Search Patents
  • Patent number: 3959466
    Abstract: A cytomegalovirus (CMV) vaccine, capable of inducing immunity in humans against cytomegalic inclusion disease (CID), without spread to contacts and with minimal excretion of the virus, is prepared by serially passaging virulent CMV in human diploid lung fibroblasts.
    Type: Grant
    Filed: April 15, 1974
    Date of Patent: May 25, 1976
    Assignee: The Wistar Institute
    Inventor: Stanley A. Plotkin
  • Patent number: 5591439
    Abstract: The present invention provides a non-defective adenovirus recombinant expression system for the expression of the HCMV gB subunit and for the expression of non-structural immediate-early exon 4 proteins, said recombinant HCMV-expressing adenovirus being useful as a vaccine.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: January 7, 1997
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Stanley A. Plotkin, Robert P. Ricciardi, Ewa Gonczol
  • Patent number: 5552143
    Abstract: The present invention provides a non-defective adenovirus recombinant expression system for the expression of the HCMV gB subunit, an immunogenic fragment of the gB subunit, and for the expression of non-structural immediate-early exon 4 proteins, said recombinant HCMV-expressing adenovirus being useful as a vaccine.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: September 3, 1996
    Assignees: The Wistar Institute of Anatomy & Biology, The United States of America as represented by the Department of Health and Human Services
    Inventors: Stanley A. Plotkin, Robert P. Ricciardi, Ewa Gonczol, Klara Berencsi, Robert F. Rando
  • Patent number: 6113910
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: September 5, 2000
    Assignees: The Children's Hospital of Philadelphia, The Winstar Institute of Anatomy and Biology
    Inventors: H Fred Clark, Paul Offit, Stanley A. Plotkin
  • Patent number: 5750109
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: May 12, 1998
    Assignees: The Wistar Institute of Anatomy & Biology, The Children's Hospital of Philadelphia
    Inventors: H. Fred Clark, Paul Offit, Stanley A. Plotkin
  • Patent number: 6290968
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: September 18, 2001
    Assignees: Children's Hospital of Philadelphia, Wistar Institute of Anatomy and Biology
    Inventors: H Fred Clark, Paul Offit, Stanley A. Plotkin
  • Patent number: 5626851
    Abstract: The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: May 6, 1997
    Assignees: The Wistar Institute of Anatomy and Biology, The Children's Hospital of Philadelphia
    Inventors: H. Fred Clark, Paul Offit, Stanley A. Plotkin
  • Patent number: 4636385
    Abstract: A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in FIG. 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: January 13, 1987
    Assignee: The Wistar Institute of Anatomy & Biology
    Inventors: Stanley A. Plotkin, H. Fred Clark
  • Patent number: 6559095
    Abstract: An exhaust gas purifying catalyst has an Ir powder. The Ir powder has a two peak particle size distribution, with a peak in a particle size D>25 nm region, and the other peak in a particle size D<25 nm region, respectively.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: May 6, 2003
    Assignee: Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Tomomi Sugiyama, Kazuhide Terada, Takeshi Narishige
  • Patent number: 6346378
    Abstract: A nucleic acid analog comprising a polymeric strand which includes a sequence of ligands bound to a backbone made up of linked backbone moieties, which analog is capable of hybridization to a nucleic acid of complementary sequence, further comprising a chelating moiety capable of binding at least one metal ion by chelation.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: February 12, 2002
    Assignee: PNA Diagnostics A/S
    Inventors: Christopher John Stanley, Henrik Orum, Mikkel Jorgensen
  • Patent number: 6602815
    Abstract: An exhaust system comprising a heat-resistant HC adsorbent comprising an MFI metallo-silicate including at least one of gallium (Ga) and indium (In) as a skeleton forming element, and a metal component ME including at least one of an alkali metal and an alkali earth metal in a content of ME≦0.05% by weight. Such an HC adsorbent has an excellent heat resistance.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: August 5, 2003
    Assignee: Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Takahiro Naka, Tetsuo Endo, Haruhiko Shimizu, Yoshikazu Fujisawa
  • Patent number: 6471398
