Patents Represented by Attorney Bruce J. Barclay

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  • 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
    Patent number: 4983622
    Abstract: (.+-.)-4-substitutedamino-6-alkoxy, benzyloxy, acyloxy, or hydroxy-1,3,4,5-tetrahydrobenz[c,d]indoles, pharmaceutically acceptable salts thereof, are anti-depressants.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: January 8, 1991
    Assignee: Eli Lilly and Company
    Inventor: Michael E. Flaugh
  • Processes for preparing intermediates of picenadol
    Patent number: 4931558
    Abstract: The present invention relates to processes for preparing precursors of picenadol, (.+-.)3-(1,3.alpha.-dimethyl-4.alpha.-propyl-4.beta.-piperidinyl)phenol, hydrochloride, a known analgesic. Certain of the compounds prepared by the present process are novel as well.
    Type: Grant
    Filed: January 13, 1987
    Date of Patent: June 5, 1990
    Assignee: Eli Lilly and Company
    Inventor: Charles J. Barnett
  • Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
    Patent number: 4918185
    Abstract: This invention relates to certain 3-acylamino-4-(2'-substituted or unsubstituted allyl)-azetidinone products of the formula ##STR1## wherein R.sub.12 is an acyl group;R.sub.13 is hydrogen or methoxy;R.sub.14 is hydrogen, C.sub.1 to C.sub.6 alkyl or cycloalkyl, phenyl, phenyl-C.sub.1 to C.sub.4 alkyl or (protected carboxy)-methyl; andR.sub.15 is hydrogen or an amino protecting group.
    Type: Grant
    Filed: May 19, 1988
    Date of Patent: April 17, 1990
    Assignee: Eli Lilly and Company
    Inventor: Larry C. Blaszczak
  • Method of preparing beta-2',2'-difluoronucleosides
    Patent number: 4914028
    Abstract: A process for preparing .beta.-2',2'-difluoronucleosides, and a novel intermediate thereto, are disclosed.
    Type: Grant
    Filed: February 10, 1988
    Date of Patent: April 3, 1990
    Assignee: Eli Lilly and Company
    Inventors: Larry W. Hertel, Cora Sue Grossman, Julian S. Kroin
  • Orally administerable sustained release pharmaceutical formulations
    Patent number: 4847092
    Abstract: This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.
    Type: Grant
    Filed: August 19, 1988
    Date of Patent: July 11, 1989
    Assignee: Eli Lilly and Company
    Inventors: Arvind L. Thakkar, Lowell L. Gibson
  • Phenethanolamines, compositions containing the same and method for effecting weight control
    Patent number: 4845127
    Abstract: Optically active N-3-(4-substituted phenyl)propyl-.beta.-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese animals utilizing optically active phenethanolamine is disclosed. Novel intermediates useful in the preparation of optically active .beta.-phenethanolamines are provided.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: July 4, 1989
    Assignee: Eli Lilly and Company
    Inventors: Jack Mills, Klaus K. Schmiegel, Walter N. Shaw
  • Orally administerable sustained release pharmaceutical formulations
    Patent number: 4797286
    Abstract: This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: January 10, 1989
    Assignee: Eli Lilly and Company
    Inventors: Arvind L. Thakkar, Lowell L. Gibson
  • Racemization process
    Patent number: 4777291
    Abstract: The present invention provides a process for the epimerization of (+)-N-methyl-3-(2-methylphenoxy)- 3-phenylpropylamine to its racemic form with an anion forming compound in a suitable solvent.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: October 11, 1988
    Assignee: Eli Lilly and Company
    Inventor: Jerry W. Misner
  • Injectable semi-solid formulations
    Patent number: 4775659
    Abstract: This invention provides injectable semi-solid formulations comprising a pharmaceutically or veterinary active agent, an oil and a suitable glyceride release modifying agent.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: October 4, 1988
    Assignee: Eli Lilly and Company
    Inventors: Arvind L. Thakkar, Roger G. Harrison
  • Process of making ketoalkanol esters of dihydrolysergic acid
    Patent number: 4772709
    Abstract: Ketoalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful and 5HT receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: September 20, 1988
