Abstract: The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, ?-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.
Type:
Grant
Filed:
September 7, 2004
Date of Patent:
April 17, 2007
Assignee:
Abbott Laboratories
Inventors:
Zhonghua Pei, Xiaofeng Li, Kenton L. Longenecker, Hing L. Sham, Paul E. Wiedeman