Abstract: A method for ranking analytes includes the steps of analyzing an experimental analyte in a mass spectrometer. The method includes comparing the experimental analyte to a plurality of candidate analytes in a library hit list, and assigning a cumulative confidence score to each candidate analyte based on the steps of comparing the experimental analyte to the candidate analytes based on a library similarity score, comparing the experimental analyte to the candidate analytes based on of a presence of the most abundant isotope of a molecular ion and its mass, comparing the experimental analyte to the candidate analytes based on an abundance of fragment ions and a mass of the fragment ions, and, in some implementations, comparing the experimental analyte to the candidate analytes based on a retention index value. The method includes ranking the candidate analytes based on the cumulative confidence score of each candidate analyte.

Abstract: A LIDAR sensing system includes a light source that is controlled to project a collimated beam at various wavelengths. An interferometer receives the collimated beam and projects an object beam corresponding to the collimated beam at a diffraction grating. The object beam is diffracted from the diffraction grating at different angles corresponding to the wavelength of the collimated beam, creating a two dimensional scan along a first axis. The object beam is also controlled along a second axis that is perpendicular to the first axis. As a result, the LIDAR sensing system generates a horizontal and vertical scan (e.g., a three-dimensional scan) of the external environment.

Abstract: Provided is a process, including: obtaining movement transactions without having server-side access to information by which the members of the population undergoing the changes in geolocation indicated by the movement transactions can be identified, either personally or pseudonymously; obtaining for movement transactions corresponding to a designated window of time, geographic-pathogen-risk scores of starting geolocations that include the starting geographic positions; updating for the movement transactions corresponding to the designated window of time, geographic-pathogen-risk scores of the ending geolocations based on both geographic-pathogen-risk scores of the starting geolocations involved in movement transactions ending at the ending geolocations and rates of traffic at the ending geolocations indicated by movement transactions ending or starting at the ending geolocations.

Abstract: Methods for characterizing spillover spreading originating from a first fluorochrome in fluorescent flow cytometer data collected for a second fluorochrome are provided. In some embodiments, methods include partitioning the fluorescent flow cytometer data according to the intensity of the data relative to the first fluorochrome. In embodiments, methods also include estimating with a first linear regression a zero-adjusted standard deviation for the intensity of light collected from the second fluorochrome for each of the partitioned quantiles based on the assumption that the intensity of light collected from the first fluorochrome is zero, and obtaining with a second linear regression a spillover spreading coefficient from the zero-adjusted standard deviations. Systems and computer-readable media for characterizing spillover spreading originating from a first fluorochrome in fluorescent flow cytometer data collected for a second fluorochrome are also provided.

Abstract: Embodiments of a method and/or system (e.g., for improved single molecule sequencing, etc.) can include preparing a set of unique molecular identifier (UMI)-based molecules associated with a set of target nucleic acid sequences; facilitating generation of (e.g., generating, etc.) a set of tagged nucleic acid molecules based on the set of UMI-based molecules and a set of nucleic acid molecules corresponding to (e.g., including, etc.) the set of target nucleic acid sequences; and/or facilitating (e.g., performing, etc.) single molecule sequencing with the set of tagged nucleic acid molecules.

Abstract: A device for determining a heart rate of a user has a PPG sensor and an accelerometer to compensate for acceleration artifacts within the PPG signal. The device transforms time domain PPG and accelerometer signals into the frequency domain using a Fourier transformation and utilizes the Fourier coefficient magnitudes as indicative of the probability of candidate heart rate values. Candidate heart rate values are determined at sampling times over a time interval and a most probable heart rate path during the time interval is determined using a reward/penalty algorithm.

Abstract: A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

Abstract: Embodiments predict response to neoadjuvant chemotherapy (NAC) in breast cancer (BCa) from pre-treatment dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).

Abstract: A cooked millet prolamin peptide for inhibiting ?-amylase and ?-glucosidase, an application thereof, and a screening method thereof are disclosed. The sequence of the peptide is selected from SEQ ID NOS: 1-6. The peptide provided in the present disclosure can effectively inhibit the activities of ?-glucosidase and ?-amylase simultaneously and is safe and non-toxic and has no side effects. Therefore, the peptide has a good potential and application prospect as a functional component in food, health products, and hypoglycemic drugs.

Abstract: There is a need for more effective and efficient predictive data analysis solutions for processing genetic sequencing data. This need can be addressed by, for example, techniques for performing predictive data analysis based on genetic sequences that utilize at least one of cross-variant polygenic risk modeling using genetic risk profiles, cross-variant polygenic risk modeling using functional genetic risk profiles, per-condition polygenic clustering operations, cross-condition polygenic predictive inferences, and cross-condition polygenic diagnoses.

