Abstract: Novel recombinant polypeptides are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a mammalian immunoglobulin heavy chain. The portion or the IgG is fused at its C-terminus with a polypeptide comprising a tailpiece from the C-terminus of the heavy chain of an IgA antibody ara tailpiece from a C-terminus of the heavy chain of an IgM antibody. Also disclosed herein are methods for using these CD4 fusion proteins.
Type:
Grant
Filed:
October 24, 2002
Date of Patent:
May 6, 2008
Assignee:
The United States of America as represented by the Department of Health and Human Services
Inventors:
James Arthos, Claudia Cicala, Anthony S. Fauci