Search Patents
  • Publication number: 20160075708
    Abstract: Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.
    Type: Application
    Filed: April 9, 2014
    Publication date: March 17, 2016
    Applicants: GUANGZHOU HUI BO RUI BIOLOGICAL PHARMACEUTICAL TECHNOLOGY CO., LTD., ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN UNIVERSITY
    Inventors: Rui Hou, Kang Zhang
  • Publication number: 20180353645
    Abstract: The disclosure herein includes uses and systems for cataract removal and lens regeneration using endogenous stem cells that results in improved outcomes.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 13, 2018
    Inventors: Kang ZHANG, Rui HOU
  • Publication number: 20170218009
    Abstract: Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with protein aggregation.
    Type: Application
    Filed: February 2, 2017
    Publication date: August 3, 2017
    Inventors: Rui HOU, Kang ZHANG
  • Publication number: 20170239273
    Abstract: The disclosure generally relates to compositions and uses thereof to treat vision disorders that affect the normal function of the lens in the eye in a subject having or at risk of developing such vision disorders.
    Type: Application
    Filed: August 22, 2015
    Publication date: August 24, 2017
    Inventors: Kang ZHANG, Stanley KIM, Jie ZHU, Rui HOU, J Jefferson PERRY
  • Publication number: 20190136327
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 9, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Publication number: 20180010192
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Application
    Filed: February 16, 2017
    Publication date: January 11, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Publication number: 20180094325
    Abstract: Disclosed herein are methods and kits for identifying a subject as having esophagus cancer, pancreatic cancer, or stomach cancer. Also provided herein are methods and kits for generating the methylation profile of a biomarker associated with esophagus cancer, pancreatic cancer, or stomach cancer.
    Type: Application
    Filed: December 12, 2017
    Publication date: April 5, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Publication number: 20180341745
    Abstract: Disclosed herein are methods, systems, platforms, non-transitory computer-readable medium, services, and kits for determining a cancer type in an individual. Also described herein include methods, systems, platforms, non-transitory computer-readable medium, and compositions for generating a CpG methylation profile database.
    Type: Application
    Filed: January 8, 2018
    Publication date: November 29, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Publication number: 20190110753
    Abstract: Disclosed herein are systems, methods, devices, and media for carrying out medical diagnosis of ophthalmic diseases and conditions. Deep learning algorithms enable the automated analysis of ophthalmic images to generate predictions of comparable accuracy to clinical experts.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Patent number: 10093986
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: October 9, 2018
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Publication number: 20180119122
    Abstract: Disclosed herein are methods and pharmaceutical compositions for the treatment of retinitis pigmentosa, macular degeneration and other retinal conditions by interfering with expression of genes, such as those encoding photoreceptor cell-specific nuclear receptor and neural retina-specific leucine zipper protein, in cells of the eye. These methods and compositions employ nucleic acid based therapies.
    Type: Application
    Filed: November 3, 2017
    Publication date: May 3, 2018
    Inventors: Kang ZHANG, Rui HOU, Gen LI
  • Publication number: 20180274039
    Abstract: Disclosed herein, in certain embodiments, are methods and kits for diagnosing a subject as having hepatocellular carcinoma (HCC) or lung cancer. In some instances, also described herein are methods of determining the prognosis of the subject having HCC or lung cancer. In additional instances, described herein are methods of determining the specific staging of HCC or lung cancer in a subject.
    Type: Application
    Filed: March 2, 2018
    Publication date: September 27, 2018
    Inventors: Kang ZHANG, Rui HOU, Lianghong ZHENG
  • Patent number: 9984201
    Abstract: Disclosed herein are methods, systems, platforms, non-transitory computer-readable medium, services, and kits for determining a cancer type in an individual. Also described herein include methods, systems, platforms, non-transitory computer-readable medium, and compositions for generating a CpG methylation profile database.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: May 29, 2018
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Patent number: 10093694
    Abstract: Described herein are compounds that inhibit or prevent protein aggregation, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with protein aggregation.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: October 9, 2018
    Assignees: GUANGZHOU KANGRUI BIOLOGICAL PHARMACEUTICAL TECHNOLOGY CO, LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rui Hou, Kang Zhang, Gen Li
  • Publication number: 20130031554
    Abstract: Provided is a hardware accelerator and method, central processing unit, and computing device. A hardware accelerating method includes, in response to a request for a new task issued by a hardware thread, accelerating processing of the new task and producing a processing result for the task. A predicting step predicts total waiting time of the new task for returning to a specified address associated with the hardware thread.
    Type: Application
    Filed: August 13, 2012
    Publication date: January 31, 2013
    Applicant: International Business Machines Corporation
    Inventors: Rui Hou, Yi Ge, Kun Wang, Zhen Bo Zhu
  • Publication number: 20170119768
    Abstract: Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.
    Type: Application
    Filed: October 20, 2016
    Publication date: May 4, 2017
    Inventors: Rui HOU, Gen LI
  • Publication number: 20170065617
    Abstract: The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.
    Type: Application
    Filed: April 26, 2016
    Publication date: March 9, 2017
    Inventors: Kang Zhang, Rui Hou
  • Publication number: 20160103768
    Abstract: A TLB management method and computer are provided. The method includes querying a TLB storage directory table using a VPID of a first VCPU as an index, to obtain an address of a TLB storage table corresponding to the first VCPU; then accessing, according to the address of the TLB storage table corresponding to the first VCPU, the TLB storage table corresponding to the first VCPU, and reading a valid TLB entry in the TLB storage table corresponding to the first VCPU into a physical TLB.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 14, 2016
    Inventors: Tao Jiang, Rui Hou, Lele Zhang, Yi Zhang, Lixin Zhang
  • Patent number: 10064864
    Abstract: Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 4, 2018
    Assignee: GUANGZHOU KANGRUI BIOLOGICAL PHARMACEUTICAL TECHNOLOGY CO., LTD.
    Inventors: Rui Hou, Gen Li
  • Publication number: 20160196073
    Abstract: A memory segment access method and apparatus relates to the field of computer technologies, which are used to resolve a problem of a relatively low memory access bandwidth caused by relatively low utilization of bandwidth resources in a multichannel memory system. The method includes acquiring, by a first scheduler, a quantity of to-be-sent memory access requests in a second scheduler, and receiving, by the first scheduler, a memory access request, and sending the memory access request through a second memory channel corresponding to the second scheduler.
    Type: Application
    Filed: March 15, 2016
    Publication date: July 7, 2016
    Inventors: Lixin Zhang, Cong Wang, Rui Hou, Ke Zhang
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