Patents Represented by Attorney, Agent or Law Firm Barbara L. Renda
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Patent number: 6162455Abstract: There is provided a method for increasing lean meat, improving the lean meat to fat ratio and improving amino acid utilization in warm-blooded animals by administering an effective amount of an alpha-2 adrenergic receptor antagonist.Type: GrantFiled: December 8, 1997Date of Patent: December 19, 2000Assignee: American Cyanamid CompanyInventors: Ralph M. Cleale, IV, Mark H. Pausch, John R. Hadcock
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Patent number: 6159956Abstract: The present invention provides an improved process and intermediate compounds for the preparation of difluorovinylsilane insecticide and acaricidal agents of the formula I ##STR1## wherein Ar is phenyl, 1- or 2-napthyl or a 5- or 6-membered heteroaromatic ring, each of which may be optionally substituted by any combination of from one to three halogen,C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, haloalkoxy, C(O)R.sub.2 or S(O).sub.n R.sub.3 groups,R and R.sub.1 are each independently C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.5 cycloalkyl;Ar.sub.1 is phenoxyphenyl, phenyl, biphenyl, phenoxypyridyl, benzylpyridyl, benzylphenyl,1- or 2-napthyl or a 5- or 6-membered heteroaromatic ring, each of which may be optionally substituted by any combination of from one to five halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy or C(O)R.sub.4 groups,n is an integer of 0, 1 or 2;R.sub.2 and R.sub.4 are each independently C.sub.Type: GrantFiled: July 8, 1998Date of Patent: December 12, 2000Assignee: American Cyanamid Co.Inventors: Keith D. Barnes, Yulin Hu
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Patent number: 6127570Abstract: Substituted 2-hydroxybenzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.Type: GrantFiled: June 10, 1999Date of Patent: October 3, 2000Assignee: American Cyanamid CompanyInventors: Juergen Curtze, Gerd Morschhaeuser, Henry Van Tuyl Cotter
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Patent number: 6124301Abstract: Adjuvants selected from liquid polyalkoxylated aliphatic alcohols, solid sodium hydrocarbyl sulfonates and polyalkoxylated trisiloxanes enhance the efficacy of fungicidal triazolopyrimidines. They can be incorporated into formulations of the fungicidal compounds or be added to spray mixtures (tank mix) as separately formulated additives in order to improve the efficacy, systemicity and spectrum of these fungicides.Type: GrantFiled: March 15, 1999Date of Patent: September 26, 2000Assignee: American Cyanamid CompanyInventors: Michael Aven, Henry Van Tuyl Cotter, Leslie May
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Patent number: 6110871Abstract: The novel cyanopyridines of the general formula (I) ##STR1## (A, B, R.sup.1, R.sup.2, X, m and n are defined in the specification) show selective herbicidal activity.The new compounds can be prepared according to known methods and can be used as herbicides in agriculture and related fields.Type: GrantFiled: July 15, 1999Date of Patent: August 29, 2000Assignee: American Cyanamid CompanyInventors: Thomas Maier, Stefan Scheiblich, Helmut Siegfried Baltruschat
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Patent number: 6096769Abstract: The invention relates a concentrated liquid fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent and(a) at least one compound of formula I, ##STR1## (b) one or more additional fungicidal active ingredients, which exist as a suspension of fire particles;(c) a solubilizing agent; and(d) a dispersing agent, which has the capability to adsorb irreversibly on the surfaces of hydrophobic particles suspended in water or polar organic solvents.Type: GrantFiled: April 20, 1998Date of Patent: August 1, 2000Assignee: American Cyanamid CompanyInventors: Michael Perlitz, Friedrich Schmidt, Annerose Edith Elise Rehnig, Ewald Gerhard Sieverding, Christopher William Horsler
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Patent number: 6090806Abstract: The invention relates to fungicidal compositions comprising synergistically effective amounts ofat least one acrylic acid morpholide of formula I ##STR1## in which R.sup.1 and R.sup.2 have the meaning given in claim 1 and at least one fungicidal oxazolidinone of formula II ##STR2## in which R.sup.3.sub.1 R.sup.4 and Ar have the meaning given in claim 1, and to a method of controlling the growth of phythopathogenic fungi and/or the plant disease caused by them at a locus which comprises applying synergistically effective amounts of at least one acrylic acid morpholide of formula I (a) and at least one fungicidal compound of formula II (b) to the locus, together with a fungicidally acceptable carrier and/or surface active agent.Type: GrantFiled: August 31, 1998Date of Patent: July 18, 2000Assignee: American Cyanamid CompanyInventor: Henry Van Tuyl Cotter
