Abstract: The present invention relates to measuring equipment (1) that includes at least two sensors (2, 3), each being adapted to sense a measurement magnitude, a measuring card (6) to which said sensors (2, 3) are coupled, and a computer unit to which the measuring card is coupled. At least one of the sensors (2) is adapted to sense prevailing frequencies of an object (11) to be measured. At least one of the sensors (3) is adapted to evaluate prevailing tacho-pulses of an object (11) to be measured. The circuits in said measuring card (16) are adapted to evaluate prevailing sound and vibrations generated by the rotating object (11) in response to information received with respect to prevailing frequency and prevailing tacho-pulses, by dividing the time distance between two tacho-pulses into a number of sub-sections and generating a circuit-internal tacho-signal for each sub-section.
Abstract: To increase the effective affinity of soluble analogs of peptide/MHC molecules for their cognate ligands, divalent peptide/MHC complexes were constructed. Using a recombinant DNA strategy, DNA encoding the MHC class I was ligated to DNA coding for murine Ig heavy chain. MHC/Ig complexes were exploited to homogeneously load with peptides of interest. The results of flow cytometry demonstrated that the pepMHC/Ig complexes bound specifically with high affinity to cells bearing their cognate receptors.
pepMHC/Ig complexes are also useful in modulating effector functions of antigen-specific T cells. These pepMHC/Ig complexes are useful for studying TCR/MHC interactions and lymphocyte tracking and have uses as specific regulators of immune responses.
Type:
Grant
Filed:
September 10, 1998
Date of Patent:
July 31, 2001
Assignee:
The Johns Hopkins University
Inventors:
Jonathan Schneck, Drew Pardoll, Sean O'Herrin, Jill Slansky, Tim Greten
Abstract: A word line driving circuit drives four word lines in response to a signal supplied from a main row decoder through a main word line and in response to a word line driving voltage supplied from a sub-row decoder. When the word line driving circuit is not selected by the main word line, a first reset circuit allows each word line to be short-circuited. When the word line driving circuit is selected by the main word line, second to fifth reset circuits allow the non-selected word line to bear a ground potential by using a signal of the selected word line.