Abstract: N-substituted dithiocarbamate esters, pharmaceutical compositions containing them, and methods of treating hyperproliferative disorders such as cancer by administering the N-substituted dithiocarbamate esters.
Type:
Grant
Filed:
March 21, 2001
Date of Patent:
June 8, 2004
Assignee:
AtheroGenics, Inc.
Inventors:
Russell M. Medford, Uday Saxena, Lee K. Hoong, Patricia K. Somers
Abstract: The use of compounds of the formula
and pharmaceutically acceptable salts thereof, alone or in combination for the treatment of transplant rejection, wherein the substituents are further defined in the application.
Type:
Grant
Filed:
October 25, 2001
Date of Patent:
December 30, 2003
Assignee:
AtheroGenics, Inc.
Inventors:
David B. Edwards, Patricia K. Somers, Mitchell Glass
Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
Type:
Grant
Filed:
August 7, 2000
Date of Patent:
June 5, 2001
Assignee:
G. D. Searle & Co.
Inventors:
Matthew J. Graneto, Michael L. Vazquez, Susan J. Hartmann, Suzanne Metz, John J. Talley, David L. Brown, Richard M. Weier, Michael A. Stealey, Xiangdong Xu
Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
March 11, 1998
Date of Patent:
March 27, 2001
Assignee:
G. D. Searle & Company
Inventors:
Rolando E. Gapud, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Barnett S. Pitzele, Suzanne S. Metz, R. Keith Webber, Foe S. Tjoeng, Robert E. Manning, Mihaly V. Toth
Abstract: There is disclosed a novel amino glycol derivatives of L-N.sup.6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
September 6, 1996
Date of Patent:
November 7, 2000
Assignee:
G.D. Searle & Co.
Inventors:
E. Ann Hallinan, Foe S. Tjoeng, Kam F. Fok, Timothy J. Hagen, Mihaly V. Toth, Sofya Tsymbalov, Barnett S. Pitzele
Abstract: This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.
Type:
Grant
Filed:
November 18, 1999
Date of Patent:
November 7, 2000
Assignee:
G. D. Searle & Co.
Inventors:
Matthew J. Graneto, Michael L. Vazquez, Susan J. Hartmann, Suzanne Metz, John J. Talley, David L. Brown, Richard M. Weier, Michael A. Stealey, Xiaodong C. Xu
Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
July 19, 1999
Date of Patent:
October 24, 2000
Assignee:
G.D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Ariia A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R.sup.1, R.sup.2, Ar.sup.1 and HetAr.sup.2 are as described in the specification.
Type:
Grant
Filed:
April 1, 1999
Date of Patent:
July 11, 2000
Assignee:
G. D. Searle & Co.
Inventors:
Ashok Anantanarayan, Michael Clare, Lifeng Geng, Gunnar J. Hanson, Richard A. Partis, Michael A. Stealey, Richard M. Weier
Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
July 28, 1998
Date of Patent:
June 6, 2000
Assignee:
G. D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
May 6, 1998
Date of Patent:
April 4, 2000
Assignee:
G.D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
Abstract: The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
November 25, 1998
Date of Patent:
March 28, 2000
Assignee:
G. D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
Abstract: The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
March 27, 1998
Date of Patent:
January 4, 2000
Assignee:
G.D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., E. Ann. Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
Abstract: The present invention discloses novel pharmaceutical compositions having steroid nitrate ester(ONO.sub.2) derivatives, and to their use treating undesired smooth muscle contractions and inflammatory diseases.
Type:
Grant
Filed:
May 2, 1996
Date of Patent:
November 16, 1999
Assignee:
G.D. Searle & Co.
Inventors:
Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
July 22, 1997
Date of Patent:
November 9, 1999
Assignee:
G.D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
March 5, 1997
Date of Patent:
November 9, 1999
Assignee:
G.D. Searle & Co.
Inventors:
Rolando E. Gapud, Timothy J. Hagen, Ann E. Hallinan, Donald W. Hansen, Jr., Robert E. Manning, Suzanne Metz, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, R. Keith Webber
Abstract: 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
January 14, 1999
Date of Patent:
September 28, 1999
Assignee:
G.D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud