Abstract: A profile of a rack, that may have zero, one, or a plurality of containers may be obtained using an ultrasonic sensor. The sensor emits a plurality of ultrasonic bursts and the rack is transported under the sensor at a slew speed that allows the sensor to detect at least first and second echoes from each of the bursts. Data points, corresponding to each of the first and second echoes, are generated and the data points are captured in a memory device. The data points, generally reflecting the levels of the rack and any containers, are processed to dynamically and non-invasively (i.e., without physically contacting the liquid with a probe) determine information about the container types, whether any container is capped, and, if one or more containers are uncapped, the liquid level in the uncapped containers.

Abstract: A robotic arm has a pair of gripper fingers designed to grip a variety of containers, including capped and uncapped test tubes as well as containers having unique gripping means. The fingers each have upper and lower projections separated by a groove, the respective projections facing each other when mounted to grippers on the robotic arm. The projections and groove serve to firmly hold the containers as well as self-align the unique gripping means on initially unaligned containers within the fingers as the fingers close around the containers. The fingers have clearance to avoid contact with caps on capped test tubes. Stops are provided at the top of each finger to engage one another and prevent fully closed fingers from deforming. The robotic arm may be transported along a rail mounted above the instrument and a gripper assembly, having a gripper arm, mounted to the robotic arm may be rotated above the instrument to move the container to various locations within the instrument.

Abstract: An analytical instrument has a sample handler for inputting racks of containers, including various types and sizes of test tubes, both capped and uncapped, and inserts, into the instrument. The sample handler has an infeed, an outfeed and a cross-feed between the infeed and outfeed. The infeed and outfeed advance the racks of containers using walking beam mechanisms which lift the racks by tabs on the right and left sides of the rack, which are positioned at a substantially identical height. Racks input into the infeed are transferred by the walking beam mechanism to a track on the cross-feed. They are then pushed, by a transport subassembly having a platform with pivotable pusher fingers to cam the rack and to push it in only one direction, from behind the infeed to a fixed position behind the outfeed.

Abstract: The present invention provides a reagent for extracting lead ions from a variety of biological matrices such as human whole blood that has been anticoagulated with either heparin or EDTA, and lyophilized human blood and bovine EDTA whole blood. The released lead is measured in situ with a calorimetric porphyrin reagent without further manipulation of the supernatant. The lead ion releasing reagent can be used in conjunction with a variety of assay formats for the determination of lead in various biological fluids.

Abstract: A method for aiding in the diagnosis of, and monitoring the progression or course of, colon cancer in a patient by measuring the amount of NCA 50/90 in a blood sample, e.g., serum sample, obtained from the patient. Measurement in a single sample of an amount of NCA 50/90 significantly higher than the mean amount of NCA 50/90 in the normal population is an indication of colon cancer in a symptomatic patient. The course of colon cancer can also be monitored by performing a series of specific immunoassays over time to determine changes in the level of NCA 50/90 in blood samples. Increases in blood NCA 50/90 levels over time are indicative of a deteriorating condition whereas decreasing levels of blood NCA 50/90 over time indicate an improving condition.

Abstract: A robotic arm has a pair of gripper fingers designed to grip a variety of containers, including capped and uncapped test tubes as well as containers having unique gripping means. The fingers each have upper and lower projections separated by a groove, the respective projections facing each other when mounted to grippers on the robotic arm. The projections and groove serve to firmly hold the containers as well as self-align the unique gripping means on initially unaligned containers within the fingers as the fingers close around the containers. The fingers have clearance to avoid contact with caps on capped test tubes. Stops are provided at the top of each finger to engage one another and prevent fully closed fingers from deforming. The robotic arm may be transported along a rail mounted above the instrument and a gripper assembly, having a gripper arm, mounted to the robotic arm may be rotated above the instrument to move the container to various locations within the instrument.

Abstract: The read head for luminometer includes a housing that encloses a cylindrical core. The housing has a through opening that aligns with a central passageway of the cylindrical core to define a confinement space. The housing and the cylindrical core are formed in two parts that diverge or converge with respect to each other under the influence of a manually controlled actuator member. When the housing parts and the core parts are in a closed convergent position an analytical line that extends through the housing and the core is maintained in a confined position within the confinement space of the housing and the core. Actuation of the housing parts and the core parts into a diverged open position opens the confinement space that accommodates the analytical line. The analytical line can thus be lifted away from the previous confinement space or reinstalled back into the open confinement space and then locked in place by an actuation of the housing parts into a closed converged position along with the core parts.

