Abstract: A composition for administration to the nasal mucosa of a subject comprises a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent. The composition has a nicotine concentration less than 10 mg/ml. The composition used alone assists in reduction of the desire of a subject to smoke tobacco. It also reduces the nasal symptoms associated with administration of higher concentrations of nicotine to the nasal mucosa.
Abstract: Improved formulations for detecting asthma are disclosed. The formulations comprise methacholine or histamine in a dry particulate form wherein the particles are of a respirable size, preferably 2 &mgr;m to 5 &mgr;m. The dry formulations can be inhaled directly from an inhaler and can be used to detect airway narrowing which is diagnostic of asthma.
Type:
Grant
Filed:
April 21, 2000
Date of Patent:
October 8, 2002
Assignee:
Ontario Inc.
Inventors:
Arthur Slutsky, Noe Zamel, Harold Wulffhart