Abstract: A system and method for evaluating blood-neural barrier permeability. Phospholipid liposomes are labeled with a fluorescent phospholipase A2 substrate and exposed to cerebrospinal fluid. The change in fluorescence is monitored to determine PLA2 activity. The PLA2 activity is used to evaluate the permeability and function of the blood-neural barrier.

Abstract: Provided is a high-voltage solid electrolytic capacitor having a rated voltage of several hundreds of volts. After an anodic oxide film layer is formed on a roughened surface of an aluminum foil by way of a first conversion treatment, a hydrated film is formed by way of boiling water immersion; the hydrated film is provided with a second conversion treatment at a formation voltage lower than that of the first conversion treatment such that an anodic foil is formed; and a conductive polymeric layer is formed on a surface of the anodic foil.

Abstract: A light source adapter to mechanically interconnect a light box and a fiber optic cable. The adapter engages the light box and defines an interior cavity to receive a ferruled fiber optic cable. The exterior surface of the ferrule comprises a circumferential ridge and groove that reversibly interacts with a spring inside the adapter cavity. The spring is biased to require sufficient force to insert or remove the ferrule. The geometry of the circumferential ridge or groove can optionally be modified to increase or decrease the amount of force required to effect insertion or removal of the ferrule inside the cavity.

Abstract: The present invention relates to a neurotrophic peptide having an amino acid sequence selected from the group consisting of VGDGGLFEKKL (SEQ ID NO: 1), EDQQVHFTPTEG (SEQ ID NO: 2) and IPENEADGMPATV (SEQ ID NO: 3).

Abstract: A hoist system with an overspeed detection sub-system for detecting overspeed by comparing an actual drum assembly speed with a target value. For example, the rotation of a motor may be determined by a first rotary encoder and the rotation of a drum may be determined by a second rotary encoder. The output of the first rotary encoder (the basis of a target value) is compared with the output of the second rotary encoder (corresponding to actual motion of the drum). If the difference between the target value and the actual motion is too large, then a problem, such as a broken hoist hardware component may exist, and appropriate remedial action is taken, such as braking the motor and/or the drum.

Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.

Abstract: A light collection and concentration system includes a primary light concentrator, a light transport structure, and a light directing structure optically associated with the primary light concentrator. The system may include an optional secondary light concentrator. Each unit-system includes a plurality of the primary light concentrators and a respective plurality of the light directing structures, and only a single light transport structure. A photo-voltaic (PV) cell may advantageously be associated with each unit-system. Solar radiation is focused by the primary concentrators onto respective light directing structures incorporated in a low aspect ratio, sheet-type waveguide light transport structure. Each respective light directing structure intercepts the focused light and deflects it transversely to travel along the length of the light transport structure primarily via total internal reflection (TIR) towards an exit-end of the light transport structure, where it can be input to the PV cell.

Abstract: A shutter panel having multiple louvers that may be opened or closed in unison and which provide a flat, non-overlapping surface when placed in the closed position. Each louver is provided with a pivot post and a drive post, and the drive posts of each louver are interconnected to one or more control rods hidden within the stiles of the shutter panel. Each louver is beveled to encourage movement between the open and closed positions, and to assist with the formation of a substantially flat surface when the louvers are placed in the closed positions. The substantially flat surface formed when the louvers are closed may include an aesthetic design applied thereon or engraved therein.

Abstract: A self-powered sensor (e.g., 100, 180, 220, 400) can wake-up systems requiring a trigger signal to wake-up circuits or systems in power-sleep mode, conserving the battery power for emergency computations and communications. In a humidity sensor embodiment 100, radioisotope generated voltage biases are employed to power sensor capacitors to realize self-powered sensors. A first self-powered capacitor biasing architecture 160 is based on changes in the leakage resistance of the polymer capacitor 110, and a second self-powered capacitor biasing architecture 140 uses changes in the capacitance of the polymer capacitor. Another sensor embodiment uses changes in the capacitance or leakage resistance of the sensor capacitor to modulate conductance of a MOSFET 114, realizing an easily readable electronic output signal. A temperature sensor embodiment 180 and a MEMS cantilever structure based fissile material proximity sensor embodiment 400 are also disclosed.

Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

Abstract: A PCLC flake/fluid host suspension that enables dual-frequency, reverse drive reorientation and relaxation of the PCLC flakes is composed of a fluid host that is a mixture of: 94 to 99.5 wt % of a non-aqueous fluid medium having a dielectric constant value ?, where 1<?<7, a conductivity value ?, where 10?9>?>10?7 Siemens per meter (S/m), and a resistivity r, where 107>r>1010 ohm-meters (?-m), and which is optically transparent in a selected wavelength range ??; 0.0025 to 0.25 wt % of an inorganic chloride salt; 0.0475 to 4.75 wt % water; and 0.25 to 2 wt % of an anionic surfactant; and 1 to 5 wt % of PCLC flakes suspended in the fluid host mixture. Various encapsulation forms and methods are disclosed including a Basic test cell, a Microwell, a Microcube, Direct encapsulation (I), Direct encapsulation (II), and Coacervation encapsulation. Applications to display devices are disclosed.

