Abstract: A composition including superoxide dismutase (SOD) and prickly pear cactus (OFI) protects against, minimizes the effects of, and hastens recovery from the typical symptoms associated with an alcohol induced hangover. In addition, sesamin and alpha-lipoic acid work with the SOD and OFI for enhanced antioxidant and therapeutic effects. Thiamine, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, milk thistle seed extract, flower pollen extract, eleuthero root extract, guggulsterones EZ, white willow bark extract, sclareolide, ginkgo biloba extract, caffeine, and boswellia serrata extract can be added to the composition for additional treatment of symptoms.