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • Process for carbon-carbon bond formation at the C-4 position of 3-acylaminoazetidinones and products and starting materials therefor
    Patent number: 4771135
    Abstract: The invention encompasses a process for stereoselective carbon-carbon bond formation at C-4 position of a 3-(acylamino)azetidinone. The process is carried out under free radical conditions using a (2-substituted or unsubstituted allyl)tin reagent. Also encompassed by the invention are certain 4-(substituted selenyl)azetidinone starting materials and the corresponding 4-(2'-substituted or unsubstituted allyl)-azetidinone products.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: September 13, 1988
    Assignee: Eli Lilly and Company
    Inventor: Larry C. Blaszczak
  • Quantification of endogenous histamine
    Patent number: 4769322
    Abstract: A new procedure for isolating histamine N-methyltransferase in pure form has permitted the development of a new and highly sensitive radioenzymatic assay for histamine.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: September 6, 1988
    Assignee: Eli Lilly and Company
    Inventors: David P. Henry, Kenneth M. Verburg
  • Synthesis of 2-aminopyrimido[4,5-g]quinolines
    Patent number: 4764609
    Abstract: This invention provides a process for preparing trans 2-aminopyrimido[4,5-g]quinolines employing novel intermediates.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: August 16, 1988
    Assignee: Eli Lilly and Company
    Inventors: Leland O. Weigel, Gilbert S. Staten
  • Selective method for blocking 5HT2 receptors
    Patent number: 4762842
    Abstract: Method of blocking 5HT without effect on alpha receptors with 1-loweralkyl-6-straight chain alkyl-8.beta.-hydroxycycloalkyloxycarbonylergolines.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: August 9, 1988
    Assignee: Eli Lilly and Company
    Inventors: Marlene L. Cohen, Ray W. Fuller, William L. Garbrecht, Kathleen R. Whitten
  • Chewable capsules
    Patent number: 4755389
    Abstract: A hard gelatin capsule is filled with a chewable composition containing an ingredient for buccal absorption or having buccal activity.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: July 5, 1988
    Assignee: Lilly Industries Limited
    Inventors: Brian E. Jones, Paula M. Knight, Mark A. Walker
  • Sustained release tablets
    Patent number: 4753801
    Abstract: The present invention provides sustained release tablets in unit dosage form comprising an active agent which has low aqueous solubility.
    Type: Grant
    Filed: October 25, 1985
    Date of Patent: June 28, 1988
    Assignee: Eli Lilly and Company
    Inventors: Peter L. Oren, Werner M. K. Seidler
  • Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
    Patent number: 4745126
    Abstract: The present invention provides a method of treating anxiety in humans employing a 4-substituted-1,3,4,5-tetrahydrobenz[c,d]indole-6-carboxamide derivative.
    Type: Grant
    Filed: March 12, 1987
    Date of Patent: May 17, 1988
    Assignee: Eli Lilly and Company
    Inventor: J. David Leander
  • Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
    Patent number: 4714704
    Abstract: Alkoxycycloalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acids, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: December 22, 1987
    Assignee: Eli Lilly and Company
    Inventors: William L. Garbrecht, Gifford P. Marzoni, Kathleen R. Whitten
  • Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
    Patent number: 4713385
    Abstract: Alkoxy or dialkoxyalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: December 15, 1987
    Assignee: Eli Lilly and Company
    Inventors: Gifford P. Marzoni, William L. Garbrecht
  • Selective method for blocking 5HT.sub.2 receptors
    Patent number: 4713384
    Abstract: Method of blocking 5HT without effect on alpha receptors with 1-loweralkyl-6-straight chain alkyl-8.beta.-hydroxycycloalkyloxycarbonylergolines.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: December 15, 1987
    Assignee: Eli Lilly and Company
    Inventors: Marlene L. Cohen, Ray W. Fuller, William L. Garbrecht, Kathleen R. Whitten