Abstract: The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
Type:
Application
Filed:
July 5, 2010
Publication date:
July 12, 2012
Applicant:
INSTITUTE FOR ANIMAL HEALTH
Inventors:
Paul Britton, Erica Bickerton, Maria Armesto
Abstract: The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
Type:
Grant
Filed:
July 5, 2010
Date of Patent:
September 9, 2014
Assignee:
The Pirbright Institute
Inventors:
Paul Britton, Erica Bickerton, Maria Armesto