Abstract: Methods are described for identifying an RNA target for an allele-specific RNA inhibitor by identifying a sequence variance in an RNA encoded by a gene of interest, and determining whether the secondary structure of the RNA comprising the variance differs from that of an otherwise identical RNA not comprising the variance.
Type:
Grant
Filed:
February 29, 2000
Date of Patent:
February 3, 2004
Assignee:
Nuvelo, Inc.
Inventors:
Ling X. Shen, Gregory L. Verdine, James P. Basilion, Vincent P. Stanton, Jr.