Patents Represented by Attorney Bloom, Allen

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  • Spontaneous vesticulation of multilamellar liposomes
    Patent number: 4963297
    Abstract: A new method is disclosed for making unilamellar vesicles from multilamellar vesicles. Such vesicles are formed without the use of physical of chemical disruption processes known in the art for forming unilamellar vesicles. The liposomes are incubated at neutral pH at or near the transition temperature of the lipids used, in low ionic strength media such as distilled water. The liposomes may comprise bioactive agents and may be used in vivo or in vitro.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: October 16, 1990
    Assignee: The Liposome Company, Inc.
    Inventor: Thomas D. Madden