Abstract: In a method of calibrating a quadrature transmitter, a first calibration signal is injected into an in-phase transmit branch of the quadrature transmitter, and a second calibration signal is injected into a quadrature transmit branch of the quadrature transmitter. The first and second calibration signals are injected before performing up-conversion in the transmitter and are produced by first and second digital signals. A detector detects an up-converted signal. The detected up-converted signal is digitized. The in-phase and quadrature transmit branches are calibrated by alternately determining the first and second calibration signals while at least varying respective most significant bits of the first and second digital signals, upon said varying the at least most significant bits keeping calibration bit values that correspond to minimum values of the digitized detected up-converted signal.