Abstract: There is disclosed a novel and improved method of synthesizing aporphines utilizing the Pschorr cyclization of 1-(2'-aminobenzyl)-7 hydroxy-1,2,3,4-tetrahydroisoquinolines in place of the corresponding 7-methoxy compounds.In the novel process of the present invention the amino group is diazotized and cyclized in the presence of copper powder.

Abstract: A magazine apparatus adapted for presenting run off spools to a rewinding machine comprising a drive mechanism, a rotating means driven by said drive mechanism, a plurality of free hanging arm means pivotally connected to a said rotating means and a spool support plate connected to said free hanging arm means for supporting the spools during presentation to the machine. According to a preferred embodiment, the rotating means comprises a single bar but also disclosed are embodiments in which the rotating means comprises a three pointed star or a disc means. The rotating means is driven in a plane that is parallel with respect to the pull of gravity. The free hanging arm means and the associated spool support plates are adapted to maintain the spool in an upright position during the entire course of rotation of the rotating means. The disclosed apparatus is relatively simple in structure and allows a machine attendant to swiftly and easily replace exhausted spools.

Abstract: A circular saw includes a plurality of teeth having an improved metal breaking geometry. The saw is especially adapted to cut hard, brittle materials such as steel bars and the like. The saw teeth are generated by a cup shaped grinding wheel having a grinding face on its inside surface. By bringing the rotating inner surface of the grinding wheel into contact with each tooth, it is possible to produce a working surface on each tooth which exhibits improved metal breaking and self-cleaning characteristics. The working surface thus generated is characterized by the fact that all points on the working surface which lie in the same given plane perpendicular to the axis of rotation of the grinding wheel are equally distant from any given point on that axis. The working surface is preferably a section of a cylinder or cone, but may exhibit irregularities or discontinuities for special applications.

Abstract: The present invention relates to novel 1-oxacephems of the formula ##STR1## wherein R.sup.9 is hydrogen and R.sup.8 is hydrogen orRCO-wherein R is selected from the group consisting of lower alkyl ##STR2## wherein Ar is a monovalent radical selected from the group consisting of ##STR3## wherein R.sub.1, R.sub.2 and R.sub.3 are each a member selected from the group consisting of hydrogen, chloro, bromo, iodo, trifluoromethyl, phenyl, lower-alkyl and lower alkoxy, but only one of said R.sub.1, R.sub.2 and R.sub.3 may represent phenyl;R.sup.4 is hydrogen, amino, carbobenzoxyamino, phenyl, fluoro, chloro, bromo, iodo, carboxyl, SO.sub.3 H, azido, hydroxy, loweralkanoyloxy or loweralkoxy;X is oxygen or sulfur;R.sup.5 and R.sup.6 are hydrogen, phenyl, benzyl, phenethyl or loweralkyl;Z.sup.1, z.sup.2 and Z.sup.3 are loweralkyl or the Ar- group;R.sup.12 is 2,2,2-trichloroethyl or benzyl;Provided that when R.sup.8 and R.sup.

Abstract: A sample of fluid is processed in a sandwich-like processing card comprising an upper layer and a lower layer, at least one of which layers has pliable characteristics. The space between the two layers is completely filled with a liquid preferably having certain grease-like characteristics so as to exclude all contaminating air. The liquid filled space is referred to as the activity plane. In operation, a sample of the fluid to be tested in the form of a small droplet is injected into the activity plane so as to constitute a blister. The blister may be moved throughout the activity plane by an external pusher of appropriate geometry. The pusher acts upon the blister by pressing on and moving along the pliable layer. Also located in the activity plane are a plurality of chemical, physical or detecting process stations to which the blister may be moved by the pusher as desired. The entire apparatus preferably is rectangular in shape but also may be circular or cylindrical.

Abstract: There are provided novel diterpenoid triepoxides, derived from Tripterygium wilfordii Hook F. which possess high and surprising antileukemic activity at dosage levels of micrograms/kilogram body weight.

Abstract: A pneumatic apparatus is employed to automatically load blood extracting devices. The apparatus includes a cylinder and a piston slidably receivable therein. The piston is connected to a casing or housing which supports a blood extracting device. The cylinder may be partially evacuated by forcing it into the housing. Once evacuated the cylinder is maintained in the biased position by a locking lever. The cylinder may be connected either to a blood receiving vessel or to a piston receivable within the blood receiving vessel through which the blood may be extracted. In order to extract blood the extracting device is first positioned in the vein of a patient in the conventional manner. The locking lever is then released and the partial vacuum within the cylinder causes the plunger within the blood receiving vessel to draw blood inwardly. A check valve and parallel channel arrangement in the plug at one end of the cylinder serves to slow and control the rate at which the blood is extracted.

Abstract: There is provided a yarn guide unit for use with Jacquard controlled warp knitting machines. The guides comprise a plurality of conventional yarn guides and, between each yarn guide there is provided a shorter, rigid tab. The guides and the tabs are mutually oriented so that the head of the tab contacts an adjacent face of its neighboring yarn guide. The contacted face of the yarn guide is always the side of the yarn guide other than that contacted by the influencing Jacquard dropper pin. The effect achieved by the presence of rigid contacting tabs is to both reduce feathering of the yarn guides after withdrawal of the influencing Jacquard dropper pin and to insure that the yarn guide, on the immediately following stitch cycle is correctly oriented in the warp knitting machine with respect to the needle bed.