Abstract: Three-dimensional grating device includes two (crossed) diffraction gratings, exhibits diffraction efficiency substantially independent of the incident polarization inside an optical communication spectral window from 1.5-1.6 ?m. The gratings are characterized by different periods in two directions, chosen to support only one dispersive diffraction order in addition to the zero-(specular) order. Gratings may be orthogonal. Exemplary grating profiles include but are not limited to sinusoidal and truncated pyramidal (trapezoidal) profiles. A method for diffracting polarization independent light with 90% or higher efficiency. Applications include various wavelength control devices particularly useful in telecommunications.

Abstract: The present invention is directed to a semiconductor device that includes at least one p-n junction including a p-type material, an n-type material, and a depletion region. The at least one p-n junction is configured to generate bulk photocurrent in response to incident light. The at least one p-n junction is characterized by a conduction band energy level, a valence band energy level and a surface Fermi energy level. The surface Fermi energy level is pinned either near or above the conduction band energy level or near or below the valence band energy level. A unipolar barrier structure is disposed in a predetermined region within the at least one p-n junction.

Abstract: Vibration sources are applied to a body or other object to image a region of interest. The mechanical vibrations introduced by the sources interfere in the region of interest to produce a crawling wave, which is detected by an ultrasound probe A relationship between crawling wave phase derivatives and local shear wave velocity is derived with phase derivatives estimated using either one-dimensional (1D) or two-dimensional (2D) autocorrelation-based techniques to image the region of interest.

Abstract: Embodiments of the invention are directed to apparatus, methods, and applications involving the actuation of a semi-insulative working fluid by electromechanical forces based on electrowetting-on-dielectric (EWOD) and liquid dielectrophoresis (liquid DEP) mechanisms that are controlled by the frequency, but not the magnitude, of an AC voltage (i.e., ‘frequency-addressable). In the various apparatus embodiments of the invention, a single, frequency-addressable electrode pair includes at least one electrode that has a spatially-varying dielectric coating thickness and thus a spatially-varying electrode gap wherein at least a portion of which a volume of a working fluid can stably reside under no influence of an applied voltage. In an exemplary aspect, a frequency-addressable, bistable apparatus includes at least one wider gap and one narrower gap associated, respectively, with a thicker and a thinner dielectric coating thickness of the electrode(s).

Abstract: Apparatus and methods for measuring a dynamic deformation characteristic of a deformable target surface during a deformation interval. The measurement principles may be applied to a large variety of organic and inorganic materials having a surface that can be deformed by an applied non-contact force. The surface may be light diffusing and non-transparent or non-diffusing and transparent. A device for measuring a dynamic deformation characteristic of an in-vivo cornea during a deformation interval includes a corneal topographer and an air puff generator that are operationally integrated. Use of the inventive device enables a method for making a measurement of a deformation characteristic of the in-vivo cornea during a deformation interval, further allowing a determination of spatially-resolved in-vivo corneal biomechanical and biodynamic properties such as corneal elasticity and corneal viscosity.

Abstract: A method for in vivo imaging of at least one cell including: first obtaining a first image of at least one cell; second obtaining a second image of the at least one cell; adjusting at least one of the first image and the second image to account for a movement of the at least one cell; generating a final image based at least in part on the adjusting.

Abstract: Apparatus and method for detecting micro-calcifications in mammograms using novel algorithms and stochastic resonance noise is provided, where a suitable dose of noise is added to the abnormal mammograms such that the performance of a suboptimal lesion detector is improved without altering the detector's parameters. A stochastic resonance noise-based detection approach is presented to improve suboptimal detectors which suffer from model mismatch due to the Gaussian assumption. Furthermore, a stochastic resonance noise-based detection enhancement framework is presented to deal with more general model mismatch cases.

Abstract: Microfabricated tools useful for manipulating small, delicate samples are formed from thin plastic films. The films have a small thickness (preferably 5 to 50 micrometers and typically 10 micrometers) and small lateral dimensions (preferably 2 mm or less and typically 0.1 to 1 mm) so that they are reasonably flexible, but are preferably curved by being wrapped around a cylindrical or flat post to give them some rigidity. The softness and thinness of the plastic reduce risk of sample damage during incidental contact with the tool. Its thinness makes it optically and X-ray transparent, so that the samples can be clearly visualized during manipulations and so that the tools can be used to collect X-ray data from samples. As an option, an X-ray sensitive phosphor is incorporated in the film at low concentration. This allows the X-ray beam to be visually located on the mount or tool.

Abstract: A light guide apparatus includes a light guide layer having a top surface and a bottom surface, and a transversely oriented side-end surface that forms an output aperture of the light guide, characterized by an index of refraction, n1, and further characterized by a length dimension in an intended light propagation direction towards the output aperture, where the intended light propagation direction is a z-axis direction of a Cartesian coordinate system; and a plurality of light injection elements disposed in the form of at least one linear strip in at least one of the top and bottom surfaces of the light guide layer, wherein some of the plurality of light injection elements are disposed on one lateral side of the strip and some other of the plurality of light injection elements are disposed on an opposing lateral side of the strip, further wherein each light injection element is disposed outwardly at a rotation angle ?z about the y-axis.