Abstract: Disclosed herein are systems, methods and computer-program products to create synthetic immunohistochemistry (IHC) stained digital slides generated using artificial neural networks (ANNs). In some implementations, the created digital slides can be used as a ground truth to evaluate a method of analyzing IHC stained tissues.

Abstract: The present disclosure provides for recombinant oncolytic viruses with gene deletions or insertions which result in downregulation of Major Histocompatibility Complex class I and alternatively or additively upregulation of Major Histocompatibility Complex class II. Immunologic and pharmaceutical compositions comprising these recombinant viruses and methods of using these compositions are also presented.

Abstract: There is provided an information processing device that processes detection information of an external recognition sensor. The information processing device includes: a recognition unit that performs recognition processing on an object on the basis of a detection signal of the sensor; and a processing unit that performs fusion processing on first data before the recognition by the recognition unit and another data. The information processing device further includes a second recognition unit that performs recognition processing on the object on the basis of a detection signal of a second sensor. The processing unit performs fusion processing on third data before the recognition by the second recognition unit and the first data, fusion processing on fourth data after the recognition by the second recognition unit and the first data, and the like.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

Abstract: A first trend chart and a second trend chart are displayed along with a chromatogram. The first trend chart is generated based on a plurality of first representative value arrays obtained from a plurality of mass spectra. The second trend chart is generated based on a plurality of second representative value arrays obtained from the plurality of mass spectra. A mass spectrum stable period is determined based on the first trend chart and the second trend chart.

Abstract: A method for detecting a tandem duplication in an FLT3 gene of a sample, includes mapping reads corresponding to targeted regions of exons of the FLT3 gene to a reference sequence. A partially mapped read includes a mapped portion, a soft-clipped portion and a breakpoint. Analyzing the partially mapped reads intersecting a column of the pileup includes detecting a duplication in the soft-clipped portion by comparing the soft-clipped portion to the mapped portion adjacent to the breakpoint; determining an insert size of the duplication in the soft-clipped portion; and assigning the partially mapped read to a category based on the insert size. Categories correspond to insert sizes. The categories are filtered and converted into features corresponding to the column. The features corresponding to one or more columns representing a same insert are merged to determine a location and size of a tandem duplication.

Abstract: A method and system for providing a data analysis in the form of a customized geographic visualization on a graphical user interface (GUI) on a remote client computing device using only a web browser on the remote client device. The system receives a user's selected data analysis to be performed by the system for display on the remote client device. The system verifies the data access permissions of the user to render a data analysis solution customized to that particular user, and automatically prevents that user from gaining access to data analysis solutions to which that user is prohibited. The system is configured to respond to the user's data analysis request, perform the necessary computations on the server side on the fly, and send a dataset interpretable by the client device's web browser for display on the client device or on a device associated with the client device.

Abstract: Elderly people suffer from health issues, and timely detection can save lives. State of the art techniques either make certain assumptions or require clinical data in order to perform the frailty detection, which affects the quality as well as cause inconvenience to the users. The disclosure herein generally relates to patient monitoring and, more particularly, to frailty detection using pedometer sensor data, PIR sensor data, and door sensor data. The system determines activity levels of the user being monitored, based on data from the pedometer sensors, PIR sensors, and door sensors, and based on the determined activity levels, further determines whether the user has frailty or not.

Abstract: Systems, methods, and apparatuses monitor mammal conditions, report condition changes, and provide neurocode-based treatment in response to condition changes. A mammal implantable controller includes modules to monitor, wirelessly communicate to external computers, and administer treatment received from a remote computer based on monitoring of changes in mammal condition as analyzed by the remote computer. External computers can be provided in the form of a mobile device (e.g., smartphone/tablet), resident treatment pods, and treatment servers. Treatment can be provided to change biological function or trigger cell death in cancer cells.

Abstract: The disclosure provides systems and methods for data analysis of experimental data. The analysis can include reference data that are not directly generated from the present experiment, which reference data may be values of the experimental parameters that were either provided by a user, computed by the system with input from a user, or computed by the system without using any input from a user. Another example of such reference data may be information about the instrument, such as the calibration method of the instrument.

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 113, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

Abstract: An information processing apparatus includes a processor, and a memory storing a program. The program, when executed by the processor, causes the information processing apparatus to: acquire a medical image obtained by imaging a subject, acquire an inspection result of the medical image, perform inference on the medical image; and control outputting of an inference result of the medical image inference to an external device based on the inspection result of the medical image.

