Abstract: The present invention relates generally to assays for the detection of Xenotropic Murine Leukemia Virus-related Retrovirus (“XMRV”) and diseases associated with XMRV infection. Additionally, the invention relates to specific XMRV antigens capable of inducing an immunogenic response as well as XMRV-related nucleic acids having significant diagnostic, screening, and therapeutic utilities.

Abstract: The invention relates to a process for sticking edging material (12, 10) onto lightweight building boards (1) comprising two thin-walled outer layers (2, 4) and a core layer (6) of lightweight filler material disposed between the outer layers, having the steps: provision of a lightweight building board (1), a decor edge (10) and a stabilizing edge (12), and sticking on of the decor edge (10) and/or the stabilizing edge (12) in the region of a narrow surface (1?) of the lightweight building board (1). The process according to the invention is characterized in that the stabilizing edge (12) is introduced into a section between two outer layers (2, 4) in the region of the narrow surface (1?) without having first created a recess of at least one outer layer and/or of the core layer in this section, said recess corresponding substantially to the stabilizing edge.

Abstract: A fire resistant slipsheet in roll form includes a fiber mat having first and second sides and a coating containing expandable graphite, a filler, and a binder. The coating is coated on at least one of the first and second sides of the fiber mat, and a single layer of the slipsheet achieves a Class A rating when tested according to UL 790 and/or ASTM E-108 Standard Test Methods for Fire Tests of Roof Coverings. A fire resistant roofing system and a method for installing a fire resistant roofing system that achieves a Class A rating when tested according to UL 790 and/or ASTM E-108 Standard Test Methods for Fire Tests of Roof Coverings is also provided.

Abstract: A system for generating a summary of a plurality of documents and presenting the summary information to a user is provided which includes a computer readable document collection containing a plurality of related documents stored in electronic form. Documents can be pre-processed to group documents into document clusters. The document clusters can also be assigned to predetermined document categories for presentation to a user. A number of multiple document summarization engines are provided which generate summaries for specific classes of multiple documents clusters. A summarizer router is employed to determining a relationship of the documents in a cluster and select one of the document summarization engines for use in generating a summary of the cluster. A single event engine is provided to generate summaries of documents which are closely related temporally and to a specific event.

Abstract: The present invention relates to the discovery that, in human cancer, an 11q deletion of ATM together with an increase in ATR and CHEK1 expression correlates with resistance to ionizing radiation which could be overcome by inhibition of the ATR/CHEK1 pathway. It provides for methods of identifying patients unlikely to exhibit an adequate response to radiation therapy and/or chemotherapy who may benefit from ATR/CHEK1 pathway inhibition, as well as methods of treating said patients.

Abstract: This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.

Abstract: The disclosed subject matter relates to a multilayer stretchy drawstring and methods of making the same. The drawstring of the disclosed subject matter is a stretched multilayer coextruded or laminated film that offers good balance between easy stretching at low strain and high strain hardening at high strain. The multilayer film includes a first layer of elastomeric polymer and second and third layers of thermoplastic polymer and is stretched beyond the deformation limit of the thermoplastic polymer and allowed to recover. This novel drawstring can be incorporated into a bag to enable the bag to be securely fitted to the upper portion of a trash container while not interfering with the intrinsic strength and operation of the drawstring.

Abstract: A molding apparatus can include a primary mold, a stripper, and a swinging member. The swinging member can comprise a molding surface defining an undercut portion of a molded item. The swinging member can directly contact or attached to the stripper and the primary mold. To facilitate removal of a molded item, the swinging member can withdraw through a hole in the primary mold as a direct result of a motion of the stripper to pull the molded item off the primary mold. The molded item can then be easily removed.

Abstract: One apparatus for releasing a chemical in a well bore includes a casing collar configured to couple to a casing string. A chemical container is disposed within the casing collar, and the casing collar is configured to release the chemical from the chemical reservoir.

Abstract: An apparatus for reverse circulation cementing of surface casing in subterranean formations and associated methods are provided. One example of a method may involve a method of reverse circulation cementing a surface casing in a well bore with a conductor casing positioned therein comprising: providing a tool comprising at least one isolation device coupled to the surface casing; positioning the isolation device in the well bore to isolate an annulus between the surface casing and the conductor casing; flowing cement through a port in the conductor casing in a reverse circulation direction; and allowing the cement to set therein.

Abstract: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural cells. Also provided are differentiated cells, cell populations and transgenic animals comprising same and uses of same. The present invention further provides methods for treating nervous tissue degeneration and for identifying an agent for use in treating nervous tissue degeneration. Methods for promoting apoptosis in neoplastic cells and for treating or preventing tumors, and identifying agents for use in treating or preventing tumors are also provided by the present invention. The present invention further provides methods for identifying agents that inhibit ATF5, agents identified by these methods.

Abstract: The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity.

Abstract: Methods and systems for characterizing drilling fluids laden with LCM (Lost Circulation Material) and other solid materials are disclosed. A test cell for analyzing a fluid is provided with a first conical inner portion and an axial positioning device positioned along an axis of the test cell. A first conical plug is coupled to the axial positioning device and is movable in and out of the first conical inner portion along the axis of the test cell. A fluid inlet is positioned at a first location on the test cell and a fluid outlet at a second location.

Abstract: A downhole tool assembly has a sleeve with a continuous j-slot, a lug rotator ring configured to move axially relative to the sleeve and having a lug configured to move within the continuous j-slot, and a rupture disk configured to prevent the lug from moving within the continuous j-slot during run-in. A method of activating the downhole tool assembly includes lowering the downhole tool assembly into a well bore on a tool string, rupturing the rupture disk, allowing the lug to move within the continuous j-slot, and setting the downhole tool assembly by lifting upward and pushing downward on the tool string.

Abstract: The present invention relates, in general, to subterranean fluids, and more particularly, to subterranean drilling fluids that may be useful for reducing the production of water from a portion of a subterranean formation and/or stabilizing an unconsolidated portion of a subterranean formation while drilling. In some embodiments, the present invention provides methods of reducing the flow of water from a portion of a subterranean formation that comprise contacting the portion of the subterranean formation with an organoaluminum compound, the organoaluminum compound being capable of forming a reaction product in the presence of water. The present invention also includes methods of drilling a well bore in a subterranean formation, methods of enhancing the stability of an unconsolidated portion of a subterranean formation, methods of stabilizing an unconsolidated portion of a subterranean formation, and drilling fluids.

Abstract: The present invention relates, in general, to subterranean fluids, and more particularly, to subterranean drilling fluids that may be useful for reducing the production of water from a portion of a subterranean formation and/or stabilizing an unconsolidated portion of a subterranean formation while drilling. In some embodiments, the present invention provides methods of reducing the flow of water from a portion of a subterranean formation that comprise contacting the portion of the subterranean formation with an organoaluminum compound, the organoaluminum compound being capable of forming a reaction product in the presence of water. The present invention also includes methods of drilling a well bore in a subterranean formation, methods of enhancing the stability of an unconsolidated portion of a subterranean formation, methods of stabilizing an unconsolidated portion of a subterranean formation, and drilling fluids.

Abstract: Methods and apparatuses for releasing a chemical in a well bore are disclosed. One apparatus includes a curved member configured for coupling to a casing, and a hollow member is connected to the curved member. A chemical container is disposed, at least in part, within the hollow space, and the hollow member extends at least partially around a hollow space.