Abstract: Novel “bispolyamine” inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. These compounds display desirable activities both for diagnostic and research assays and therapy.
Type:
Grant
Filed:
May 31, 2000
Date of Patent:
November 11, 2003
Inventors:
Nicolaas M. J. Vermeulin, Christine L. O'Day, Heather K. Webb, Mark R. Burns, Donald E. Bergstrom
Abstract: A polyol composition consisting essentially of a homogenous liquid admixture of propylene glycol and a diol obtained by alkoxylating a propylene glycol dispersion of 3,3',5,5'-tetrabromobisphenol A with ethylene oxide, propylene oxide or mixtures thereof. These polyol compositions are useful in preparing fire and chemical resistant thermosetting resinous compositions.
Abstract: A liquid detergent system wherein the active content is a combination of an anionic surfactant and a nonionic surfactant in the form of ethoxylated partial glycerol esters of a higher, detergent grade fatty acid and optionally containing a foam stabilizing agent. These systems are particularly useful for formulating shampoos and light duty liquid household cleaning compositions having low eye and skin irritation properties.
Abstract: A polyol composition consisting essentially of a homogeneous liquid or low melting solid admixture of propylene glycol and a diol obtained by alkoxylating a propylene glycol dispersion of 3,3',5,5' tetrabromobisphenol A with ethylene oxide, propylene oxide or mixtures thereof. These polyol compositions are useful in preparing fire and chemical resistant thermosetting resinous compositions.
Abstract: A liquid detergent system wherein the active content is a combination of an anionic surfactant and a nonionic surfactant in the form of alkoxylated partial glycerol esters of a detergent grade fatty acid and optionally containing a foam stabilizing agent. The indicated nonionics are characterized in having a polyoxyalkylene chain composed of randomly distributed oxyethylene and oxypropylene residues. These systems are particularly useful for formulating shampoos and light duty liquid household cleaning compositions having low eye and skin irritation properties.
Abstract: Disclosed are additives for hydrocarbon fuels which are the reaction products of a polyamine and an alkyl ester of acrylic or alkyl acrylic acid. A preferred composition is a mixture of the reaction product and oxygenated or non-oxygenated mono- or polyamines.
Abstract: 7-Ethyl-undeca-2,4-dione as a chelation collector for the liquid-liquid extraction of transition metals from dilute ammoniacal leach solutions thereof exhibits the combination of requisite physical and dynamic properties marking an industrially attractive reagent for this purpose.