Abstract: A system for generating a hypoglycemia risk signal associated with exercise-induced Hypoglycemia. The system can include a processor configured to obtain a blood glucose signal (BGstart), a ratio of absolute insulin on board over total daily insulin signal (IOBabs/TDI), and an initial glycemic slope signal (S0); generate a hypoglycemia risk signal based on a hypoglycemia prediction algorithm that determines the probability of a user being hypoglycemic during or after exercise based on the obtained BGstart, IOBabs/TDI and S0.

Abstract: A method, and corresponding apparatus, for identifying a feature in an image comprises determining a plurality of characteristic values for each pixel or group of pixels within the image, and determining a confidence value for a target area of the image on the basis of the plurality of characteristic values of the pixels within the target area. Each of the plurality of characteristic values relates to a different characteristic of the feature. The confidence value is indicative of whether the feature is represented by the target area of the image.

Abstract: The radiographic system includes an exposure table on which a breast of a subject is placed, a compression plate that compresses the breast placed on the exposure table, a marker having a two-dimensional pattern provided on the compression plate, a radiation source that irradiates the compressed breast with radiation, a camera that captures a visible light image including the marker, and a processor that derives height information of the compression plate with respect to the exposure table based on a marker image showing the marker reflected in the visible light image.

Abstract: Contemplated systems and methods use high-accuracy in silico HLA analysis to so establish a transplant match database suitable for transplantation, and particularly stem cell and solid organ transplant.

Abstract: A method comprising at least one light source configured to generate a light of at least one wavelength and project the light over an optical path, a sample device, the device containing a sample obtained from exhalation of a person, a vortex mask configured to receive the light after the light passes through at least a portion of the sample device, the vortex mask including a series of concentric circles etched in a substrate, the vortex mask configured to provide destructive interference of coherent light received from the at least one light source, a detector configured to detect and measure wavelength intensities from the light in the optical path, the wavelength intensities being impacted by the light passing through the sample, the detector receiving the light that remained after passing through the vortex mask, and a processor configured to provide measurement results based on the wavelength intensities.

Abstract: Nominal values of parameters, and perturbations of the nominal values, that are associated with previously defined radiation treatment plans are accessed. For each treatment field of the treatment plans, a field-specific planning target volume (fsPTV) is determined based on those perturbations. At least one clinical target volume (CTV) and at least one organ-at-risk (OAR) volume are also delineated. Each OAR includes at least one sub-volume that is delineated based on spatial relationships between each OAR and the CTV and the fsPTV for each treatment field. Dose distributions for the sub-volumes are determined based on the nominal values and the perturbations. One or more dose prediction models are generated for each sub-volume. The dose prediction model(s) are trained using the dose distributions.

Abstract: A task processing method, a processing apparatus, and a computer system are provided. Implementation of the method includes: generating, by a first processing apparatus, a plurality of tasks, and determining task description information of the plurality of tasks, where the task description information of the plurality of tasks is used to indicate a dependency relationship between the plurality of tasks; sending an instruction to a second processing apparatus, where the instruction includes the plurality of tasks and the task description information of the plurality of tasks; and receiving the instruction, and processing the plurality of tasks based on the dependency relationship between the plurality of tasks. The method can effectively reduce a waiting delay, fully exploit a computing capability of an acceleration chip, and improve task processing efficiency.

Abstract: A system and method utilizing three-dimensional (3D) data to identify objects. A database of profiles can be created for goods, product, object, or part information by producing object representations that permit rapid, highly-accurate object identification, matching, and obtaining information about the object. The database can be part of a different recognition system than the system used to identify the object. The profiles can be compared to a profile of an unknown object to identify, match, or obtain information about the unknown object, and the profiles can be filtered to identify or match the profiles of known objects to identify and/or gather information about an unknown object. Comparison, filtering, and identification may be performed prior to, subsequent to, or in conjunction with other systems, such as image-based machine learning algorithms.

Abstract: Method of determining insulin injection amount, computer storage medium, and devices, the method includes including: obtaining characteristic information and a blood glucose content at a current time of a target user; and determining an insulin injection amount at each time of the target user based on the characteristic information of the target user, the blood glucose content at the current time of the target user, a predetermined blood glucose prediction model, and a predetermined insulin injection amount prediction model. The method can facilitate the determination of the insulin injection amount at each time.

