Patents Represented by Attorney, Agent or Law Firm Bruce A. Pokras
  • Patent number: 5084442
    Abstract: Linear and cyclic Growth Hormone Releasing Factor Analogs and a method for stimulating the release of Growth Hormone in subjects by administering to the subject an effective amount of the compounds of the invention.
    Type: Grant
    Filed: September 6, 1988
    Date of Patent: January 28, 1992
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur M. Felix, David C. Fry, Edgar P. Heimer, Vincent S. Madison
  • Patent number: 5082785
    Abstract: A process of producing 2-keto-L-gulonic acid from sorbose via a recombinant bacteria including expression vectors and probes for producing said recombinant bacteria.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: January 21, 1992
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ronald F. Manning, Maria S. Kahn
  • Patent number: 5075333
    Abstract: The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein n represents 1 or 2, Z represents--SR, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower alkyl, mono-lower-alkylamino, di-lower-alkylamino, mono-lower-alkylamido, or di-lower-alkylamidoand pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: December 24, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Graeme F. Bryce, Stanley S. Shapiro
  • Patent number: 5061733
    Abstract: The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinklin, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein n represents 1 or 2, Z represents --S(O)R, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl, lower-alkoxy, hydroxy, mono-lower-alkyl amino or di-lower-alkylaminoand pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: October 29, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Graeme F. Bryce, Stanley S. Shapiro
  • Patent number: 5041438
    Abstract: A method for treating viral infections in a patient with a benzodiazepine derivative compound and compositions.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: August 20, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Ming-Chu Hsu
  • Patent number: 5039805
    Abstract: The compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and arteriosclerosis as well as for the treatment of tumours.
    Type: Grant
    Filed: November 24, 1989
    Date of Patent: August 13, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Leo Alig, Albrecht Edenhofer, Marcel Muller, Arnold Trzeciak, Thomas Weller
  • Patent number: 5036101
    Abstract: A method for treating viral infections in a patient with aryl-(2-pyrryl) ketone compound and compositions.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: July 30, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ming-Chu Hsu, Steve Y. Tam
  • Patent number: 5017619
    Abstract: The invention is directed to phenethanolamine derivatives and their pharmaceutically compatible salts, having the formula ##STR1## wherein n is the number 1 or 2; L.sup.1 and L.sup.2 are hydrogen, C.sub.1-3 -(alkyl)carbonyl or C.sub.1-3 (alkoxy) carbonyl; T is hydrogen or methyl; X.sup.1 and X.sup.2 are phenyl or phenyl which is monosubstituted in the m-position by Br, Cl, F, CF.sub.3 and NO.sub.2 ; Y is --(CH.sub.2).sub.1-6 --O--G, --(CH.sub.2).sub.1-6 --CH.dbd.CH--C(O)--Z, --C(O)--Z or --CH(COOR").sub.2 ; G is C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl or --(CH.sub.2).sub.1-4 --Q; Q is phenoxy, phenyl, p-fluorophenyl or p-phenoxyphenyl; Z is a --OR or --N(R,R'); R and R' are hydrogen or C.sub.1-4 -alkyl or R and R' together with the N-atom to which they are attached form a 5- or 6-membered saturated ring which optionally contains an O-atom or an additional N-atom; and R" is C.sub.1-4 -alkyl.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: May 21, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Leo Alig, Marcel Muller
  • Patent number: 5013722
    Abstract: Cholecystokinin analogs useful for suppressing food intake in mammals and humans.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: May 7, 1991
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Waleed Danho, Vincent S. Madison, Joseph Triscari
  • Patent number: RE33887
    Abstract: A-B-C wherein A and C are each independently 2',3'dideoxynucleosides and B is a linking group; and a method of treating or preventing a retroviral injection in a subject by administering the compounds of the invention.
    Type: Grant
    Filed: November 2, 1990
    Date of Patent: April 14, 1992
    Assignees: Hoffmann-La Roche Inc., United States of America
    Inventors: Steve Tam, Manfred Weigele, Samuel Broder, Hiroaki Mitsuya