Abstract: A data processing system is coupled to a facsimile device which receives and transmits facsimile images between the data processing system and a telephone line. The data processing system includes the capability to receive a facsimile image, interpret certain images as specified commands for the data processor, and to retrieve, manipulate and transmit data in response to the specified commands.

Abstract: An apparatus and a process useful for producing patterned gelatin ribbons for forming patterned soft gelatin capsules are disclosed. The apparatus and process use multiple spreader boxes to form a wide variety of possible patterns.

Abstract: The present invention provides methods for screening drug compounds utilizing compounds of formulas I and II, where formulas I and II are ##STR1## and the pharmaceutically acceptable salts thereof where: R.sub.1, R.sub.2, R.sub.3, and R.sub.4 represent hydrogen, halogen, alkyl or alkoxy substituents;R5 is hydrogen or lower alkyl;X and Y represent hydrogen, halogen, alkyl or alkoxy substituents; andZ is hydrogen or fluorine.The invention also provides tritium or iodine isotope radiolabeled compounds of the formulas I and II radiolabeled with tritium or isotopes of iodine.The invention further provides novel GABAa receptor subtypes which specifically bind to compounds of formulas I or II.The invention also provides GABAa receptor subtypes which are bound in situ to a compound of formula I or II.The compounds provided herein bind selectively to a novel subtype of the GABAa binding site.

Abstract: An improved packaging device designed for the filling of flexible, tubular casing and for the sealing of the casing in discreet lengths which may then be further processed or packaged. The device includes a mounting assembly having a floor mounted frame with a rotatable platform supported by the frame. Adjacent the frame and platform is a device for feeding product through a product horn into casing which is shirred on the horn. The platform includes a plurality of specially designed clippers arranged in a circular array. As filled casing is discharged from the feeding mechanism it is directed tangentially into the circular array of rotating clippers which are equally spaced from each other. The clippers sequentially operate to gather the casing, apply spaced, double clips to the casing, sever the connection between adjacent clips, and to then discharge the packaged link from the device.

Abstract: A device for performing the continuous cutting of materials of any form and nature, provided they are stratified and not flexionally rigid. The device generally comprises: fixed and mobile support surfaces; a mobile cutting shear cooperating with a fixed cutting shear; a fixed blocking unit on the fixed support surface side of the cutting shears; a mobile blocking unit on the mobile support surface side of the cutting shears; an eccentric for driving mobile portions of the device, including the mobile cutting shear, the eccentric being synchronized with the fixed and mobile blocking units; and a link block and slide guide. Non-rigid, stratified materials thereby may be more easily cut in that the invention substantially reduces or eliminates the dragging effect of the material that typically occurs during the cutting process.

Abstract: Compounds of general formula I: ##STR1## are presented that have collagenase inhibition activity and are useful in the management of disease involving the tissue degradation and the promotion of would healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumor invasion.

Abstract: A heat exchanger comprises a clam shell having a first passage, a second passage and a third passage connected sequentially in a plane. A hot collector box made from metal, for example, aluminized steel, in connected to the third passage. A secondary heat exchanger coil is operatively connected to the hot collector box. A second collector box or cold collector box made from plastic is connected to the outlet of the secondary heat exchanger coil. Condensate from the flue and condensate from the cold collector box may be discharged in a common line from the furnace. The clam shell is constructed and arranged to remove about 90%-95% of the energy from the flue products flowing therethrough. The heat exchanger is disposed in a passage between the inlet and the outlet in the housing of a furnace. Air is forced over the heat exchanger, which is disposed in the passage, by a blower in the housing.

Abstract: This invention relates to antiviral peptide compounds and to methods of inhibiting infection of human cells by viruses. This invention pertains more specifically to peptides that are chemically blocked at the amino- and carboxy-termini. In particular the invention relates to peptides comprised of prolylalanine or prolylphenylalanine compounds that have antiviral activity. The invention is specifically directed to methods for preventing infection of human cells in vivo and in vitro with the human immunodeficiency virus HIV-1 and methods for treating human infected with this and other viruses. The invention also relates to the diagnostic and therapeutic use of these antiviral peptide compounds.

Abstract: The present invention relates to a novel mammalian adenosine receptor. The invention is directed toward the isolation, characterization and pharmacological use of the rat A3 adenosine receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing the rat A3 adenosine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize the rat A3 adenosine receptor. The invention also provides methods for screening adenosine-receptor agonists and antagonists in vitro using preparations of the rat A3 adenosine receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the rat A3 adenosine receptor gene.

Abstract: Apparatus and method for managing transmission of digital data between a digital telephone line and a computer network. First and second modems, a telephone control circuit and a network control circuit respond to management instruction signals to execute predetermined management objectives and generate management response signals representing one or more conditions of the first and second modems, telephone control circuit and network control circuit. In response to a single packet of management signals from the network, a management circuit generates the management instruction signals and independently addresses them to one or more of the first and second modems, telephone control circuit and network control circuit.