Abstract: Methods, computer program products, and systems are presented. The method computer program products, and systems can include, for instance: predicting an exhibited sentiment of a certain user on being presented one or more candidate education segment, wherein the predicting is in dependence on historical sentiment parameter values of one or more user on being exposed to presented educational content, the historical sentiment parameter values being stored in a data repository, wherein the presented education segments comprise digital media content adapted for playing by a digital media player; selecting at least one of the one or more candidate education segment in dependence on a result of the predicting so that a selected at least one of the one or more candidate education resulting from the selecting is personalized for the certain user; and presenting to the certain user the selected at least one of the one or more candidate education segment.

Abstract: The present invention provides a method of detecting mutational signatures in a DNA sample. The invention relates to method of detecting signatures arising from rearrangements in the DNA in the sample and determining the contributions of known rearrangement signatures to said rearrangements. In particular embodiments, the contributions are determined by computing the cosine similarity between the rearrangement mutations in said catalogue and the rearrangement mutational signatures. The rearrangement signatures are classified based on whether they are clustered or not, whether they are tandem duplications, deletions, inversions or translocations and on the basis of their size.

Abstract: A sensing device monitors and tracks food intake events and details. A processor, appropriately programmed, controls aspects of the sensing device to capture data, store data, analyze data and provide suitable feedback related to food intake. More generally, the methods might include detecting, identifying, analyzing, quantifying, tracking, processing and/or influencing, related to the intake of food, eating habits, eating patterns, and/or triggers for food intake events, eating habits, or eating patterns. Feedback might be targeted for influencing the intake of food, eating habits, or eating patterns, and/or triggers for those. The sensing device can also be used to track and provide feedback beyond food-related behaviors and more generally track behavior events, detect behavior event triggers and behavior event patterns and provide suitable feedback.

Abstract: The present invention relates to a method of creating a biomarker profile, the method comprising the steps of: obtaining a sample of biofluid from a subject, wherein the sample is stored on a sample collection apparatus; removing the sample from the sample collection apparatus; extracting nucleic acids from the sample; sequencing the extracted nucleic acids to generate sequence data; and analyzing the sequence data using a two-step analytical methodology to create the biomarker profile. The present invention is also directed to methods of determining the sex of an in utero fetus, predicting onset of a migraine in a subject, and of tracking athletic performance in a subject.

Abstract: The subject technology provides compact, searchable, random-access storage of genome data, particularly for large datasets, such as an entire human genome. The genome data may be stored in binary format, and compressed, in part, by leveraging characteristics of genome data itself, and in a way that maintains searchability of the stored compressed data.

Abstract: In part, the invention relates to a method for sizing a stent for placement in a vessel. In one embodiment, the method includes the steps of: dividing the vessel into a plurality of segments, each segment being defined as the space between branches of the vessel; selecting a starting point that appears to have substantially no disease; defining the diameter at this point to be the maximum diameter; calculating the maximal diameter of the next adjacent segment according to a power law; measuring the actual diameter of the next adjacent segment; selecting either the calculated maximum diameter or the measured maximum diameter depending upon which diameter is larger; using the selected maximum diameter to find the maximum diameter of this next segment; iteratively proceeding until the entire length of the vessel is examined; and selecting a stent in response to the diameters of the end proximal and distal segments.

Abstract: A method and system for remote diagnosis of a congestive heart failure in humans is presented. The method includes receiving a facial image of a patient, wherein the facial image is retrieved from a data store and captured from the patient; extracting, from the facial image, at least one facial feature indicative of a heart condition; classifying the extracted at least one facial feature using a classifier, wherein the classifier maps a plurality of candidate facial features to a plurality of scores indicating a stage of the heart condition; and determining a positive diagnosis and the stage of the heart condition of the patient based on the plurality of scores.

Abstract: A system, according to various embodiments, includes eyewear (or any other suitable wearable device) that includes at least one environmental pollution monitoring sensor (e.g., at least one light pollution, air pollution, radioactive pollution, thermal pollution, and/or noise pollution sensor) that may be used to monitor the presence of environmental pollution adjacent a wearer of the eyewear. The system may further include one or more health monitoring sensors to determine the health effects of the environmental pollution on the wearer. In certain circumstances, the system may alert the user to potentially harmful environmental conditions, or convey preventative healthcare advice to the wearer.

Abstract: A plant tracking apparatus, system, and method for tracking planting locations of a plurality of plants configured to be planted in a ground surface using a planting utensil having a handle, a blade, and a shaft defined between the handle and the blade is disclosed herein. The plant tracking apparatus includes a housing configured to be coupled to the planting utensil. The plant track apparatus further includes a Global Navigation Satellite System (GNSS) sensor, a planting sensor, and a controller positioned within or coupled to the housing. The controller is configured to record location data from the GNSS sensor in response to a planting signal from the planting sensor. In certain embodiments, the controller may determine the planting signal by comparing data from the planting sensor to a predetermined motion profile.

Abstract: The present disclosure relates to systems and methods for positioning a region of interest (ROI). The systems may obtain an image of an object captured by an imaging device. The systems may extract image information of the image. The systems may obtain feature information of a region of interest (ROI) in the object. The systems may determine position information of the ROI in the image using a positioning model based on the image information of the image and the feature information of the ROI.

Abstract: The present invention relates to methods for the in vitro diagnosis of lung cancer in a subject, comprising the detection of progastrin using at least one progastrin-binding antibody. According to the method of the invention, the subject is diagnosed with a lung cancer when progastrin is detected in the sample.

Abstract: An animal management system has one or more imaging devices, and a computing device coupled to the one or more image devices for receiving one or more images captured by the one or more imaging devices, processing at least one image using an artificial intelligence (AI) pipeline for: (i) detecting and locating in the image one or more animals, (ii) for each detected animal: (a) generating at least one section of the detected animal, (b) determining a plurality of key points in each section, (c) generating an embedding for each section based on the plurality of key points in the section, and (d) combining the embeddings for generating an identification of the detected animal with a confidence score. Key points and bounding boxes may also have associated confidence scores.

Abstract: Disclosed are methods, apparatuses, etc. for determination and application of a metric for assessing a patient's glycemic health. In one particular implementation, a computed metric may be used to balance short-term and long-term risks associated with a particular therapy.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for governing phenotypic outcomes in plants. One method includes obtaining a model input comprising time series data, wherein the time series data comprises, for each previous time point of one or more previous time points, at least one of i) first multi-omics data corresponding to a plant at the previous time point, or ii) phenotypic data corresponding to the plant at the previous time point; and processing the model input using a machine learning model to obtain a model output that comprises, for each future time point of one or more of future time points, a prediction of at least one of i) a phenotype of the plant at the future time point, or ii) second multi-omics data corresponding to the plant at the future time point.

Abstract: Systems and methods are provided for characterizing shuttle capture events in a nanopore sensor. The method first collects time-dependent current blockage signatures for at least one bias voltage. The method then identifies each signature as corresponding to a permanent or transient event. The method then generates a protein dynamics landscape (PDL) for the transient event signatures. The PDL comprises a set of histograms of nanopore current data and characterizes current through the nanopore during shuttle capture events. The method can then comprise identifying an entrance level blockage value based on the permanent event signatures. Permanent event captures can be determined by time duration which is larger than a certain threshold time value. Applying a voltage between the fluidic chambers above a threshold voltage level can be used to control that the vast majority of events are permanent.

Abstract: Disclosed is a sequence analysis method for analyzing nucleic acid sequence, the sequence analysis method including: obtaining a plurality of read sequences read from the nucleic acid sequence; and determining each nucleic acid sequence by aligning each read sequence with reference to a single reference sequence, wherein the reference sequence includes at least a first rearrangement sequence and a second rearrangement sequence that is different from the first rearrangement sequence.

Abstract: The present disclosure relates to methods and systems of determining swimming metrics of a user during a swimming session. The method can include receiving, by a processor circuit of a user device, motion information from one or more motion sensors of the user device; determining, by the processor circuit using the motion information, a first set of rotational data of the user device, wherein the first set of rotational data is expressed in a first frame of reference; converting, by the processor circuit, the first set of rotational data into a second set of rotational data, wherein the second set of rotational data is expressed in a second frame of reference; determining, by the processor circuit, one or more swimming metrics of the user; and outputting the one or more swimming metrics.

Abstract: The present invention includes a method for representing a plurality of pre-calculated solutions in radiation therapy that are stored in a database and displayed in a manner controllable by a user. Arrays of DVH curves provide the user with essential information on the ‘quality of a plan’. A DVH diagram is displayed as a main diagram, wherein only one of the solutions is visually represented at a time. By selecting a first starting point on a selected DVH curve as the main diagram, a first straight axis extending through the first starting point is placed. A first region, located around the first starting point and on the first straight axis, is highlighted as a first control region for controllable visualization of the plurality of currently non-displayed solutions stored in the database, the DVH curves of which correspond to the selected DVH curve and intersect the first straight axis.