nicolaos J. Christodoulides, Pierre N. Floriano, Gary N. Douglas, Patrick E. Rogers
  • Method and system for the detection of cardiac risk factors
    Publication number: 20040029259
    Abstract: A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
    Type: Application
    Filed: April 28, 2003
    Publication date: February 12, 2004
    Inventors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J. Christodoulides
  • Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
    Publication number: 20060257992
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 16, 2006
    Inventors: John McDevitt, Karri Ballard, Pierre Floriano, Nick Christodoulides, Dean Neikirk, Eric Anslyn, Jason Shear
  • Integration of fluids and reagents into self-contained cartridges containing particle and membrane sensor elements
    Publication number: 20060257941
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 16, 2006
    Inventors: John McDevitt, Karri Ballard, Pierre Floriano, Nick Christodoulides, Dean Neikirk, Eric Anslyn, Jason Shear
  • Determining extracellular analyte concentration with nanoplasmonic sensors
    Patent number: 10761028
    Abstract: Methods and systems for determining extracellular concentration data of an analyte are disclosed. A method for determining extracellular concentration data of an analyte includes receiving sensor data from one or more arrays of functionalized plasmonic nanostructures on a localized surface plasmon resonance imaging chip in contact with a fluid containing at least one living cell for a plurality of times, determining intensity data for the one or more arrays, determining fractional occupancy based on the intensity data, and determining extracellular concentration data based on the fractional occupancy data. A system for determining extracellular concentration data of an analyte includes a LSPRi chip, a sensor component, an intensity component, a fractional occupancy component, a concentration component, and a processor to implement the components.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 1, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers, James B. Delehanty
  • Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
    Publication number: 20060257991
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Application
    Filed: December 22, 2004
    Publication date: November 16, 2006
    Inventors: John McDevitt, Karri Ballard, Pierre Floriano, Nick Christodoulides, Dean Neikirk, Eric Anslyn, Jason Shear
  • LIGHT MICROSCOPY CHIPS AND DATA ANALYSIS METHODOLOGY FOR QUANTITATIVE LOCALZIED SURFACE PLASMON RESONANCE (LSPR) BIOSENSING AND IMAGING
    Publication number: 20140093977
    Abstract: A chip for localized surface plasmon resonance (LSPR) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times. Also disclosed is a method for determining the fractional occupancy values for surface-bound receptors as a function of time for LSPR biosensing from the spectroscopic response of the array and modeling the photon count in each spectrometer channel, allowing for a functional relationship to be determined between the acquired spectrum and the fractional occupancy of binding sites on the array. Additionally disclosed is a method for the spatiotemporal mapping of receptor-ligand binding kinetics in LSPR imaging using the chip and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 3, 2014
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
  • LIGHT MICROSCOPY CHIPS AND DATA ANALYSIS METHODOLOGY FOR QUANTITATIVE LOCALZIED SURFACE PLASMON RESONANCE (LSPR) BIOSENSING AND IMAGING
    Publication number: 20180164309
    Abstract: A chip for localized surface plasmon resonance (LSPR) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times. Also disclosed is a method for determining the fractional occupancy values for surface-bound receptors as a function of time for LSPR biosensing from the spectroscopic response of the array and modeling the photon count in each spectrometer channel, allowing for a functional relationship to be determined between the acquired spectrum and the fractional occupancy of binding sites on the array. Additionally disclosed is a method for the spatiotemporal mapping of receptor-ligand binding kinetics in LSPR imaging using the chip and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array.
