Patents Represented by Attorney Amy S. Hellenkamp

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  • Method for screening for agents which increase telomerase activity in a cell
    Patent number: 5830644
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: November 3, 1998
    Assignees: Geron Corporation, Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring E. Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5707795
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 13, 1998
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Methods for screening for agents which modulate telomere length
    Patent number: 5686245
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 11, 1997
    Assignee: University of Texas System Board of Regents
    Inventors: Michael D. West, Jerry Shay, Woodring Wright
  • Methods and reagents for lengthening telomeres
    Patent number: 5686306
    Abstract: Method and compositions for increasing telomere length in normal cells can be used to increase the proliferative capacity of cells and to delay the onset of cellular senescence.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: November 11, 1997
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael D. West, Jerry Shay, Woodring E. Wright
  • Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
    Patent number: 5645986
    Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: July 8, 1997
    Assignees: Board of Reagents, The University of Texas System, The Reagents of the University of California, Geron Corporation
    Inventors: Michael D. West, Calvin B. Harley, Catherine M. Strahl, Michael J. McEachern, Jerry Shay, Woodring E. Wright, Elizabeth H. Blackburn, Homayoun Vaziri
  • Telomerase activity assays
    Patent number: 5629154
    Abstract: Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: May 13, 1997
    Assignee: Geron Corporation
    Inventors: Nam W. Kim, Calvin B. Harley, Scott L. Weinrich
  • Method and Kit for enhanced differential display
    Patent number: 5580726
    Abstract: An improved method for detecting and isolating differentially expressed mRNAs which comprises using first oligonucleotide primers for reverse transcription of mRNAs and both the first oligonucleotide primers and second oligonucleotide primers for amplification of the resultant cDNAs. The improvement of this method comprises providing first and second oligonucleotide primers with a length of at least 21 oligonucleotides. The method further comprises using a two-step PCR amplification, wherein non-stringent conditions are used for the first 1 to 4 cycles, and stringent conditions are used for the next 16 to 22 cycles. This highly reproducible method will permit the preparation of comprehensive catalogs of gene expression for any given cell type.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: December 3, 1996
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, Maarten H. K. Linskens