    Abstract: A temperature management apparatus for foodstuffs stored in a storage cabinet, wherein a temperature sensor is placed in the storage cabinet to detect an inside temperature of the cabinet thereby to calculate an ambient temperature of the foodstuffs based on the detected inside temperature, and wherein an internal temperature of the foodstuffs is presumed on a basis of the calculated ambient temperature. The temperature management apparatus is provided with a foodstuff temperature indicator for indicating the presumed internal temperature of the foodstuffs and an alarm device for issuing an alarm sound when the presumed internal temperature of the foodstuffs becomes lower than a lower limit temperature or higher than an upper limit temperature.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: October 29, 2002
    Assignee: Hoshizaki Denki Kabushiki Kaisha
    Inventor: Yoshiyuki Ukai
  • Patent number: 6168310
    Abstract: Pulsed laser beams are applied to an object to be measured. A first laser beam of a pulsed laser beam having a first wavelength which is oscillated immediately after the rise of the pulsed laser beam, and a second laser beam having a second wavelength which is oscillated thereafter are used. Based on a difference between an intensity of first interfered light of reflected light of the first laser beam or transmitted light thereof, and an intensity of reflected light of the second laser beam or transmitted light thereof, temperatures of the object to be measured, and whether the temperatures are on increase or on decrease are judged. The method and device can be realized by simple structures and can measure a direction of changes of the physical quantities.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: January 2, 2001
    Assignee: Fujitsu Limited
    Inventors: Ryo Kurosaki, Jun Kikuchi, Haruhiko Serizawa, Shuzo Fujimura
  • Patent number: 6109931
    Abstract: Disclosed is an improved CF card adapter comprising a synthetic resin frame, upper and bottom metal covers attached to the synthetic resin frame, a CF card receptacle formed on the rear side of the synthetic resin frame, a pin header having pin contacts exposed on its rear side; a printed circuit board whose printed circuit is connected to the pin contacts of the pin header, and a female receptacle connector part formed on the front side of the adapter body. The female receptacle connector part is electrically connected to the printed circuit, and is adapted to be inserted in the PC card slot of an electric or electronic device. One of the upper and bottom metal covers has grounding pieces integrally connected to the length round the outside of the rectangular metal sheet. These grounding pieces are CF card grounding pieces, printed circuit grounding pieces, and grounding pieces to the PC card slot and the other metal cover.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: August 29, 2000
    Assignee: Honda Tsushin Kogyo Co., Ltd.
    Inventor: Kenichi Yotsutani
  • Patent number: 6576208
    Abstract: A catalyst for selective oxidation of carbon monoxide present in a hydrogen-containing gas is provided in which the catalyst comprises ruthenium supported on an alumina hydrate. This catalyst has a high selective oxidation activity to carbon monoxide. A carbon monoxide elimination method using this catalyst is also provided. In this method, to a gas containing at least hydrogen and carbon monoxide and being richer in the hydrogen than the carbon monoxide on the basis of volume, oxygen is added in an amount necessary for oxidizing at least part of carbon monoxide present in that gas, and thereafter the gas to which the oxygen has been added is brought into contact with the catalyst described above. Also provided is a solid polymer electrolyte fuel cell system that utilizes this method.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: June 10, 2003
    Assignees: N.E. Chemcat Corporation, Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Takashi Itoh, Katsumi Kurabayashi, Takahiro Naka, Masako Takayama, Osamu Usaka, Shoji Isobe
  • Patent number: 6523999
    Abstract: A method to accurately evaluate a thermal cycle life of an article with a restraint rate as an evaluating parameter without providing a thermal cycle under actual service conditions to the article subjected to the thermal cycle.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: February 25, 2003
    Assignee: Honda Giken Kogyo Kabushiki Kaisha
    Inventors: Kazuo Ishii, Makoto Nakada, Masaru Enomoto, Yasunori Konishi, Shinichi Takahashi
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