Search Patents
  • Leukemia methylation markers and uses thereof
    Patent number: 10093986
    Abstract: Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia in a subject.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: October 9, 2018
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Method and system for determining cancer status
    Patent number: 9984201
    Abstract: Disclosed herein are methods, systems, platforms, non-transitory computer-readable medium, services, and kits for determining a cancer type in an individual. Also described herein include methods, systems, platforms, non-transitory computer-readable medium, and compositions for generating a CpG methylation profile database.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: May 29, 2018
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Compositions and methods to treat vision disorders
    Patent number: 10471076
    Abstract: The present invention provides sterols and uses thereof to treat vision disorders. In one embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat and/or prevent vision disorders in a subject. In another embodiment, composition comprising pharmaceutically effective amount of lanosterol is used to treat cataract or blindness/impaired vision in a subject. In yet another embodiment, composition comprising lanosterol is used to dissolve amyloid-like fibrils of crystallin proteins.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: November 12, 2019
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Huimin Cai
  • Methods for evaluating, monitoring, and modulating aging process
    Patent number: 11279978
    Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: March 22, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YouHealth Biotech, Limited
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng
  • Methods for monitoring and gene expression following treatment with vitamin C
    Patent number: 10202650
    Abstract: Disclosed herein are methods of increasing the expression rate of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof). Also described herein are methods of modulating the methylation pattern of epigenetic markers such as ELOVL2, KLF14, and PENK with administration of a therapeutic agent (e.g., vitamin C or its derivatives, analogs, metabolites, prodrugs, or pharmaceutically acceptable salts thereof).
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: February 12, 2019
    Assignees: YOUHEALTH BIOTECH, LIMITED, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kang Zhang, Rui Hou, Lianghong Zheng