Abstract: Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipoatrophy. Leptin is effective against conditions of lipoatrophy for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including subcutaneously and using gene therapy methods. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having a leptin level of approximately 4 ng/ml or less before treatment.
Type:
Grant
Filed:
May 9, 2011
Date of Patent:
November 27, 2012
Assignees:
Amgen, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services, Board of Regents, The University of Texas System
Inventors:
Alexander M. DePaoli, Elif Arioglu Oral, Simeon I. Taylor, Abhimanyu Garg
Abstract: Methods and compositions for treating psychiatric diseases and disorders are disclosed. The methods provided generally involve the administration of an NMX peptide, an FNX peptide, or an NMX receptor agonist, or analogs or derivatives thereof, to a subject in order to treat psychiatric diseases and disorders, and conditions associated with psychiatric diseases and disorders.
Type:
Grant
Filed:
February 4, 2008
Date of Patent:
November 13, 2012
Assignee:
Amylin Pharmaceuticals, LLC
Inventors:
Kevin D. Laugero, Michael R. Hanley, Christine M. Mack, David G. Parkes, Paul McGonigle
Abstract: Compositions and methods for preventing, treating or controlling conditions or disorders associated with obesity, diet and nutrition are provided. The methods provided generally involve the administration of an Amylin or an Amylin agonist to a subject in order to prevent, treat or control conditions or disorders associated with obesity, diet and nutrition.
Type:
Grant
Filed:
December 9, 2010
Date of Patent:
October 2, 2012
Assignee:
Amylin Pharmaceuticals, LLC
Inventors:
Christian Weyer, Kevin D. Laugero, Christine M. Mack, David G. Parkes