Abstract: GAPDH binds to expanded polyglutamine regions which are found in proteins encoded by genes with CAG repeat domains, which genes cause inherited neurodegenerative disorders and are associated with certain psychiatric disorders. Therapeutic methods are based on inhibiting the binding of GAPDH to expanded polyglutamine regions. A method of screening compounds for the ability to inhibit binding of GAPDH to polyglutamine regions is described.

Abstract: The present invention relates mainly to a wrapping method and to apparatus for implementing the method. The invention provides a method of wrapping a palletized load, the method comprising a step of depositing one or more plastic films around the palletized load, thereby covering the palletized load and closing the inlets to the pallet, the method including a step that consists in disengaging permanent passages in the film where it obstructs the inlets of the pallet for passing the forks of handling equipment. The present invention is particularly applicable to wrapping palletized loads. A main application of the present invention lies in wrapping loads that are palletized on standard pallets.

Abstract: A novel method of preparing a spinel Li.sub.1+X Mn.sub.2-X O.sub.4+Y intercalation compound with low lattice distortion and a highly ordered and homogeneous structure for 4 V secondary lithium and lithium ion cells is provided. The method of preparing the spinel Li.sub.1+X Mn.sub.2-X O.sub.4+Y intercalation compound comprises providing a spinel Li.sub.1+X Mn.sub.2-X O.sub.4 intercalation compound having a lithium to manganese mole ratio of between about 1.02:2 and 1.1:2 and firing the spinel at different temperature ranges with corresponding gas flow rates to form the spinel Li.sub.1+X Mn.sub.2-X O.sub.4+Y intercalation compounds. The spinel Li.sub.1+X Mn.sub.2-X O.sub.4+Y intercalation compounds have a mean X value of between about 0.01 and 0.05, a mean Y value of between about -0.02 and 0.04 and a full width at half maximum of the x-ray diffraction peaks at a diffraction angle 2.theta. of planes (400) and (440) using CuK.alpha..sub.1 rays of between about 0.08.degree. and 0.13.degree.. The spinel Li.sub.

Abstract: An apparatus for trimming multiple-sheet, folded printed products utilizing two processing drums adjacently arranged. The drums are each rotated about a horizontal axis by a drive mechanism. Each processing drum comprises radial compartments for receiving the printed products to be trimmed. Arranged on each end side of the first processing drum are two stationary cutting elements, one of which is in the operative position. The cutting element interacts with cutting elements which are fastened on the end side of the compartments on the compartment walls. In the first processing drum, the printed products are trimmed on their side borders running at right angles to the folding edge. Arranged on the circumferential edge of the second processing drum are stationary cutting elements with a cutting element in an operative position to interact with cutting elements which are assigned to the individual compartments and are arranged circumferentially in the compartments.

Abstract: A resilient and flexible base for a two-piece traffic channelizer is provided that does not require external ballasting to stabilize the channelizer against wind forces and vacuum forces created by passing vehicles and minor impacts from a vehicle. The base is formed of a hardenable liquid resin such that the base is resilient and flexible after curing and has a specific gravity greater than about 1.25. The base further includes at least one flexible footpad for generating a restoring moment when the channelizer is subjected to a tipping force, such as a minor impact. The composition of the liquid resin includes at least one off-grade polyvinylchloride (PVC) resin, a plasticizer and a specific gravity increasing agent. A method is also provided for forming the base by slush molding at least a portion of the hardenable liquid resin adjacent the interior surface of a molding cavity. The base formed by the disclosed method is also self-lubricating and resistant to chemical degradation and extreme temperatures.

Abstract: A surface inspection system and methods of inspecting a surface of a workpiece are provided for detecting particles, defects, or other surface characteristics in or on a surface of the workpiece. The surface inspection system preferably has a transporter arranged for transporting a workpiece along a material path and a rotator associated with the transporter and arranged for rotating a workpiece during translational travel along the material path. A scanner is positioned and arranged for scanning a surface of a workpiece during rotational and translational travel along the material path. The scanner preferably includes a light source arranged to generate a light beam therefrom and a deflector positioned to receive the light beam and arranged for deflecting the light beam along a predetermined scan path across a surface of the workpiece as the workpiece rotationally and translationally travels along the material path.

Abstract: A process for preparing thioxanthone and derivatives thereof is disclosed. In the process, an aromatic compound, such as cumene, is reacted with thiosalicylic acid (TSA) or dithiosalicylic acid (DTSA) in the presence of sulfuric acid. The reaction mixture, which includes thioxanthone or a derivative thereof, is thereafter distilled under reduced pressure to recover the thioxanthone compound.

Abstract: In a mechanically redundant actuator system, the actuator has a structurally redundant members for attaching it between a stationary anchor point to a movable control surface. Specifically the actuator consists of a cylinder body, a double action piston with a piston rod attached to the control surface at one end and a swivel bar at the other end. Single or multiple tie rods are attached between the swivel bar and the movable control surface. Each tie rod can withstand one half the load of the piston rod. Also, trunnion links attach the cylinder body to the structure. Each trunnion links can withstand the full limit load with or without any load factors. The trunnion fittings can be any configuration that provides a structural reaction, and provides a dual load path and freedom of movement in at least two axes. At least two of these actuator units are required per surface. Also, a dual tandem control valve with a hydraulic compensator for each actuator is required.

Abstract: An integrated circuit output driver system includes a first power line channel extending along the integrated circuit. The first power line channel includes a first power supply voltage line and a first ground voltage line. A second power line channel also extends along the integrated circuit and is spaced apart from the first power line channel. The second power line channel includes a second power supply voltage line and a second ground voltage line. A plurality of output drivers are located between the first and second spaced apart power line channels. Each output driver includes an output node, a pull-up circuit which pulls up the output node in response to a pull-up input signal, and a pull-down circuit which pulls down the output node in response to a pull-down input signal.

Abstract: The invention relates to a cooling assembly for a fiber spinning machine, which forms a cooling zone for the fibers and has openings, through which a cooling fluid flows to the fibers. The cooling assembly is formed by a plurality of overlying annular elements. Arranged between the elements are spacers so as to permit air to flow between the elements into the cooling assembly.

Abstract: Permanent magnets affixed to one structure produce a repelling force to magnets affixed to a larger structure that encloses the one structure to suspend and hold the one structure entirely within the larger structure, without physical contact therebetween.

Abstract: The spade-type boring bit includes an elongate shank defining a central longitudinal axis and a blade portion joined to one end of the shank. The blade portion includes a pair of generally flat side segments extending laterally from the central longitudinal axis and having a respective forward cutting edge and a respective chamfered corner portion. Each chamfered corner portion includes a chamfered edge which extends both axially rearward and laterally outward from the respective forward cutting edge so as repeatedly cut the peripheral wall of the resulting hole as the spade bit is rotatably advanced through a workpiece. The spade bit therefore produces a high-quality hole having a smooth peripheral wall and relatively clean entry and exit points. In addition, the forward cutting edges of the spade bit can be aligned with each other along a centerline which passes through the central longitudinal axis of the elongate shaft so as to increase the efficiency with which the spade bit drills.

Abstract: A flexible decorative sheet material for use in surfacing automobile body panels and the like is disclosed. The sheet material is characterized by having the appearance of a base coat/clear coat paint finish. The material comprises a substantially transparent outer layer, and a pigmented coating on the undersurface of the outer layer which is visible therethrough. The pigmented coating preferably has reflective flakes uniformly distributed therein to impart to the sheet material the appearance of a base coat/clear coat paint finish. Also disclosed are shaped articles which have such sheet materials adhered to one side thereof, and a method for making such sheet materials.