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Patents Represented by Attorney Amy P. Stark

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Trypsin-sensitive agent able to reduce PAI-1 and .beta.APP expression in senescent cells and increase the ability of fibroblasts to divide in culture

Patent number: 5482838

Abstract: Purified trypsin-sensitive agent or analog thereof, able to downregulate collagenase, PAI-1 and .beta.APP expression in senescent cells isolatable from culture medium having growing fibroblasts or U937 promyelocytic cells.

Type: Grant

Filed: February 8, 1993

Date of Patent: January 9, 1996

Assignee: Geron Corporation

Inventor: Michael D. West