Abstract: A folding invalid walker includes an improved mechanism for rigidly locking the walker in its unfolded state. The mechanism comprises a pair of tubular telescoping members each having an inner portion which telescopes into an outer portion. A spring loaded button is used to lock the tubular telescoping member in its extended state. One end of each of the tubular telescoping members is riveted to the rear leg of the walker support and the other end is pivotally connected to a transversely disposed bar connecting both front legs of said walker. The rivet connection is slightly flexible so that the tubular telescoping member can flex a small amount with respect to the rear leg of said support as the walker is folded from its folded to its unfolded state and vice versa. The location of the pivot joint on the rear leg is such that a rivet can be used and a more expensive and less rigid pivot connection can be avoided.

Abstract: This invention relates to ortho-alkoxy anilines having the amino group substituted with an amino lower alkyl carboxylic residue, as well as their physiologically-compatible acid-addition salts and their optically-active isomers.

Abstract: An in-line book making system produces sets of signatures ready for "come and go" binding. Webs printing in respective presses are slit collated and folded into signatures which are fed in succession to two collecting pockets, one pocket receiving a batch of signatures totalling all the pages of the book and then the other pocket receiving a similar batch. The batches are fed in identical orientations from the respective pockets to respective conveyors, which cause a relative rotation of the batches through 180.degree.. The two batches are then brought together, when they together contain all the pages for two books in a disposition which can be bound in come and go binding and then cut apart.The signatures may be made by a former-folding process.The conveyor system may additionally be operable to eliminate the 180.degree. relative rotation, in case simple binding is desired.

Abstract: This invention relates to indazole derivatives, to processes for their preparation and to pharmaceutical compositions containing them.More specifically this invention relates to 4, 5, 6, 7-tetrahydroindazoles bearing at the 3-position an amino substituent.This invention also relates to processes for producing the same which include the steps of condensing a substituted cyclohexanone with a secondary amine, reacting the thus formed enamine either with an isocyanate or thiocyanate or with phosgene imonium salt and cyclizing the intermediate compound with a hydrazino derivative.The compounds of the invention have therapeutic utility, namely as a means for controlling fertility in mammals.

Abstract: There is disclosed a novel total synthesis of Thalicarpine which includes inter alia a total synthesis of hernandaline. The novel process is characterized in utilizing simple and readily available starting materials to form a diaryl ether system which is then condensed with a 3,4-dihydroisoquinolinium salt which is then converted to hernandaline. Hernandaline is reacted with a bicyclic Reissert compound to yield a compound having the thalicarpine skeleton, nascent hydrogen reduction yields N-monodesmethyl thalicarpine which is methylated.

Abstract: Heterocyclic amides of the formula: ##EQU1## wherein: X is N or CH;n is O or 1 andR is ##EQU2## wherein: R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar - A- or ##EQU3## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methylenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

Abstract: Heterocyclic amides of the formula: ##SPC1##Wherein:X is N or CH;n is O or 1 andR is ##EQU1## or ##SPC2##Wherein:R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3 which are the same, are lower alkyl or joined together, represent a polymethylenic chain from C.sub.4 to C.sub.7 optionally including an oxygen atom, andR' is saturated or unsaturated acyclic hydrocarbon radicals from C.sub.1 to C.sub.20, cycloalkyl from C.sub.3 to C.sub.7, Ar -- A-- or Ar ##EQU2## wherein: A is a single bond or a saturated or unsaturated acyclic hydrocarbon chain from C.sub.1 to C.sub.6 optionally including an oxygen atom, andAr and R" are aromatic, alkoxy aromatic, methlenedioxy aromatic or polymethylenedioxy aromatic.These compounds are used as medicine, especially in the treatment of gastric hypersecretion, gastroduodenal ulcers and central nervous system disorders.

Abstract: There is provided a novel simaroubolide derived from Brucea antidysenterica which possesses high and surprising anti-leukemic activity at dosage levels of micrograms per kilogram body weight.

Abstract: Pharmaceutical compositions containing tetrahydroalstonine or a therapeutically acceptable salt thereof are disclosed. These compositions are useful for treating circulation disorders and more particularly brain circulation disorders.

Abstract: A warp knitting machine includes an improved thread feeding apparatus. The thread feeding apparatus includes a source of weft threads which are drawn through a plurality of flexible tubes and are connected in groups to a plurality of slideable blocks. The blocks are adapted to move sequentially in synchronization with a conventional weft thread transfer chain having standard weft thread pick-up clamps attached thereto. The invention allows a large number of threads to be fed to a conventional warp knitting machine at one time.

Abstract: A cup-shaped grinding wheel having an abrasive inner rim is brought into grinding contact with a tooth of a circular saw. The angle of attack of the grinding wheel is such that it imparts a second surface to the face of the saw tooth. The second generated surface has a continuous curved contour and a more negative average rake angle than the remaining portion of the face of said tooth. The apparatus and method are especially adapted to grinding the carbide tipped teeth of steel cutting saws but this technique may be used on other saw blades. Movements of the machine elements are automatically governed by a programmed electronic unit which, in turn, controls a system of hydraulic pistons.

Abstract: A stacking mechanism and method brings batches of articles from a shingled formation on a conveyor to a vertically stacked formation without stopping the progress of any of them. Shingled articles are pushed forward from behind by a pusher at a speed greater than that of a conveyor on which they are supported while at the same time a slower-moving obstruction is erected in their path offering a vertical rear wall. The articles successively align against the rear wall of the obstruction until when the longitudinal distance between the pusher and the obstruction has become substantially the same as the length of the articles, so that all of a batch of shingled articles must have been stacked, the obstruction is withdrawn and the stack is driven on by the pusher. Hooks may travel at the same speed as the conveyor and engage over a trailing edge of the last article in a shingled batch of articles to help define the end of the batch.