Patents Represented by Attorney, Agent or Law Firm Andrea L. C. Robidoux
  • Isoxazole compositions useful as inhibitors of ERK
    Patent number: 6495582
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: December 17, 2002
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao, Robert Mashal