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Patent number: 6087506Abstract: The invention relates to a process for the preparation of heteroarylcarboxylic amides and esters of formula I ##STR1## in which one or two of the groups A.sup.1, A.sup.2, A.sup.3, A.sup.4, and A.sup.5 represent a nitrogen atom and the other groups each independently represent CR.sup.3,Hal represent s a halogen atom,X represents oxygen or NR.sup.2,R.sup.1 represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group,R.sup.2 represents a hydrogen atom or an alkyl group, orR.sup.1 and R.sup.2 together with the interjacent ring form a heterocyclic group, andR.sup.3 each independently represent a hydrogen atom or an alkyl group,which comprises heating a mixture of a compound of formula II, ##STR2## and concentrated sulfuric acid, and reacting the resulting intermediate with in alcohol or amine of formula IIIHXR.sup.1 III.Type: GrantFiled: July 17, 1998Date of Patent: July 11, 2000Assignee: American Cyanamid CompanyInventors: Marcus Knell, Monika Brink, Jan Hendrik Wevers, Willi Heinz
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Patent number: 6087498Abstract: There is provided a process for the preparation of unsymmetrical 4,6-bis(aryloxy)pyrimidine compounds. The unsymmetrical 4,6-bis(aryloxy)pyrimidine compounds are useful as pesticidal agents.Type: GrantFiled: March 16, 1999Date of Patent: July 11, 2000Assignee: American Cyanamid CompanyInventors: William Wakefield Wood, Salvatore John Cuccia, Robert Brigance
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Patent number: 6034253Abstract: There is provided a process for the preparation of 5-(alkoxymethyl)-2,3-pyridinedicarboximide compounds having the structural formula I ##STR1## The 5-(alkoxymethyl)-2,3-pyridinedicarboximide compounds are useful as intermediates in the preparation of herbicidal 5-(alkoxymethyl)-2-(2-imidazolin-2-yl)-nicotinic acid, ester and salt compounds.Type: GrantFiled: January 22, 1999Date of Patent: March 7, 2000Assignee: America Cyanamid CompanyInventors: Kenneth Alfred Martin Kremer, Wen-Xue Wu, Donald Roy Maulding, deceased
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Patent number: 6030924Abstract: The novel solid formulations obtained by low pressure extrusion of a mixture comprisingat least one active ingredient; andat least one defoaming agent and/or foam breaking agent from thegroup consisting of perfluoroalkylphosphinic acids and/orperfluoroalkylphosphonic acids and/or their salts,show foam breaking activities even after extrusion, drying and storage at elevated temperatures and are thus very suitable for preparing tank mixtures for use in crop protection.Type: GrantFiled: May 1, 1998Date of Patent: February 29, 2000Assignee: American Cyanamid CompanyInventors: Winfried Mayer, Christian Wassmer, Sandra Doerr
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Patent number: 6002012Abstract: There is provided a process for the preparation of [(5,6-dicarboxy-3-pyridyl)methyl]ammonium halides having the structural formula I ##STR1## The [(5,6-dicarboxy-3-pyridyl)methyl]ammonium halides are useful as intermediates in the preparation of herbicidal 5-(alkoxymethyl)-2-(2-imidazolin-2-yl)-nicotinic acids, esters and salts.Type: GrantFiled: March 20, 1998Date of Patent: December 14, 1999Assignee: American Cyanamid CompanyInventor: Wen-Xue Wu
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Patent number: 5989566Abstract: The invention relates to certain stable vaccine compositions comprising a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof; at least one antigen; a dispersing agent; an adjuvant; a water soluble organic solvent; and saline or water or mixtures thereof. The invention further relates to stable compositions as described above of a macrocyclic lactone compound, a milbemycin compound, an avermectin compound or mixtures thereof, but without an antigen. The invention also relates to a method for preventing or controlling helminthiasis, infection by acarids and arthropod endo-and ectoparasites and bacterial and viral disease in warm-blooded animals by the parenteral administration of compositions of the invention. The invention further relates to a process for the preparation of the invention compositions.Type: GrantFiled: June 28, 1996Date of Patent: November 23, 1999Assignee: American Cyanamid CompanyInventors: Ramune Marija Cobb, Christopher Leigh Schwartzkoff
