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  • Patent number: 7368114
    Abstract: Novel recombinant polypeptides are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a mammalian immunoglobulin heavy chain. The portion or the IgG is fused at its C-terminus with a polypeptide comprising a tailpiece from the C-terminus of the heavy chain of an IgA antibody ara tailpiece from a C-terminus of the heavy chain of an IgM antibody. Also disclosed herein are methods for using these CD4 fusion proteins.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: May 6, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: James Arthos, Claudia Cicala, Anthony S. Fauci