Patents Represented by Attorney Beth A. Burrous

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  • 3-(cycloalkanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
    Patent number: 6579897
    Abstract: The present invention relates to novel 3-(cycloalkano-heteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: December 31, 2001
    Date of Patent: June 17, 2003
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Li Sun, Gerlad McMahon
  • rdgB proteins and related products and methods
    Patent number: 6576442
    Abstract: The present invention features a method for treatment of an organism having a disease or condition characterized by an abnormality in a signal transduction pathway, wherein the signal transduction pathway includes a rdgB protein. The invention also features methods for diagnosing such diseases and for screening for agents that will be useful in treating such diseases. The invention also features purified and/or isolated nucleic acid encoding a rdgB protein.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: June 10, 2003
    Assignees: Sugen, Inc., New York University Medical Center
    Inventors: Sima Lev, Gregory D. Plowman, Joseph Schlessinger
  • Pyrrole substituted 2-indolinone protein kinase inhibitors
    Patent number: 6573293
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: June 3, 2003
    Assignees: Sugen, Inc., Pharmacia & Upjohn Co.
    Inventors: Peng Cho Tang, Todd A. Miller, Xiaoyuan Li, Li Sun, Chung Chen Wei, Shahrzad Shirazian, Congxin Liang, Tomas Vojkovsky, Asaad S. Nematalla, Michael Hawley
  • 2-indolinone derivatives as modulators of protein kinase activity
    Patent number: 6569868
    Abstract: The present invention relates to novel imidazoly 2-indolinones and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: May 27, 2003
    Assignee: Sugen, Inc.
    Inventors: Peng Cho Tang, Li Sun, Gerald McMahon, G. David Harris
  • PTP 1D: a novel protein tyrosine phosphatase
    Patent number: 6548641
    Abstract: A novel protein tyrosine phosphatase is the protein designated PTP 1D. The PTP 1D protein may be produced by recombinant means, for example using a nucleic acid construct encoding the protein as provided herein. Also disclosed is an antibody specific for an epitope of PTP 1D, protein. Methods for identifying compounds which bind to a PTP 1D protein and inhibit or stimulate its enzymatic activity, pharmaceutical compositions comprising PTP 1D, and methods for treating a disease associated with PTP 1D, and methods for treating a disease associated with PTP 1D protein using such compositions, are provided.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: April 15, 2003
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Axel Ullrich, Wolfgang Vogel
  • 3-Methylidenyl-2-indolinone modulators of protein kinase
    Patent number: 6531502
    Abstract: The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: March 11, 2003
    Assignee: Sugen, Inc.
    Inventors: Pen Cho Tang, Li Sun, Todd Anthony Miller, Congxin Liang, Ngoc My Tran, Anh Thi Nguyen, Asaad Nematalla