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Patent number: 5905154Abstract: There is provided a process for the preparation of 5-(alkoxymethyl)-2,3-pyridinedicarboximide compounds having the structural formula I ##STR1## The 5-(alkoxymethyl)-2,3-pyridinedicarboximide compounds are useful as intermediates in the preparation of herbicidal 5-(alkoxymethyl)-2-(2-imidazolin-2-yl)nicotinic acid, ester and salt compounds.Type: GrantFiled: June 10, 1997Date of Patent: May 18, 1999Assignee: American Cyanamid CompanyInventors: Kenneth Alfred Martin Kremer, Wen-Xue Wu, Donald Roy Maulding, deceased
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Patent number: 5856576Abstract: There are provided aryne intermediates of formula I, useful in the manufacture of herbicidal compounds. ##STR1## Also provided is a method to prepare the formula I intermediates via the palladium catalyzed coupling of an o-halonitrobenzene or o-haloaniline with 3-butyne-1-ol.Type: GrantFiled: January 29, 1998Date of Patent: January 5, 1999Assignee: American Cyanamid CompanyInventors: Philip M. Harrington, Kenneth A. M. Kremer
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Patent number: 5849916Abstract: There is provided a process for the preparation of 2,3-pyridinedicarboximides having the structural formula I ##STR1## The 2,3-pyridinedicarboximides are useful as intermediates in the preparation of herbicidal 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts.Type: GrantFiled: June 10, 1997Date of Patent: December 15, 1998Assignee: American Cyanamid CompanyInventors: Kenneth Alfred Martin Kremer, Wen-Xue Wu, Donald Roy Maulding, deceased
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Patent number: 5763615Abstract: This invention is directed to certain substituted aryloxy benzotriazole compounds which are herbicidal agents. The invention is further directed to methods for the preparation of the aryloxy benzotriazole compounds.Type: GrantFiled: June 25, 1997Date of Patent: June 9, 1998Assignee: American Cyanamid CompanyInventor: Thomas Andrew Lies
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Patent number: 5760239Abstract: There is provided an improved method for the conversion of 5,6-dicarboxyl-3-pyridylmethyl ammonium halide to 5-(alkoxymethyl)pyridine-2,3-dicarboxylate salt via a single step closed reaction with the appropriate alcohol and a base at a temperature of about 120.degree.-180.degree. C.The product pyridinedicarboxylate salt is an important intermediate in the manufacture of pyridine imidazolinone herbicidal agents.Type: GrantFiled: July 16, 1997Date of Patent: June 2, 1998Assignee: American Cyanamid CompanyInventor: Wen-Xue Wu
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Patent number: 4769372Abstract: A method of treating patients in chronic pain or suffering from chronic cough over a prolonged period to provide systemic analgesia or central antitussive effect while simultaneously avoiding the onset of intestinal hypomotility. The method includes the oral administration to the patient of dosage units comprising in combination opioid analgesics or antitussives and selected opioid antagonists which are substantially devoid of systemic antagonist activity when administered orally.Type: GrantFiled: June 18, 1986Date of Patent: September 6, 1988Assignee: The Rockefeller UniversityInventor: Mary J. Kreek
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Patent number: RE32788Abstract: The invention comprises a negative-pressure plastic bag leader in the form of a cylindrical chamber into which the plastic bag is received. The chamber is double-walled, an outer wall being imperforate, and the inner wall being foraminous, and the two being spaced apart, in a substantial concentricity, to define an annular void therebetween. A closure caps the upper, open end of the chamber, and has a conduit in traverse thereof through which to admit gas, and refuse suspended in such gas into the chamber. Further, the closure has an aperture formed therethrough for communicating with a source of negative pressure, and for extracting gas from the chamber. The aperture opens into the chamber and also into the annular void. Accordingly, both the chamber and the annular void experience the same negative pressure, and the plastic, refuse-collecting bag is held securely in place against the inner wall of the chamber.Type: GrantFiled: February 13, 1987Date of Patent: November 22, 1988Inventor: William G. Disanza, Jr.