    Type: Application
    Filed: January 29, 2018
    Publication date: June 14, 2018
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
  • Diffraction free, self-bending airy wave arrangement
    Patent number: 8101929
    Abstract: Methods and systems for Airy waves and Airy wavepackets or Airy beam generation from an input beam or pulse. Airy wavefronts and Airy wavepackets can be generated using Airy beam generation through Fourier synthesis using phase masks or filters in the spatial domain; Airy beam generation using amplitude and phase filters in the spatial domain; and Airy pulse generation through Fourier synthesis using phase and/or amplitude filters in the temporal frequency domain. The Airy waves are highly asymmetric and as a result their energy is more tightly confined in one quadrant thus increasing the energy density in the main lobes. These wavepackets can be one, two, and three-dimensional waves. In addition they tend to self-heal themselves which is important in adverse environments.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: January 24, 2012
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Demetrios N. Christodoulides, Aristide Dogariu, Georgios Siviloglou
  • Topological insulator laser system
    Patent number: 11283244
    Abstract: A topological laser system is described. The laser system comprises an array of optical elements arranged in an array and coupled between them such that the array is configured for supporting one or more topological modes. The plurality of optical elements comprises optical elements carrying gain material configured for emitting optical radiation in response to pumping energy. The laser system further comprises a pumping unit configured to provide pumping of a group of the optical elements of the array within at least a portion of the spatial region corresponding with said topological mode; and at least one output port optically coupled to one or more of the optical elements associated with said topological mode. The at least one output ports is configured for extracting a portion of light intensity from said laser system.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: March 22, 2022
    Assignees: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION, LTD., THE UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Mordechai Segev, Gal Harari, Demetrios N. Christodoulides, Miguel Angel Bandres Motola
  • Light microscopy chips and data analysis methodology for quantitative localzied surface plasmon resonance (LSPR) biosensing and imaging
    Patent number: 11067573
    Abstract: A chip for localized surface plasmon resonance (LSPR) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times. Also disclosed is a method for determining the fractional occupancy values for surface-bound receptors as a function of time for LSPR biosensing from the spectroscopic response of the array and modeling the photon count in each spectrometer channel, allowing for a functional relationship to be determined between the acquired spectrum and the fractional occupancy of binding sites on the array. Additionally disclosed is a method for the spatiotemporal mapping of receptor-ligand binding kinetics in LSPR imaging using the chip and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 20, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A Christodoulides, Jeff M Byers
  • Light microscopy chips and data analysis methodology for quantitative localized surface plasmon resonance (LSPR) biosensing and imaging
    Patent number: 9915654
    Abstract: A chip for localized surface plasmon resonance (LSPR) biosensing and imaging having a glass coverslip compatible for use in a standard microscope and at least one array of functionalized plasmonic nanostructures patterned onto the glass coverslip with electron beam nanolithography. The nanostructures can be regenerated allowing the chip to be used multiple times. Also disclosed is a method for determining the fractional occupancy values for surface-bound receptors as a function of time for LSPR biosensing from the spectroscopic response of the array and modeling the photon count in each spectrometer channel, allowing for a functional relationship to be determined between the acquired spectrum and the fractional occupancy of binding sites on the array. Additionally disclosed is a method for the spatiotemporal mapping of receptor-ligand binding kinetics in LSPR imaging using the chip and projecting a magnified image of the array to a CCD camera and monitoring the binding kinetics of the array.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: March 13, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Marc P. Raphael, Joseph A. Christodoulides, Jeff M. Byers
  • Method and system for the detection of cardiac risk factors
    Patent number: 8257967
    Abstract: A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: September 4, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: John T. McDevitt, Eric V. Anslyn, Jason B. Shear, Dean P. Neikirk, Nick J. Christodoulides
  • Communication method and apparatus
    Publication number: 20040114547
    Abstract: A set of formats and protocols is proposed for a satellite communications system. In these formats, a pilot signal (PS) is inserted after every 25 or 29 data symbols. The formats consist of SCPC frames (F) which may contain either data (D) and in-band signalling information (SU), or only signalling information (SU). In either case, the contents of each frame (F) are error-correction coded before transmission with the same coding rate. Each data frame (F) carries the data content of an integral number of input user data frames (M), each of which comprises four subframes. Different symbol transmission rates are used for different input data rates, the symbol transmission rates being selected so that their different synchronising clock rates can easily be obtained from a common clock. Data bursts may be preceded by a constant power level preamble (P).
    Type: Application
    Filed: October 2, 2003
    Publication date: June 17, 2004
    Applicant: Inmarsat, Ltd.
    Inventors: Louis Mimis Christodoulides, Howard Ray Feldman, Eyal Trachtman, Siu Wah Wong, Hok Shuen Wong
  • INTEGRATED OPTICAL CIRCULATOR APPARATUS, METHOD, AND APPLICATIONS
    Publication number: 20170365983
    Abstract: An optical circulator is a device that routes optical pulses from port to port in a predetermined manner, e.g. in a 3-port optical circulator, optical pulses entering port 1 are routed out of port 2, while optical pulses entering port 2 exit out of port 3 and optical pulses fed into port 3 exit out of port 3. Currently such an optical circulator is made of discrete components such as magnetooptic garnets, rare-earth magnets and optical polarizers that are packaged together with fiber optic elements. Disclosed herein is a different kind of optical circulator that is monolithically integrated on a single semiconductor substrate and that is applicable for the routing of optical pulses. The embodied invention will enable photonic integrated circuits to incorporate on-chip optical circulator functionality thereby allowing much more complex optical designs to be implemented monolithically.
    Type: Application
    Filed: June 20, 2017
    Publication date: December 21, 2017
    Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Demetrios Christodoulides, Patrick L. LiKamWa, Parinaz Aleahmad, Ramy El-Ganainy
  • Integration of fluids and reagents into self-contained cartridges containing sensor elements
    Patent number: 8105849
    Abstract: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: January 31, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: John T. McDevitt, Karri L. Ballard, Pierre N. Floriano, Nick J. Christodoulides, Dean Neikirk, Eric Anslyn, Jason Shear
Narrow Results

Filter by US Classification