Abstract: A system and method for displaying parameters in a smoothed normalized star diagram where parameters are received from a medical laboratory instrument and processed. The processing includes calculating a normalized parameter value for each parameter using a predetermined mean and standard deviation and scaling the resulting normalized parameter value using a range restricting function. Each scaled parameter is assigned to a spoke and rays are drawn between adjacent spokes at a small angular interval. The ends of the rays are then joined by line segments, thereby constructing a smooth overall diagram.

Abstract: A user interface for use on the computer of a biomedical analyzer system having at least one biomedical analyzer instrument. The user interface inputs work orders, including sample and test id's, and transmits them to the instrument. The instrument performs the requested tests and sends the results to the computer, where they are stored. The test results are compared to exception review criteria to identify exception test results for operator review. Exception test results are indicated by a graphic icon on the display of the computer. The exception test results are compared by an operator to validation data gathered from the instrument and stored in the computer. The operator may then select a disposition for the exception test results. Alarm conditions are communicated by the instrument to the computer and the user interface communicates the alarm conditions to an operator by using a graphic image of the instrument and an affected part.

Abstract: The sample dilution module includes an oil filled aspiration probe and mixing chamber that communicate with each other while the mixing chamber is maintained at an angle of approximately 5 to 45 degrees below a horizontal axis. The aspiration probe is maintained in a vertical orientation. A micro-bubble is aspirated between separate aspirations of test sample and diluent to prevent contact between the sample and diluent in the aspiration probe. The test sample and diluent are then drawn from the vertically oriented aspiration probe into the mixing chamber. After the sample and diluent are in the mixing chamber the micro-bubble of air can migrate away from the test sample and diluent to enable the test sample and diluent to contact each other. Mixing of the test sample and diluent is accomplished by moving the test sample and diluent back and forth in the mixing chamber without physical agitation of the mixing chamber and without any mixing element in the mixing chamber.

Abstract: An automatic decapper removes caps from capped test tubes by gripping the cap on a test tube with the upper grippers and holding the cap stationary while the test tube is rotated and translated downward with lower grippers. In a preferred embodiment, the upper grippers comprise three jaws coupled to a cam to be moved, as appropriate, from a first position in which a test tube cap may be inserted between the jaws to a second position in which the jaws grip the inserted cap. The upper grippers are mounted to a decapping arm that is pivotable between a first position above the lower grippers, in which the decapping takes place, to a second position above the exterior of the decapper, where it remains while the test tube is inserted into or removed from the lower grippers and where a removed cap may be released into a container for disposal or reuse. The lower grippers comprise a pair of lever arms for holding the test tube.

Abstract: A profile of a rack, that may have zero, one, or a plurality of containers may be obtained using an ultrasonic sensor. The sensor emits a plurality of ultrasonic bursts and the rack is transported under the sensor at a slew speed that allows the sensor to detect at least first and second echoes from each of the bursts. Data points, corresponding to each of the first and second echoes, are generated and the data points are captured in a memory device. The data points, generally reflecting the levels of the rack and any containers, are processed to dynamically and non-invasively (i.e., without physically contacting the liquid with a probe) determine information about the container types, whether any container is capped, and, if one or more containers are uncapped, the liquid level in the uncapped containers.

Abstract: The conveyor system for clinical test apparatus includes a main transport conveyor and a plurality of auxiliary conveyors located alongside the main transport conveyor. The auxiliary conveyors define straight line paths of travel parallel to the straight line paths of travel of the main conveyor. Each of the auxiliary conveyors is operated by drive means separate from the main transport conveyor. Two crossover points are provided between the main transport conveyor and the auxiliary conveyor. One crossover point is an entrance from the main transport conveyor to the auxiliary conveyor and the other crossover point is an exit from the auxiliary conveyor to the main transport conveyor. Each crossover point is controlled by a gate. One of the gates is a divert gate which can be actuated to block the main transport path thereby diverting puck traffic onto the auxiliary conveyor.