Abstract: Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation. Cleavable streptokinase/hirudin heterodimers are claimed.

Abstract: A hybridoma (termed "UIC2 hybridoma", ATCC Accession No. HB11207) producing monoclonal antibodies (termed "UIC2 mAb") directed against an extracellular domain of a cell surface P-glycoprotein antigen associated with multidrug resistance in primate cells was produced by fusing a human myeloma cell with a spleen cell derived from a BALB/c mouse immunized with syngeneic 3T3 fibroblasts previously transfected with the isolated human mdr1 cDNA. UIC2 mAb, thus produced, as well as fragments and recombinant derivatives thereof, may be used to detect and isolate multidrug resistant primate cells and human mdr1 gene products, and to reverse multidrug resistance in primate cells, including cells of multidrug resistant human tumors.

Abstract: This invention is a method for measuring the ability of a human to absorb cholesterol. The method uses two different cholesterol tracers, the first injected into the blood stream and the second ingested by the human subject. After a waiting period a blood sample is taken from the human subject and analyzed to determine percent cholesterol absorption based on the actual amounts of the two naturally occurring, metabolically stable cholesterol tracers in the blood. The method of this invention is useful in identifying human subjects as high cholesterol absorbers and thereafter administering therapeutic agents to the subject that inhibit the absorption of cholesterol.

Abstract: A coupling for no-hub pipe segments has a shield covering an elastomeric gasket. The shield has a plurality on corrugations oriented transverse to the pipe axis and arranged in discrete areas. These corrugations are separated by corrugations oriented parallel to the pipe axis arranged in discrete areas. Clamping bands securely clamp the shield and gasket to the pipe segments. The pattern of corrugations permits the shield to assume a shouldered shape when the clamping bands are tightened and the coupling is installed on pipes of slightly varying diameter. The gasket is provided with a pattern of thick sealing sectors and adjacent groove sectors laterally spaced relative to thick sealing sectors. This pattern permits the clamping bands and shield to form a restriction impeding the movement of the shield relative to the gasket when the clamping bands are tightened.

Abstract: A method for reducing reducible metals comprising combining one or more reducible metals with an elemental metal, and then with a reducing agent to form a reduced metal. The mixture may then be stabilized and recovered.

Abstract: An exercise device for use with free weight plates. A weight lifting bar has a length sufficient to provide for two hand lifting of the bar. The weight lifting bar is supported by a support structure. A mechanism is operatively connected to and associated with the weight lifting bar, storage bars for storage of the free weight plates, and the weight lifting bar support structure. The mechanism causes the storage bars and the weight lifting bar to occupy positions of alignment and proximity of the storage bars with the weight lifting bar, when desired. Free weight plates may be moved manually off the weight lifting bar into storage on the storage bars, and alternatively, moved manually off the storage bars and onto the weight lifting bar, by sliding of the free weight plates along the storage bars and along the weight lifting bar while the storage bars and weight lifting bar are in alignment and proximity with each other.

Abstract: Intestinal cell endogenous heparin mediated absorption of cholesterol or fatty acids in mammals is inhibited through the oral administration of heparin, an active heparin subfraction or heparinase. Suppression of cholesterol esterase-mediated absorption in humans can be inhibited by soluble heparin by two mechanisms, i.e. displacement of the enzyme from the intestinal cell membrane and inhibition of enzymatic activity of the displaced enzyme.

Abstract: The invention encompasses compounds of general formula I: ##STR1## wherein W represents an imidazo[4,5-c]pyridyl group, optionally substituted with one or more substituents selected from C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, CF, and CN; and Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 are variables. These compounds are useful as antagonists of platelet activating factor.

Abstract: The present invention relates to the isolation, characterization and pharmacological uses for the human D5 dopamine receptor, the gene corresponding to this receptor, pseudogenes of this receptor gene, a recombinant eukaryotic expression vector capable of expressing the human D5 dopamine receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize the human D5 dopamine receptor. The invention relates to the biochemical and physiological characterization of the human D5 dopamine receptor and the development and testing of drugs useful for treating or preventing human disease.

Abstract: An improved vacuum motor for actuating heat, ventilating and air conditioning control systems (HVAC), which uses a conical spiral spring and a bonded connection between the housing and cap to reduce weight, size, cost and noise. The motor includes a bellows which forms an airtight compartment inside the motor housing with the cap and a plunger connected to the bellows. The conical spring biases the bellows to a fully expanded position. A negative pressure or vacuum in the air line connected to the housing causes the bellows to collapse and compress the spring. As the bellows collapses, the attached plunger is pulled axially into the motor housing. The movement of the plunger actuates the connected HVAC device.