Patents Represented by Attorney Billups, Richard C.

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  • Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates
    Patent number: 5340927
    Abstract: A novel process for preparing 2-diazo-3-trisubstituted silyloxy-3-butenoates, synthons useful in the conversion of 3-substituted-4-acetoxy azetidinones and penicillin to thienamycin, imipenem and other carbapenem antibiotic compounds is provided, comprising the reaction of the appropriate diazo acetoacetate with the substituted silane, base and salt.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: August 23, 1994
    Assignee: Merck & Co., Inc.
    Inventor: David L. Hughes