Abstract: Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
Type:
Grant
Filed:
March 24, 1993
Date of Patent:
February 6, 1996
Assignee:
University of Texas System Board of Regents
Inventors:
Michael D. West, Jerry Shay, Woodring Wright