Abstract: The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below.
Type:
Grant
Filed:
November 25, 2003
Date of Patent:
January 23, 2007
Assignee:
Pfizer, Inc.
Inventors:
Robert L. Dow, Kevin K. Liu, Bradley P. Morgan, Andrew G. Swick
Abstract: The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1–R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.
Type:
Grant
Filed:
July 8, 2003
Date of Patent:
November 21, 2006
Assignees:
Pfizer, Inc., Pfizer Products, Inc.
Inventors:
Yves A. Chantigny, Edward F. Kleinman, Ralph P. Robinson