Abstract: The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.
Type:
Grant
Filed:
May 13, 2009
Date of Patent:
December 4, 2012
Assignee:
Five Prime Therapeutics, Inc.
Inventors:
Kalyani Penta, Srinivas Kothakota, Lewis T. Williams, Kevin Hestir, Shannon Marshall, Jeffrey Finer, Yan Wang