Abstract: The reagent package includes a container housing section and a container lid that are sealed together to define one or more inside chambers. An opening in the container lid provides access to a corresponding chamber. The chamber opening is controlled by a valve that is pivotable from an open position to a closed position and vice versa. When the valve is in an open position the container chamber can be accessed through the valve with an aspiration probe and a dispensation probe. The reagent package accommodates a filter screen member and a glass ampoule in the container chamber. The glass ampoule contains one reagent ingredient, which can be a dry powder and the space within the chamber outside the glass ampoule can contain a reconstituting liquid. When the reagent package is ready for use a pressure force is imposed on the outside wall of the chamber adjacent the glass ampoule to crush the ampoule and permit the liquid within the chamber to mix with the dry powder released from the glass ampoule.

Abstract: The present invention relates to a cup handling subsystem for an automated clinical chemistry analyzer system which includes a nestable sample cup for holding sample mixtures, a cup dispenser mechanism for holding and dispensing a supply of the cups into a sample shuttle for transporting them, and an incubator for controlling the temperature of the cup and its contents. In one embodiment, the cups include a conical lower portion and a cylindrical upper portion having a top flange, a bottom flange and a groove formed therebetween. An apparatus is provided for holding and dispensing a plurality of such cups including a supply tube for holding the cups in a stack wherein the stack has a bottom-most cup and a next-bottom-most cup located above the bottom-most cup. The apparatus also includes an escapement located at a lower end of the supply tube which includes a disk having an aperture formed therein, a first leaf attached to a top side of the disk and a second leaf attached to a bottom side of the disk.

Abstract: A method for determining the complexed forms of immunologically determinable prostate specific antigen (cPSA) in a blood sample, e.g., by two-site immunometric assays, in which the blood sample is treated to render free PSA (fPSA) immunologically nondetectable. A particularly preferred immunometric assay method employs three anti-PSA antibodies: an antibody that binds to both cPSA and fPSA (anti-tPSA), a second anti-tPSA antibody which is characterized by the unique property that binding to fPSA is blocked by binding of fPSA-specific antibodies, and a third antibody which is a fPSA-specific antibody. Thus, binding of the fPSA-specific antibody to PSA in the sample allows only cPSA to be measured in the immunometric assay. Measurement of cPSA blood levels has been found to provide a method for aiding in the diagnosis and monitoring of prostate cancer that is highly sensitive and specific, and eliminates the need for a significant number of patients to undergo unnecessary prostate biopsy.

Abstract: A method for determining the complexed forms of immunologically determinable prostate specific antigen (cPSA) in a blood sample, e.g., by two-site immunometric assays, in which the blood sample is treated to render free PSA (fPSA) immunologically nondetectable. A particularly preferred immunometric assay method employs three anti-PSA antibodies: an antibody that binds to both cPSA and fPSA (anti-tPSA), a second anti-tPSA antibody which is characterized by the unique property that binding to fPSA is blocked by binding of fPSA-specific antibodies, and a third antibody which is a fPSA-specific antibody. Thus, binding of the fPSA-specific antibody to PSA in the sample allows only cPSA to be measured in the immunometric assay. Measurement of cPSA blood levels has been found to provide a method for aiding in the diagnosis and monitoring of prostate cancer that is highly sensitive and specific, and eliminates the need for a significant number of patients to undergo unnecessary prostate biopsy.

Abstract: Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers thereon on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierced stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe.

Abstract: Integrated sampler apparatus and method are provided and include a sample liquid container support component which is operable to support both closed and open sample liquid containers thereon on a random basis. Sample liquids from the open sample liquid containers are presented directly to a sample liquid analysis system probe for access thereby; while sample liquids from the closed sample liquid containers, which take the form of sample liquid containers closed by sample needle-pierced stoppers, are transferred by virtue of a sampling needle assembly and connected sample liquid transfer conduits and transfer valve, to a sample liquid dispensing well for access by the same sample liquid analysis system probe.

Abstract: A method for aiding in the diagnosis of, and monitoring the progression or course of, lung cancer in a patient by measuring the amount of NCA 50/90 in a blood sample, e.g., serum sample, obtained from the patient. Measurement in a single sample of an amount of NCA 50/90 significantly higher than the mean amount of NCA 50/90 in the normal population is an indication of lung cancer in a symptomatic patient. The course of lung cancer can also be monitored by performing a series of specific immunoassays over time to determine changes in the level of NCA 50/90 in blood samples. Increases in blood NCA 50/90 levels over time are indicative of a deteriorating condition whereas decreasing levels of blood NCA 50/90 over time indicate an improving condition.